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Items: 36


Heat Inactivation Renders Sputum Safe and Preserves Mycobacterium tuberculosis RNA for Downstream Molecular Tests.

Sabiiti W, Azam K, Esmeraldo E, Bhatt N, Rachow A, Gillespie SH.

J Clin Microbiol. 2019 Mar 28;57(4). pii: e01778-18. doi: 10.1128/JCM.01778-18. Print 2019 Apr.


TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - a study protocol.

Rachow A, Ivanova O, Wallis R, Charalambous S, Jani I, Bhatt N, Kampmann B, Sutherland J, Ntinginya NE, Evans D, Lönnroth K, Niemann S, Schaible UE, Geldmacher C, Sanne I, Hoelscher M, Churchyard G.

BMC Pulm Med. 2019 Jan 7;19(1):4. doi: 10.1186/s12890-018-0777-3.


Xpert MTB/RIF Ultra assay for the diagnosis of pulmonary tuberculosis in children: a multicentre comparative accuracy study.

Sabi I, Rachow A, Mapamba D, Clowes P, Ntinginya NE, Sasamalo M, Kamwela L, Haraka F, Hoelscher M, Paris DH, Saathoff E, Reither K.

J Infect. 2018 Oct;77(4):321-327. doi: 10.1016/j.jinf.2018.07.002. Epub 2018 Jul 20.


The impact of repeated NALC/NaOH- decontamination on the performance of Xpert MTB/RIF assay.

Rachow A, Saathoff E, Mtafya B, Mapamba D, Mangu C, Rojas-Ponce G, Ntinginya NE, Boeree M, Heinrich N, Gillespie SH, Hoelscher M; PanACEA-Consortium.

Tuberculosis (Edinb). 2018 May;110:56-58. doi: 10.1016/ Epub 2018 Apr 5.


First report on bla NDM-1-producing Acinetobacter baumannii in three clinical isolates from Ethiopia.

Pritsch M, Zeynudin A, Messerer M, Baumer S, Liegl G, Schubert S, Löscher T, Hoelscher M, Belachew T, Rachow A, Wieser A.

BMC Infect Dis. 2017 Mar 1;17(1):180. doi: 10.1186/s12879-017-2289-9.


Drug resistance and population structure of M.tuberculosis isolates from prisons and communities in Ethiopia.

Ali S, Beckert P, Haileamlak A, Wieser A, Pritsch M, Heinrich N, Löscher T, Hoelscher M, Niemann S, Rachow A.

BMC Infect Dis. 2016 Nov 21;16(1):687.


Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Stucki D, Brites D, Jeljeli L, Coscolla M, Liu Q, Trauner A, Fenner L, Rutaihwa L, Borrell S, Luo T, Gao Q, Kato-Maeda M, Ballif M, Egger M, Macedo R, Mardassi H, Moreno M, Tudo Vilanova G, Fyfe J, Globan M, Thomas J, Jamieson F, Guthrie JL, Asante-Poku A, Yeboah-Manu D, Wampande E, Ssengooba W, Joloba M, Henry Boom W, Basu I, Bower J, Saraiva M, Vaconcellos SEG, Suffys P, Koch A, Wilkinson R, Gail-Bekker L, Malla B, Ley SD, Beck HP, de Jong BC, Toit K, Sanchez-Padilla E, Bonnet M, Gil-Brusola A, Frank M, Penlap Beng VN, Eisenach K, Alani I, Wangui Ndung'u P, Revathi G, Gehre F, Akter S, Ntoumi F, Stewart-Isherwood L, Ntinginya NE, Rachow A, Hoelscher M, Cirillo DM, Skenders G, Hoffner S, Bakonyte D, Stakenas P, Diel R, Crudu V, Moldovan O, Al-Hajoj S, Otero L, Barletta F, Jane Carter E, Diero L, Supply P, Comas I, Niemann S, Gagneux S.

Nat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 31.


Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings.

Sabiiti W, Mtafya B, Kuchaka D, Azam K, Viegas S, Mdolo A, Farmer EC, Khonga M, Evangelopoulos D, Honeyborne I, Rachow A, Heinrich N, Ntinginya NE, Bhatt N, Davies GR, Jani IV, McHugh TD, Kibiki G, Hoelscher M, Gillespie SH; PANBIOME (Pan-African Biomarker Expansion Programme) consortium.

Int J Tuberc Lung Dis. 2016 Aug;20(8):1004-9. doi: 10.5588/ijtld.15.0951.


Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial.

Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K.

Lancet. 2016 Mar 19;387(10024):1187-97. doi: 10.1016/S0140-6736(15)01092-2. Epub 2016 Mar 10.


Pulmonary TB bacteriologically confirmed by induced sputum among children at Bugando Medical Centre, Tanzania.

Sabi I, Kabyemera R, Mshana SE, Kidenya BR, Kasanga G, Gerwing-Adima LE, Meremo A, Clowes P, Rachow A, Peck RN.

Int J Tuberc Lung Dis. 2016 Feb;20(2):228-34. doi: 10.5588/ijtld.15.0354.


Screening for pulmonary tuberculosis in a Tanzanian prison and computer-aided interpretation of chest X-rays.

Steiner A, Mangu C, van den Hombergh J, van Deutekom H, van Ginneken B, Clowes P, Mhimbira F, Mfinanga S, Rachow A, Reither K, Hoelscher M.

Public Health Action. 2015 Dec 21;5(4):249-54. doi: 10.5588/pha.15.0037.


Prevalence of Pulmonary Tuberculosis among Prison Inmates in Ethiopia, a Cross-Sectional Study.

Ali S, Haileamlak A, Wieser A, Pritsch M, Heinrich N, Loscher T, Hoelscher M, Rachow A.

PLoS One. 2015 Dec 7;10(12):e0144040. doi: 10.1371/journal.pone.0144040. eCollection 2015.


Test characteristics and potential impact of the urine LAM lateral flow assay in HIV-infected outpatients under investigation for TB and able to self-expectorate sputum for diagnostic testing.

Peter J, Theron G, Chanda D, Clowes P, Rachow A, Lesosky M, Hoelscher M, Mwaba P, Pym A, Dheda K; TB-NEAT team.

BMC Infect Dis. 2015 Jul 9;15:262. doi: 10.1186/s12879-015-0967-z.


Early Identification of Progressive TB Disease Using Host Biomarkers.

Rachow A, Heinrich N, Geldmacher C.

EBioMedicine. 2015 Jan 16;2(2):107-8. doi: 10.1016/j.ebiom.2015.01.009. eCollection 2015 Feb. Review. No abstract available.


Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study.

Theron G, Peter J, Zijenah L, Chanda D, Mangu C, Clowes P, Rachow A, Lesosky M, Hoelscher M, Pym A, Mwaba P, Mason P, Naidoo P, Pooran A, Sohn H, Pai M, Stein DJ, Dheda K.

BMC Infect Dis. 2015 Jul 1;15:253. doi: 10.1186/s12879-015-0964-2.


Performance of urine lipoarabinomannan assays for paediatric tuberculosis in Tanzania.

Kroidl I, Clowes P, Reither K, Mtafya B, Rojas-Ponce G, Ntinginya EN, Kalomo M, Minja LT, Kowuor D, Saathoff E, Kroidl A, Heinrich N, Maboko L, Bates M, O'Grady J, Zumla A, Hoelscher M, Rachow A.

Eur Respir J. 2015 Sep;46(3):761-70. doi: 10.1183/09031936.00003315. Epub 2015 Jun 25.


Maturation and Mip-1β Production of Cytomegalovirus-Specific T Cell Responses in Tanzanian Children, Adolescents and Adults: Impact by HIV and Mycobacterium tuberculosis Co-Infections.

Portevin D, Moukambi F, Mpina M, Bauer A, Haraka F, Chachage M, Metzger P, Saathoff E, Clowes P, Ntinginya NE, Rachow A, Hoelscher M, Reither K, Daubenberger CA, Geldmacher C.

PLoS One. 2015 May 14;10(5):e0126716. doi: 10.1371/journal.pone.0126716. eCollection 2015.


Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients.

Heinrich N, Dawson R, du Bois J, Narunsky K, Horwith G, Phipps AJ, Nacy CA, Aarnoutse RE, Boeree MJ, Gillespie SH, Venter A, Henne S, Rachow A, Phillips PP, Hoelscher M, Diacon AH; Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA); Pan African Consortium for the Evaluation of Antituberculosis Antibiotics PanACEA.

J Antimicrob Chemother. 2015 May;70(5):1558-66. doi: 10.1093/jac/dku553. Epub 2015 Jan 27.


Ascertaining in vivo virulence of Mycobacterium tuberculosis lineages in patients in Mbeya, Tanzania.

Olaru ID, Rachow A, Lange C, Ntinginya NE, Reither K, Hoelscher M, Vollrath O, Niemann S.

Int J Tuberc Lung Dis. 2015 Jan;19(1):70-3. doi: 10.5588/ijtld.14.0403.


The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations.

Bowness R, Boeree MJ, Aarnoutse R, Dawson R, Diacon A, Mangu C, Heinrich N, Ntinginya NE, Kohlenberg A, Mtafya B, Phillips PP, Rachow A, Plemper van Balen G, Gillespie SH.

J Antimicrob Chemother. 2015 Feb;70(2):448-55. doi: 10.1093/jac/dku415. Epub 2014 Oct 25.


Xpert MTB/RIF assay for diagnosis of pulmonary tuberculosis in children: a prospective, multi-centre evaluation.

Reither K, Manyama C, Clowes P, Rachow A, Mapamba D, Steiner A, Ross A, Mfinanga E, Sasamalo M, Nsubuga M, Aloi F, Cirillo D, Jugheli L, Lwilla F.

J Infect. 2015 Apr;70(4):392-9. doi: 10.1016/j.jinf.2014.10.003. Epub 2014 Oct 13.


Assessment of the novel T-cell activation marker-tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study.

Portevin D, Moukambi F, Clowes P, Bauer A, Chachage M, Ntinginya NE, Mfinanga E, Said K, Haraka F, Rachow A, Saathoff E, Mpina M, Jugheli L, Lwilla F, Marais BJ, Hoelscher M, Daubenberger C, Reither K, Geldmacher C.

Lancet Infect Dis. 2014 Oct;14(10):931-8. doi: 10.1016/S1473-3099(14)70884-9. Epub 2014 Aug 31.


The molecular bacterial load assay replaces solid culture for measuring early bactericidal response to antituberculosis treatment.

Honeyborne I, Mtafya B, Phillips PP, Hoelscher M, Ntinginya EN, Kohlenberg A, Rachow A, Rojas-Ponce G, McHugh TD, Heinrich N; Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics.

J Clin Microbiol. 2014 Aug;52(8):3064-7. doi: 10.1128/JCM.01128-14. Epub 2014 May 28.


Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment.

Friedrich SO, Rachow A, Saathoff E, Singh K, Mangu CD, Dawson R, Phillips PP, Venter A, Bateson A, Boehme CC, Heinrich N, Hunt RD, Boeree MJ, Zumla A, McHugh TD, Gillespie SH, Diacon AH, Hoelscher M; Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics (PanACEA).

Lancet Respir Med. 2013 Aug;1(6):462-70. doi: 10.1016/S2213-2600(13)70119-X. Epub 2013 Jul 1.


Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population.

Kroidl I, Clowes P, Mwakyelu J, Maboko L, Kiangi A, Rachow A, Reither K, Jung J, Nsojo A, Saathoff E, Hoelscher M.

Scand J Infect Dis. 2014 Feb;46(2):144-8. doi: 10.3109/00365548.2013.853133. Epub 2013 Nov 25.


A continuously monitored colorimetric method for detection of Mycobacterium tuberculosis complex in sputum.

Rojas-Ponce G, Rachow A, Guerra H, Mapamba D, Joseph J, Mlundi R, Marimoto S, Ntinginya NE, Mangu C, Framhein A, Butler A, Kohlenberg A, Ngatemelela D, Froeschl G, Maboko L, Hoelscher M, Heinrich N.

Int J Tuberc Lung Dis. 2013 Dec;17(12):1607-12. doi: 10.5588/ijtld.13.0317.


Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial.

Theron G, Zijenah L, Chanda D, Clowes P, Rachow A, Lesosky M, Bara W, Mungofa S, Pai M, Hoelscher M, Dowdy D, Pym A, Mwaba P, Mason P, Peter J, Dheda K; TB-NEAT team.

Lancet. 2014 Feb 1;383(9915):424-35. doi: 10.1016/S0140-6736(13)62073-5. Epub 2013 Oct 28.


Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study.

Bates M, O'Grady J, Maeurer M, Tembo J, Chilukutu L, Chabala C, Kasonde R, Mulota P, Mzyece J, Chomba M, Mukonda L, Mumba M, Kapata N, Rachow A, Clowes P, Hoelscher M, Mwaba P, Zumla A.

Lancet Infect Dis. 2013 Jan;13(1):36-42. doi: 10.1016/S1473-3099(12)70245-1. Epub 2012 Nov 5.


Performance of the Xpert® MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania.

Ntinginya EN, Squire SB, Millington KA, Mtafya B, Saathoff E, Heinrich N, Rojas-Ponce G, Kowuor D, Maboko L, Reither K, Clowes P, Hoelscher M, Rachow A.

Int J Tuberc Lung Dis. 2012 Nov;16(11):1468-70. doi: 10.5588/ijtld.12.0127. Epub 2012 Sep 7.


Evaluation of the burden of unsuspected pulmonary tuberculosis and co-morbidity with non-communicable diseases in sputum producing adult inpatients.

Bates M, O'Grady J, Mwaba P, Chilukutu L, Mzyece J, Cheelo B, Chilufya M, Mukonda L, Mumba M, Tembo J, Chomba M, Kapata N, Rachow A, Clowes P, Maeurer M, Hoelscher M, Zumla A.

PLoS One. 2012;7(7):e40774. doi: 10.1371/journal.pone.0040774. Epub 2012 Jul 27.


Evaluation of the Xpert MTB/RIF assay at a tertiary care referral hospital in a setting where tuberculosis and HIV infection are highly endemic.

O'Grady J, Bates M, Chilukutu L, Mzyece J, Cheelo B, Chilufya M, Mukonda L, Mumba M, Tembo J, Chomba M, Kapata N, Maeurer M, Rachow A, Clowes P, Hoelscher M, Mwaba P, Zumla A.

Clin Infect Dis. 2012 Nov;55(9):1171-8. doi: 10.1093/cid/cis631. Epub 2012 Jul 17. Erratum in: Clin Infect Dis. 2013 Jan;56(2):313.


Increased and expedited case detection by Xpert MTB/RIF assay in childhood tuberculosis: a prospective cohort study.

Rachow A, Clowes P, Saathoff E, Mtafya B, Michael E, Ntinginya EN, Kowour D, Rojas-Ponce G, Kroidl A, Maboko L, Heinrich N, Reither K, Hoelscher M.

Clin Infect Dis. 2012 May;54(10):1388-96. doi: 10.1093/cid/cis190. Epub 2012 Apr 3.


Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo.

Schuetz A, Haule A, Reither K, Ngwenyama N, Rachow A, Meyerhans A, Maboko L, Koup RA, Hoelscher M, Geldmacher C.

PLoS One. 2011;6(11):e27284. doi: 10.1371/journal.pone.0027284. Epub 2011 Nov 7.


Rapid and accurate detection of Mycobacterium tuberculosis in sputum samples by Cepheid Xpert MTB/RIF assay--a clinical validation study.

Rachow A, Zumla A, Heinrich N, Rojas-Ponce G, Mtafya B, Reither K, Ntinginya EN, O'Grady J, Huggett J, Dheda K, Boehme C, Perkins M, Saathoff E, Hoelscher M.

PLoS One. 2011;6(6):e20458. doi: 10.1371/journal.pone.0020458. Epub 2011 Jun 29.


Rapid molecular detection of tuberculosis.

Heinrich N, Rachow A, Hoelscher M.

N Engl J Med. 2011 Jan 13;364(2):182; author reply 184-5. doi: 10.1056/NEJMc1011919. No abstract available.


Homogeneous hepatitis A virus particles. Proteolytic release of the assembly signal 2A from procapsids by factor Xa.

Rachow A, Gauss-Müller V, Probst C.

J Biol Chem. 2003 Aug 8;278(32):29744-51. Epub 2003 Jun 2.

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