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Items: 14

1.

A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.

Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV.

J Immunol. 2018 Oct 1;201(7):1907-1917. doi: 10.4049/jimmunol.1800465. Epub 2018 Aug 20.

2.

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.

Schloss J, Ali R, Racine JJ, Chapman HD, Serreze DV, DiLorenzo TP.

J Immunol. 2018 May 15;200(10):3353-3363. doi: 10.4049/jimmunol.1701652. Epub 2018 Apr 9.

3.

Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development.

Racine JJ, Stewart I, Ratiu J, Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, Roopenian D, Schloss J, DiLorenzo TP, Serreze DV.

Diabetes. 2018 May;67(5):923-935. doi: 10.2337/db17-1467. Epub 2018 Feb 22.

4.

MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice.

Zhang M, Racine JJ, Lin Q, Liu Y, Tang S, Qin Q, Qi T, Riggs AD, Zeng D.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2329-E2337. doi: 10.1073/pnas.1720169115. Epub 2018 Feb 20.

5.

Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.

Wang Q, Racine JJ, Ratiu JJ, Wang S, Ettinger R, Wasserfall C, Atkinson MA, Serreze DV.

J Immunol. 2017 Dec 1;199(11):3757-3770. doi: 10.4049/jimmunol.1700822. Epub 2017 Oct 20.

6.

Antibiotic-associated Manipulation of the Gut Microbiota and Phenotypic Restoration in NOD Mice.

Fahey JR, Lyons BL, Olekszak HL, Mourino AJ, Ratiu JJ, Racine JJ, Chapman HD, Serreze DV, Baker DL, Hendrix NK.

Comp Med. 2017 Aug 1;67(4):335-343.

7.

Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.

Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM, Serreze DV.

J Immunol. 2017 Jun 1;198(11):4255-4267. doi: 10.4049/jimmunol.1700024. Epub 2017 May 1.

8.

Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.

Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, Leeth CM, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV.

Diabetes. 2017 Mar;66(3):710-721. doi: 10.2337/db16-0846. Epub 2016 Dec 5.

9.

MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice.

Racine JJ, Zhang M, Wang M, Morales W, Shen C, Zeng D.

J Immunol. 2015 Jan 1;194(1):407-17. doi: 10.4049/jimmunol.1401584. Epub 2014 Nov 26.

10.

Administration of anti-CD20 mAb is highly effective in preventing but ineffective in treating chronic graft-versus-host disease while preserving strong graft-versus-leukemia effects.

Johnston HF, Xu Y, Racine JJ, Cassady K, Ni X, Wu T, Chan A, Forman S, Zeng D.

Biol Blood Marrow Transplant. 2014 Aug;20(8):1089-103. doi: 10.1016/j.bbmt.2014.04.028. Epub 2014 May 4.

11.

Depletion of host CCR7(+) dendritic cells prevented donor T cell tissue tropism in anti-CD3-conditioned recipients.

He W, Racine JJ, Johnston HF, Li X, Li N, Cassady K, Liu C, Deng R, Martin P, Forman S, Zeng D.

Biol Blood Marrow Transplant. 2014 Jul;20(7):920-8. doi: 10.1016/j.bbmt.2014.03.029. Epub 2014 Mar 30.

12.

Induction of mixed chimerism depletes pre-existing and de novo-developed autoreactive B cells in autoimmune NOD mice.

Racine JJ, Wang M, Zhang M, Zeng D.

Diabetes. 2014 Jun;63(6):2051-62. doi: 10.2337/db13-1532. Epub 2014 Jan 23.

13.

Mixed chimerism and growth factors augment β cell regeneration and reverse late-stage type 1 diabetes.

Wang M, Racine JJ, Song X, Li X, Nair I, Liu H, Avakian-Mansoorian A, Johnston HF, Liu C, Shen C, Atkinson M, Todorov I, Kandeel F, Forman S, Wilson B, Zeng D.

Sci Transl Med. 2012 May 9;4(133):133ra59. doi: 10.1126/scitranslmed.3003835.

14.

Induction of chimerism permits low-dose islet grafts in the liver or pancreas to reverse refractory autoimmune diabetes.

Zhang C, Wang M, Racine JJ, Liu H, Lin CL, Nair I, Lau J, Cao YA, Todorov I, Atkinson M, Zeng D.

Diabetes. 2010 Sep;59(9):2228-36. doi: 10.2337/db10-0450. Epub 2010 Jun 8.

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