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Items: 1 to 50 of 181

1.

Discovery and functional characterization of a yeast sugar alcohol phosphatase.

Xu YF, Lu W, Chen JC, Johnson SA, Gibney PA, Thomas DG, Brown G, May AL, Campagna SR, Yakunin AF, Botstein D, Rabinowitz JD.

ACS Chem Biol. 2018 Sep 21. doi: 10.1021/acschembio.8b00804. [Epub ahead of print]

PMID:
30240188
2.

An unexpected trigger for calorie burning in brown fat.

Hui S, Rabinowitz JD.

Nature. 2018 Aug;560(7716):38-39. doi: 10.1038/d41586-018-05619-7. No abstract available.

PMID:
30061641
3.

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.

Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA.

Cell. 2018 Aug 9;174(4):831-842.e12. doi: 10.1016/j.cell.2018.06.031. Epub 2018 Jul 26.

PMID:
30057115
4.

Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions.

Li SH, Li Z, Park JO, King CG, Rabinowitz JD, Wingreen NS, Gitai Z.

Nat Microbiol. 2018 Aug;3(8):939-947. doi: 10.1038/s41564-018-0199-2. Epub 2018 Jul 23.

PMID:
30038306
5.

5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination.

Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT; Undiagnosed Diseases Network (UDN).

Mol Genet Metab. 2018 Jun 15. pii: S1096-7192(18)30114-8. doi: 10.1016/j.ymgme.2018.06.006. [Epub ahead of print]

PMID:
30031689
6.

Four Key Steps Control Glycolytic Flux in Mammalian Cells.

Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD.

Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27.

PMID:
29960885
7.

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ.

Nat Med. 2018 Jun 12. doi: 10.1038/s41591-018-0047-1. [Epub ahead of print]

PMID:
29895835
8.

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.

Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA.

Elife. 2018 Jun 12;7. pii: e33246. doi: 10.7554/eLife.33246.

9.

Ribosomes on the night shift.

Nofal M, Rabinowitz JD.

Science. 2018 May 18;360(6390):710-711. doi: 10.1126/science.aat7121. No abstract available.

PMID:
29773733
10.

Metabolomics and Isotope Tracing.

Jang C, Chen L, Rabinowitz JD.

Cell. 2018 May 3;173(4):822-837. doi: 10.1016/j.cell.2018.03.055. Review.

PMID:
29727671
11.

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD.

Cell Metab. 2018 May 1;27(5):1067-1080.e5. doi: 10.1016/j.cmet.2018.03.018.

PMID:
29685734
12.

Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ.

Nat Med. 2018 May;24(4):518-524. doi: 10.1038/nm.4514. Epub 2018 Mar 26. Erratum in: Nat Med. 2018 Jun 12;:.

PMID:
29578539
13.

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.

Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR.

J Clin Invest. 2018 Jun 1;128(6):2226-2238. doi: 10.1172/JCI94427. Epub 2018 Apr 23.

14.

Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape.

Lin KC, Torga G, Wu A, Rabinowitz JD, Murray WJ, Sturm JC, Pienta KJ, Austin R.

Converg Sci Phys Oncol. 2017 Dec;3(4). pii: 045001. Epub 2017 Aug 30.

15.

Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.

Gibney PA, Schieler A, Chen JC, Bacha-Hummel JM, Botstein M, Volpe M, Silverman SJ, Xu Y, Bennett BD, Rabinowitz JD, Botstein D.

Mol Biol Cell. 2018 Apr 15;29(8):897-910. doi: 10.1091/mbc.E17-11-0666. Epub 2018 Mar 30.

16.

Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.

McKee SE, Zhang S, Chen L, Rabinowitz JD, Reyes TM.

J Neurochem. 2018 Jun;145(5):362-373. doi: 10.1111/jnc.14319. Epub 2018 Apr 16.

PMID:
29423909
17.

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.

Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD.

Cell Metab. 2018 Feb 6;27(2):351-361.e3. doi: 10.1016/j.cmet.2017.12.016.

PMID:
29414685
18.

Mitochondrial translation requires folate-dependent tRNA methylation.

Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD.

Nature. 2018 Feb 1;554(7690):128-132. doi: 10.1038/nature25460. Epub 2018 Jan 24.

19.

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.

Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J.

Cell Metab. 2018 Feb 6;27(2):428-438.e5. doi: 10.1016/j.cmet.2017.12.006. Epub 2018 Jan 11.

PMID:
29337136
20.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J.

Cell. 2017 Dec 14;171(7):1545-1558.e18. doi: 10.1016/j.cell.2017.10.037. Epub 2017 Nov 16.

PMID:
29153836
21.

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.

Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9.

22.

Glucose feeds the TCA cycle via circulating lactate.

Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan, Yanxiang Guo J, White E, Rabinowitz JD.

Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. Epub 2017 Oct 18.

23.

Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR.

Wooldridge AL, Bischof RJ, Liu H, Heinemann GK, Hunter DS, Giles LC, Simmons RA, Lien YC, Lu W, Rabinowitz JD, Kind KL, Owens JA, Clifton VL, Gatford KL.

Am J Physiol Regul Integr Comp Physiol. 2018 Jan 1;314(1):R22-R33. doi: 10.1152/ajpregu.00549.2016. Epub 2017 Oct 4.

24.

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.

Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader DJ.

Am J Hum Genet. 2017 Oct 5;101(4):489-502. doi: 10.1016/j.ajhg.2017.08.008. Epub 2017 Sep 21.

25.

PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.

Liu LX, Rowe GC, Yang S, Li J, Damilano F, Chan MC, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann BK, Rabinowitz JD, Das S, Rosenzweig A, Arany Z.

Circ Res. 2017 Dec 8;121(12):1370-1378. doi: 10.1161/CIRCRESAHA.117.311456. Epub 2017 Sep 19.

PMID:
28928113
26.

mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.

Nofal M, Zhang K, Han S, Rabinowitz JD.

Mol Cell. 2017 Sep 21;67(6):936-946.e5. doi: 10.1016/j.molcel.2017.08.011. Epub 2017 Sep 14.

27.

Chemical Basis for Deuterium Labeling of Fat and NADPH.

Zhang Z, Chen L, Liu L, Su X, Rabinowitz JD.

J Am Chem Soc. 2017 Oct 18;139(41):14368-14371. doi: 10.1021/jacs.7b08012. Epub 2017 Oct 4.

PMID:
28911221
28.

Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ.

Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004.

29.

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate.

Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD.

Nat Chem Biol. 2017 Oct;13(10):1081-1087. doi: 10.1038/nchembio.2453. Epub 2017 Aug 7.

30.

An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate.

Chen L, Ducker GS, Lu W, Teng X, Rabinowitz JD.

Anal Bioanal Chem. 2017 Oct;409(25):5955-5964. doi: 10.1007/s00216-017-0514-4. Epub 2017 Aug 10.

PMID:
28799108
31.

Dynamic Control of dNTP Synthesis in Early Embryos.

Song Y, Marmion RA, Park JO, Biswas D, Rabinowitz JD, Shvartsman SY.

Dev Cell. 2017 Aug 7;42(3):301-308.e3. doi: 10.1016/j.devcel.2017.06.013. Epub 2017 Jul 20.

32.

Metabolite Measurement: Pitfalls to Avoid and Practices to Follow.

Lu W, Su X, Klein MS, Lewis IA, Fiehn O, Rabinowitz JD.

Annu Rev Biochem. 2017 Jun 20;86:277-304. doi: 10.1146/annurev-biochem-061516-044952. Review.

33.

Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.

Rajeshkumar NV, Yabuuchi S, Pai SG, De Oliveira E, Kamphorst JJ, Rabinowitz JD, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang CV.

Clin Cancer Res. 2017 Sep 15;23(18):5639-5647. doi: 10.1158/1078-0432.CCR-17-1115. Epub 2017 Jun 13.

34.

Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle.

Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang CC, Qian J, Lie N, Lanzillotta C, Rabinowitz JD, Sun Z.

Mol Cell Endocrinol. 2018 Aug 15;471:22-32. doi: 10.1016/j.mce.2017.05.024. Epub 2017 May 26. Review.

PMID:
28554803
35.

A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae.

Choi J, Rajagopal A, Xu YF, Rabinowitz JD, O'Shea EK.

PLoS One. 2017 May 17;12(5):e0176085. doi: 10.1371/journal.pone.0176085. eCollection 2017.

36.

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors.

Lu W, Wang L, Chen L, Hui S, Rabinowitz JD.

Antioxid Redox Signal. 2018 Jan 20;28(3):167-179. doi: 10.1089/ars.2017.7014. Epub 2017 Jul 19.

PMID:
28497978
37.

Metabolite Spectral Accuracy on Orbitraps.

Su X, Lu W, Rabinowitz JD.

Anal Chem. 2017 Jun 6;89(11):5940-5948. doi: 10.1021/acs.analchem.7b00396. Epub 2017 May 18.

38.

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.

Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG.

Nat Med. 2017 Feb;23(2):235-241. doi: 10.1038/nm.4256. Epub 2016 Dec 26.

39.

Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion.

Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z.

Nat Med. 2017 Feb;23(2):223-234. doi: 10.1038/nm.4245. Epub 2016 Dec 19.

40.

Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.

Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA.

Cell Metab. 2016 Dec 13;24(6):863-874. doi: 10.1016/j.cmet.2016.10.012. Epub 2016 Nov 17.

41.

Systems-level analysis of mechanisms regulating yeast metabolic flux.

Hackett SR, Zanotelli VR, Xu W, Goya J, Park JO, Perlman DH, Gibney PA, Botstein D, Storey JD, Rabinowitz JD.

Science. 2016 Oct 28;354(6311). pii: aaf2786. Epub 2016 Oct 27.

42.

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD.

Cell Metab. 2016 Oct 11;24(4):640-641. doi: 10.1016/j.cmet.2016.09.011. No abstract available.

43.

One-Carbon Metabolism in Health and Disease.

Ducker GS, Rabinowitz JD.

Cell Metab. 2017 Jan 10;25(1):27-42. doi: 10.1016/j.cmet.2016.08.009. Epub 2016 Sep 15. Review.

44.

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.

Moloughney JG, Kim PK, Vega-Cotto NM, Wu CC, Zhang S, Adlam M, Lynch T, Chou PC, Rabinowitz JD, Werlen G, Jacinto E.

Mol Cell. 2016 Sep 1;63(5):811-26. doi: 10.1016/j.molcel.2016.07.015. Epub 2016 Aug 25.

45.
46.

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.

Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E.

Genes Dev. 2016 Aug 1;30(15):1704-17. doi: 10.1101/gad.283416.116. Epub 2016 Aug 11.

47.

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.

Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA.

Cell Metab. 2016 Aug 9;24(2):269-82. doi: 10.1016/j.cmet.2016.07.005.

48.

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC.

Cell Metab. 2016 Jul 12;24(1):104-17. doi: 10.1016/j.cmet.2016.06.007.

49.

Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis.

Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD.

ACS Chem Biol. 2016 Sep 16;11(9):2420-7. doi: 10.1021/acschembio.6b00290. Epub 2016 Jul 7.

50.

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.

Titchenell PM, Quinn WJ, Lu M, Chu Q, Lu W, Li C, Chen H, Monks BR, Chen J, Rabinowitz JD, Birnbaum MJ.

Cell Metab. 2016 Jun 14;23(6):1154-1166. doi: 10.1016/j.cmet.2016.04.022. Epub 2016 May 26.

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