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Items: 1 to 50 of 65

1.

Missing data handling in non-inferiority and equivalence trials: A systematic review.

Rabe BA, Day S, Fiero MH, Bell ML.

Pharm Stat. 2018 May 25. doi: 10.1002/pst.1867. [Epub ahead of print]

PMID:
29797777
2.

RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.

Bartsch K, Damme M, Regen T, Becker L, Garrett L, Hölter SM, Knittler K, Borowski C, Waisman A, Glatzel M, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rabe B.

Front Immunol. 2018 Mar 29;9:587. doi: 10.3389/fimmu.2018.00587. eCollection 2018.

3.

The Transpolar Drift conveys methane from the Siberian Shelf to the central Arctic Ocean.

Damm E, Bauch D, Krumpen T, Rabe B, Korhonen M, Vinogradova E, Uhlig C.

Sci Rep. 2018 Mar 14;8(1):4515. doi: 10.1038/s41598-018-22801-z.

4.

High colored dissolved organic matter (CDOM) absorption in surface waters of the central-eastern Arctic Ocean: Implications for biogeochemistry and ocean color algorithms.

Gonçalves-Araujo R, Rabe B, Peeken I, Bracher A.

PLoS One. 2018 Jan 5;13(1):e0190838. doi: 10.1371/journal.pone.0190838. eCollection 2018.

5.

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.

6.

The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids.

Osseman Q, Gallucci L, Au S, Cazenave C, Berdance E, Blondot ML, Cassany A, Bégu D, Ragues J, Aknin C, Sominskaya I, Dishlers A, Rabe B, Anderson F, Panté N, Kann M.

J Hepatol. 2018 Mar;68(3):441-448. doi: 10.1016/j.jhep.2017.10.032. Epub 2017 Nov 4.

PMID:
29113909
7.

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.

Bartsch K, Knittler K, Borowski C, Rudnik S, Damme M, Aden K, Spehlmann ME, Frey N, Saftig P, Chalaris A, Rabe B.

Hum Mol Genet. 2017 Oct 15;26(20):3960-3972. doi: 10.1093/hmg/ddx283.

PMID:
29016854
8.

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.

Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C.

Oncotarget. 2017 Jul 4;8(33):54873-54888. doi: 10.18632/oncotarget.18966. eCollection 2017 Aug 15.

9.

Using biological-physical modelling for informing sea lice dispersal in Loch Linnhe, Scotland.

Salama NKG, Dale AC, Ivanov VV, Cook PF, Pert CC, Collins CM, Rabe B.

J Fish Dis. 2018 Jun;41(6):901-919. doi: 10.1111/jfd.12693. Epub 2017 Aug 7.

PMID:
28782801
10.

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.

11.

Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.

Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P.

Biochim Biophys Acta. 2017 Jan;1864(1):217-230. doi: 10.1016/j.bbamcr.2016.11.003. Epub 2016 Nov 3.

12.

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.

Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D.

Hepatology. 2017 Jan;65(1):89-103. doi: 10.1002/hep.28874. Epub 2016 Nov 22.

PMID:
27770462
13.

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.

Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.

J Immunol. 2016 Nov 1;197(9):3705-3715. Epub 2016 Oct 3.

14.

The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.

Nivarthi H, Gordziel C, Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S, Friedrich K, Moriggl R.

Oncotarget. 2016 Aug 9;7(32):51096-51106. doi: 10.18632/oncotarget.9315.

15.

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.

Sci Rep. 2016 May 6;6:25550. doi: 10.1038/srep25550.

16.

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.

Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.

J Biol Chem. 2016 May 13;291(20):10551-61. doi: 10.1074/jbc.M115.710541. Epub 2016 Mar 9.

17.

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

Mackenzie KJ, Carroll P, Lettice L, Tarnauskaitė Ž, Reddy K, Dix F, Revuelta A, Abbondati E, Rigby RE, Rabe B, Kilanowski F, Grimes G, Fluteau A, Devenney PS, Hill RE, Reijns MA, Jackson AP.

EMBO J. 2016 Apr 15;35(8):831-44. doi: 10.15252/embj.201593339. Epub 2016 Feb 22.

18.

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.

Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.

J Leukoc Biol. 2016 May;99(5):749-60. doi: 10.1189/jlb.3A0515-207R. Epub 2015 Nov 11.

PMID:
26561568
19.

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.

Schumacher N, Meyer D, Mauermann A, von der Heyde J, Wolf J, Schwarz J, Knittler K, Murphy G, Michalek M, Garbers C, Bartsch JW, Guo S, Schacher B, Eickholz P, Chalaris A, Rose-John S, Rabe B.

J Biol Chem. 2015 Oct 23;290(43):26059-71. doi: 10.1074/jbc.M115.649509. Epub 2015 Sep 10.

20.

Shallow methylmercury production in the marginal sea ice zone of the central Arctic Ocean.

Heimbürger LE, Sonke JE, Cossa D, Point D, Lagane C, Laffont L, Galfond BT, Nicolaus M, Rabe B, van der Loeff MR.

Sci Rep. 2015 May 20;5:10318. doi: 10.1038/srep10318.

21.

Simulated environmental transport distances of Lepeophtheirus salmonis in Loch Linnhe, Scotland, for informing aquaculture area management structures.

Salama NK, Murray AG, Rabe B.

J Fish Dis. 2016 Apr;39(4):419-28. doi: 10.1111/jfd.12375. Epub 2015 Apr 30.

PMID:
25929159
22.

Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3.

Oldefest M, Düsterhöft S, Desel C, Thysen S, Fink C, Rabe B, Lories R, Grötzinger J, Lorenzen I.

Biochem J. 2015 Jun 15;468(3):507-18. doi: 10.1042/BJ20141231. Epub 2015 Apr 7.

PMID:
25846075
23.

A regression-based differential expression detection algorithm for microarray studies with ultra-low sample size.

Vasiliu D, Clamons S, McDonough M, Rabe B, Saha M.

PLoS One. 2015 Mar 4;10(3):e0118198. doi: 10.1371/journal.pone.0118198. eCollection 2015.

24.

Characterization of tweety gene (ttyh1-3) expression in Xenopus laevis during embryonic development.

Halleran AD, Sehdev M, Rabe BA, Huyck RW, Williams CC, Saha MS.

Gene Expr Patterns. 2015 Jan;17(1):38-44. doi: 10.1016/j.gep.2014.12.002. Epub 2014 Dec 23.

25.

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.

Effenberger T, von der Heyde J, Bartsch K, Garbers C, Schulze-Osthoff K, Chalaris A, Murphy G, Rose-John S, Rabe B.

FASEB J. 2014 Nov;28(11):4847-56. doi: 10.1096/fj.14-254565. Epub 2014 Jul 30.

PMID:
25077560
26.

Risks and risk governance in unconventional shale gas development.

Small MJ, Stern PC, Bomberg E, Christopherson SM, Goldstein BD, Israel AL, Jackson RB, Krupnick A, Mauter MS, Nash J, North DW, Olmstead SM, Prakash A, Rabe B, Richardson N, Tierney S, Webler T, Wong-Parodi G, Zielinska B.

Environ Sci Technol. 2014;48(15):8289-97. doi: 10.1021/es502111u. Epub 2014 Jul 16.

PMID:
24983403
27.

Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA.

Diabetes. 2014 Sep;63(9):2984-95. doi: 10.2337/db13-1121. Epub 2014 May 8.

28.

The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).

Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J.

J Biol Chem. 2014 Jun 27;289(26):18442-50. doi: 10.1074/jbc.M114.568857. Epub 2014 May 6.

29.

Temperate Streptococcus thermophilus phages expressing superinfection exclusion proteins of the Ltp type.

Ali Y, Koberg S, Heßner S, Sun X, Rabe B, Back A, Neve H, Heller KJ.

Front Microbiol. 2014 Mar 13;5:98. doi: 10.3389/fmicb.2014.00098. eCollection 2014.

30.

Shale play politics: the intergovernmental Odyssey of American shale governance.

Rabe BG.

Environ Sci Technol. 2014;48(15):8369-75. doi: 10.1021/es4051132. Epub 2014 Feb 20.

PMID:
24512301
31.

Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.

Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A.

J Biol Chem. 2014 Jan 31;289(5):3080-93. doi: 10.1074/jbc.M113.536847. Epub 2013 Dec 13.

32.

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A.

Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367. doi: 10.1016/j.bbamcr.2013.10.005. Epub 2013 Oct 14.

33.

Aicardi-Goutières syndrome: clues from the RNase H2 knock-out mouse.

Rabe B.

J Mol Med (Berl). 2013 Nov;91(11):1235-40. doi: 10.1007/s00109-013-1061-x. Epub 2013 Jun 7. Review.

PMID:
23744109
34.

Political impediments to a tobacco endgame.

Rabe BG.

Tob Control. 2013 May;22 Suppl 1:i52-4. doi: 10.1136/tobaccocontrol-2012-050799.

35.

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.

Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H.

J Clin Invest. 2013 Mar;123(3):1019-31. doi: 10.1172/JCI64931. Epub 2013 Feb 15.

36.

Export of algal biomass from the melting Arctic sea ice.

Boetius A, Albrecht S, Bakker K, Bienhold C, Felden J, Fernández-Méndez M, Hendricks S, Katlein C, Lalande C, Krumpen T, Nicolaus M, Peeken I, Rabe B, Rogacheva A, Rybakova E, Somavilla R, Wenzhöfer F; RV Polarstern ARK27-3-Shipboard Science Party.

Science. 2013 Mar 22;339(6126):1430-2. doi: 10.1126/science.1231346. Epub 2013 Feb 14.

37.

Development and assessment of a biophysical dispersal model for sea lice.

Salama NK, Collins CM, Fraser JG, Dunn J, Pert CC, Murray AG, Rabe B.

J Fish Dis. 2013 Mar;36(3):323-37. doi: 10.1111/jfd.12065. Epub 2013 Jan 10.

PMID:
23305449
38.

Dissection, culture, and analysis of Xenopus laevis embryonic retinal tissue.

McDonough MJ, Allen CE, Ng-Sui-Hing NK, Rabe BA, Lewis BB, Saha MS.

J Vis Exp. 2012 Dec 23;(70). pii: 4377. doi: 10.3791/4377.

39.

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, Taylor MS, Lawson KA, Dorin JR, Jackson AP.

Cell. 2012 May 25;149(5):1008-22. doi: 10.1016/j.cell.2012.04.011. Epub 2012 May 10.

40.

Cloning and characterization of GABAA α subunits and GABAB subunits in Xenopus laevis during development.

Kaeser GE, Rabe BA, Saha MS.

Dev Dyn. 2011 Apr;240(4):862-73. doi: 10.1002/dvdy.22580. Epub 2011 Mar 7.

41.

The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.

Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J.

Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. doi: 10.1016/j.ejcb.2010.10.007. Epub 2010 Dec 8. Review.

PMID:
21145125
42.

Nucleoporin 153 arrests the nuclear import of hepatitis B virus capsids in the nuclear basket.

Schmitz A, Schwarz A, Foss M, Zhou L, Rabe B, Hoellenriegel J, Stoeber M, Panté N, Kann M.

PLoS Pathog. 2010 Jan 29;6(1):e1000741. doi: 10.1371/journal.ppat.1000741.

43.

Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation.

Wittkop L, Schwarz A, Cassany A, Grün-Bernhard S, Delaleau M, Rabe B, Cazenave C, Gerlich W, Glebe D, Kann M.

Cell Microbiol. 2010 Jul;12(7):962-75. doi: 10.1111/j.1462-5822.2010.01444.x. Epub 2010 Jan 26.

PMID:
20109160
44.

Nuclear entry of hepatitis B virus capsids involves disintegration to protein dimers followed by nuclear reassociation to capsids.

Rabe B, Delaleau M, Bischof A, Foss M, Sominskaya I, Pumpens P, Cazenave C, Castroviejo M, Kann M.

PLoS Pathog. 2009 Aug;5(8):e1000563. doi: 10.1371/journal.ppat.1000563. Epub 2009 Aug 28.

45.

Interleukin-6 trans-signaling regulates glycogen consumption after D-galactosamine-induced liver damage.

Drucker C, Rabe B, Chalaris A, Schulz E, Scheller J, Rose-John S.

J Interferon Cytokine Res. 2009 Nov;29(11):711-8. doi: 10.1089/jir.2008.0095.

PMID:
19642894
46.

Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.

Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J.

J Virol. 2009 May;83(10):5117-26. doi: 10.1128/JVI.01601-08. Epub 2009 Mar 4.

47.

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J.

J Biol Chem. 2008 Oct 3;283(40):27200-7. doi: 10.1074/jbc.M803694200. Epub 2008 Jul 23.

48.

Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.

Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J.

Blood. 2008 Feb 1;111(3):1021-8. Epub 2007 Nov 7.

49.

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.

Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J.

Blood. 2007 Sep 15;110(6):1748-55. Epub 2007 Jun 13.

50.

Intracellular transport of hepatitis B virus.

Kann M, Schmitz A, Rabe B.

World J Gastroenterol. 2007 Jan 7;13(1):39-47. Review.

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