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Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment.

Quarles E, Basisty N, Chiao YA, Merrihew G, Gu H, Sweetwyne MT, Fredrickson J, Nguyen NH, Razumova M, Kooiker K, Moussavi-Harami F, Regnier M, Quarles C, MacCoss M, Rabinovitch PS.

Aging Cell. 2019 Dec 10:e13086. doi: 10.1111/acel.13086. [Epub ahead of print]


Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure.

Dai DF, Liu Y, Basisty N, Karunadharma P, Dastidar SG, Chiao YA, Chen T, Beyer RP, Chin MT, Maccoss M, La Spada AR, Rabinovitch PS.

Geroscience. 2019 Oct 24. doi: 10.1007/s11357-019-00119-6. [Epub ahead of print]


DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease.

Wen KW, Umetsu SE, Goldblum JR, Gill RM, Kim GE, Joseph NM, Rabinovitch PS, Kakar S, Lauwers GY, Choi WT.

Histopathology. 2019 Oct;75(4):578-588. doi: 10.1111/his.13923. Epub 2019 Aug 13.


Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue.

Wen KW, Kim GE, Rabinovitch PS, Wang D, Mattis AN, Choi WT.

Mod Pathol. 2019 Sep;32(9):1291-1302. doi: 10.1038/s41379-019-0272-2. Epub 2019 Apr 11.


Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice.

Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Merrihew GE, Egertson JD, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, MacCoss MJ, Qian WJ, Marcinek DJ.

Free Radic Biol Med. 2019 Apr;134:268-281. doi: 10.1016/j.freeradbiomed.2018.12.031. Epub 2018 Dec 28.


Utility of DNA Flow Cytometric Analysis of Paraffin-embedded Tissue in the Risk Stratification and Management of 'Indefinite for dysplasia' in Patients With Inflammatory Bowel Disease.

Wen KW, Rabinovitch PS, Wang D, Huang D, Mattis AN, Choi WT.

J Crohns Colitis. 2019 Mar 30;13(4):472-481. doi: 10.1093/ecco-jcc/jjy193.


Identifying ubiquitinated proteins and aggregates.

Basisty N, Schilling B, Rabinovitch PS.

Aging (Albany NY). 2018 Oct 18;10(10):2549-2550. doi: 10.18632/aging.101605. No abstract available.


Heart specific knockout of Ndufs4 ameliorates ischemia reperfusion injury.

Zhang H, Gong G, Wang P, Zhang Z, Kolwicz SC, Rabinovitch PS, Tian R, Wang W.

J Mol Cell Cardiol. 2018 Oct;123:38-45. doi: 10.1016/j.yjmcc.2018.08.022. Epub 2018 Aug 27.


Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.

Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT.

Mod Pathol. 2018 Oct;31(10):1578-1587. doi: 10.1038/s41379-018-0062-2. Epub 2018 May 22.


DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas.

Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM.

Histopathology. 2018 Sep;73(3):464-472. doi: 10.1111/his.13652. Epub 2018 Jun 28.


Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.

Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Fulop GA, Hertelendy P, Gautam T, Farkas E, Perz A, Rabinovitch PS, Sonntag WE, Csiszar A, Ungvari Z.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12731. Epub 2018 Feb 6.


Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment.

Basisty NB, Liu Y, Reynolds J, Karunadharma PP, Dai DF, Fredrickson J, Beyer RP, MacCoss MJ, Rabinovitch PS.

J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):561-570. doi: 10.1093/gerona/glx047.


Rapamycin treatment attenuates age-associated periodontitis in mice.

An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M.

Geroscience. 2017 Aug;39(4):457-463. doi: 10.1007/s11357-017-9994-6. Epub 2017 Sep 9.


Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease.

Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi WT.

Gastroenterology. 2017 Dec;153(6):1492-1495.e4. doi: 10.1053/j.gastro.2017.08.031. Epub 2017 Aug 24.


Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue.

Choi WT, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S.

Gut. 2018 Jul;67(7):1229-1238. doi: 10.1136/gutjnl-2017-313815. Epub 2017 Jun 22.


Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.

Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT.

Diabetes. 2017 Aug;66(8):2072-2081. doi: 10.2337/db16-1334. Epub 2017 May 5.


Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models.

Dai DF, Chiao YA, Martin GM, Marcinek DJ, Basisty N, Quarles EK, Rabinovitch PS.

Prog Mol Biol Transl Sci. 2017;146:203-241. doi: 10.1016/bs.pmbts.2016.12.015. Epub 2017 Feb 4. Review.


The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.

Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ.

Kidney Int. 2017 May;91(5):1126-1145. doi: 10.1016/j.kint.2016.10.036. Epub 2017 Jan 4.


Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?

Basisty N, Dai DF, Gagnidze A, Gitari L, Fredrickson J, Maina Y, Beyer RP, Emond MJ, Hsieh EJ, MacCoss MJ, Martin GM, Rabinovitch PS.

Aging Cell. 2016 Aug;15(4):634-45. doi: 10.1111/acel.12472. Epub 2016 Apr 8.


Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts.

Chiao YA, Kolwicz SC, Basisty N, Gagnidze A, Zhang J, Gu H, Djukovic D, Beyer RP, Raftery D, MacCoss M, Tian R, Rabinovitch PS.

Aging (Albany NY). 2016 Feb;8(2):314-27.


Healthy aging: The ultimate preventative medicine.

Kaeberlein M, Rabinovitch PS, Martin GM.

Science. 2015 Dec 4;350(6265):1191-3. doi: 10.1126/science.aad3267. Review.


AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.

Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, Wu X, Shulman GI, Rabinovitch PS, Russell RR 3rd, Young LH.

J Mol Cell Cardiol. 2016 Feb;91:104-13. doi: 10.1016/j.yjmcc.2015.12.032. Epub 2015 Dec 30.


Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner.

Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ.

Aging Cell. 2016 Feb;15(1):89-99. doi: 10.1111/acel.12412. Epub 2015 Oct 25.


The Aging Heart.

Chiao YA, Rabinovitch PS.

Cold Spring Harb Perspect Med. 2015 Sep 1;5(9):a025148. doi: 10.1101/cshperspect.a025148. Review.


Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M.

Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015.


High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett's Esophagus.

Srivastava A, Golden KL, Sanchez CA, Liu K, Fong PY, Li X, Cowan DS, Rabinovitch PS, Reid BJ, Blount PL, Odze RD.

PLoS One. 2015 Jul 31;10(7):e0133403. doi: 10.1371/journal.pone.0133403. eCollection 2015.


Mitochondrial dysfunction in cardiac aging.

Tocchi A, Quarles EK, Basisty N, Gitari L, Rabinovitch PS.

Biochim Biophys Acta. 2015 Nov;1847(11):1424-33. doi: 10.1016/j.bbabio.2015.07.009. Epub 2015 Jul 17. Review.


Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.

Karunadharma PP, Basisty N, Chiao YA, Dai DF, Drake R, Levy N, Koh WJ, Emond MJ, Kruse S, Marcinek D, Maccoss MJ, Rabinovitch PS.

FASEB J. 2015 Aug;29(8):3582-92. doi: 10.1096/fj.15-272666. Epub 2015 May 14.


Outcome of "indefinite for dysplasia" in inflammatory bowel disease: correlation with DNA flow cytometry and other risk factors of colorectal cancer.

Choi WT, Rabinovitch PS, Wang D, Westerhoff M.

Hum Pathol. 2015 Jul;46(7):939-47. doi: 10.1016/j.humpath.2015.03.009. Epub 2015 Apr 11.


Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.

Karunadharma PP, Basisty N, Dai DF, Chiao YA, Quarles EK, Hsieh EJ, Crispin D, Bielas JH, Ericson NG, Beyer RP, MacKay VL, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2015 Aug;14(4):547-57. doi: 10.1111/acel.12317. Epub 2015 Mar 23.


"Indefinite for Dysplasia" in Barrett's Esophagus: Inflammation and DNA Content Abnormality are Significant Predictors of Early Detection of Neoplasia.

Choi WT, Emond MJ, Rabinovitch PS, Ahn J, Upton MP, Westerhoff M.

Clin Transl Gastroenterol. 2015 Mar 12;6:e81. doi: 10.1038/ctg.2015.7.


Quality control systems in cardiac aging.

Quarles EK, Dai DF, Tocchi A, Basisty N, Gitari L, Rabinovitch PS.

Ageing Res Rev. 2015 Sep;23(Pt A):101-15. doi: 10.1016/j.arr.2015.02.003. Epub 2015 Feb 19. Review.


Modulating mTOR in aging and health.

Johnson SC, Sangesland M, Kaeberlein M, Rabinovitch PS.

Interdiscip Top Gerontol. 2015;40:107-27. doi: 10.1159/000364974. Epub 2014 Oct 13. Review.


MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.

Pavelitz T, Renfro L, Foster NR, Caracol A, Welsch P, Lao VV, Grady WB, Niedzwiecki D, Saltz LB, Bertagnolli MM, Goldberg RM, Rabinovitch PS, Emond M, Monnat RJ Jr, Maizels N.

PLoS One. 2014 Oct 13;9(10):e108483. doi: 10.1371/journal.pone.0108483. eCollection 2014.


Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy.

Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd.

Circ Res. 2014 Jul 18;115(3):348-53. doi: 10.1161/CIRCRESAHA.115.304384. Epub 2014 May 29.


Mitochondrial oxidative stress in aging and healthspan.

Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS.

Longev Healthspan. 2014 May 1;3:6. doi: 10.1186/2046-2395-3-6. eCollection 2014. Review.


The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA.

Cell. 2014 Apr 24;157(3):565-79. doi: 10.1016/j.cell.2014.03.032. Erratum in: Cell. 2014 May 22;157(5):1243.


Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.

Dai DF, Karunadharma PP, Chiao YA, Basisty N, Crispin D, Hsieh EJ, Chen T, Gu H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2014 Jun;13(3):529-39. doi: 10.1111/acel.12203. Epub 2014 Feb 25.



Risques RA, Ussakli C, Salk JJ, Rabinovitch PS, Brentnall TA.

J Natl Cancer Inst. 2014 Feb;106(2):djt437. doi: 10.1093/jnci/djt437. Epub 2014 Jan 8. No abstract available.


Macrophage mitochondrial oxidative stress promotes atherosclerosis and nuclear factor-κB-mediated inflammation in macrophages.

Wang Y, Wang GZ, Rabinovitch PS, Tabas I.

Circ Res. 2014 Jan 31;114(3):421-33. doi: 10.1161/CIRCRESAHA.114.302153. Epub 2013 Dec 2.


mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M.

Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14.


Preserving youth: does rapamycin deliver?

Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M.

Sci Transl Med. 2013 Nov 13;5(211):211fs40. doi: 10.1126/scitranslmed.3007316.


A novel radial water tread maze tracks age-related cognitive decline in mice.

Pettan-Brewer C, Touch DV, Wiley JC, Hopkins HC, Rabinovitch PS, Ladiges WC.

Pathobiol Aging Age Relat Dis. 2013 Oct 4;3. doi: 10.3402/pba.v3i0.20679. eCollection 2013.


Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.

Salk JJ, Bansal A, Lai LA, Crispin DA, Ussakli CH, Horwitz MS, Bronner MP, Brentnall TA, Loeb LA, Rabinovitch PS, Risques RA.

Inflamm Bowel Dis. 2013 Nov;19(12):2593-602. doi: 10.1097/MIB.0b013e3182a87640.


Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides.

Dai DF, Hsieh EJ, Chen T, Menendez LG, Basisty NB, Tsai L, Beyer RP, Crispin DA, Shulman NJ, Szeto HH, Tian R, MacCoss MJ, Rabinovitch PS.

Circ Heart Fail. 2013 Sep 1;6(5):1067-76. doi: 10.1161/CIRCHEARTFAILURE.113.000406. Epub 2013 Aug 9.


Mitochondria and tumor progression in ulcerative colitis.

Ussakli CH, Ebaee A, Binkley J, Brentnall TA, Emond MJ, Rabinovitch PS, Risques RA.

J Natl Cancer Inst. 2013 Aug 21;105(16):1239-48. doi: 10.1093/jnci/djt167. Epub 2013 Jul 12.


Molecular mechanisms underlying genotype-dependent responses to dietary restriction.

Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Holmberg M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Vander Wende H, An EH, Fletcher M, Jelic M, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M.

Aging Cell. 2013 Dec;12(6):1050-61. doi: 10.1111/acel.12130. Epub 2013 Aug 11.


Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.

Siegel MP, Kruse SE, Percival JM, Goh J, White CC, Hopkins HC, Kavanagh TJ, Szeto HH, Rabinovitch PS, Marcinek DJ.

Aging Cell. 2013 Oct;12(5):763-71. doi: 10.1111/acel.12102. Epub 2013 Jun 11.


Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women.

Mason C, Risques RA, Xiao L, Duggan CR, Imayama I, Campbell KL, Kong A, Foster-Schubert KE, Wang CY, Alfano CM, Blackburn GL, Rabinovitch PS, McTiernan A.

Obesity (Silver Spring). 2013 Dec;21(12):E549-54. doi: 10.1002/oby.20509. Epub 2013 Jul 29.


mTOR is a key modulator of ageing and age-related disease.

Johnson SC, Rabinovitch PS, Kaeberlein M.

Nature. 2013 Jan 17;493(7432):338-45. doi: 10.1038/nature11861. Review.

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