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Items: 1 to 50 of 67

1.

Methods for Construction of Yeast Display Libraries of Four-Domain T-Cell Receptors.

Sádio F, Stadlmayr G, Eibensteiner K, Stadlbauer K, Rüker F, Wozniak-Knopp G.

Methods Mol Biol. 2020;2070:223-248. doi: 10.1007/978-1-4939-9853-1_13.

PMID:
31625099
2.

Stabilization of soluble high-affinity T-cell receptor with de novo disulfide bonds.

Sádio F, Stadlmayr G, Stadlbauer K, Gräf M, Scharrer A, Rüker F, Wozniak-Knopp G.

FEBS Lett. 2019 Sep 25. doi: 10.1002/1873-3468.13616. [Epub ahead of print]

PMID:
31552676
3.

Constant domain-exchanged Fab enables specific light chain pairing in heterodimeric bispecific SEED-antibodies.

Dietrich S, Gross AW, Becker S, Hock B, Stadlmayr G, Rüker F, Wozniak-Knopp G.

Biochim Biophys Acta Proteins Proteom. 2019 Jul 8:140250. doi: 10.1016/j.bbapap.2019.07.003. [Epub ahead of print]

4.

Yeast Surface Display and Cell Sorting of Antigen-Binding Fc Fragments.

Sádio F, Stadlmayr G, Stadlbauer K, Rüker F, Wozniak-Knopp G.

Methods Mol Biol. 2019;1923:287-308. doi: 10.1007/978-1-4939-9024-5_13.

PMID:
30737746
5.

Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting.

Vogt S, Stadlmayr G, Stadlbauer K, Sádio F, Andorfer P, Grillari J, Rüker F, Wozniak-Knopp G.

Pharmaceutics. 2018 Aug 27;10(3). pii: E138. doi: 10.3390/pharmaceutics10030138.

6.

Enhancement and Analysis of Human Antiaflatoxin B1 (AFB1) scFv Antibody-Ligand Interaction Using Chain Shuffling.

Rangnoi K, Choowongkomon K, O'Kennedy R, Rüker F, Yamabhai M.

J Agric Food Chem. 2018 Jun 6;66(22):5713-5722. doi: 10.1021/acs.jafc.8b01141. Epub 2018 May 29.

PMID:
29781609
7.

An antibody with Fab-constant domains exchanged for a pair of CH3 domains.

Wozniak-Knopp G, Stadlmayr G, Perthold JW, Stadlbauer K, Gotsmy M, Becker S, Rüker F.

PLoS One. 2018 Apr 9;13(4):e0195442. doi: 10.1371/journal.pone.0195442. eCollection 2018.

8.

Novel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies.

Bönisch M, Sellmann C, Maresch D, Halbig C, Becker S, Toleikis L, Hock B, Rüker F.

Protein Eng Des Sel. 2017 Sep 1;30(9):685-696. doi: 10.1093/protein/gzx044.

9.

Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments.

Wozniak-Knopp G, Stadlmayr G, Perthold JW, Stadlbauer K, Woisetschläger M, Sun H, Rüker F.

Protein Eng Des Sel. 2017 Sep 1;30(9):657-671. doi: 10.1093/protein/gzx042.

PMID:
28981753
10.

Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies.

Lobner E, Humm AS, Göritzer K, Mlynek G, Puchinger MG, Hasenhindl C, Rüker F, Traxlmayr MW, Djinović-Carugo K, Obinger C.

Structure. 2017 Jun 6;25(6):878-889.e5. doi: 10.1016/j.str.2017.04.014. Epub 2017 May 18.

11.

IgG Fc Fragment as a Scaffold for Development of Targeted Therapeutics.

Knopp GW, Stadlmayr G, Ruker F.

Curr Pharm Biotechnol. 2016;17(15):1315-1323. doi: 10.2174/1389201018666161114152527.

PMID:
27842481
12.

Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution.

Traxlmayr MW, Lobner E, Hasenhindl C, Stadlmayr G, Oostenbrink C, Rüker F, Obinger C.

Biotechnol J. 2014 Aug;9(8):1013-22. doi: 10.1002/biot.201300483.

13.

In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites.

Woisetschläger M, Antes B, Borrowdale R, Wiederkum S, Kainer M, Steinkellner H, Wozniak-Knopp G, Moulder K, Rüker F, Mudde GC.

Biotechnol J. 2014 Jun;9(6):844-51. doi: 10.1002/biot.201300387. Epub 2014 May 8.

PMID:
24806546
14.

Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.

Hasenhindl C, Lai B, Delgado J, Traxlmayr MW, Stadlmayr G, Rüker F, Serrano L, Oostenbrink C, Obinger C.

Biochim Biophys Acta. 2014 Sep;1844(9):1530-40. doi: 10.1016/j.bbapap.2014.04.020. Epub 2014 May 2.

15.

Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc.

Hasenhindl C, Traxlmayr MW, Wozniak-Knopp G, Jones PC, Stadlmayr G, Rüker F, Obinger C.

Protein Eng Des Sel. 2013 Oct;26(10):675-82. doi: 10.1093/protein/gzt041. Epub 2013 Sep 4.

16.

Structural studies of several clinically important oncology drugs in complex with human serum albumin.

Wang ZM, Ho JX, Ruble JR, Rose J, Rüker F, Ellenburg M, Murphy R, Click J, Soistman E, Wilkerson L, Carter DC.

Biochim Biophys Acta. 2013 Dec;1830(12):5356-74. doi: 10.1016/j.bbagen.2013.06.032. Epub 2013 Jul 6.

PMID:
23838380
17.

Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display.

Traxlmayr MW, Lobner E, Antes B, Kainer M, Wiederkum S, Hasenhindl C, Stadlmayr G, Rüker F, Woisetschläger M, Moulder K, Obinger C.

Protein Eng Des Sel. 2013 Apr;26(4):255-65. doi: 10.1093/protein/gzs102. Epub 2012 Dec 23.

PMID:
23267121
18.

Guest editor's introduction--antibody engineering.

Rüker F.

Arch Biochem Biophys. 2012 Oct 15;526(2):85-6. doi: 10.1016/j.abb.2012.07.002. No abstract available.

PMID:
22944043
19.

Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing.

Traxlmayr MW, Hasenhindl C, Hackl M, Stadlmayr G, Rybka JD, Borth N, Grillari J, Rüker F, Obinger C.

J Mol Biol. 2012 Oct 26;423(3):397-412. doi: 10.1016/j.jmb.2012.07.017. Epub 2012 Jul 27.

20.

Correlation between CD16a binding and immuno effector functionality of an antigen specific immunoglobulin Fc fragment (Fcab).

Kainer M, Antes B, Wiederkum S, Wozniak-Knopp G, Bauer A, Rüker F, Woisetschläger M.

Arch Biochem Biophys. 2012 Oct 15;526(2):154-8. doi: 10.1016/j.abb.2012.05.010. Epub 2012 May 23.

PMID:
22634259
21.

Significant impact of single N-glycan residues on the biological activity of Fc-based antibody-like fragments.

Jez J, Antes B, Castilho A, Kainer M, Wiederkum S, Grass J, Rüker F, Woisetschläger M, Steinkellner H.

J Biol Chem. 2012 Jul 13;287(29):24313-9. doi: 10.1074/jbc.M112.360701. Epub 2012 May 15.

22.

A C-terminal interdomain disulfide bond significantly stabilizes the Fc fragment of IgG.

Wozniak-Knopp G, Rüker F.

Arch Biochem Biophys. 2012 Oct 15;526(2):181-7. doi: 10.1016/j.abb.2012.03.024. Epub 2012 Mar 29.

PMID:
22483683
23.

Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast.

Traxlmayr MW, Faissner M, Stadlmayr G, Hasenhindl C, Antes B, Rüker F, Obinger C.

Biochim Biophys Acta. 2012 Apr;1824(4):542-9. doi: 10.1016/j.bbapap.2012.01.006. Epub 2012 Jan 20.

24.

Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds.

Wozniak-Knopp G, Stadlmann J, Rüker F.

PLoS One. 2012;7(1):e30083. doi: 10.1371/journal.pone.0030083. Epub 2012 Jan 17.

25.

Integrin binding human antibody constant domains--probing the C-terminal structural loops for grafting the RGD motif.

Traxlmayr MW, Wozniak-Knopp G, Antes B, Stadlmayr G, Rüker F, Obinger C.

J Biotechnol. 2011 Sep 10;155(2):193-202. doi: 10.1016/j.jbiotec.2011.06.042. Epub 2011 Jul 8.

PMID:
21771617
26.

Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties.

Wozniak-Knopp G, Bartl S, Bauer A, Mostageer M, Woisetschläger M, Antes B, Ettl K, Kainer M, Weberhofer G, Wiederkum S, Himmler G, Mudde GC, Rüker F.

Protein Eng Des Sel. 2010 Apr;23(4):289-97. doi: 10.1093/protein/gzq005. Epub 2010 Feb 11.

PMID:
20150180
27.

Influence of the unusual covalent adduct on the kinetics and formation of radical intermediates in synechocystis catalase peroxidase: a stopped-flow and EPR characterization of the MET275, TYR249, and ARG439 variants.

Jakopitsch C, Ivancich A, Schmuckenschlager F, Wanasinghe A, Pöltl G, Furtmüller PG, Rüker F, Obinger C.

J Biol Chem. 2004 Oct 29;279(44):46082-95. Epub 2004 Aug 23.

28.

The iron superoxide dismutase from the filamentous cyanobacterium Nostoc PCC 7120. Localization, overexpression, and biochemical characterization.

Regelsberger G, Laaha U, Dietmann D, Rüker F, Canini A, Grilli-Caiola M, Furtmüller PG, Jakopitsch C, Peschek GA, Obinger C.

J Biol Chem. 2004 Oct 22;279(43):44384-93. Epub 2004 Aug 9.

29.

An ELISA for the detection of TIMP-1 based on recombinant single chain Fv fusion proteins.

Wozniak G, Obermayr E, Jeras M, Knezevic M, Rüker F.

Clin Chim Acta. 2003 Sep;335(1-2):49-57.

PMID:
12927684
30.

Distal site aspartate is essential in the catalase activity of catalase-peroxidases.

Jakopitsch C, Auer M, Regelsberger G, Jantschko W, Furtmüller PG, Rüker F, Obinger C.

Biochemistry. 2003 May 13;42(18):5292-300.

PMID:
12731870
31.

Total conversion of bifunctional catalase-peroxidase (KatG) to monofunctional peroxidase by exchange of a conserved distal side tyrosine.

Jakopitsch C, Auer M, Ivancich A, Rüker F, Furtmüller PG, Obinger C.

J Biol Chem. 2003 May 30;278(22):20185-91. Epub 2003 Mar 20.

32.

The catalytic role of the distal site asparagine-histidine couple in catalase-peroxidases.

Jakopitsch C, Auer M, Regelsberger G, Jantschko W, Furtmüller PG, Rüker F, Obinger C.

Eur J Biochem. 2003 Mar;270(5):1006-13.

33.

Expression of TIMP-1 in Pichia pastoris. Selection of an anti-TIMP-1 specific single-chain Fv antibody from a large non-immune library.

Wozniak G, Obermayr E, Jeras M, Knezevic M, Rüker F.

Clin Chim Acta. 2003 Jan;327(1-2):171-9.

PMID:
12482633
34.
35.

Biochemical characterization of a membrane-bound manganese-containing superoxide dismutase from the cyanobacterium Anabaena PCC 7120.

Regelsberger G, Atzenhofer W, Ruker F, Peschek GA, Jakopitsch C, Paumann M, Furtmüller PG, Obinger C.

J Biol Chem. 2002 Nov 15;277(46):43615-22. Epub 2002 Sep 4.

36.

Engineering the proximal heme cavity of catalase-peroxidase.

Jakopitsch C, Regelsberger G, Furtmüller PG, Rüker F, Peschek GA, Obinger C.

J Inorg Biochem. 2002 Jul 25;91(1):78-86.

PMID:
12121764
37.

The atomic structure of human methemalbumin at 1.9 A.

Wardell M, Wang Z, Ho JX, Robert J, Ruker F, Ruble J, Carter DC.

Biochem Biophys Res Commun. 2002 Mar 8;291(4):813-9.

PMID:
11866438
38.

Catalase-peroxidase from synechocystis is capable of chlorination and bromination reactions.

Jakopitsch C, Regelsberger G, Furtmüller PG, Rüker F, Peschek GA, Obinger C.

Biochem Biophys Res Commun. 2001 Sep 28;287(3):682-7.

PMID:
11563849
39.
40.

Nucleotide sequence analysis, overexpression in Escherichia coli and kinetic characterization of Anacystis nidulans catalase-peroxidase.

Engleder M, Regelsberger G, Jakopitsch C, Furtmüller PG, Rüker F, Peschek GA, Obinger C.

Biochimie. 2000 Mar;82(3):211-9.

PMID:
10863004
41.

Effect of distal cavity mutations on the formation of compound I in catalase-peroxidases.

Regelsberger G, Jakopitsch C, Rüker F, Krois D, Peschek GA, Obinger C.

J Biol Chem. 2000 Jul 28;275(30):22854-61.

42.

Catalase-peroxidases in cyanobacteria--similarities and differences to ascorbate peroxidases.

Obinger C, Regelsberger G, Furtmüller PG, Jakopitsch C, Rüker F, Pircher A, Peschek GA.

Free Radic Res. 1999 Dec;31 Suppl:S243-9.

PMID:
10694066
43.

Conformational transitions of the three recombinant domains of human serum albumin depending on pH.

Dockal M, Carter DC, Rüker F.

J Biol Chem. 2000 Feb 4;275(5):3042-50.

44.

Catalase-peroxidase from the cyanobacterium Synechocystis PCC 6803: cloning, overexpression in Escherichia coli, and kinetic characterization.

Jakopitsch C, Rüker F, Regelsberger G, Dockal M, Peschek GA, Obinger C.

Biol Chem. 1999 Sep;380(9):1087-96.

PMID:
10543446
45.
46.

Spectral and kinetic studies of the oxidation of monosubstituted phenols and anilines by recombinant Synechocystis catalase-peroxidase compound I.

Regelsberger G, Jakopitsch C, Engleder M, Rüker F, Peschek GA, Obinger C.

Biochemistry. 1999 Aug 10;38(32):10480-8.

PMID:
10441144
48.

Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus.

Eckhart L, Raffelsberger W, Ferko B, Klima A, Purtscher M, Katinger H, Rüker F.

J Gen Virol. 1996 Sep;77 ( Pt 9):2001-8.

PMID:
8810996
49.

Interaction between a Fab fragment against gp41 of human immunodeficiency virus 1 and its peptide epitope: characterization using a peptide epitope library and molecular modeling.

Stigler RD, Rüker F, Katinger D, Elliott G, Höhne W, Henklein P, Ho JX, Keeling K, Carter DC, Nugel E, et al.

Protein Eng. 1995 May;8(5):471-9.

PMID:
8532669
50.

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