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Direct coupling analysis improves the identification of beneficial amino acid mutations for the functional thermostabilization of a delicate decarboxylase.

Peng M, Maier M, Esch J, Schug A, Rabe KS.

Biol Chem. 2019 Aug 31. pii: /j/bchm.ahead-of-print/hsz-2019-0156/hsz-2019-0156.xml. doi: 10.1515/hsz-2019-0156. [Epub ahead of print]


Comparison of PD-L1 expression between paired cytologic and histologic specimens from non-small cell lung cancer patients.

Kuempers C, van der Linde LIS, Reischl M, Vogel W, Stellmacher F, Reck M, Heigener D, Rabe KF, Kirfel J, Perner S, Welker L.

Virchows Arch. 2019 Aug 7. doi: 10.1007/s00428-019-02632-7. [Epub ahead of print]


Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

Clay-Gilmour AI, Rishi AR, Goldin LR, Greenberg-Worisek AJ, Achenbach SJ, Rabe KG, Maurer MJ, Kay NE, Shanafelt TD, Call TG, Brice Weinberg J, Camp NJ, Cerhan JR, Leis J, Norman A, Murray DL, Vincent Rajkumar S, Caporaso NE, Landgren O, McMaster ML, Slager SL, Vachon CM.

Blood Cancer J. 2019 Aug 5;9(8):59. doi: 10.1038/s41408-019-0220-x.


Gait Phase Identification During Level, Incline and Decline Ambulation Tasks Using Portable Sonomyographic Sensing.

Jahanandish MH, Rabe KG, Fey NP, Hoyt K.

IEEE Int Conf Rehabil Robot. 2019 Jun;2019:988-993. doi: 10.1109/ICORR.2019.8779534.


Dupilumab Efficacy in Uncontrolled, Moderate-to-Severe Asthma With Self-reported Chronic Rhinosinusitis.

Maspero JF, Katelaris CH, Busse WW, Castro M, Corren J, Chipps BE, Peters AT, Pavord ID, Ford LB, Sher L, Rabe KF, Rice MS, Rowe P, Lu Y, Harel S, Jagerschmidt A, Khan A, Kamat S, Pirozzi G, Amin N, Ruddy M, Graham NMH, Mannent L, Teper A.

J Allergy Clin Immunol Pract. 2019 Jul 24. pii: S2213-2198(19)30633-6. doi: 10.1016/j.jaip.2019.07.016. [Epub ahead of print]


Microfluidic Chips for Life Sciences-A Comparison of Low Entry Manufacturing Technologies.

Grösche M, Zoheir AE, Stegmaier J, Mikut R, Mager D, Korvink JG, Rabe KS, Niemeyer CM.

Small. 2019 Aug;15(35):e1901956. doi: 10.1002/smll.201901956. Epub 2019 Jul 15.


Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia.

Giacopelli B, Zhao Q, Ruppert AS, Agyeman A, Weigel C, Wu YZ, Gerber MM, Rabe KG, Larson MC, Lu J, Blachly JS, Rogers KA, Wierda WG, Brown JR, Rai KR, Keating M, Rassenti LZ, Kipps TJ, Zenz T, Shanafelt TD, Kay NE, Abruzzo LV, Coombes KR, Woyach JA, Byrd JC, Oakes CC.

Blood. 2019 Aug 22;134(8):688-698. doi: 10.1182/blood.2019000490. Epub 2019 Jul 10.


Machine-assisted cultivation and analysis of biofilms.

Hansen SH, Kabbeck T, Radtke CP, Krause S, Krolitzki E, Peschke T, Gasmi J, Rabe KS, Wagner M, Horn H, Hubbuch J, Gescher J, Niemeyer CM.

Sci Rep. 2019 Jun 20;9(1):8933. doi: 10.1038/s41598-019-45414-6.


Clinical characteristics and outcomes of Richter transformation: Experience of 204 patients from a single center.

Wang Y, Tschautscher MA, Rabe KG, Call TG, Leis JF, Kenderian SS, Kay NE, Muchtar E, Van Dyke DL, Koehler AB, Schwager SM, Slager SL, Parikh SA, Ding W.

Haematologica. 2019 Jun 13. pii: haematol.2019.224121. doi: 10.3324/haematol.2019.224121. [Epub ahead of print]


Machine Learning Applied to Predicting Microorganism Growth Temperatures and Enzyme Catalytic Optima.

Li G, Rabe KS, Nielsen J, Engqvist MKM.

ACS Synth Biol. 2019 Jun 21;8(6):1411-1420. doi: 10.1021/acssynbio.9b00099. Epub 2019 Jun 7.


Prognostic risk score for patients with relapsed or refractory chronic lymphocytic leukaemia treated with targeted therapies or chemoimmunotherapy: a retrospective, pooled cohort study with external validations.

Soumerai JD, Ni A, Darif M, Londhe A, Xing G, Mun Y, Kay NE, Shanafelt TD, Rabe KG, Byrd JC, Chanan-Khan AA, Furman RR, Hillmen P, Jones J, Seymour JF, Sharman JP, Ferrante L, Mobasher M, Stark T, Reddy V, Dreiling LK, Bhargava P, Howes A, James DF, Zelenetz AD.

Lancet Haematol. 2019 Jul;6(7):e366-e374. doi: 10.1016/S2352-3026(19)30085-7. Epub 2019 May 17. Erratum in: Lancet Haematol. 2019 Jul;6(7):e348.


Rapid disease progression following discontinuation of ibrutinib in patients with chronic lymphocytic leukemia treated in routine clinical practice.

Hampel PJ, Ding W, Call TG, Rabe KG, Kenderian SS, Witzig TE, Muchtar E, Leis JF, Chanan-Khan AA, Koehler AB, Fonder AL, Schwager SM, Slager SL, Shanafelt TD, Kay NE, Parikh SA.

Leuk Lymphoma. 2019 Apr 24:1-8. doi: 10.1080/10428194.2019.1602268. [Epub ahead of print]


Psychological Impact of Learning CDKN2A Variant Status as a Genetic Research Result.

Zhu X, Leof ER, Rabe KG, McCormick JB, Petersen GM, Radecki Breitkopf C.

Public Health Genomics. 2018;21(3-4):154-163. doi: 10.1159/000496556. Epub 2019 Apr 18.


Pancreatic cancer and melanoma related perceptions and behaviors following disclosure of CDKN2A variant status as a research result.

Leof ER, Zhu X, Rabe KG, McCormick JB, Petersen GM, Radecki Breitkopf C.

Genet Med. 2019 Apr 17. doi: 10.1038/s41436-019-0517-y. [Epub ahead of print]


Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: A randomized controlled trial.

Watz H, Nagelschmitz J, Kirsten A, Pedersen F, van der Mey D, Schwers S, Bandel TJ, Rabe KF.

Pulm Pharmacol Ther. 2019 Jun;56:86-93. doi: 10.1016/j.pupt.2019.03.009. Epub 2019 Mar 24.


Effects of airway obstruction and hyperinflation on electrocardiographic axes in COPD.

Alter P, Watz H, Kahnert K, Rabe KF, Biertz F, Fischer R, Jung P, Graf J, Bals R, Vogelmeier CF, Jörres RA.

Respir Res. 2019 Mar 27;20(1):61. doi: 10.1186/s12931-019-1025-y.


Cryobiopsy for Interstitial Lung Disease: The Heat Is On.

Raghu G, Lederer DJ, Rabe KF.

Am J Respir Crit Care Med. 2019 May 15;199(10):1183-1184. doi: 10.1164/rccm.201903-0682ED. No abstract available.


Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study.

Postma DS, Brightling C, Baldi S, Van den Berge M, Fabbri LM, Gagnatelli A, Papi A, Van der Molen T, Rabe KF, Siddiqui S, Singh D, Nicolini G, Kraft M; ATLANTIS study group.

Lancet Respir Med. 2019 May;7(5):402-416. doi: 10.1016/S2213-2600(19)30049-9. Epub 2019 Mar 12. Erratum in: Lancet Respir Med. 2019 Sep;7(9):e28.


KRAS, NRAS, and BRAF mutations are highly enriched in trisomy 12 chronic lymphocytic leukemia and are associated with shorter treatment-free survival.

Vendramini E, Bomben R, Pozzo F, Benedetti D, Bittolo T, Rossi FM, Dal Bo M, Rabe KG, Pozzato G, Zaja F, Chiarenza A, Di Raimondo F, Braggio E, Parikh SA, Kay NE, Shanafelt TD, Del Poeta G, Gattei V, Zucchetto A.

Leukemia. 2019 Aug;33(8):2111-2115. doi: 10.1038/s41375-019-0444-6. Epub 2019 Mar 14. No abstract available.


Rating sputum cell quality in clinical trials for asthma and COPD treatment.

Pedersen F, Zissler UM, Watz H, Rabe KF, Hohlfeld JM, Holz O.

Int J Chron Obstruct Pulmon Dis. 2019 Jan 8;14:195-198. doi: 10.2147/COPD.S188033. eCollection 2019. No abstract available.


Applications of Protein Engineering and Directed Evolution in Plant Research.

Engqvist MKM, Rabe KS.

Plant Physiol. 2019 Mar;179(3):907-917. doi: 10.1104/pp.18.01534. Epub 2019 Jan 9. Review. No abstract available.


Solid-Phase Synthesis and Purification of Protein-DNA Origami Nanostructures.

Burgahn T, Garrecht R, Rabe KS, Niemeyer CM.

Chemistry. 2019 Mar 7;25(14):3483-3488. doi: 10.1002/chem.201805506. Epub 2019 Jan 24.


IGH translocations in chronic lymphocytic leukemia: Clinicopathologic features and clinical outcomes.

Fang H, Reichard KK, Rabe KG, Hanson CA, Call TG, Ding W, Kenderian SS, Muchtar E, Schwager SM, Leis JF, Chanan-Khan AA, Slager SL, Braggio E, Smoley SA, Kay NE, Shanafelt TD, Van Dyke DL, Parikh SA.

Am J Hematol. 2019 Mar;94(3):338-345. doi: 10.1002/ajh.25385. Epub 2019 Jan 8.


Economic burden of bronchiectasis in Germany.

Diel R, Chalmers JD, Rabe KF, Nienhaus A, Loddenkemper R, Ringshausen FC.

Eur Respir J. 2019 Feb 28;53(2). pii: 1802033. doi: 10.1183/13993003.02033-2018. Print 2019 Feb.


[Statement of the German Respiratory Society (DGP) and the Association of Pneumological Clinics (VPK) on the Role of Pneumology in Tiered Emergency Care].

Randerath WJ, Hetzel M, Pfeifer M, Voshaar T, Rabe K.

Pneumologie. 2018 Dec;72(12):817-819. doi: 10.1055/a-0775-3517. Epub 2018 Nov 30. German. No abstract available.


Rhinovirus infections change DNA methylation and mRNA expression in children with asthma.

Pech M, Weckmann M, König IR, Franke A, Heinsen FA, Oliver B, Ricklefs I, Fuchs O, Rabe K, Hansen G, V Mutius E, Kopp MV; ALLIANCE-study group.

PLoS One. 2018 Nov 28;13(11):e0205275. doi: 10.1371/journal.pone.0205275. eCollection 2018.


New Biologics for Severe Asthma: What Patients, What Agents, What Results, at What Cost?

Rabe KF.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):406-408. doi: 10.1164/rccm.201810-1974ED. No abstract available.


[Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology].

Buhl R, Bals R, Baur X, Berdel D, Criée CP, Gappa M, Gillissen A, Greulich T, Haidl P, Hamelmann E, Kardos P, Kenn K, Klimek L, Korn S, Lommatzsch M, Magnussen H, Nicolai T, Nowak D, Pfaar O, Rabe KF, Riedler J, Ritz T, Schultz K, Schuster A, Spindler T, Taube C, Taube K, Vogelmeier C, von Leupoldt A, Wantke F, Weise S, Wildhaber J, Worth H, Zacharasiewicz A.

Pneumologie. 2017 Dec;71(12):e3. doi: 10.1055/a-0790-0021. Epub 2018 Nov 7. German. No abstract available.


Correction to: The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study.

Fuchs O, Bahmer T, Weckmann M, Dittrich AM, Schaub B, Rösler B, Happle C, Brinkmann F, Ricklefs I, König IR, Watz H, Rabe KF, Kopp MV, Hansen G, von Mutius E; ALLIANCE Study Group as part of the German Centre for Lung Research (DZL).

BMC Pulm Med. 2018 Nov 7;18(1):165. doi: 10.1186/s12890-018-0717-2.


Oriented immobilization of a delicate glucose-sensing protein on silica nanoparticles.

Leidner A, Bauer J, Ebrahimi Khonachah M, Takamiya M, Strähle U, Dickmeis T, Rabe KS, Niemeyer CM.

Biomaterials. 2019 Jan;190-191:76-85. doi: 10.1016/j.biomaterials.2018.10.035. Epub 2018 Oct 31.


Self-Assembling All-Enzyme Hydrogels for Flow Biocatalysis.

Peschke T, Bitterwolf P, Gallus S, Hu Y, Oelschlaeger C, Willenbacher N, Rabe KS, Niemeyer CM.

Angew Chem Int Ed Engl. 2018 Dec 21;57(52):17028-17032. doi: 10.1002/anie.201810331. Epub 2018 Nov 20.


Corrigendum: Improvement in the Thermostability of a β-Amino Acid Converting ω-Transaminase by Using FoldX.

Buß O, Muller D, Jager S, Rudat J, Rabe KS.

Chembiochem. 2018 Oct 18;19(20):2241. doi: 10.1002/cbic.201700465. No abstract available.


Cardiovascular disease and COPD: dangerous liaisons?

Rabe KF, Hurst JR, Suissa S.

Eur Respir Rev. 2018 Oct 3;27(149). pii: 180057. doi: 10.1183/16000617.0057-2018. Print 2018 Sep 30. Review. Erratum in: Eur Respir Rev. 2018 Nov 21;27(150):.


Is muscle strength in a painful limb affected by knee pain status of the contralateral limb? - Data from the Osteoarthritis Initiative.

Steidle-Kloc E, Rabe K, Eckstein F, Wirth W, Glass NA, Segal NA.

Ann Anat. 2019 Jan;221:68-75. doi: 10.1016/j.aanat.2018.08.003. Epub 2018 Sep 18.


Triple therapy with budesonide/glycopyrrolate/formoterol fumarate with co-suspension delivery technology versus dual therapies in chronic obstructive pulmonary disease (KRONOS): a double-blind, parallel-group, multicentre, phase 3 randomised controlled trial.

Ferguson GT, Rabe KF, Martinez FJ, Fabbri LM, Wang C, Ichinose M, Bourne E, Ballal S, Darken P, DeAngelis K, Aurivillius M, Dorinsky P, Reisner C.

Lancet Respir Med. 2018 Oct;6(10):747-758. doi: 10.1016/S2213-2600(18)30327-8. Epub 2018 Sep 16. Erratum in: Lancet Respir Med. 2018 Oct 4;:. Lancet Respir Med. 2019 Feb;7(2):e9.


Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial.

Rabe KF, Watz H, Baraldo S, Pedersen F, Biondini D, Bagul N, Hanauer G, Göhring UM, Purkayastha D, Román J, Alagappan VKT, Saetta M.

Lancet Respir Med. 2018 Nov;6(11):827-836. doi: 10.1016/S2213-2600(18)30331-X. Epub 2018 Sep 14. Erratum in: Lancet Respir Med. 2018 Oct 12;:.


Influence of body mass on predicted values of static hyperinflation in COPD.

Alter P, Rabe KF, Schulz H, Vogelmeier CF, Jörres RA.

Int J Chron Obstruct Pulmon Dis. 2018 Aug 23;13:2551-2555. doi: 10.2147/COPD.S164096. eCollection 2018.


Inhaled corticosteroids in COPD: friend or foe?

Agusti A, Fabbri LM, Singh D, Vestbo J, Celli B, Franssen FME, Rabe KF, Papi A.

Eur Respir J. 2018 Dec 13;52(6). pii: 1801219. doi: 10.1183/13993003.01219-2018. Print 2018 Dec. Review.


The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study.

Fuchs O, Bahmer T, Weckmann M, Dittrich AM, Schaub B, Rösler B, Happle C, Brinkmann F, Ricklefs I, König IR, Watz H, Rabe KF, Kopp MV, Hansen G, von Mutius E; ALLIANCE Study Group as part of the German Centre for Lung Research (DZL).

BMC Pulm Med. 2018 Aug 20;18(1):140. doi: 10.1186/s12890-018-0705-6. Erratum in: BMC Pulm Med. 2018 Nov 7;18(1):165.


Strongly correlated perovskite lithium ion shuttles.

Sun Y, Kotiuga M, Lim D, Narayanan B, Cherukara M, Zhang Z, Dong Y, Kou R, Sun CJ, Lu Q, Waluyo I, Hunt A, Tanaka H, Hattori AN, Gamage S, Abate Y, Pol VG, Zhou H, Sankaranarayanan SKRS, Yildiz B, Rabe KM, Ramanathan S.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9672-9677. doi: 10.1073/pnas.1805029115. Epub 2018 Aug 13.


Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease.

Heinbockel L, Marwitz S, Schromm AB, Watz H, Kugler C, Ammerpohl O, Schnepf K, Rabe KF, Droemann D, Goldmann T.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 26;13:2255-2259. doi: 10.2147/COPD.S161958. eCollection 2018.


The antibiotic peptaibol alamethicin from Trichoderma permeabilises Arabidopsis root apical meristem and epidermis but is antagonised by cellulase-induced resistance to alamethicin.

Dotson BR, Soltan D, Schmidt J, Areskoug M, Rabe K, Swart C, Widell S, Rasmusson AG.

BMC Plant Biol. 2018 Aug 10;18(1):165. doi: 10.1186/s12870-018-1370-x.


Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis.

Goldmann T, Zissel G, Watz H, Drömann D, Reck M, Kugler C, Rabe KF, Marwitz S.

Respir Res. 2018 Jul 24;19(1):138. doi: 10.1186/s12931-018-0841-9.


Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues.

Marwitz S, Heinbockel L, Scheufele S, Kugler C, Reck M, Rabe KF, Perner S, Goldmann T, Ammerpohl O.

Int J Cancer. 2018 Dec 15;143(12):3061-3070. doi: 10.1002/ijc.31641. Epub 2018 Oct 16.


Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists.

Busse WW, Bateman ED, Caplan AL, Kelly HW, O'Byrne PM, Rabe KF, Chinchilli VM.

N Engl J Med. 2018 Jun 28;378(26):2497-2505. doi: 10.1056/NEJMoa1716868.


Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma.

Rabe KF, Nair P, Brusselle G, Maspero JF, Castro M, Sher L, Zhu H, Hamilton JD, Swanson BN, Khan A, Chao J, Staudinger H, Pirozzi G, Antoni C, Amin N, Ruddy M, Akinlade B, Graham NMH, Stahl N, Yancopoulos GD, Teper A.

N Engl J Med. 2018 Jun 28;378(26):2475-2485. doi: 10.1056/NEJMoa1804093. Epub 2018 May 21.


Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.

Castro M, Corren J, Pavord ID, Maspero J, Wenzel S, Rabe KF, Busse WW, Ford L, Sher L, FitzGerald JM, Katelaris C, Tohda Y, Zhang B, Staudinger H, Pirozzi G, Amin N, Ruddy M, Akinlade B, Khan A, Chao J, Martincova R, Graham NMH, Hamilton JD, Swanson BN, Stahl N, Yancopoulos GD, Teper A.

N Engl J Med. 2018 Jun 28;378(26):2486-2496. doi: 10.1056/NEJMoa1804092. Epub 2018 May 21.


Determinants of Response to Roflumilast in Severe Chronic Obstructive Pulmonary Disease. Pooled Analysis of Two Randomized Trials.

Martinez FJ, Rabe KF, Calverley PMA, Fabbri LM, Sethi S, Pizzichini E, McIvor A, Anzueto A, Alagappan VKT, Siddiqui S, Reisner C, Zetterstrand S, Román J, Purkayastha D, Bagul N, Rennard SI.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1268-1278. doi: 10.1164/rccm.201712-2493OC.


Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma.

Busse WW, Maspero JF, Rabe KF, Papi A, Wenzel SE, Ford LB, Pavord ID, Zhang B, Staudinger H, Pirozzi G, Amin N, Akinlade B, Eckert L, Chao J, Graham NMH, Teper A.

Adv Ther. 2018 May;35(5):737-748. doi: 10.1007/s12325-018-0702-4. Epub 2018 May 3.

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