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Items: 1 to 50 of 57

1.

C-H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543.

Fox RJ, Cuniere NL, Bakrania L, Wei C, Strotman NA, Hay M, Fanfair D, Regens C, Beutner GL, Lawler M, Lobben P, Soumeillant MC, Cohen B, Zhu K, Skliar D, Rosner T, Markwalter CE, Hsiao Y, Tran K, Eastgate MD.

J Org Chem. 2018 Nov 12. doi: 10.1021/acs.joc.8b02383. [Epub ahead of print]

PMID:
30388009
2.

Immune Effector Functions of Human IgG2 Antibodies against EGFR.

Rösner T, Kahle S, Montenegro F, Matlung HL, Jansen JHM, Evers M, Beurskens F, Leusen JHW, van den Berg TK, Valerius T.

Mol Cancer Ther. 2019 Jan;18(1):75-88. doi: 10.1158/1535-7163.MCT-18-0341. Epub 2018 Oct 3.

PMID:
30282813
3.

Fc Glyco- and Fc Protein-Engineering: Design of Antibody Variants with Improved ADCC and CDC Activity.

Kellner C, Derer S, Klausz K, Rosskopf S, Wirt T, Rösner T, Otte A, Cappuzzello E, Peipp M.

Methods Mol Biol. 2018;1827:381-397. doi: 10.1007/978-1-4939-8648-4_20.

PMID:
30196508
4.

Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution.

Strotman NA, Ramirez A, Simmons EM, Soltani O, Parsons AT, Fan Y, Sawyer JR, Rosner T, Janey JM, Tran K, Li J, La Cruz TE, Pathirana C, Ng AT, Deerberg J.

J Org Chem. 2018 Sep 21;83(18):11133-11144. doi: 10.1021/acs.joc.8b01734. Epub 2018 Aug 13.

PMID:
30102035
5.

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes.

Beutner G, Carrasquillo R, Geng P, Hsiao Y, Huang EC, Janey J, Katipally K, Kolotuchin S, La Porte T, Lee A, Lobben P, Lora-Gonzalez F, Mack B, Mudryk B, Qiu Y, Qian X, Ramirez A, Razler TM, Rosner T, Shi Z, Simmons E, Stevens J, Wang J, Wei C, Wisniewski SR, Zhu Y.

Org Lett. 2018 Jul 6;20(13):3736-3740. doi: 10.1021/acs.orglett.8b01218. Epub 2018 Jun 17.

PMID:
29909639
6.

Remembering "primed" words: A counter-intuitive effect of repetition on recognition memory.

Rosner TM, López-Benítez R, D'Angelo MC, Thomson D, Milliken B.

Can J Exp Psychol. 2018 Mar;72(1):24-37. doi: 10.1037/cep0000139.

PMID:
29517266
7.

Remembering 'primed' words: The effect of prime encoding demands.

Collins RN, Rosner TM, Milliken B.

Can J Exp Psychol. 2018 Mar;72(1):9-23. doi: 10.1037/cep0000138.

PMID:
29517265
8.

Constitutive and Inducible Systems for Genetic In Vivo Modification of Mouse Hepatocytes Using Hydrodynamic Tail Vein Injection.

Hubner EK, Lechler C, Rösner TN, Kohnke-Ertel B, Schmid RM, Ehmer U.

J Vis Exp. 2018 Feb 2;(132). doi: 10.3791/56613.

PMID:
29443066
9.

Antibody Isotypes for Tumor Immunotherapy.

Kretschmer A, Schwanbeck R, Valerius T, Rösner T.

Transfus Med Hemother. 2017 Sep;44(5):320-326. doi: 10.1159/000479240. Epub 2017 Sep 7. Review.

10.

An Fc Double-Engineered CD20 Antibody with Enhanced Ability to Trigger Complement-Dependent Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity.

Wirt T, Rosskopf S, Rösner T, Eichholz KM, Kahrs A, Lutz S, Kretschmer A, Valerius T, Klausz K, Otte A, Gramatzki M, Peipp M, Kellner C.

Transfus Med Hemother. 2017 Sep;44(5):292-300. doi: 10.1159/000479978. Epub 2017 Sep 11.

11.

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

Lohse S, Loew S, Kretschmer A, Jansen JHM, Meyer S, Ten Broeke T, Rösner T, Dechant M, Derer S, Klausz K, Kellner C, Schwanbeck R, French RR, Tipton TRW, Cragg MS, Schewe DM, Peipp M, Leusen JHW, Valerius T.

Br J Haematol. 2018 May;181(3):413-417. doi: 10.1111/bjh.14624. Epub 2017 Apr 27. No abstract available.

PMID:
28449349
12.

Monoclonal Antibodies against Epidermal Growth Factor Receptor Acquire an Ability To Kill Tumor Cells through Complement Activation by Mutations That Selectively Facilitate the Hexamerization of IgG on Opsonized Cells.

Tammen A, Derer S, Schwanbeck R, Rösner T, Kretschmer A, Beurskens FJ, Schuurman J, Parren PW, Valerius T.

J Immunol. 2017 Feb 15;198(4):1585-1594. doi: 10.4049/jimmunol.1601268. Epub 2017 Jan 6.

13.

Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.

Degnan AP, Tora GO, Huang H, Conlon DA, Davis CD, Hanumegowda UM, Hou X, Hsiao Y, Hu J, Krause R, Li YW, Newton AE, Pieschl RL, Raybon J, Rosner T, Sun JH, Taber MT, Taylor SJ, Wong MK, Zhang H, Lodge NJ, Bronson JJ, Macor JE, Gillman KW.

ACS Chem Neurosci. 2016 Dec 21;7(12):1635-1640. doi: 10.1021/acschemneuro.6b00337. Epub 2016 Oct 18.

PMID:
27744678
14.

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

Lohse S, Meyer S, Meulenbroek LA, Jansen JH, Nederend M, Kretschmer A, Klausz K, Möginger U, Derer S, Rösner T, Kellner C, Schewe D, Sondermann P, Tiwari S, Kolarich D, Peipp M, Leusen JH, Valerius T.

Cancer Res. 2016 Jan 15;76(2):403-17. doi: 10.1158/0008-5472.CAN-15-1232. Epub 2015 Dec 3.

15.

A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells.

Derer S, Cossham M, Rösner T, Kellner C, Beurskens FJ, Schwanbeck R, Lohse S, Sina C, Peipp M, Valerius T.

J Immunol. 2015 Nov 15;195(10):5077-87. doi: 10.4049/jimmunol.1501458. Epub 2015 Oct 16.

16.

Mono-Oxidation of Bidentate Bis-phosphines in Catalyst Activation: Kinetic and Mechanistic Studies of a Pd/Xantphos-Catalyzed C-H Functionalization.

Ji Y, Plata RE, Regens CS, Hay M, Schmidt M, Razler T, Qiu Y, Geng P, Hsiao Y, Rosner T, Eastgate MD, Blackmond DG.

J Am Chem Soc. 2015 Oct 21;137(41):13272-81. doi: 10.1021/jacs.5b01913. Epub 2015 Oct 13.

PMID:
26461028
17.

Perceptual blurring and recognition memory: A desirable difficulty effect revealed.

Rosner TM, Davis H, Milliken B.

Acta Psychol (Amst). 2015 Sep;160:11-22. doi: 10.1016/j.actpsy.2015.06.006. Epub 2015 Jun 29.

PMID:
26134415
18.

Congruency effects on recognition memory: a context effect.

Rosner TM, Milliken B.

Can J Exp Psychol. 2015 Jun;69(2):206-12. doi: 10.1037/cep0000049. Epub 2015 Mar 16.

PMID:
25774995
19.

Epidermal growth factor receptor targeting IgG3 triggers complement-mediated lysis of decay-accelerating factor expressing tumor cells through the alternative pathway amplification loop.

Rösner T, Lohse S, Peipp M, Valerius T, Derer S.

J Immunol. 2014 Aug 1;193(3):1485-95. doi: 10.4049/jimmunol.1400329. Epub 2014 Jun 27.

20.

Complement in antibody-based tumor therapy.

Derer S, Beurskens FJ, Rosner T, Peipp M, Valerius T.

Crit Rev Immunol. 2014;34(3):199-214. Review.

PMID:
24941073
21.

Selective attention and recognition: effects of congruency on episodic learning.

Rosner TM, D'Angelo MC, MacLellan E, Milliken B.

Psychol Res. 2015 May;79(3):411-24. doi: 10.1007/s00426-014-0572-6. Epub 2014 May 24.

PMID:
24859839
22.

Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization.

Derer S, Kellner C, Rösner T, Klausz K, Glorius P, Valerius T, Peipp M.

Methods Mol Biol. 2014;1131:525-40. doi: 10.1007/978-1-62703-992-5_33.

PMID:
24515488
23.

An IgG3 switch variant of rituximab mediates enhanced complement-dependent cytotoxicity against tumour cells with low CD20 expression levels.

Rösner T, Derer S, Kellner C, Dechant M, Lohse S, Vidarsson G, Peipp M, Valerius T.

Br J Haematol. 2013 Apr;161(2):282-6. doi: 10.1111/bjh.12209. Epub 2013 Jan 7. No abstract available.

PMID:
23294176
24.

Efficient and scalable enantioselective synthesis of a CGRP antagonist.

Leahy DK, Fan Y, Desai LV, Chan C, Zhu J, Luo G, Chen L, Hanson RL, Sugiyama M, Rosner T, Cuniere N, Guo Z, Hsiao Y, Gao Q.

Org Lett. 2012 Sep 21;14(18):4938-41. Epub 2012 Sep 6.

PMID:
22954228
25.

[Extracorporeal membrane oxygenation and severe traumatic brain injury. Is the ECMO-therapy in traumatic lung failure and severe traumatic brain injury really contraindicated?].

Muellenbach RM, Redel A, Küstermann J, Brack A, Gorski A, Rösner T, Roewer N, Wurmb T.

Anaesthesist. 2011 Jul;60(7):647-52. doi: 10.1007/s00101-011-1872-5. Epub 2011 Mar 16. Review. German.

PMID:
21424309
26.

Hearing threshold estimation using concurrent measurement of distortion product otoacoustic emissions and auditory steady-state responses.

Rosner T, Kandzia F, Oswald JA, Janssen T.

J Acoust Soc Am. 2011 Feb;129(2):840-51. doi: 10.1121/1.3531934.

PMID:
21361442
27.

Mild and general method for the alpha-arylation of heteroaromatic ketones.

Desai LV, Ren DT, Rosner T.

Org Lett. 2010 Mar 5;12(5):1032-5. doi: 10.1021/ol1000318.

PMID:
20146430
28.

Highly efficient asymmetric synthesis of sitagliptin.

Hansen KB, Hsiao Y, Xu F, Rivera N, Clausen A, Kubryk M, Krska S, Rosner T, Simmons B, Balsells J, Ikemoto N, Sun Y, Spindler F, Malan C, Grabowski EJ, Armstrong JD 3rd.

J Am Chem Soc. 2009 Jul 1;131(25):8798-804. doi: 10.1021/ja902462q.

PMID:
19507853
29.

Pumpless extracorporeal lung assist as supportive therapy in a patient with diffuse alveolar hemorrhage.

Renner A, Neukam K, Rösner T, Elert O, Lange V.

Int J Artif Organs. 2008 Mar;31(3):279-81.

PMID:
18373323
30.

Multiparallel microfluidic high-performance liquid chromatography for high-throughput normal-phase chiral analysis.

Sajonz P, Schafer W, Gong X, Shultz S, Rosner T, Welch CJ.

J Chromatogr A. 2007 Mar 23;1145(1-2):149-54. Epub 2007 Jan 26.

PMID:
17300788
31.

On the mechanism of an asymmetric alpha,beta-unsaturated carboxylic acid hydrogenation: application to the synthesis of a PGD2 receptor antagonist.

Tellers DM, McWilliams JC, Humphrey G, Journet M, DiMichele L, Hinksmon J, McKeown AE, Rosner T, Sun Y, Tillyer RD.

J Am Chem Soc. 2006 Dec 27;128(51):17063-73.

PMID:
17177459
32.
33.

Detection and elimination of product inhibition from the asymmetric catalytic hydrogenation of enamines.

Hansen KB, Rosner T, Kubryk M, Dormer PG, Armstrong JD 3rd.

Org Lett. 2005 Oct 27;7(22):4935-8.

PMID:
16235926
34.

Highly efficient synthesis of beta-amino acid derivatives via asymmetric hydrogenation of unprotected enamines.

Hsiao Y, Rivera NR, Rosner T, Krska SW, Njolito E, Wang F, Sun Y, Armstrong JD 3rd, Grabowski EJ, Tillyer RD, Spindler F, Malan C.

J Am Chem Soc. 2004 Aug 18;126(32):9918-9.

PMID:
15303855
35.

An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction.

Song ZJ, King AO, Waters MS, Lang F, Zewge D, Bio M, Leazer JL Jr, Javadi G, Kassim A, Tschaen DM, Reamer RA, Rosner T, Chilenski JR, Mathre DJ, Volante RP, Tillyer R.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5776-81. Epub 2004 Apr 12.

36.

Observation of unusual kinetics in Heck reactions of aryl halides: the role of non-steady-state catalyst concentration.

Rosner T, Pfaltz A, Blackmond DG.

J Am Chem Soc. 2001 May 16;123(19):4621-2. No abstract available.

PMID:
11457257
37.
38.

Assessment of the androgen environment within the human testis: minimally invasive method to obtain intratesticular fluid.

Jarow JP, Chen H, Rosner TW, Trentacoste S, Zirkin BR.

J Androl. 2001 Jul-Aug;22(4):640-5.

39.
40.

Enantioselective hydrogenation of olefins with phosphinooxazoline-iridium catalysts.

Blackmond DG, Lightfoot A, Pfaltz A, Rosner T, Schnider P, Zimmermann N.

Chirality. 2000 Jun;12(5-6):442-9.

PMID:
10824167
41.

Kinetic Influences on Enantioselectivity for Non-Diastereopure Catalyst Mixtures.

Blackmond DG, Rosner T, Neugebauer T, Reetz MT.

Angew Chem Int Ed Engl. 1999 Aug;38(15):2196-2199.

PMID:
10425479
42.

Prostate cancer: an intimate view from patients and wives.

Heyman EN, Rosner TT.

Urol Nurs. 1996 Jun;16(2):37-44. No abstract available.

PMID:
8826151
43.

[Tourette syndrome].

Rosner TA, Pollice SA.

Taehan Kanho. 1992;31(1-2):35-9, 27. Korean. No abstract available.

PMID:
1552726
44.

Tourette's syndrome.

Rosner TA, Pollice SA.

J Psychosoc Nurs Ment Health Serv. 1991 Jan;29(1):4-9.

PMID:
1995841
45.

Visual barriers to prevent ambulatory Alzheimer's patients from exiting through an emergency door.

Namazi KH, Rosner TT, Calkins MP.

Gerontologist. 1989 Oct;29(5):699-702.

PMID:
2599427
46.

Exodontic complications involving the maxillary sinus.

Rosner TM.

Compendium. 1989 Mar;10(3):138-40, 143-4. No abstract available.

PMID:
2598208
47.

Physician use among the old-old. Factors affecting variability.

Rosner TT, Namazi KH, Wykle ML.

Med Care. 1988 Oct;26(10):982-91.

PMID:
3172868
48.

[Respiration- and ECG-gated data collection in a data processing system controlled by a microcomputer].

Nickles D, Rösner T, Mohnike W, Millebrandt F.

Radiobiol Radiother (Berl). 1987;28(2):217-20. German. No abstract available.

PMID:
3659309
49.

[Construction of a nuclear medicine data collecting and processing system by coupling 2 microcomputers].

Rösner T, Mohnike W.

Radiobiol Radiother (Berl). 1987;28(2):207-10. German. No abstract available.

PMID:
3659308

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