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Items: 8

1.

Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption.

Hatton GB, Madla CM, Rabbie SC, Basit AW.

Drug Discov Today. 2019 Feb;24(2):417-427. doi: 10.1016/j.drudis.2018.11.009. Epub 2018 Nov 16. Review.

2.

All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance.

Hatton GB, Madla CM, Rabbie SC, Basit AW.

Int J Pharm. 2018 Sep 5;548(1):408-422. doi: 10.1016/j.ijpharm.2018.06.054. Epub 2018 Jun 30. Review.

PMID:
29969711
3.

Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study.

Ahn MJ, Kim DW, Cho BC, Kim SW, Lee JS, Ahn JS, Kim TM, Lin CC, Kim HR, John T, Kao S, Goldman JW, Su WC, Natale R, Rabbie S, Harrop B, Overend P, Yang Z, Yang JC.

Lancet Respir Med. 2017 Nov;5(11):891-902. doi: 10.1016/S2213-2600(17)30378-8. Epub 2017 Oct 19.

PMID:
29056570
4.

AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases.

Yang Z, Guo Q, Wang Y, Chen K, Zhang L, Cheng Z, Xu Y, Yin X, Bai Y, Rabbie S, Kim DW, Ahn MJ, Yang JC, Zhang X.

Sci Transl Med. 2016 Dec 7;8(368):368ra172.

PMID:
27928026
5.

Estimating the variability in fraction absorbed as a paradigm for informing formulation development in early clinical drug development.

Rabbie SC, Martin PD, Flanagan T, Basit AW, Standing JF.

Eur J Pharm Sci. 2016 Jun 30;89:50-60. doi: 10.1016/j.ejps.2016.04.005. Epub 2016 Apr 9.

PMID:
27072431
6.

Inter-subject variability in intestinal drug solubility.

Rabbie SC, Flanagan T, Martin PD, Basit AW.

Int J Pharm. 2015 May 15;485(1-2):229-34. doi: 10.1016/j.ijpharm.2015.03.006. Epub 2015 Mar 7.

PMID:
25758158
7.

Gastrointestinal characterisation and drug solubility determination in animals.

Merchant HA, Afonso-Pereira F, Rabbie SC, Youssef SA, Basit AW.

J Pharm Pharmacol. 2015 May;67(5):630-9. doi: 10.1111/jphp.12361. Epub 2015 Jan 5.

PMID:
25560785
8.

Influence of ageing on the gastrointestinal environment of the rat and its implications for drug delivery.

Merchant HA, Rabbie SC, Varum FJ, Afonso-Pereira F, Basit AW.

Eur J Pharm Sci. 2014 Oct 1;62:76-85. doi: 10.1016/j.ejps.2014.05.004. Epub 2014 May 13.

PMID:
24834990

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