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Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity.

Stevens RV, Esposito D, Rittinger K.

Life Sci Alliance. 2019 Apr 26;2(3). pii: e201900295. doi: 10.26508/lsa.201900295. Print 2019 Jun.


Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.

Johansson H, Isabella Tsai YC, Fantom K, Chung CW, Kümper S, Martino L, Thomas DA, Eberl HC, Muelbaier M, House D, Rittinger K.

J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.


Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB.

Jennings E, Esposito D, Rittinger K, Thurston TLM.

J Biol Chem. 2018 Sep 28;293(39):15316-15329. doi: 10.1074/jbc.RA118.004255. Epub 2018 Jul 26.


Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis E Sousa C, Cusack S, Rittinger K.

Nat Commun. 2018 May 8;9(1):1820. doi: 10.1038/s41467-018-04214-8.


RBR ligase-mediated ubiquitin transfer: a tale with many twists and turns.

Walden H, Rittinger K.

Nat Struct Mol Biol. 2018 Jun;25(6):440-445. doi: 10.1038/s41594-018-0063-3. Epub 2018 May 7. Review.


Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3.

Esposito D, Günster RA, Martino L, El Omari K, Wagner A, Thurston TLM, Rittinger K.

J Biol Chem. 2018 Apr 6;293(14):5064-5078. doi: 10.1074/jbc.RA118.001796. Epub 2018 Feb 15.


Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases.

Martino L, Brown NR, Masino L, Esposito D, Rittinger K.

Sci Rep. 2018 Jan 8;8(1):68. doi: 10.1038/s41598-017-18513-5.


Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.

Dove KK, Olszewski JL, Martino L, Duda DM, Wu XS, Miller DJ, Reiter KH, Rittinger K, Schulman BA, Klevit RE.

Structure. 2017 Jun 6;25(6):890-900.e5. doi: 10.1016/j.str.2017.04.013. Epub 2017 May 25.


Linear ubiquitin chains: enzymes, mechanisms and biology.

Rittinger K, Ikeda F.

Open Biol. 2017 Apr;7(4). pii: 170026. doi: 10.1098/rsob.170026. Review.


Transparency and openness in science.

Sanders J, Blundy J, Donaldson A, Brown S, Ivison R, Padgett M, Padian K, Rittinger K, Rowe K, Stace A, Viding E, Chambers C, Chaplain M.

R Soc Open Sci. 2017 Jan 11;4(1):160979. doi: 10.1098/rsos.160979. eCollection 2017 Jan. No abstract available.


Determination of the pKa of the N-terminal amino group of ubiquitin by NMR.

Oregioni A, Stieglitz B, Kelly G, Rittinger K, Frenkiel T.

Sci Rep. 2017 Mar 2;7:43748. doi: 10.1038/srep43748.


Structural determinants of TRIM protein function.

Esposito D, Koliopoulos MG, Rittinger K.

Biochem Soc Trans. 2017 Feb 8;45(1):183-191. doi: 10.1042/BST20160325. Review.


In Vitro Analysis of Tem1 GTPase Activity and Regulation by the Bfa1/Bub2 GAP.

Geymonat M, Spanos A, Rittinger K.

Methods Mol Biol. 2017;1505:71-80.


Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

Asaoka T, Almagro J, Ehrhardt C, Tsai I, Schleiffer A, Deszcz L, Junttila S, Ringrose L, Mechtler K, Kavirayani A, Gyenesei A, Hofmann K, Duchek P, Rittinger K, Ikeda F.

EMBO Rep. 2016 Nov;17(11):1624-1640. Epub 2016 Oct 4.


The Biophysical Characterisation and SAXS Analysis of Human NLRP1 Uncover a New Level of Complexity of NLR Proteins.

Martino L, Holland L, Christodoulou E, Kunzelmann S, Esposito D, Rittinger K.

PLoS One. 2016 Oct 11;11(10):e0164662. doi: 10.1371/journal.pone.0164662. eCollection 2016.


SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H.

Cell Rep. 2016 Aug 30;16(9):2271-80. doi: 10.1016/j.celrep.2016.07.086. Epub 2016 Aug 18.


Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.

Dove KK, Stieglitz B, Duncan ED, Rittinger K, Klevit RE.

EMBO Rep. 2016 Aug;17(8):1221-35. doi: 10.15252/embr.201642641. Epub 2016 Jun 16.


Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.

Koliopoulos MG, Esposito D, Christodoulou E, Taylor IA, Rittinger K.

EMBO J. 2016 Jun 1;35(11):1204-18. doi: 10.15252/embj.201593741. Epub 2016 May 6.


LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.

Draber P, Kupka S, Reichert M, Draberova H, Lafont E, de Miguel D, Spilgies L, Surinova S, Taraborrelli L, Hartwig T, Rieser E, Martino L, Rittinger K, Walczak H.

Cell Rep. 2015 Dec 15;13(10):2258-72. doi: 10.1016/j.celrep.2015.11.009. Epub 2015 Dec 6.


pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit.

Dove KK, Klevit RE, Rittinger K.

EMBO J. 2015 Oct 14;34(20):2486-8. doi: 10.15252/embj.201592857. Epub 2015 Sep 7. No abstract available.


Sedimentation equilibrium studies.

Taylor IA, Rittinger K, Eccleston JF.

Methods Mol Biol. 2015;1278:205-22. doi: 10.1007/978-1-4939-2425-7_12.


Editorial overview: Multi-protein assemblies in signaling.

Fass D, Rittinger K.

Curr Opin Struct Biol. 2014 Dec;29:vi-viii. doi: 10.1016/ No abstract available.


Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.

Parkhouse R, Boyle JP, Mayle S, Sawmynaden K, Rittinger K, Monie TP.

FEBS Lett. 2014 Aug 25;588(17):2830-6. doi: 10.1016/j.febslet.2014.06.035. Epub 2014 Jun 21.


Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.

Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K.

Nature. 2013 Nov 21;503(7476):422-426. doi: 10.1038/nature12638. Epub 2013 Oct 20.


Mechanism and function of Vav1 localisation in TCR signalling.

Ksionda O, Saveliev A, Köchl R, Rapley J, Faroudi M, Smith-Garvin JE, Wülfing C, Rittinger K, Carter T, Tybulewicz VL.

J Cell Sci. 2012 Nov 15;125(Pt 22):5302-14. doi: 10.1242/jcs.105148. Epub 2012 Sep 6.


LUBAC synthesizes linear ubiquitin chains via a thioester intermediate.

Stieglitz B, Morris-Davies AC, Koliopoulos MG, Christodoulou E, Rittinger K.

EMBO Rep. 2012 Sep;13(9):840-6. doi: 10.1038/embor.2012.105. Epub 2012 Jul 13.


Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization.

Stieglitz B, Rittinger K, Haire LF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):816-9. doi: 10.1107/S1744309112022208. Epub 2012 Jun 28.


Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.

Stieglitz B, Haire LF, Dikic I, Rittinger K.

J Biol Chem. 2012 Jun 15;287(25):20823-9. doi: 10.1074/jbc.M112.359547. Epub 2012 May 1.


The tandem CARDs of NOD2: intramolecular interactions and recognition of RIP2.

Fridh V, Rittinger K.

PLoS One. 2012;7(3):e34375. doi: 10.1371/journal.pone.0034375. Epub 2012 Mar 28.


SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.

Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814.


In silico phosphorylation of the autoinhibited form of p47(phox): insights into the mechanism of activation.

Autore F, Pagano B, Fornili A, Rittinger K, Fraternali F.

Biophys J. 2010 Dec 1;99(11):3716-25. doi: 10.1016/j.bpj.2010.09.008.


Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus.

Esposito D, Sankar A, Morgner N, Robinson CV, Rittinger K, Driscoll PC.

Structure. 2010 Oct 13;18(10):1378-90. doi: 10.1016/j.str.2010.08.006.


Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.

Dutta S, Rittinger K.

PLoS One. 2010 May 4;5(5):e10478. doi: 10.1371/journal.pone.0010478.


Function of the nucleotide exchange activity of vav1 in T cell development and activation.

Saveliev A, Vanes L, Ksionda O, Rapley J, Smerdon SJ, Rittinger K, Tybulewicz VL.

Sci Signal. 2009 Dec 15;2(101):ra83. doi: 10.1126/scisignal.2000420.


Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis.

Groves E, Rittinger K, Amstutz M, Berry S, Holden DW, Cornelis GR, Caron E.

J Biol Chem. 2010 Feb 5;285(6):4087-98. doi: 10.1074/jbc.M109.071035. Epub 2009 Nov 19.


Snapshots form a big picture of guanine nucleotide exchange.

Rittinger K.

Sci Signal. 2009 Oct 6;2(91):pe63. doi: 10.1126/scisignal.291pe63.


Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins.

Rufer AC, Rumpf J, von Holleben M, Beer S, Rittinger K, Groemping Y.

J Mol Biol. 2009 Jul 31;390(5):939-50. doi: 10.1016/j.jmb.2009.05.025. Epub 2009 May 21.


NEMO oligomerization and its ubiquitin-binding properties.

Ivins FJ, Montgomery MG, Smith SJ, Morris-Davies AC, Taylor IA, Rittinger K.

Biochem J. 2009 Jun 26;421(2):243-51. doi: 10.1042/BJ20090427.


Structures of dimeric GIT1 and trimeric beta-PIX and implications for GIT-PIX complex assembly.

Schlenker O, Rittinger K.

J Mol Biol. 2009 Feb 20;386(2):280-9. doi: 10.1016/j.jmb.2008.12.050. Epub 2008 Dec 30.


Reply to "The binding stoichiometry of CIN85 SH3 domain A and Cbl-b".

Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J.

Nat Struct Mol Biol. 2008 Sep;15(9):891-2. No abstract available.


Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.

Rapley J, Tybulewicz VL, Rittinger K.

EMBO Rep. 2008 Jul;9(7):655-61. doi: 10.1038/embor.2008.80. Epub 2008 May 30.


Cbl promotes clustering of endocytic adaptor proteins.

Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J.

Nat Struct Mol Biol. 2005 Nov;12(11):972-9.


Activation and assembly of the NADPH oxidase: a structural perspective.

Groemping Y, Rittinger K.

Biochem J. 2005 Mar 15;386(Pt 3):401-16. Review.


Sedimentation equilibrium studies.

Taylor IA, Eccleston JF, Rittinger K.

Methods Mol Biol. 2004;261:119-36. Review.


Molecular basis of phosphorylation-induced activation of the NADPH oxidase.

Groemping Y, Lapouge K, Smerdon SJ, Rittinger K.

Cell. 2003 May 2;113(3):343-55.


Preparation of GTPases for structural and biophysical analysis.

Smith SJ, Rittinger K.

Methods Mol Biol. 2002;189:13-24. No abstract available.


Control of mitotic exit in budding yeast. In vitro regulation of Tem1 GTPase by Bub2 and Bfa1.

Geymonat M, Spanos A, Smith SJ, Wheatley E, Rittinger K, Johnston LH, Sedgwick SG.

J Biol Chem. 2002 Aug 9;277(32):28439-45. Epub 2002 Jun 4.


MgF(3)(-) as a transition state analog of phosphoryl transfer.

Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF.

Chem Biol. 2002 Mar;9(3):375-81.


Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox.

Lapouge K, Smith SJ, Groemping Y, Rittinger K.

J Biol Chem. 2002 Mar 22;277(12):10121-8. Epub 2002 Jan 16.

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