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Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer.

Jung M, Russell AJ, Kennedy C, Gifford AJ; Australian Ovarian Cancer Study Group, Mallitt KA, Sivarajasingam S, Bowtell DD, DeFazio A, Haber M, Norris MD, Henderson MJ.

JNCI Cancer Spectr. 2018 Nov 16;2(3):pky047. doi: 10.1093/jncics/pky047. eCollection 2018 Jul.


Self-reported motivations for offending by autistic sexual offenders.

Payne KL, Maras K, Russell AJ, Brosnan MJ.

Autism. 2019 Jun 28:1362361319858860. doi: 10.1177/1362361319858860. [Epub ahead of print]


Charge-Preserving Atom Transfer Radical Polymerization Initiator Rescues the Lost Function of Negatively Charged Protein-Polymer Conjugates.

Baker SL, Murata H, Kaupbayeva B, Tasbolat A, Matyjaszewski K, Russell AJ.

Biomacromolecules. 2019 Jun 10;20(6):2392-2405. doi: 10.1021/acs.biomac.9b00379. Epub 2019 May 22.


Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.

Gamble LD, Purgato S, Murray J, Xiao L, Yu DMT, Hanssen KM, Giorgi FM, Carter DR, Gifford AJ, Valli E, Milazzo G, Kamili A, Mayoh C, Liu B, Eden G, Sarraf S, Allan S, Di Giacomo S, Flemming CL, Russell AJ, Cheung BB, Oberthuer A, London WB, Fischer M, Trahair TN, Fletcher JI, Marshall GM, Ziegler DS, Hogarty MD, Burns MR, Perini G, Norris MD, Haber M.

Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.


Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

Cruz-Migoni A, Canning P, Quevedo CE, Bataille CJR, Bery N, Miller A, Russell AJ, Phillips SEV, Carr SB, Rabbitts TH.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2545-2550. doi: 10.1073/pnas.1811360116. Epub 2019 Jan 25.


Can enzyme proximity accelerate cascade reactions?

Kuzmak A, Carmali S, von Lieres E, Russell AJ, Kondrat S.

Sci Rep. 2019 Jan 24;9(1):455. doi: 10.1038/s41598-018-37034-3.


Molecular Sieving on the Surface of a Nano-Armored Protein.

Kaupbayeva B, Murata H, Lucas A, Matyjaszewski K, Minden JS, Russell AJ.

Biomacromolecules. 2019 Mar 11;20(3):1235-1245. doi: 10.1021/acs.biomac.8b01651. Epub 2019 Feb 4.


Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury.

Billin AN, Honeycutt SE, McDougal AV, Kerr JP, Chen Z, Freudenberg JM, Rajpal DK, Luo G, Kramer HF, Geske RS, Fang F, Yao B, Clark RV, Lepore J, Cobitz A, Miller R, Nosaka K, Hinken AC, Russell AJ.

Skelet Muscle. 2018 Dec 10;8(1):38. doi: 10.1186/s13395-018-0185-7.


HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury.

Billin AN, Honeycutt SE, McDougal AV, Kerr JP, Chen Z, Freudenberg JM, Rajpal DK, Luo G, Kramer HF, Geske RS, Fang F, Yao B, Clark RV, Lepore J, Cobitz A, Miller R, Nosaka K, Hinken AC, Russell AJ.

Skelet Muscle. 2018 Nov 13;8(1):35. doi: 10.1186/s13395-018-0179-5. Erratum in: Skelet Muscle. 2018 Dec 10;8(1):38.


Biocatalytic "Oxygen-Fueled" Atom Transfer Radical Polymerization.

Enciso AE, Fu L, Lathwal S, Olszewski M, Wang Z, Das SR, Russell AJ, Matyjaszewski K.

Angew Chem Int Ed Engl. 2018 Dec 3;57(49):16157-16161. doi: 10.1002/anie.201809018. Epub 2018 Nov 8.


Adapting Psychological Therapies for Autism - Therapist Experience, Skills and Confidence.

Cooper K, Loades ME, Russell AJ.

Res Autism Spectr Disord. 2018 Jan 1;45:43-50. doi: 10.1016/j.rasd.2017.11.002.


Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.

Stefaniak J, Lewis AM, Conole D, Galan SRG, Bataille CJR, Wynne GM, Castaldi MP, Lundbäck T, Russell AJ, Huber KVM.

ACS Chem Biol. 2018 Oct 19;13(10):2849-2854. doi: 10.1021/acschembio.8b00665. Epub 2018 Sep 19.


Tailoring Site Specificity of Bioconjugation Using Step-Wise Atom-Transfer Radical Polymerization on Proteins.

Carmali S, Murata H, Matyjaszewski K, Russell AJ.

Biomacromolecules. 2018 Oct 8;19(10):4044-4051. doi: 10.1021/acs.biomac.8b01064. Epub 2018 Sep 20.


Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.

Quevedo CE, Cruz-Migoni A, Bery N, Miller A, Tanaka T, Petch D, Bataille CJR, Lee LYW, Fallon PS, Tulmin H, Ehebauer MT, Fernandez-Fuentes N, Russell AJ, Carr SB, Phillips SEV, Rabbitts TH.

Nat Commun. 2018 Aug 9;9(1):3169. doi: 10.1038/s41467-018-05707-2.


Intramolecular Interactions of Conjugated Polymers Mimic Molecular Chaperones to Stabilize Protein-Polymer Conjugates.

Baker SL, Munasinghe A, Murata H, Lin P, Matyjaszewski K, Colina CM, Russell AJ.

Biomacromolecules. 2018 Sep 10;19(9):3798-3813. doi: 10.1021/acs.biomac.8b00927. Epub 2018 Aug 22.


The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.

White JP, Billin AN, Campbell ME, Russell AJ, Huffman KM, Kraus WE.

Stem Cell Reports. 2018 Aug 14;11(2):425-439. doi: 10.1016/j.stemcr.2018.06.014. Epub 2018 Jul 19.


In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury.

Patsalos A, Simandi Z, Hays TT, Peloquin M, Hajian M, Restrepo I, Coen PM, Russell AJ, Nagy L.

Aging Cell. 2018 Oct;17(5):e12815. doi: 10.1111/acel.12815. Epub 2018 Jul 12.


2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm.

Partridge FA, Forman R, Willis NJ, Bataille CJR, Murphy EA, Brown AE, Heyer-Chauhan N, Marinič B, Sowood DJC, Wynne GM, Else KJ, Russell AJ, Sattelle DB.

PLoS Negl Trop Dis. 2018 Jul 11;12(7):e0006487. doi: 10.1371/journal.pntd.0006487. eCollection 2018 Jul.


Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages.

Recio C, Lucy D, Purvis GSD, Iveson P, Zeboudj L, Iqbal AJ, Lin D, O'Callaghan C, Davison L, Griesbach E, Russell AJ, Wynne GM, Dib L, Monaco C, Greaves DR.

Front Immunol. 2018 Jun 20;9:1419. doi: 10.3389/fimmu.2018.01419. eCollection 2018.


Single-Cell (Multi)omics Technologies.

Chappell L, Russell AJC, Voet T.

Annu Rev Genomics Hum Genet. 2018 Aug 31;19:15-41. doi: 10.1146/annurev-genom-091416-035324. Epub 2018 May 4. Review.


Gender Identity in Autism: Sex Differences in Social Affiliation with Gender Groups.

Cooper K, Smith LGE, Russell AJ.

J Autism Dev Disord. 2018 Dec;48(12):3995-4006. doi: 10.1007/s10803-018-3590-1.


Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome.

Wang JJ, Reed JH, Colella AD, Russell AJ, Murray-Brown W, Chataway TK, Jackson KJL, Goodnow CC, Gordon TP.

Arthritis Rheumatol. 2018 Oct;70(10):1617-1625. doi: 10.1002/art.40539. Epub 2018 Aug 3.


Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

Collibee SE, Bergnes G, Muci A, Browne WF 4th, Garard M, Hinken AC, Russell AJ, Suehiro I, Hartman J, Kawas R, Lu PP, Lee KH, Marquez D, Tomlinson M, Xu D, Kennedy A, Hwee D, Schaletzky J, Leung K, Malik FI, Morgans DJ Jr, Morgan BP.

ACS Med Chem Lett. 2018 Feb 13;9(4):354-358. doi: 10.1021/acsmedchemlett.7b00546. eCollection 2018 Apr 12.


Solid-phase synthesis of protein-polymers on reversible immobilization supports.

Murata H, Carmali S, Baker SL, Matyjaszewski K, Russell AJ.

Nat Commun. 2018 Feb 27;9(1):845. doi: 10.1038/s41467-018-03153-8.


Cognitive-behavioural therapy for adult attention-deficit hyperactivity disorder: a proof of concept randomised controlled trial.

Dittner AJ, Hodsoll J, Rimes KA, Russell AJ, Chalder T.

Acta Psychiatr Scand. 2018 Feb;137(2):125-137. doi: 10.1111/acps.12836. Epub 2017 Dec 27.


Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform.

Venturi E, Lindsay C, Lotteau S, Yang Z, Steer E, Witschas K, Wilson AD, Wickens JR, Russell AJ, Steele D, Calaghan S, Sitsapesan R.

Br J Pharmacol. 2018 Mar;175(6):938-952. doi: 10.1111/bph.14136. Epub 2018 Feb 5.


A Breathing Atom-Transfer Radical Polymerization: Fully Oxygen-Tolerant Polymerization Inspired by Aerobic Respiration of Cells.

Enciso AE, Fu L, Russell AJ, Matyjaszewski K.

Angew Chem Int Ed Engl. 2018 Jan 22;57(4):933-936. doi: 10.1002/anie.201711105. Epub 2018 Jan 2.


An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.

Partridge FA, Brown AE, Buckingham SD, Willis NJ, Wynne GM, Forman R, Else KJ, Morrison AA, Matthews JB, Russell AJ, Lomas DA, Sattelle DB.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):8-21. doi: 10.1016/j.ijpddr.2017.11.004. Epub 2017 Dec 2.


The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease.

Recio C, Lucy D, Iveson P, Iqbal AJ, Valaris S, Wynne G, Russell AJ, Choudhury RP, O'Callaghan C, Monaco C, Greaves DR.

Antioxid Redox Signal. 2018 Jul 20;29(3):237-256. doi: 10.1089/ars.2017.7168. Epub 2018 Jan 17.


Safety at The William Quarrier Scottish Epilepsy Centre.

Anderson J, Grant V, Elgammal M, Campbell A, Hampshire J, Hansen S, Russell AJC.

Seizure. 2017 Dec;53:10-12. doi: 10.1016/j.seizure.2017.10.003. Epub 2017 Oct 16.


Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi.

Tempone AG, Ferreira DD, Lima ML, Costa Silva TA, Borborema SET, Reimão JQ, Galuppo MK, Guerra JM, Russell AJ, Wynne GM, Lai RYL, Cadelis MM, Copp BR.

Eur J Med Chem. 2017 Oct 20;139:947-960. doi: 10.1016/j.ejmech.2017.08.055. Epub 2017 Sep 1.


The William Quarrier Scottish Epilepsy Centre, Glasgow, Scotland.

Russell AJC, Anderson J, Razvi S, Oto M, Hill J, Gahagan G.

Epilepsy Behav. 2017 Nov;76S:S41-S45. doi: 10.1016/j.yebeh.2017.07.029. Epub 2017 Aug 31. No abstract available.


Probing Competitive and Co-operative Hydroxyl and Ammonium Hydrogen-Bonding Directed Epoxidations.

Brambilla M, Brennan MB, Csatayová K, Davies SG, Fletcher AM, Kennett AMR, Lee JA, Roberts PM, Russell AJ, Thomson JE.

J Org Chem. 2017 Oct 6;82(19):10297-10309. doi: 10.1021/acs.joc.7b01774. Epub 2017 Sep 19.


Bactericidal Specificity and Resistance Profile of Poly(Quaternary Ammonium) Polymers and Protein-Poly(Quaternary Ammonium) Conjugates.

Ji W, Koepsel RR, Murata H, Zadan S, Campbell AS, Russell AJ.

Biomacromolecules. 2017 Aug 14;18(8):2583-2593. doi: 10.1021/acs.biomac.7b00705. Epub 2017 Jul 14.


ATRP-grown protein-polymer conjugates containing phenylpiperazine selectively enhance transepithelial protein transport.

Cummings CS, Fein K, Murata H, Ball RL, Russell AJ, Whitehead KA.

J Control Release. 2017 Jun 10;255:270-278. doi: 10.1016/j.jconrel.2017.04.035. Epub 2017 Apr 25.


Polymer-Based Protein Engineering: Synthesis and Characterization of Armored, High Graft Density Polymer-Protein Conjugates.

Carmali S, Murata H, Cummings C, Matyjaszewski K, Russell AJ.

Methods Enzymol. 2017;590:347-380. doi: 10.1016/bs.mie.2016.12.005. Epub 2017 Feb 16.


A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.

Kerr AG, Tam LCS, Hale AB, Cioroch M, Douglas G, Agkatsev S, Hibbitt O, Mason J, Holt-Martyn J, Bataille CJR, Wynne GM, Channon KM, Russell AJ, Wade-Martins R.

J Pharmacol Exp Ther. 2017 Jun;361(3):417-428. doi: 10.1124/jpet.116.239574. Epub 2017 Mar 30.


Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.

Bataille CJ, Brennan MB, Byrne S, Davies SG, Durbin M, Fedorov O, Huber KV, Jones AM, Knapp S, Liu G, Nadali A, Quevedo CE, Russell AJ, Walker RG, Westwood R, Wynne GM.

Bioorg Med Chem. 2017 May 1;25(9):2657-2665. doi: 10.1016/j.bmc.2017.02.056. Epub 2017 Feb 28.


Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.

Partridge FA, Murphy EA, Willis NJ, Bataille CJ, Forman R, Heyer-Chauhan N, Marinič B, Sowood DJ, Wynne GM, Else KJ, Russell AJ, Sattelle DB.

PLoS Negl Trop Dis. 2017 Feb 9;11(2):e0005359. doi: 10.1371/journal.pntd.0005359. eCollection 2017 Feb.


Pharmacological inhibition of myostatin protects against skeletal muscle atrophy and weakness after anterior cruciate ligament tear.

Wurtzel CN, Gumucio JP, Grekin JA, Khouri RK Jr, Russell AJ, Bedi A, Mendias CL.

J Orthop Res. 2017 Nov;35(11):2499-2505. doi: 10.1002/jor.23537. Epub 2017 Feb 15.


Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear.

Gumucio JP, Flood MD, Bedi A, Kramer HF, Russell AJ, Mendias CL.

Bone Joint Res. 2017 Jan;6(1):57-65. doi: 10.1302/2046-3758.61.BJR-2016-0232.R1.


Design of Stomach Acid-Stable and Mucin-Binding Enzyme Polymer Conjugates.

Cummings CS, Campbell AS, Baker SL, Carmali S, Murata H, Russell AJ.

Biomacromolecules. 2017 Feb 13;18(2):576-586. doi: 10.1021/acs.biomac.6b01723. Epub 2017 Jan 31.


A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

Jung M, Russell AJ, Liu B, George J, Liu PY, Liu T, DeFazio A, Bowtell DD, Oberthuer A, London WB, Fletcher JI, Haber M, Norris MD, Henderson MJ.

Cancer Res. 2017 Feb 15;77(4):971-981. doi: 10.1158/0008-5472.CAN-15-2906. Epub 2016 Dec 6.


The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle.

Hwee DT, Cheng AJ, Hartman JJ, Hinken AC, Lee K, Durham N, Russell AJ, Malik FI, Westerblad H, Jasper JR.

J Physiol. 2017 Mar 1;595(5):1657-1670. doi: 10.1113/JP273248. Epub 2017 Jan 24.


What's 'difficult'? A multi-stage qualitative analysis of secondary care specialists' experiences with medically unexplained symptoms.

Maatz A, Wainwright M, Russell AJ, Macnaughton J, Yiannakou Y.

J Psychosom Res. 2016 Nov;90:1-9. doi: 10.1016/j.jpsychores.2016.09.005. Epub 2016 Sep 9.


The Quality and Outcomes Framework: Body commodification in UK general practice.

Norman AH, Russell AJ, Merli C.

Soc Sci Med. 2016 Dec;170:77-86. doi: 10.1016/j.socscimed.2016.10.009. Epub 2016 Oct 11.


MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4.

Xue C, Yu DM, Gherardi S, Koach J, Milazzo G, Gamble L, Liu B, Valli E, Russell AJ, London WB, Liu T, Cheung BB, Marshall GM, Perini G, Haber M, Norris MD.

Oncotarget. 2016 Aug 23;7(34):54937-54951. doi: 10.18632/oncotarget.10709.


Polymer-based protein engineering grown ferrocene-containing redox polymers improve current generation in an enzymatic biofuel cell.

Campbell AS, Murata H, Carmali S, Matyjaszewski K, Islam MF, Russell AJ.

Biosens Bioelectron. 2016 Dec 15;86:446-453. doi: 10.1016/j.bios.2016.06.078. Epub 2016 Jun 29.


The Effect of Covalently-Attached ATRP-Synthesized Polymers on Membrane Stability and Cytoprotection in Human Erythrocytes.

Clafshenkel WP, Murata H, Andersen J, Creeger Y, Koepsel RR, Russell AJ.

PLoS One. 2016 Jun 22;11(6):e0157641. doi: 10.1371/journal.pone.0157641. eCollection 2016.


Chemical-Induced Naive Pluripotency.

Russell AJ, Silpa L.

Cell Chem Biol. 2016 May 19;23(5):532-534. doi: 10.1016/j.chembiol.2016.05.002.

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