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Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial.

Rovati LC, Brambilla N, Blicharski T, Connell J, Vitalini C, Bonazzi A, Giacovelli G, Girolami F, D'Amato M.

Osteoarthritis Cartilage. 2019 Sep 14. pii: S1063-4584(19)31208-7. doi: 10.1016/j.joca.2019.09.002. [Epub ahead of print]


CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons.

Vellani V, Sabatini C, Milia C, Caselli G, Lanza M, Letari O, Rovati LC, Giacomoni C.

Br J Pharmacol. 2019 Aug 27. doi: 10.1111/bph.14845. [Epub ahead of print]


Type 2 diabetes mellitus and osteoarthritis.

Veronese N, Cooper C, Reginster JY, Hochberg M, Branco J, Bruyère O, Chapurlat R, Al-Daghri N, Dennison E, Herrero-Beaumont G, Kaux JF, Maheu E, Rizzoli R, Roth R, Rovati LC, Uebelhart D, Vlaskovska M, Scheen A.

Semin Arthritis Rheum. 2019 Aug;49(1):9-19. doi: 10.1016/j.semarthrit.2019.01.005. Epub 2019 Jan 11. Review.


Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Gregori D, Giacovelli G, Minto C, Barbetta B, Gualtieri F, Azzolina D, Vaghi P, Rovati LC.

JAMA. 2018 Dec 25;320(24):2564-2579. doi: 10.1001/jama.2018.19319.


Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug.

Caselli G, Bonazzi A, Lanza M, Ferrari F, Maggioni D, Ferioli C, Giambelli R, Comi E, Zerbi S, Perrella M, Letari O, Di Luccio E, Colovic M, Persiani S, Zanelli T, Mennuni L, Piepoli T, Rovati LC.

Arthritis Res Ther. 2018 Mar 1;20(1):39. doi: 10.1186/s13075-018-1537-8.


Comparison of V-Y Advancement Flap Versus Lotus Petal Flap for Plastic Reconstruction After Surgery in Case of Vulvar Malignancies: A Retrospective Single Center Experience.

Confalonieri PL, Gilardi R, Rovati LC, Ceccherelli A, Lee JH, Magni S, Del Bene M, Buda A.

Ann Plast Surg. 2017 Aug;79(2):186-191. doi: 10.1097/SAP.0000000000001094.


Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis.

Comi E, Lanza M, Ferrari F, Mauri V, Caselli G, Rovati LC.

J Pain Res. 2017 May 4;10:1033-1043. doi: 10.2147/JPR.S132026. eCollection 2017.


Regarding: Vulvar Reconstruction by Perforator Flaps. Algorithm for Flap Choice Based on the Topography of the Defect.

Buda A, Confalonieri P, Rovati LC.

Int J Gynecol Cancer. 2016 Feb;26(2):224-5. doi: 10.1097/IGC.0000000000000580. No abstract available.


The role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study.

Runhaar J, Deroisy R, van Middelkoop M, Barretta F, Barbetta B, Oei EH, Vroegindeweij D, Giacovelli G, Bruyère O, Rovati LC, Reginster JY, Bierma-Zeinstra SM.

Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S42-8. doi: 10.1016/j.semarthrit.2015.11.001. Epub 2015 Nov 19.


Effects of glucosamine sulfate on the use of rescue non-steroidal anti-inflammatory drugs in knee osteoarthritis: Results from the Pharmaco-Epidemiology of GonArthroSis (PEGASus) study.

Rovati LC, Girolami F, D'Amato M, Giacovelli G.

Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S34-41. doi: 10.1016/j.semarthrit.2015.10.009. Epub 2015 Oct 29.


The Pros and the Cons for the Use of Silybin-Rich Oral Formulations in Treatment of Liver Damage (NAFLD in Particular).

Rosso N, Marin V, Giordani A, Persiani S, Sala F, Cavicchioli L, Rovati LC, Tiribelli C.

Curr Med Chem. 2015;22(25):2954-71. Review.


Evaluation of Levothyroxine Bioavailability after Oral Administration of a Fixed Combination of Soy Isoflavones in Post-menopausal Female Volunteers.

Persiani S, Sala F, Manzotti C, Colovic M, Zangarini M, Donazzolo Y, Barbetta B, Vitalini C, Giacovelli G, Benvenuti C, Rovati LC.

Drug Res (Stuttg). 2016 Mar;66(3):136-40. doi: 10.1055/s-0035-1555784. Epub 2015 Jun 30.


A reference case for economic evaluations in osteoarthritis: an expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

Hiligsmann M, Cooper C, Guillemin F, Hochberg MC, Tugwell P, Arden N, Berenbaum F, Boers M, Boonen A, Branco JC, Maria-Luisa B, Bruyère O, Gasparik A, Kanis JA, Kvien TK, Martel-Pelletier J, Pelletier JP, Pinedo-Villanueva R, Pinto D, Reiter-Niesert S, Rizzoli R, Rovati LC, Severens JL, Silverman S, Reginster JY.

Semin Arthritis Rheum. 2014 Dec;44(3):271-82. doi: 10.1016/j.semarthrit.2014.06.005. Epub 2014 Jun 27.


Development and validation of two liquid chromatography-tandem mass spectrometry methods for the determination of silibinin and silibinin hemisuccinate in human plasma.

Sala F, Albares P, Colovic M, Persiani S, Rovati LC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 15;945-946:1-9. doi: 10.1016/j.jchromb.2013.11.028. Epub 2013 Nov 25.


Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

Hiligsmann M, Cooper C, Arden N, Boers M, Branco JC, Luisa Brandi M, Bruyère O, Guillemin F, Hochberg MC, Hunter DJ, Kanis JA, Kvien TK, Laslop A, Pelletier JP, Pinto D, Reiter-Niesert S, Rizzoli R, Rovati LC, Severens JL, Silverman S, Tsouderos Y, Tugwell P, Reginster JY.

Semin Arthritis Rheum. 2013 Dec;43(3):303-13. doi: 10.1016/j.semarthrit.2013.07.003. Epub 2013 Aug 29.


Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis.

Chiusaroli R, Visentini M, Galimberti C, Casseler C, Mennuni L, Covaceuszach S, Lanza M, Ugolini G, Caselli G, Rovati LC, Visintin M.

Osteoarthritis Cartilage. 2013 Nov;21(11):1807-10. doi: 10.1016/j.joca.2013.08.015. Epub 2013 Aug 15.


Silibinin hemisuccinate binding to proteins in plasma and blood cell/plasma partitioning in mouse, rat, dog and man in vitro.

Persiani S, Sala F, Cole R, Webber G, Caselli G, Vaghi P, Rovati LC.

Drug Metabol Drug Interact. 2013;28(2):115-22. doi: 10.1515/dmdi-2013-0013.


Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties.

Rovati LC, Girolami F, Persiani S.

Ther Adv Musculoskelet Dis. 2012 Jun;4(3):167-80. doi: 10.1177/1759720X12437753.


Tunneled modified lotus petal flap for surgical reconstruction of severe introital stenosis after radical vulvectomy.

Buda A, Confalonieri PL, Rovati LC, Signorelli M, Del Bene M.

Int J Surg Case Rep. 2012;3(7):299-301. doi: 10.1016/j.ijscr.2012.03.024. Epub 2012 Mar 30.


Better anatomical and cosmetic results using tunneled lotus petal flap for plastic reconstruction after demolitive surgery for vulvar malignancy.

Buda A, Confalonieri PL, Rovati LC, Fruscio R, Giuliani D, Signorelli M, Dell'Anna T, Pirovano C, Milani R.

Int J Gynecol Cancer. 2012 Jun;22(5):860-4. doi: 10.1097/IGC.0b013e318249bf02.


A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis.

Berenbaum F, Grifka J, Cazzaniga S, D'Amato M, Giacovelli G, Chevalier X, Rannou F, Rovati LC, Maheu E.

Ann Rheum Dis. 2012 Sep;71(9):1454-60. doi: 10.1136/annrheumdis-2011-200972. Epub 2012 Jan 31.


Crystalline glucosamine sulfate in the treatment of osteoarthritis: evidence of long-term cardiovascular safety from clinical trials.

Palma Dos Reis R, Giacovelli G, Girolami F, André R, Bonazzi A, Rovati LC.

Open Rheumatol J. 2011;5:69-77. doi: 10.2174/1874312901105010069. Epub 2011 Nov 29.


Experimental pharmacology of glucosamine sulfate.

Chiusaroli R, Piepoli T, Zanelli T, Ballanti P, Lanza M, Rovati LC, Caselli G.

Int J Rheumatol. 2011;2011:939265. doi: 10.1155/2011/939265. Epub 2011 Oct 9.


Modified lotus petal flap for vulvo-vaginal reconstruction after resection for vulvar cancer: a single institution experience.

Misani M, Rovati LC, Confalonieri P, Buda A, Giuliani D, Del Bene M.

Handchir Mikrochir Plast Chir. 2011 Aug;43(4):250-4. doi: 10.1055/s-0031-1280802. Epub 2011 Aug 10. No abstract available.


OARSI/OMERACT initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. An OMERACT 10 Special Interest Group.

Gossec L, Paternotte S, Bingham CO 3rd, Clegg DO, Coste P, Conaghan PG, Davis AM, Giacovelli G, Gunther KP, Hawker G, Hochberg MC, Jordan JM, Katz JN, Kloppenburg M, Lanzarotti A, Lim K, Lohmander LS, Mahomed NN, Maillefert JF, Manno RL, March LM, Mazzuca SA, Pavelka K, Punzi L, Roos EM, Rovati LC, Shi H, Singh JA, Suarez-Almazor ME, Tajana-Messi E, Dougados M; OARSI-OMERACT Task Force Total Articular Replacement as Outcome Measure in OA.

J Rheumatol. 2011 Aug;38(8):1765-9. doi: 10.3899/jrheum.110403.


Identification and quantification of glucosamine in rabbit cartilage and correlation with plasma levels by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

Pastorini E, Vecchiotti S, Colliva C, Persiani S, Rotini R, Roatti G, Zaccarelli L, Rovati LC, Roda A.

Anal Chim Acta. 2011 Jun 10;695(1-2):77-83. doi: 10.1016/j.aca.2011.04.003. Epub 2011 Apr 12.


Glucosamine and osteoarthritis. Conclusions not supported by methods and results.

Giacovelli G, Rovati LC.

BMJ. 2010 Nov 9;341:c6338. doi: 10.1136/bmj.c6338. No abstract available.


The need for a transparent, ethical, and successful relationship between academic scientists and the pharmaceutical industry: a view of the Group for the Respect of Ethics and Excellence in Science (GREES).

Bruyere O, Kanis JA, Ibar-Abadie ME, Alsayed N, Brandi ML, Burlet N, Cahall DL, Chines A, Devogelaer JP, Dere W, Goel N, Hughes N, Kaufman JM, Korte S, Mitlak BH, Niese D, Rizzoli R, Rovati LC, Reginster JY.

Osteoporos Int. 2010 May;21(5):713-22. doi: 10.1007/s00198-010-1190-9. Epub 2010 Mar 18.


Bioequivalence study of generic tablet formulations containing ethinylestradiol and chlormadinone acetate in healthy female volunteers.

Bonn M, Eydeler U, Barkworth M, Rovati LC.

Arzneimittelforschung. 2009;59(12):651-8. doi: 10.1055/s-0031-1296455.


Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice.

Letari O, Booth C, Bonazzi A, Garofalo P, Makovec F, Rovati LC, Caselli G.

Cancer Chemother Pharmacol. 2010 Oct;66(5):819-27. doi: 10.1007/s00280-009-1224-1. Epub 2009 Dec 30.


Development and validation of a HPLC-ES-MS/MS method for the determination of glucosamine in human synovial fluid.

Pastorini E, Rotini R, Guardigli M, Vecchiotti S, Persiani S, Trisolino G, Antonioli D, Rovati LC, Roda A.

J Pharm Biomed Anal. 2009 Dec 5;50(5):1009-14. doi: 10.1016/j.jpba.2009.07.008. Epub 2009 Jul 31.


Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis.

Malerba M, Mennuni L, Piepoli T, Caselli G, Makovec F, Rovati LC, D' Amato M, Ferrari F.

Int J Immunopathol Pharmacol. 2009 Jan-Mar;22(1):85-94.


Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression.

Piepoli T, Mennuni L, Zerbi S, Lanza M, Rovati LC, Caselli G.

Osteoarthritis Cartilage. 2009 Aug;17(8):1076-83. doi: 10.1016/j.joca.2009.02.002. Epub 2009 Feb 15.


Glucosamine binding to proteins in plasma and synovial fluid and blood cell/plasma partitioning in mouse and man in vitro.

Persiani S, Matthews A, Larger P, Hall M, Rotini R, Trisolino G, Antonioli D, Zaccarelli L, Rovati LC.

Drug Metabol Drug Interact. 2009;24(2-4):211-27.


In vitro study of the inhibition and induction of human cytochromes P450 by crystalline glucosamine sulfate.

Persiani S, Canciani L, Larger P, Rotini R, Trisolino G, Antonioli D, Rovati LC.

Drug Metabol Drug Interact. 2009;24(2-4):195-209.


Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials.

Bruyere O, Pavelka K, Rovati LC, Gatterová J, Giacovelli G, Olejarová M, Deroisy R, Reginster JY.

Osteoarthritis Cartilage. 2008 Feb;16(2):254-60. Epub 2007 Jul 27.


Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose.

Persiani S, Rotini R, Trisolino G, Rovati LC, Locatelli M, Paganini D, Antonioli D, Roda A.

Osteoarthritis Cartilage. 2007 Jul;15(7):764-72. Epub 2007 Mar 13.


The reverse glucosamine sulfate pathway: application in knee osteoarthritis.

Herrero-Beaumont G, Rovati LC, Castañeda S, Alvarez-Soria MA, Largo R.

Expert Opin Pharmacother. 2007 Feb;8(2):215-25. Review.


Pharmacokinetic profile of dexloxiglumide.

Persiani S, D'Amato M, Jakate A, Roy P, Wangsa J, Kapil R, Rovati LC.

Clin Pharmacokinet. 2006;45(12):1177-88. Review.


Development and validation of a sensitive HPLC-ESI-MS/MS method for the direct determination of glucosamine in human plasma.

Roda A, Sabatini L, Barbieri A, Guardigli M, Locatelli M, Violante FS, Rovati LC, Persiani S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Nov 21;844(1):119-26. Epub 2006 Aug 22.


Clinical significance of the long-term symptom-modifying effects of glucosamine sulfate: comment on the article by Brandt and Mazzuca.

Bruyere O, Reginster JY, Giacovelli G, Barbetta B, Rovati LC, Pavelka K.

Arthritis Rheum. 2006 Jul;54(7):2339-41; author reply 2341-3. No abstract available.


Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man.

Persiani S, Roda E, Rovati LC, Locatelli M, Giacovelli G, Roda A.

Osteoarthritis Cartilage. 2005 Dec;13(12):1041-9. Epub 2005 Sep 13.


Antiatherosclerotic efficacy of policosanol, red yeast rice extract and astaxanthin in the rabbit.

Setnikar I, Senin P, Rovati LC.

Arzneimittelforschung. 2005;55(6):312-7.


Efficacy of etidronate and sequential monofluorophosphate in severe postmenopausal osteoporosis: a pilot study.

Ringe JD, Dorst A, Faber H, Kipshoven C, Rovati LC, Setnikar I.

Rheumatol Int. 2005 May;25(4):296-300. Epub 2005 Mar 16.


Interaction of dexloxiglumide, a cholecystokinin type-1 receptor antagonist, with human cytochromes P450.

Hall M, Persiani S, Cheung YL, Matthews A, Cybulski ZR, Holding JD, Kapil R, D'Amato M, Makovec F, Rovati LC.

Biopharm Drug Dispos. 2004 May;25(4):163-76.


Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.

Bruyere O, Pavelka K, Rovati LC, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster JY.

Menopause. 2004 Mar-Apr;11(2):138-43.


Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate.

Christgau S, Henrotin Y, Tankó LB, Rovati LC, Collette J, Bruyere O, Deroisy R, Reginster JY.

Clin Exp Rheumatol. 2004 Jan-Feb;22(1):36-42.


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