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Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice.

Stincic TL, Grachev P, Bosch MA, Rønnekleiv OK, Kelly MJ.

eNeuro. 2018 Oct 10;5(4). pii: ENEURO.0103-18.2018. doi: 10.1523/ENEURO.0103-18.2018. eCollection 2018 Jul-Aug.


SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.

Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, Heras V, Velasco I, Dieguez C, Pinilla L, Gaytan F, Nogueiras R, Bosch MA, Rønnekleiv OK, Lomniczi A, Ojeda SR, Tena-Sempere M.

Nat Commun. 2018 Oct 10;9(1):4194. doi: 10.1038/s41467-018-06459-9.


Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females.

Qiu J, Rivera HM, Bosch MA, Padilla SL, Stincic TL, Palmiter RD, Kelly MJ, Rønnekleiv OK.

Elife. 2018 Aug 6;7. pii: e35656. doi: 10.7554/eLife.35656.


TRPCing around the hypothalamus.

Kelly MJ, Qiu J, Rønnekleiv OK.

Front Neuroendocrinol. 2018 Oct;51:116-124. doi: 10.1016/j.yfrne.2018.05.004. Epub 2018 May 31. Review.


Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons.

Stincic TL, Rønnekleiv OK, Kelly MJ.

Horm Behav. 2018 Aug;104:146-155. doi: 10.1016/j.yhbeh.2018.04.001. Epub 2018 Apr 21. Review.


Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance.

Qiu J, Bosch MA, Meza C, Navarro UV, Nestor CC, Wagner EJ, Rønnekleiv OK, Kelly MJ.

Endocrinology. 2018 Feb 1;159(2):647-664. doi: 10.1210/en.2017-00793.


Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels.

Qiu J, Wagner EJ, Rønnekleiv OK, Kelly MJ.

J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12501. Review.


AgRP to Kiss1 neuron signaling links nutritional state and fertility.

Padilla SL, Qiu J, Nestor CC, Zhang C, Smith AW, Whiddon BB, Rønnekleiv OK, Kelly MJ, Palmiter RD.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2413-2418. doi: 10.1073/pnas.1621065114. Epub 2017 Feb 14. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 25;114(17 ):E3584.


GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance.

Heppner KM, Baquero AF, Bennett CM, Lindsley SR, Kirigiti MA, Bennett B, Bosch MA, Mercer AJ, Rønnekleiv OK, True C, Grove KL, Smith MS.

eNeuro. 2017 Jan 20;4(1). pii: ENEURO.0198-16.2016. doi: 10.1523/ENEURO.0198-16.2016. eCollection 2017 Jan-Feb.


High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons.

Qiu J, Nestor CC, Zhang C, Padilla SL, Palmiter RD, Kelly MJ, Rønnekleiv OK.

Elife. 2016 Aug 23;5. pii: e16246. doi: 10.7554/eLife.16246.


Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice.

Nestor CC, Qiu J, Padilla SL, Zhang C, Bosch MA, Fan W, Aicher SA, Palmiter RD, Rønnekleiv OK, Kelly MJ.

Mol Endocrinol. 2016 Jun;30(6):630-44. doi: 10.1210/me.2016-1026. Epub 2016 Apr 19.


Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state.

Padilla SL, Qiu J, Soden ME, Sanz E, Nestor CC, Barker FD, Quintana A, Zweifel LS, Rønnekleiv OK, Kelly MJ, Palmiter RD.

Nat Neurosci. 2016 May;19(5):734-741. doi: 10.1038/nn.4274. Epub 2016 Mar 28.


Minireview: neural signaling of estradiol in the hypothalamus.

Kelly MJ, Rønnekleiv OK.

Mol Endocrinol. 2015 May;29(5):645-57. doi: 10.1210/me.2014-1397. Epub 2015 Mar 9. Review. No abstract available.


17β-Estradiol increases persistent Na(+) current and excitability of AVPV/PeN Kiss1 neurons in female mice.

Zhang C, Bosch MA, Qiu J, Rønnekleiv OK, Kelly MJ.

Mol Endocrinol. 2015 Apr;29(4):518-27. doi: 10.1210/me.2014-1392. Epub 2015 Mar 3.


Kisspeptin and Gonadotropin-Releasing Hormone Neuronal Excitability: Molecular Mechanisms Driven by 17β-Estradiol.

Rønnekleiv OK, Zhang C, Bosch MA, Kelly MJ.

Neuroendocrinology. 2015;102(3):184-93. doi: 10.1159/000370311. Epub 2014 Dec 8. Review.


The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.

Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB.

Endocrinology. 2015 Feb;156(2):627-37. doi: 10.1210/en.2014-1651. Epub 2014 Nov 25.


Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling.

Nestor CC, Kelly MJ, Rønnekleiv OK.

Horm Mol Biol Clin Investig. 2014 Mar;17(3):109-28. doi: 10.1515/hmbci-2013-0050. Review.


Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female.

Rønnekleiv OK, Fang Y, Zhang C, Nestor CC, Mao P, Kelly MJ.

Mol Endocrinol. 2014 Aug;28(8):1362-80. doi: 10.1210/me.2014-1103. Epub 2014 Jun 16.


Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels.

Qiu J, Zhang C, Borgquist A, Nestor CC, Smith AW, Bosch MA, Ku S, Wagner EJ, Rønnekleiv OK, Kelly MJ.

Cell Metab. 2014 Apr 1;19(4):682-93. doi: 10.1016/j.cmet.2014.03.004.


Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons.

Smith AW, Rønnekleiv OK, Kelly MJ.

Steroids. 2014 Mar;81:31-5. doi: 10.1016/j.steroids.2013.11.007. Epub 2013 Nov 20. Review.


Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area.

Zhang C, Tonsfeldt KJ, Qiu J, Bosch MA, Kobayashi K, Steiner RA, Kelly MJ, Rønnekleiv OK.

Am J Physiol Endocrinol Metab. 2013 Dec 1;305(11):E1384-97. doi: 10.1152/ajpendo.00406.2013. Epub 2013 Oct 8.


Pacemaking kisspeptin neurons.

Kelly MJ, Zhang C, Qiu J, Rønnekleiv OK.

Exp Physiol. 2013 Nov;98(11):1535-43. doi: 10.1113/expphysiol.2013.074559. Epub 2013 Jul 24. Review.


The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol.

Smith AW, Bosch MA, Wagner EJ, Rønnekleiv OK, Kelly MJ.

Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E632-40. doi: 10.1152/ajpendo.00281.2013. Epub 2013 Jul 2.


Kisspeptin activation of TRPC4 channels in female GnRH neurons requires PIP2 depletion and cSrc kinase activation.

Zhang C, Bosch MA, Rønnekleiv OK, Kelly MJ.

Endocrinology. 2013 Aug;154(8):2772-83. doi: 10.1210/en.2013-1180. Epub 2013 Jun 6.


Kisspeptin excitation of GnRH neurons.

Rønnekleiv OK, Kelly MJ.

Adv Exp Med Biol. 2013;784:113-31. doi: 10.1007/978-1-4614-6199-9_6. Review.


Kisspeptin inhibits a slow afterhyperpolarization current via protein kinase C and reduces spike frequency adaptation in GnRH neurons.

Zhang C, Rønnekleiv OK, Kelly MJ.

Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1237-44. doi: 10.1152/ajpendo.00058.2013. Epub 2013 Apr 2.


A selective membrane estrogen receptor agonist maintains autonomic functions in hypoestrogenic states.

Kelly MJ, Rønnekleiv OK.

Brain Res. 2013 Jun 13;1514:75-82. doi: 10.1016/j.brainres.2013.03.020. Epub 2013 Mar 25. Review.


Epigenetic control of female puberty.

Lomniczi A, Loche A, Castellano JM, Ronnekleiv OK, Bosch M, Kaidar G, Knoll JG, Wright H, Pfeifer GP, Ojeda SR.

Nat Neurosci. 2013 Mar;16(3):281-9. doi: 10.1038/nn.3319. Epub 2013 Jan 27.


mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol.

Bosch MA, Tonsfeldt KJ, Rønnekleiv OK.

Mol Cell Endocrinol. 2013 Mar 10;367(1-2):85-97. doi: 10.1016/j.mce.2012.12.021. Epub 2013 Jan 7.


Membrane-initiated actions of estradiol that regulate reproduction, energy balance and body temperature.

Kelly MJ, Rønnekleiv OK.

Front Neuroendocrinol. 2012 Oct;33(4):376-87. doi: 10.1016/j.yfrne.2012.07.002. Epub 2012 Aug 1. Review.


Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons.

Roepke TA, Smith AW, Rønnekleiv OK, Kelly MJ.

Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1399-406. doi: 10.1152/ajpendo.00565.2011. Epub 2012 Mar 20.


Midline thalamic paraventricular nucleus neurons display diurnal variation in resting membrane potentials, conductances, and firing patterns in vitro.

Kolaj M, Zhang L, Rønnekleiv OK, Renaud LP.

J Neurophysiol. 2012 Apr;107(7):1835-44. doi: 10.1152/jn.00974.2011. Epub 2012 Jan 4.


Kisspeptin expression in guinea pig hypothalamus: effects of 17β-estradiol.

Bosch MA, Xue C, Rønnekleiv OK.

J Comp Neurol. 2012 Jul 1;520(10):2143-62. doi: 10.1002/cne.23032.


Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse.

Gottsch ML, Popa SM, Lawhorn JK, Qiu J, Tonsfeldt KJ, Bosch MA, Kelly MJ, Rønnekleiv OK, Sanz E, McKnight GS, Clifton DK, Palmiter RD, Steiner RA.

Endocrinology. 2011 Nov;152(11):4298-309. doi: 10.1210/en.2011-1521. Epub 2011 Sep 20.


Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.

Navarro VM, Gottsch ML, Wu M, García-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA.

Endocrinology. 2011 Nov;152(11):4265-75. doi: 10.1210/en.2011-1143. Epub 2011 Sep 13.


Androgen receptor overexpression is neuroprotective in experimental stroke.

Ayala P, Uchida M, Akiyoshi K, Cheng J, Hashimoto J, Jia T, Ronnekleiv OK, Murphy SJ, Wiren KM, Hurn PD.

Transl Stroke Res. 2011 Sep;2(3):346-57. doi: 10.1007/s12975-011-0079-z. Epub 2011 Apr 15.


Fasting and 17β-estradiol differentially modulate the M-current in neuropeptide Y neurons.

Roepke TA, Qiu J, Smith AW, Rønnekleiv OK, Kelly MJ.

J Neurosci. 2011 Aug 17;31(33):11825-35. doi: 10.1523/JNEUROSCI.1395-11.2011.


Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.

Edin ML, Wang Z, Bradbury JA, Graves JP, Lih FB, DeGraff LM, Foley JF, Torphy R, Ronnekleiv OK, Tomer KB, Lee CR, Zeldin DC.

FASEB J. 2011 Oct;25(10):3436-47. doi: 10.1096/fj.11-188300. Epub 2011 Jun 22.


STX, a novel nonsteroidal estrogenic compound, induces rapid action in primate GnRH neuronal calcium dynamics and peptide release.

Kenealy BP, Keen KL, Rønnekleiv OK, Terasawa E.

Endocrinology. 2011 Aug;152(8):3182-91. doi: 10.1210/en.2011-0097. Epub 2011 May 31.


17β-oestradiol regulation of gonadotrophin-releasing hormone neuronal excitability.

Rønnekleiv OK, Bosch MA, Zhang C.

J Neuroendocrinol. 2012 Jan;24(1):122-30. doi: 10.1111/j.1365-2826.2011.02160.x. Review.


Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels.

Qiu J, Fang Y, Bosch MA, Rønnekleiv OK, Kelly MJ.

Endocrinology. 2011 Apr;152(4):1503-14. doi: 10.1210/en.2010-1285. Epub 2011 Feb 1.


Physiological consequences of membrane-initiated estrogen signaling in the brain.

Roepke TA, Ronnekleiv OK, Kelly MJ.

Front Biosci (Landmark Ed). 2011 Jan 1;16:1560-73. Review.


Regulation of endogenous conductances in GnRH neurons by estrogens.

Rønnekleiv OK, Bosch MA, Zhang C.

Brain Res. 2010 Dec 10;1364:25-34. doi: 10.1016/j.brainres.2010.08.096. Epub 2010 Sep 25. Review.


Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis.

Roepke TA, Bosch MA, Rick EA, Lee B, Wagner EJ, Seidlova-Wuttke D, Wuttke W, Scanlan TS, Rønnekleiv OK, Kelly MJ.

Endocrinology. 2010 Oct;151(10):4926-37. doi: 10.1210/en.2010-0573. Epub 2010 Aug 4.


17 β-estradiol rapidly increases ATP-sensitive potassium channel activity in gonadotropin-releasing hormone neurons [corrected] via a protein kinase signaling pathway.

Zhang C, Kelly MJ, Rønnekleiv OK.

Endocrinology. 2010 Sep;151(9):4477-84. doi: 10.1210/en.2010-0177. Epub 2010 Jul 21. Erratum in: Endocrinology. 2010 Nov;151(11):5563. Endocrinology. 2012 Jun;153(6):2933.


Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, Graves JP, Lih FB, Clark J, Myers P, Perrow AL, Lepp AN, Kannon MA, Ronnekleiv OK, Alkayed NJ, Falck JR, Tomer KB, Zeldin DC.

FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.


Leptin excites proopiomelanocortin neurons via activation of TRPC channels.

Qiu J, Fang Y, Rønnekleiv OK, Kelly MJ.

J Neurosci. 2010 Jan 27;30(4):1560-5. doi: 10.1523/JNEUROSCI.4816-09.2010.


17Beta-estradiol regulation of T-type calcium channels in gonadotropin-releasing hormone neurons.

Zhang C, Bosch MA, Rick EA, Kelly MJ, Rønnekleiv OK.

J Neurosci. 2009 Aug 26;29(34):10552-62. doi: 10.1523/JNEUROSCI.2962-09.2009.


Control of CNS neuronal excitability by estrogens via membrane-initiated signaling.

Kelly MJ, Rønnekleiv OK.

Mol Cell Endocrinol. 2009 Sep 24;308(1-2):17-25. doi: 10.1016/j.mce.2009.03.008. Epub 2009 Mar 25. Review.


Cross-talk between membrane-initiated and nuclear-initiated oestrogen signalling in the hypothalamus.

Roepke TA, Qiu J, Bosch MA, Rønnekleiv OK, Kelly MJ.

J Neuroendocrinol. 2009 Mar;21(4):263-70. doi: 10.1111/j.1365-2826.2009.01846.x. Review.

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