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Killing a zombie: a full deletion of the BUB1 gene in HAP1 cells.

Raaijmakers JA, Medema RH.

EMBO J. 2019 Nov 15;38(22):e102423. doi: 10.15252/embj.2019102423. Epub 2019 Oct 22. No abstract available.


Distinct Roles for Condensin's Two ATPase Sites in Chromosome Condensation.

Elbatsh AMO, Kim E, Eeftens JM, Raaijmakers JA, van der Weide RH, García-Nieto A, Bravo S, Ganji M, Uit de Bos J, Teunissen H, Medema RH, de Wit E, Haering CH, Dekker C, Rowland BD.

Mol Cell. 2019 Dec 5;76(5):724-737.e5. doi: 10.1016/j.molcel.2019.09.020. Epub 2019 Oct 16.


Consequences of Genomic Diversification Induced by Segregation Errors.

Soto M, Raaijmakers JA, Medema RH.

Trends Genet. 2019 Apr;35(4):279-291. doi: 10.1016/j.tig.2019.01.003. Epub 2019 Feb 8. Review.


Persistent repair intermediates induce senescence.

Feringa FM, Raaijmakers JA, Hadders MA, Vaarting C, Macurek L, Heitink L, Krenning L, Medema RH.

Nat Commun. 2018 Sep 25;9(1):3923. doi: 10.1038/s41467-018-06308-9.


Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

Janssen LME, Averink TV, Blomen VA, Brummelkamp TR, Medema RH, Raaijmakers JA.

Curr Biol. 2018 Sep 10;28(17):2685-2696.e4. doi: 10.1016/j.cub.2018.06.026. Epub 2018 Aug 16.


Chromosomes trapped in micronuclei are liable to segregation errors.

Soto M, García-Santisteban I, Krenning L, Medema RH, Raaijmakers JA.

J Cell Sci. 2018 Jul 9;131(13). pii: jcs214742. doi: 10.1242/jcs.214742.


Patterns of topical corticosteroids prescriptions in children with asthma.

Arabkhazaeli A, Vijverberg SJH, van der Lee M, van der Ent CK, Bruijnzeel-Koomen CA, de Bruin-Weller MS, Raaijmakers JA, Maitland-van der Zee AH.

Pediatr Dermatol. 2018 May;35(3):378-383. doi: 10.1111/pde.13455. Epub 2018 Mar 24.


SUMO targets the APC/C to regulate transition from metaphase to anaphase.

Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO.

Nat Commun. 2018 Mar 16;9(1):1119. doi: 10.1038/s41467-018-03486-4.


BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

Raaijmakers JA, van Heesbeen RGHP, Blomen VA, Janssen LME, van Diemen F, Brummelkamp TR, Medema RH.

Cell Rep. 2018 Feb 6;22(6):1424-1438. doi: 10.1016/j.celrep.2018.01.034.


TUBB3 overexpression has a negligible effect on the sensitivity to taxol in cultured cell lines.

Tame MA, Manjón AG, Belokhvostova D, Raaijmakers JA, Medema RH.

Oncotarget. 2017 May 10;8(42):71536-71547. doi: 10.18632/oncotarget.17740. eCollection 2017 Sep 22.


The association between a genetic risk score for allergy and the risk of developing allergies in childhood-Results of the WHISTLER cohort.

Arabkhazaeli A, Ahmadizar F, Leusink M, Arets HGM, Raaijmakers JAM, Uiterwaal CSPM, van der Ent CK, Maitland-van der Zee AH, Vijverberg SJH.

Pediatr Allergy Immunol. 2018 Feb;29(1):72-77. doi: 10.1111/pai.12824. Epub 2017 Nov 22.


Asthma treatment patterns in Dutch children using medication dispensing data.

Arabkhazaeli A, Vijverberg SJH, van der Ent CK, Raaijmakers JAM, Maitland-van der Zee AH.

Pediatr Allergy Immunol. 2017 Sep;28(6):606-608. doi: 10.1111/pai.12751. Epub 2017 Jul 27. No abstract available.


Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.

Farzan N, Vijverberg SJ, Andiappan AK, Arianto L, Berce V, Blanca-López N, Bisgaard H, Bønnelykke K, Burchard EG, Campo P, Canino G, Carleton B, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Daley D, Den Dekker HT, Dijk FN, Duijts L, Flores C, Forno E, Hawcutt DB, Hernandez-Pacheco N, de Jongste JC, Kabesch M, Koppelman GH, Manolopoulos VG, Melén E, Mukhopadhyay S, Nilsson S, Palmer CN, Pino-Yanes M, Pirmohamed M, Potočnik U, Raaijmakers JA, Repnik K, Schieck M, Sio YY, Smyth RL, Szalai C, Tantisira KG, Turner S, van der Schee MP, Verhamme KM, Maitland-van der Zee AH.

Pharmacogenomics. 2017 Jul;18(10):931-943. doi: 10.2217/pgs-2017-0035. Epub 2017 Jun 22.


p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies.

Soto M, Raaijmakers JA, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F, Medema RH.

Cell Rep. 2017 Jun 20;19(12):2423-2431. doi: 10.1016/j.celrep.2017.05.055.


Atopic dermatitis characteristics and medication-use patterns in school-age children with AD and asthma symptoms.

van der Lee M, Arabkhazaeli A, van Erp FC, Raaijmakers JA, van der Ent CK, Bruijnzeel-Koomen CAFM, de Bruin-Weller MS, Vijverberg SJH, Maitland-van der Zee AH.

Clin Exp Dermatol. 2017 Jul;42(5):503-508. doi: 10.1111/ced.13111. Epub 2017 Jun 6.


Pharmacogenomics of inhaled corticosteroids and leukotriene modifiers: a systematic review.

Farzan N, Vijverberg SJ, Arets HG, Raaijmakers JA, Maitland-van der Zee AH.

Clin Exp Allergy. 2017 Feb;47(2):271-293. doi: 10.1111/cea.12844. Epub 2016 Dec 9. Review.


Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation.

van Heesbeen RGHP, Raaijmakers JA, Tanenbaum ME, Halim VA, Lelieveld D, Lieftink C, Heck AJR, Egan DA, Medema RH.

Chromosoma. 2017 Aug;126(4):473-486. doi: 10.1007/s00412-016-0607-4. Epub 2016 Jun 29.


High incidence of oral corticosteroids prescriptions in children with asthma in early childhood.

Arabkhazaeli A, Vijverberg SJ, van der Ent CK, Raaijmakers JA, Maitland-van der Zee AH.

J Asthma. 2016 Dec;53(10):1012-7. doi: 10.1080/02770903.2016.1185439. Epub 2016 May 17.


Chromosome misalignments induce spindle-positioning defects.

Tame MA, Raaijmakers JA, Afanasyev P, Medema RH.

EMBO Rep. 2016 Mar;17(3):317-25. doi: 10.15252/embr.201541143. Epub 2016 Feb 4.


Characteristics and severity of asthma in children with and without atopic conditions: a cross-sectional study.

Arabkhazaeli A, Vijverberg SJ, van Erp FC, Raaijmakers JA, van der Ent CK, Maitland van der Zee AH.

BMC Pediatr. 2015 Nov 6;15:172. doi: 10.1186/s12887-015-0481-x.


[Threshold value for reimbursement of costs of new drugs: cost-effectiveness research and modelling are essential links].

Frederix GW, Hövels AM, Severens JL, Raaijmakers JA, Schellens JH.

Ned Tijdschr Geneeskd. 2015;159:A7728. Review. Dutch.


Genetic variation in uncontrolled childhood asthma despite ICS treatment.

Leusink M, Vijverberg SJ, Koenderman L, Raaijmakers JA, de Jongste JC, Sterk PJ, Duiverman EJ, Onland-Moret NC, Postma DS, de Boer A, de Bakker PI, Koppelman GH, Maitland-van der Zee AH.

Pharmacogenomics J. 2016 Apr;16(2):158-63. doi: 10.1038/tpj.2015.36. Epub 2015 May 12.


ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults.

Vijverberg SJ, Koster ES, Tavendale R, Leusink M, Koenderman L, Raaijmakers JA, Postma DS, Koppelman GH, Turner SW, Mukhopadhyay S, Tse SM, Tantisira KG, Hawcutt DB, Francis B, Pirmohamed M, Pino-Yanes M, Eng C, Burchard EG, Palmer CN, Maitland-van der Zee AH.

Clin Exp Allergy. 2015 Jun;45(6):1051-9. doi: 10.1111/cea.12492.


Real world cost of human epidermal receptor 2-positive metastatic breast cancer patients: a longitudinal incidence-based observational costing study in the Netherlands and Belgium.

Frederix GW, Severens JL, Hövels AM, van Hasselt JG, Hooiveld MJ, Neven P, Raaijmakers JA, Schellens JH.

Eur J Cancer Care (Engl). 2015 May;24(3):340-54. doi: 10.1111/ecc.12266. Epub 2014 Nov 21.


Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids.

Vijverberg SJ, Tavendale R, Leusink M, Koenderman L, Raaijmakers JA, Postma DS, Koppelman GH, Turner SW, Mukhopadhyay S, Palmer CN, Maitland-van der Zee AH.

Pharmacogenomics. 2014 Apr;15(6):799-806. doi: 10.2217/pgs.14.37.


Function and regulation of dynein in mitotic chromosome segregation.

Raaijmakers JA, Medema RH.

Chromosoma. 2014 Oct;123(5):407-22. doi: 10.1007/s00412-014-0468-7. Epub 2014 May 29. Review.


Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning.

Tame MA, Raaijmakers JA, van den Broek B, Lindqvist A, Jalink K, Medema RH.

Cell Cycle. 2014;13(7):1162-70. doi: 10.4161/cc.28031. Epub 2014 Feb 10.


The fiduciary obligation of the physician-researcher in phase IV trials.

Bernabe RD, van Thiel GJ, Raaijmakers JA, van Delden JJ.

BMC Med Ethics. 2014 Feb 7;15:11. doi: 10.1186/1472-6939-15-11.


Restoring trust in the pharmaceutical sector on the basis of the SSRI case.

Hernandez JF, van Thiel GJ, Mantel-Teeuwisse AK, Raaijmakers JA, Pieters T.

Drug Discov Today. 2014 May;19(5):523-7. doi: 10.1016/j.drudis.2013.11.019. Epub 2013 Dec 1. Review.


Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort.

Zuurhout MJ, Vijverberg SJ, Raaijmakers JA, Koenderman L, Postma DS, Koppelman GH, Maitland-van der Zee AH.

Pharmacogenomics. 2013 Dec;14(16):1965-71. doi: 10.2217/pgs.13.200.


ADRB2 Arg16 and the need for collaboration in childhood asthma pharmacogenomics.

Vijverberg SJ, Raaijmakers JA, Maitland-van der Zee AH.

Pharmacogenomics. 2013 Dec;14(16):1937-9. doi: 10.2217/pgs.13.195. No abstract available.


The impact of structural uncertainty on cost-effectiveness models for adjuvant endocrine breast cancer treatments: the need for disease-specific model standardization and improved guidance.

Frederix GW, van Hasselt JG, Schellens JH, Hövels AM, Raaijmakers JA, Huitema AD, Severens JL.

Pharmacoeconomics. 2014 Jan;32(1):47-61. doi: 10.1007/s40273-013-0106-x.


The cloudy crystal ball of cost-effectiveness studies.

Frederix GW, Severens JL, Hövels AM, Raaijmakers JA, Schellens JH.

Value Health. 2013 Sep-Oct;16(6):1100-2. doi: 10.1016/j.jval.2013.06.012.


Clinical utility of asthma biomarkers: from bench to bedside.

Vijverberg SJ, Hilvering B, Raaijmakers JA, Lammers JW, Maitland-van der Zee AH, Koenderman L.

Biologics. 2013;7:199-210. doi: 10.2147/BTT.S29976. Epub 2013 Aug 29. Review.


Inflammatory phenotypes underlying uncontrolled childhood asthma despite inhaled corticosteroid treatment: rationale and design of the PACMAN2 study.

Vijverberg SJ, Koenderman L, van Erp FC, van der Ent CK, Postma DS, Brinkman P, Sterk PJ, Raaijmakers JA, Maitland-van der Zee AH.

BMC Pediatr. 2013 Jun 15;13:94. doi: 10.1186/1471-2431-13-94.


Phase IV non-inferiority trials and additional claims of benefit.

Bernabe RD, Wangge G, Knol MJ, Klungel OH, van Delden JJ, de Boer A, Hoes AW, Raaijmakers JA, van Thiel GJ.

BMC Med Res Methodol. 2013 May 30;13:70. doi: 10.1186/1471-2288-13-70.


Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation.

van Heesbeen RG, Raaijmakers JA, Tanenbaum ME, Medema RH.

Commun Integr Biol. 2013 May 1;6(3):e23841. doi: 10.4161/cib.23841.


Time-dependent resource use and costs associated with different states of disease in patients diagnosed with HER-2-positive metastatic breast cancer.

Frederix GW, Severens JL, Hövels AM, van Hasselt JG, Raaijmakers JA, Schellens JH.

Breast Cancer Res Treat. 2013 Jun;139(2):489-95. doi: 10.1007/s10549-013-2532-z. Epub 2013 May 5.


Systematic dissection of dynein regulators in mitosis.

Raaijmakers JA, Tanenbaum ME, Medema RH.

J Cell Biol. 2013 Apr 15;201(2):201-15. doi: 10.1083/jcb.201208098.


Development of a framework for cohort simulation in cost-effectiveness analyses using a multistep ordinary differential equation solver algorithm in R.

Frederix GW, van Hasselt JG, Severens JL, Hövels AM, Huitema AD, Raaijmakers JA, Schellens JH.

Med Decis Making. 2013 Aug;33(6):780-92. doi: 10.1177/0272989X13476763. Epub 2013 Mar 20.


Switching Polo-like kinase-1 on and off in time and space.

Bruinsma W, Raaijmakers JA, Medema RH.

Trends Biochem Sci. 2012 Dec;37(12):534-42. doi: 10.1016/j.tibs.2012.09.005. Epub 2012 Nov 6. Review.


Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation.

Raaijmakers JA, van Heesbeen RG, Meaders JL, Geers EF, Fernandez-Garcia B, Medema RH, Tanenbaum ME.

EMBO J. 2012 Nov 5;31(21):4179-90. doi: 10.1038/emboj.2012.272. Epub 2012 Oct 2.


A 10-year analysis of the effects of media coverage of regulatory warnings on antidepressant use in The Netherlands and UK.

Hernandez JF, Mantel-Teeuwisse AK, van Thiel GJ, Belitser SV, Warmerdam J, de Valk V, Raaijmakers JA, Pieters T.

PLoS One. 2012;7(9):e45515. doi: 10.1371/journal.pone.0045515. Epub 2012 Sep 20.


Decision theory and the evaluation of risks and benefits of clinical trials.

Bernabe RD, van Thiel GJ, Raaijmakers JA, van Delden JJ.

Drug Discov Today. 2012 Dec;17(23-24):1263-9. doi: 10.1016/j.drudis.2012.07.005. Epub 2012 Jul 20.


Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy-based study.

Vijverberg SJ, Koster ES, Koenderman L, Arets HG, van der Ent CK, Postma DS, Koppelman GH, Raaijmakers JA, Maitland-van der Zee AH.

Pediatr Allergy Immunol. 2012 Sep;23(6):529-36. doi: 10.1111/j.1399-3038.2012.01279.x. Epub 2012 May 25.


The risk-benefit task of research ethics committees: an evaluation of current approaches and the need to incorporate decision studies methods.

Bernabe RD, van Thiel GJ, Raaijmakers JA, van Delden JJ.

BMC Med Ethics. 2012 Apr 20;13:6. doi: 10.1186/1472-6939-13-6.


Measuring the value of public-private partnerships in the pharmaceutical sciences.

Denee TR, Sneekes A, Stolk P, Juliens A, Raaijmakers JA, Goldman M, Crommelin DJ, Janssen JW.

Nat Rev Drug Discov. 2012 Mar 30;11(5):419. doi: 10.1038/nrd3078-c1. No abstract available.


Variation at GLCCI1 and FCER2: one step closer to personalized asthma treatment.

Maitland-van der Zee AH, Raaijmakers JA.

Pharmacogenomics. 2012 Feb;13(3):243-5. doi: 10.2217/pgs.11.177. No abstract available.


Knowledge of actions of inhaled corticosteroids in patients who did not persist drug treatment early.

Menckeberg TT, Hugtenburg JG, Lammers JW, Raaijmakers JA, Bouvy ML.

Int J Clin Pharm. 2012 Apr;34(2):277-81. doi: 10.1007/s11096-012-9611-9.


Reviewing the cost-effectiveness of endocrine early breast cancer therapies: influence of differences in modeling methods on outcomes.

Frederix GW, Severens JL, Hövels AM, Raaijmakers JA, Schellens JH.

Value Health. 2012 Jan;15(1):94-105. doi: 10.1016/j.jval.2011.08.003. Epub 2011 Oct 1. Review.

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