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Items: 1 to 50 of 197

1.

Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy.

Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE, Gangjee A, Matherly LH.

Mol Cancer Ther. 2019 Jul 9. pii: molcanther.0037.2019. doi: 10.1158/1535-7163.MCT-19-0037. [Epub ahead of print]

PMID:
31289137
2.

Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity.

Liu Q, Johnson EM, Lam RK, Wang Q, Bo Ye H, Wilson EN, Minhas PS, Liu L, Swarovski MS, Tran S, Wang J, Mehta SS, Yang X, Rabinowitz JD, Yang SS, Shamloo M, Mueller C, James ML, Andreasson KI.

Nat Immunol. 2019 Jul 1. doi: 10.1038/s41590-019-0421-2. [Epub ahead of print]

PMID:
31263278
3.

Metabolite Exchange between Mammalian Organs Quantified in Pigs.

Jang C, Hui S, Zeng X, Cowan AJ, Wang L, Chen L, Morscher RJ, Reyes J, Frezza C, Hwang HY, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido GA 2nd, Gorman JH 3rd, Gorman RC, Rabinowitz JD.

Cell Metab. 2019 Jun 26. pii: S1550-4131(19)30305-5. doi: 10.1016/j.cmet.2019.06.002. [Epub ahead of print]

PMID:
31257152
4.

Energy budget of Drosophila embryogenesis.

Song Y, Park JO, Tanner L, Nagano Y, Rabinowitz JD, Shvartsman SY.

Curr Biol. 2019 Jun 17;29(12):R566-R567. doi: 10.1016/j.cub.2019.05.025.

PMID:
31211973
5.

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism.

Schober AF, Mathis AD, Ingle C, Park JO, Chen L, Rabinowitz JD, Junier I, Rivoire O, Reynolds KA.

Cell Rep. 2019 Jun 11;27(11):3359-3370.e7. doi: 10.1016/j.celrep.2019.05.030.

6.

The Tumor Metabolic Microenvironment: Lessons from Lactate.

García-Cañaveras JC, Chen L, Rabinowitz JD.

Cancer Res. 2019 Jul 1;79(13):3155-3162. doi: 10.1158/0008-5472.CAN-18-3726. Epub 2019 Jun 6. Review.

PMID:
31171526
7.

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.

Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P.

Cell Metab. 2019 Jul 2;30(1):174-189.e5. doi: 10.1016/j.cmet.2019.05.005. Epub 2019 May 30.

PMID:
31155495
8.

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.

Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD.

Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11.

PMID:
31058257
9.

Minor Isozymes Tailor Yeast Metabolism to Carbon Availability.

Bradley PH, Gibney PA, Botstein D, Troyanskaya OG, Rabinowitz JD.

mSystems. 2019 Feb 26;4(1). pii: e00170-18. doi: 10.1128/mSystems.00170-18. eCollection 2019 Jan-Feb.

10.

Serine Metabolism Supports Macrophage IL-1β Production.

Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS.

Cell Metab. 2019 Apr 2;29(4):1003-1011.e4. doi: 10.1016/j.cmet.2019.01.014. Epub 2019 Feb 14.

PMID:
30773464
11.

Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics.

Wang L, Xing X, Chen L, Yang L, Su X, Rabitz H, Lu W, Rabinowitz JD.

Anal Chem. 2019 Feb 5;91(3):1838-1846. doi: 10.1021/acs.analchem.8b03132. Epub 2019 Jan 10.

PMID:
30586294
12.

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.

Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13347-13352. doi: 10.1073/pnas.1804149115. Epub 2018 Dec 10.

13.

Author Correction: Autophagy maintains tumour growth through circulating arginine.

Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, Rabinowitz JD, White E.

Nature. 2019 Jan;565(7737):E3. doi: 10.1038/s41586-018-0815-6.

PMID:
30523330
14.

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.

Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz JD, Andreasson KI.

Nat Immunol. 2019 Jan;20(1):50-63. doi: 10.1038/s41590-018-0255-3. Epub 2018 Nov 26.

PMID:
30478397
15.

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids.

Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z.

Cell Metab. 2019 Feb 5;29(2):417-429.e4. doi: 10.1016/j.cmet.2018.10.013. Epub 2018 Nov 15.

PMID:
30449684
16.

Autophagy maintains tumour growth through circulating arginine.

Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, Rabinowitz JD, White E.

Nature. 2018 Nov;563(7732):569-573. doi: 10.1038/s41586-018-0697-7. Epub 2018 Nov 14. Erratum in: Nature. 2018 Dec 6;:.

17.

Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase.

Xu YF, Lu W, Chen JC, Johnson SA, Gibney PA, Thomas DG, Brown G, May AL, Campagna SR, Yakunin AF, Botstein D, Rabinowitz JD.

ACS Chem Biol. 2018 Oct 19;13(10):3011-3020. doi: 10.1021/acschembio.8b00804. Epub 2018 Oct 4.

PMID:
30240188
18.

An unexpected trigger for calorie burning in brown fat.

Hui S, Rabinowitz JD.

Nature. 2018 Aug;560(7716):38-39. doi: 10.1038/d41586-018-05619-7. No abstract available.

PMID:
30061641
19.

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.

Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA.

Cell. 2018 Aug 9;174(4):831-842.e12. doi: 10.1016/j.cell.2018.06.031. Epub 2018 Jul 26.

PMID:
30057115
20.

Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions.

Li SH, Li Z, Park JO, King CG, Rabinowitz JD, Wingreen NS, Gitai Z.

Nat Microbiol. 2018 Aug;3(8):939-947. doi: 10.1038/s41564-018-0199-2. Epub 2018 Jul 23.

21.

5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination.

Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT; Undiagnosed Diseases Network (UDN).

Mol Genet Metab. 2018 Sep;125(1-2):118-126. doi: 10.1016/j.ymgme.2018.06.006. Epub 2018 Jun 15.

PMID:
30031689
22.

Four Key Steps Control Glycolytic Flux in Mammalian Cells.

Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD.

Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27.

PMID:
29960885
23.

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ.

Nat Med. 2018 Sep;24(9):1482. doi: 10.1038/s41591-018-0047-1.

PMID:
29895835
24.

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.

Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA.

Elife. 2018 Jun 12;7. pii: e33246. doi: 10.7554/eLife.33246.

25.

Ribosomes on the night shift.

Nofal M, Rabinowitz JD.

Science. 2018 May 18;360(6390):710-711. doi: 10.1126/science.aat7121. No abstract available.

PMID:
29773733
26.

Metabolomics and Isotope Tracing.

Jang C, Chen L, Rabinowitz JD.

Cell. 2018 May 3;173(4):822-837. doi: 10.1016/j.cell.2018.03.055. Review.

27.

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD.

Cell Metab. 2018 May 1;27(5):1067-1080.e5. doi: 10.1016/j.cmet.2018.03.018.

28.

Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ.

Nat Med. 2018 May;24(4):518-524. doi: 10.1038/nm.4514. Epub 2018 Mar 26. Erratum in: Nat Med. 2018 Jun 12;:.

29.

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.

Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR.

J Clin Invest. 2018 Jun 1;128(6):2226-2238. doi: 10.1172/JCI94427. Epub 2018 Apr 23.

30.

Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape.

Lin KC, Torga G, Wu A, Rabinowitz JD, Murray WJ, Sturm JC, Pienta KJ, Austin R.

Converg Sci Phys Oncol. 2017 Dec;3(4). pii: 045001. Epub 2017 Aug 30.

31.

Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.

Gibney PA, Schieler A, Chen JC, Bacha-Hummel JM, Botstein M, Volpe M, Silverman SJ, Xu Y, Bennett BD, Rabinowitz JD, Botstein D.

Mol Biol Cell. 2018 Apr 15;29(8):897-910. doi: 10.1091/mbc.E17-11-0666. Epub 2018 Mar 30.

32.

Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.

McKee SE, Zhang S, Chen L, Rabinowitz JD, Reyes TM.

J Neurochem. 2018 Jun;145(5):362-373. doi: 10.1111/jnc.14319. Epub 2018 Apr 16.

33.

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.

Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD.

Cell Metab. 2018 Feb 6;27(2):351-361.e3. doi: 10.1016/j.cmet.2017.12.016.

34.

Mitochondrial translation requires folate-dependent tRNA methylation.

Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD.

Nature. 2018 Feb 1;554(7690):128-132. doi: 10.1038/nature25460. Epub 2018 Jan 24.

35.

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.

Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J.

Cell Metab. 2018 Feb 6;27(2):428-438.e5. doi: 10.1016/j.cmet.2017.12.006. Epub 2018 Jan 11.

36.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J.

Cell. 2017 Dec 14;171(7):1545-1558.e18. doi: 10.1016/j.cell.2017.10.037. Epub 2017 Nov 16.

37.

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.

Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9.

38.

Glucose feeds the TCA cycle via circulating lactate.

Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan, Yanxiang Guo J, White E, Rabinowitz JD.

Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. Epub 2017 Oct 18.

39.

Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR.

Wooldridge AL, Bischof RJ, Liu H, Heinemann GK, Hunter DS, Giles LC, Simmons RA, Lien YC, Lu W, Rabinowitz JD, Kind KL, Owens JA, Clifton VL, Gatford KL.

Am J Physiol Regul Integr Comp Physiol. 2018 Jan 1;314(1):R22-R33. doi: 10.1152/ajpregu.00549.2016. Epub 2017 Oct 4.

40.

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.

Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader DJ.

Am J Hum Genet. 2017 Oct 5;101(4):489-502. doi: 10.1016/j.ajhg.2017.08.008. Epub 2017 Sep 21.

41.

PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.

Liu LX, Rowe GC, Yang S, Li J, Damilano F, Chan MC, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann BK, Rabinowitz JD, Das S, Rosenzweig A, Arany Z.

Circ Res. 2017 Dec 8;121(12):1370-1378. doi: 10.1161/CIRCRESAHA.117.311456. Epub 2017 Sep 19.

42.

mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.

Nofal M, Zhang K, Han S, Rabinowitz JD.

Mol Cell. 2017 Sep 21;67(6):936-946.e5. doi: 10.1016/j.molcel.2017.08.011. Epub 2017 Sep 14.

43.

Chemical Basis for Deuterium Labeling of Fat and NADPH.

Zhang Z, Chen L, Liu L, Su X, Rabinowitz JD.

J Am Chem Soc. 2017 Oct 18;139(41):14368-14371. doi: 10.1021/jacs.7b08012. Epub 2017 Oct 4.

44.

Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ.

Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004.

45.

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate.

Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD.

Nat Chem Biol. 2017 Oct;13(10):1081-1087. doi: 10.1038/nchembio.2453. Epub 2017 Aug 7.

46.

An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate.

Chen L, Ducker GS, Lu W, Teng X, Rabinowitz JD.

Anal Bioanal Chem. 2017 Oct;409(25):5955-5964. doi: 10.1007/s00216-017-0514-4. Epub 2017 Aug 10.

47.

Dynamic Control of dNTP Synthesis in Early Embryos.

Song Y, Marmion RA, Park JO, Biswas D, Rabinowitz JD, Shvartsman SY.

Dev Cell. 2017 Aug 7;42(3):301-308.e3. doi: 10.1016/j.devcel.2017.06.013. Epub 2017 Jul 20.

48.

Metabolite Measurement: Pitfalls to Avoid and Practices to Follow.

Lu W, Su X, Klein MS, Lewis IA, Fiehn O, Rabinowitz JD.

Annu Rev Biochem. 2017 Jun 20;86:277-304. doi: 10.1146/annurev-biochem-061516-044952. Review.

49.

Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.

Rajeshkumar NV, Yabuuchi S, Pai SG, De Oliveira E, Kamphorst JJ, Rabinowitz JD, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang CV.

Clin Cancer Res. 2017 Sep 15;23(18):5639-5647. doi: 10.1158/1078-0432.CCR-17-1115. Epub 2017 Jun 13.

50.

Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle.

Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang CC, Qian J, Lie N, Lanzillotta C, Rabinowitz JD, Sun Z.

Mol Cell Endocrinol. 2018 Aug 15;471:22-32. doi: 10.1016/j.mce.2017.05.024. Epub 2017 May 26. Review.

PMID:
28554803

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