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Items: 1 to 50 of 113

1.

Pathoarchitectonics of the cerebral cortex in chorea-acanthocytosis and Huntington's disease.

Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E Jr, Pasqualucci CA, Rüb U, Seidel K, den Dunnen W, Arzberger T, Schmitz C, Kiessling MC, Bader B, Danek A.

Neuropathol Appl Neurobiol. 2018 May 2. doi: 10.1111/nan.12495. [Epub ahead of print]

PMID:
29722054
2.

Subcortical neurodegeneration in chorea: Similarities and differences between chorea-acanthocytosis and Huntington's disease.

Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E Jr, Pasqualucci CA, Rüb U, den Dunnen W, Arzberger T, Schmitz C, Kiessling M, Bader B, Danek A.

Parkinsonism Relat Disord. 2018 Apr;49:54-59. doi: 10.1016/j.parkreldis.2018.01.009. Epub 2018 Jan 10.

PMID:
29402698
3.

Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.

Seidel K, Bouzrou M, Heidemann N, Krüger R, Schöls L, den Dunnen WFA, Korf HW, Rüb U.

Ann Neurol. 2017 Jun;81(6):898-903. doi: 10.1002/ana.24937. Epub 2017 Jun 2.

PMID:
28439961
4.

Alzheimer's Disease: Characterization of the Brain Sites of the Initial Tau Cytoskeletal Pathology Will Improve the Success of Novel Immunological Anti-Tau Treatment Approaches.

Rüb U, Stratmann K, Heinsen H, Seidel K, Bouzrou M, Korf HW.

J Alzheimers Dis. 2017;57(3):683-696. doi: 10.3233/JAD-161102. Review.

PMID:
28269779
5.

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.

Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT.

Neuropathol Appl Neurobiol. 2017 Aug;43(5):393-408. doi: 10.1111/nan.12387. Epub 2017 Mar 31.

6.

Longitudinal changes of cortical microstructure in Parkinson's disease assessed with T1 relaxometry.

Nürnberger L, Gracien RM, Hok P, Hof SM, Rüb U, Steinmetz H, Hilker R, Klein JC, Deichmann R, Baudrexel S.

Neuroimage Clin. 2016 Dec 21;13:405-414. doi: 10.1016/j.nicl.2016.12.025. eCollection 2017.

7.

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

Lahut S, Gispert S, Ömür Ö, Depboylu C, Seidel K, Domínguez-Bautista JA, Brehm N, Tireli H, Hackmann K, Pirkevi C, Leube B, Ries V, Reim K, Brose N, den Dunnen WF, Johnson M, Wolf Z, Schindewolf M, Schrempf W, Reetz K, Young P, Vadasz D, Frangakis AS, Schröck E, Steinmetz H, Jendrach M, Rüb U, Başak AN, Oertel W, Auburger G.

Dis Model Mech. 2017 May 1;10(5):619-631. doi: 10.1242/dmm.028035. Epub 2017 Jan 20.

8.

Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain.

Rüb U, Seidel K, Heinsen H, Vonsattel JP, den Dunnen WF, Korf HW.

Brain Pathol. 2016 Nov;26(6):726-740. doi: 10.1111/bpa.12426. Review.

PMID:
27529157
9.

Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years.

Gracien RM, Nürnberger L, Hok P, Hof SM, Reitz SC, Rüb U, Steinmetz H, Hilker-Roggendorf R, Klein JC, Deichmann R, Baudrexel S.

Eur Radiol. 2017 Apr;27(4):1568-1576. doi: 10.1007/s00330-016-4485-1. Epub 2016 Jul 5.

PMID:
27379992
10.

On the distribution of intranuclear and cytoplasmic aggregates in the brainstem of patients with spinocerebellar ataxia type 2 and 3.

Seidel K, Siswanto S, Fredrich M, Bouzrou M, den Dunnen WFA, Özerden I, Korf HW, Melegh B, de Vries JJ, Brunt ER, Auburger G, Rüb U.

Brain Pathol. 2017 May;27(3):345-355. doi: 10.1111/bpa.12412. Epub 2016 Aug 2.

PMID:
27377427
11.
12.

The Neuropathology of Huntington´s disease: classical findings, recent developments and correlation to functional neuroanatomy.

Rüb U, Vonsattel JP, Heinsen H, Korf HW.

Adv Anat Embryol Cell Biol. 2015;217:1-146. Review.

PMID:
26767207
13.

No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra.

Schöls L, Reimold M, Seidel K, Globas C, Brockmann K, Hauser TK, Auburger G, Bürk K, den Dunnen W, Reischl G, Korf HW, Brunt ER, Rüb U.

Brain. 2015 Nov;138(Pt 11):3316-26. doi: 10.1093/brain/awv255. Epub 2015 Sep 11.

PMID:
26362908
14.

Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology.

Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB, den Dunnen W, Rüb U.

Brain Pathol. 2016 May;26(3):371-86. doi: 10.1111/bpa.12289. Epub 2015 Aug 24.

15.

Polyglutamine aggregation in Huntington's disease and spinocerebellar ataxia type 3: similar mechanisms in aggregate formation.

Seidel K, Siswanto S, Fredrich M, Bouzrou M, Brunt ER, van Leeuwen FW, Kampinga HH, Korf HW, Rüb U, den Dunnen WF.

Neuropathol Appl Neurobiol. 2016 Feb;42(2):153-66. doi: 10.1111/nan.12253. Epub 2015 Jul 2.

PMID:
26095752
16.

Huntington's Disease (HD): Neurodegeneration of Brodmann's Primary Visual Area 17 (BA17).

Rüb U, Seidel K, Vonsattel JP, Lange HW, Eisenmenger W, Götz M, Del Turco D, Bouzrou M, Korf HW, Heinsen H.

Brain Pathol. 2015 Nov;25(6):701-11. doi: 10.1111/bpa.12237. Epub 2015 Jan 27.

PMID:
25495445
17.

Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.

Gispert S, Brehm N, Weil J, Seidel K, Rüb U, Kern B, Walter M, Roeper J, Auburger G.

Hum Mol Genet. 2015 Feb 15;24(4):1061-76. doi: 10.1093/hmg/ddu520. Epub 2014 Oct 8.

18.

Irradiation with X-rays phase-advances the molecular clockwork in liver, adrenal gland and pancreas.

Müller MH, Rödel F, Rüb U, Korf HW.

Chronobiol Int. 2015 Feb;32(1):27-36. doi: 10.3109/07420528.2014.949735. Epub 2014 Aug 20.

PMID:
25140390
19.

The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.

Seidel K, Mahlke J, Siswanto S, Krüger R, Heinsen H, Auburger G, Bouzrou M, Grinberg LT, Wicht H, Korf HW, den Dunnen W, Rüb U.

Brain Pathol. 2015 Mar;25(2):121-35. doi: 10.1111/bpa.12168. Epub 2014 Sep 12.

20.

Huntington's disease (HD): degeneration of select nuclei, widespread occurrence of neuronal nuclear and axonal inclusions in the brainstem.

Rüb U, Hentschel M, Stratmann K, Brunt E, Heinsen H, Seidel K, Bouzrou M, Auburger G, Paulson H, Vonsattel JP, Lange H, Korf HW, den Dunnen W.

Brain Pathol. 2014 Apr;24(3):247-60. doi: 10.1111/bpa.12115. Epub 2014 Mar 3.

21.

First patho-anatomical investigation of the brain of a SCA19 patient.

Seidel K, Küsters B, den Dunnen WF, Bouzrou M, Hageman G, Korf HW, Schelhaas HJ, Verbeek D, Rüb U.

Neuropathol Appl Neurobiol. 2014 Aug;40(5):640-4. doi: 10.1111/nan.12128. No abstract available.

PMID:
24612451
22.

Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7.

Rüb U, Schöls L, Paulson H, Auburger G, Kermer P, Jen JC, Seidel K, Korf HW, Deller T.

Prog Neurobiol. 2013 May;104:38-66. doi: 10.1016/j.pneurobio.2013.01.001. Epub 2013 Feb 21. Review.

PMID:
23438480
23.

Involvement of the cholinergic basal forebrain nuclei in spinocerebellar ataxia type 2 (SCA2).

Rüb U, Farrag K, Seidel K, Brunt ER, Heinsen H, Bürk K, Melegh B, von Gall C, Auburger G, Bohl J, Korf HW, Hoche F, den Dunnen W.

Neuropathol Appl Neurobiol. 2013 Oct;39(6):634-43. doi: 10.1111/nan.12025.

PMID:
23363055
24.

ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.

Damrath E, Heck MV, Gispert S, Azizov M, Nowock J, Seifried C, Rüb U, Walter M, Auburger G.

PLoS Genet. 2012;8(8):e1002920. doi: 10.1371/journal.pgen.1002920. Epub 2012 Aug 30.

25.

Degeneration of the cerebellum in Huntington's disease (HD): possible relevance for the clinical picture and potential gateway to pathological mechanisms of the disease process.

Rüb U, Hoche F, Brunt ER, Heinsen H, Seidel K, Del Turco D, Paulson HL, Bohl J, von Gall C, Vonsattel JP, Korf HW, den Dunnen WF.

Brain Pathol. 2013 Mar;23(2):165-77. doi: 10.1111/j.1750-3639.2012.00629.x. Epub 2012 Sep 21.

26.

Brain pathology of spinocerebellar ataxias.

Seidel K, Siswanto S, Brunt ER, den Dunnen W, Korf HW, Rüb U.

Acta Neuropathol. 2012 Jul;124(1):1-21. doi: 10.1007/s00401-012-1000-x. Epub 2012 Jun 9. Review.

PMID:
22684686
27.

Spinocerebellar ataxia type 1 (SCA1): new pathoanatomical and clinico-pathological insights.

Rüb U, Bürk K, Timmann D, den Dunnen W, Seidel K, Farrag K, Brunt E, Heinsen H, Egensperger R, Bornemann A, Schwarzacher S, Korf HW, Schöls L, Bohl J, Deller T.

Neuropathol Appl Neurobiol. 2012 Dec;38(7):665-80. doi: 10.1111/j.1365-2990.2012.01259.x.

PMID:
22309224
28.

Pathoanatomy of cerebellar degeneration in spinocerebellar ataxia type 2 (SCA2) and type 3 (SCA3).

Scherzed W, Brunt ER, Heinsen H, de Vos RA, Seidel K, Bürk K, Schöls L, Auburger G, Del Turco D, Deller T, Korf HW, den Dunnen WF, Rüb U.

Cerebellum. 2012 Sep;11(3):749-60. doi: 10.1007/s12311-011-0340-8.

PMID:
22198871
29.

Cellular protein quality control and the evolution of aggregates in spinocerebellar ataxia type 3 (SCA3).

Seidel K, Meister M, Dugbartey GJ, Zijlstra MP, Vinet J, Brunt ER, van Leeuwen FW, Rüb U, Kampinga HH, den Dunnen WF.

Neuropathol Appl Neurobiol. 2012 Oct;38(6):548-58. doi: 10.1111/j.1365-2990.2011.01220.x.

PMID:
21916928
30.

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases.

Seidel K, Vinet J, Dunnen WF, Brunt ER, Meister M, Boncoraglio A, Zijlstra MP, Boddeke HW, Rüb U, Kampinga HH, Carra S.

Neuropathol Appl Neurobiol. 2012 Feb;38(1):39-53. doi: 10.1111/j.1365-2990.2011.01198.x.

PMID:
21696420
31.

Spinocerebellar ataxia type 2 (SCA2): identification of early brain degeneration in one monozygous twin in the initial disease stage.

Hoche F, Balikó L, den Dunnen W, Steinecker K, Bartos L, Sáfrány E, Auburger G, Deller T, Korf HW, Klockgether T, Rüb U, Melegh B.

Cerebellum. 2011 Jun;10(2):245-53. doi: 10.1007/s12311-010-0239-9.

PMID:
21128038
32.

Neuroanatomical characteristics of the human pre-Bötzinger complex and its involvement in neurodegenerative brainstem diseases.

Schwarzacher SW, Rüb U, Deller T.

Brain. 2011 Jan;134(Pt 1):24-35. doi: 10.1093/brain/awq327. Epub 2010 Nov 28.

PMID:
21115469
33.

Hierarchical Distribution of the Tau Cytoskeletal Pathology in the Thalamus of Alzheimer's Disease Patients.

Rüb U, Stratmann K, Heinsen H, Del Turco D, Ghebremedhin E, Seidel K, den Dunnen W, Korf HW.

J Alzheimers Dis. 2016;49(4):905-15. doi: 10.3233/JAD-150639. Review.

PMID:
26519431
34.

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.

Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VM, Van Deerlin VM, Bonini NM, Gitler AD.

Nature. 2010 Aug 26;466(7310):1069-75. doi: 10.1038/nature09320.

35.

Axonal inclusions in spinocerebellar ataxia type 3.

Seidel K, den Dunnen WF, Schultz C, Paulson H, Frank S, de Vos RA, Brunt ER, Deller T, Kampinga HH, Rüb U.

Acta Neuropathol. 2010 Oct;120(4):449-60. doi: 10.1007/s00401-010-0717-7. Epub 2010 Jul 16.

36.

First appraisal of brain pathology owing to A30P mutant alpha-synuclein.

Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rüb U, Krüger R.

Ann Neurol. 2010 May;67(5):684-9. doi: 10.1002/ana.21966. Erratum in: Ann Neurol. 2010 Jun;67(6):841.

PMID:
20437567
37.

Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases.

Ghebremedhin E, Rosenberger A, Rüb U, Vuksic M, Berhe T, Bickeböller H, de Vos RA, Thal DR, Deller T.

J Neuropathol Exp Neurol. 2010 May;69(5):442-8. doi: 10.1097/NEN.0b013e3181d88e63.

PMID:
20418782
38.

Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease.

Baudrexel S, Nürnberger L, Rüb U, Seifried C, Klein JC, Deller T, Steinmetz H, Deichmann R, Hilker R.

Neuroimage. 2010 Jun;51(2):512-20. doi: 10.1016/j.neuroimage.2010.03.005. Epub 2010 Mar 6.

PMID:
20211271
39.

The p62 antibody reveals various cytoplasmic protein aggregates in spinocerebellar ataxia type 6.

Seidel K, Brunt ER, de Vos RA, Dijk F, van der Want HJ, Rüb U, den Dunnen WF.

Clin Neuropathol. 2009 Sep-Oct;28(5):344-9.

40.

The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?

Grinberg LT, Rüb U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H; Brazilian Brain Bank Study Group.

Neuropathol Appl Neurobiol. 2009 Aug;35(4):406-16. doi: 10.1111/j.1365-2990.2009.00997.x.

PMID:
19508444
41.

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.

Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D, Voos W, Leuner K, Müller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, García-Arencíbia M, Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G.

PLoS One. 2009 Jun 3;4(6):e5777. doi: 10.1371/journal.pone.0005777.

42.

Widespread thalamic and cerebellar degeneration in a patient with a complicated hereditary spastic paraplegia (HSP).

Seidel K, De Vos R, Derksen L, Bauer P, Riess O, den Dunnen W, Deller T, Hageman G, Rüb U.

Ann Anat. 2009 Apr;191(2):203-11. doi: 10.1016/j.aanat.2008.11.003. Epub 2009 Jan 20.

PMID:
19230631
43.

Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites.

Gierga K, Schelhaas HJ, Brunt ER, Seidel K, Scherzed W, Egensperger R, de Vos RA, den Dunnen W, Ippel PF, Petrasch-Parwez E, Deller T, Schöls L, Rüb U.

Neuropathol Appl Neurobiol. 2009 Oct;35(5):515-27. doi: 10.1111/j.1365-2990.2009.01015.x. Epub 2009 Jan 30.

PMID:
19207264
44.

The human premotor oculomotor brainstem system - can it help to understand oculomotor symptoms in Huntington's disease?

Rüb U, Heinsen H, Brunt ER, Landwehrmeyer B, Den Dunnen WF, Gierga K, Deller T.

Neuropathol Appl Neurobiol. 2009 Feb;35(1):4-15. doi: 10.1111/j.1365-2990.2008.00994.x. Review.

PMID:
19187058
45.

Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla.

Frisoni GB, Ganzola R, Canu E, Rüb U, Pizzini FB, Alessandrini F, Zoccatelli G, Beltramello A, Caltagirone C, Thompson PM.

Brain. 2008 Dec;131(Pt 12):3266-76. doi: 10.1093/brain/awn280. Epub 2008 Nov 6.

PMID:
18988639
46.

SCA3: neurological features, pathogenesis and animal models.

Riess O, Rüb U, Pastore A, Bauer P, Schöls L.

Cerebellum. 2008;7(2):125-37. doi: 10.1007/s12311-008-0013-4. Review.

PMID:
18418689
47.

Spinocerebellar ataxia 2 (SCA2).

Lastres-Becker I, Rüb U, Auburger G.

Cerebellum. 2008;7(2):115-24. doi: 10.1007/s12311-008-0019-y. Review.

PMID:
18418684
48.

Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies.

Rüb U, Jen JC, Braak H, Deller T.

Exp Brain Res. 2008 May;187(2):167-80. doi: 10.1007/s00221-008-1342-8. Epub 2008 Apr 2. Review.

PMID:
18385989
49.

New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease).

Rüb U, Brunt ER, Deller T.

Curr Opin Neurol. 2008 Apr;21(2):111-6. doi: 10.1097/WCO.0b013e3282f7673d. Review.

PMID:
18317266
50.

Involvement of the auditory brainstem system in spinocerebellar ataxia type 2 (SCA2), type 3 (SCA3) and type 7 (SCA7).

Hoche F, Seidel K, Brunt ER, Auburger G, Schöls L, Bürk K, de Vos RA, den Dunnen W, Bechmann I, Egensperger R, Van Broeckhoven C, Gierga K, Deller T, Rüb U.

Neuropathol Appl Neurobiol. 2008 Oct;34(5):479-91. doi: 10.1111/j.1365-2990.2007.00933.x. Epub 2008 Jan 24.

PMID:
18221259

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