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Items: 1 to 50 of 146

1.

Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy.

Fleischmann M, Martin D, Peña-Llopis S, Oppermann J, von der Grün J, Diefenhardt M, Chatzikonstantinou G, Fokas E, Rödel C, Strebhardt K, Becker S, Rödel F, Tselis N.

Front Oncol. 2019 Aug 14;9:742. doi: 10.3389/fonc.2019.00742. eCollection 2019.

2.

Targeted Therapies and Immune-Checkpoint Inhibition in Head and Neck Squamous Cell Carcinoma: Where Do We Stand Today and Where to Go?

von der Grün J, Rödel F, Brandts C, Fokas E, Guckenberger M, Rödel C, Balermpas P.

Cancers (Basel). 2019 Apr 3;11(4). pii: E472. doi: 10.3390/cancers11040472. Review.

3.

NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy.

Müller-Längle A, Lutz H, Hehlgans S, Rödel F, Rau K, Laube B.

Cancers (Basel). 2019 Apr 9;11(4). pii: E503. doi: 10.3390/cancers11040503.

4.

Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D.

Cancers (Basel). 2019 Mar 12;11(3). pii: E350. doi: 10.3390/cancers11030350.

5.

Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial.

Diefenhardt M, Hofheinz RD, Martin D, Beißbarth T, Arnold D, Hartmann A, von der Grün J, Grützmann R, Liersch T, Ströbel P, Grabenbauer GG, Rieger M, Fietkau R, Graeven U, Weitz J, Folprecht G, Ghadimi M, Rödel F, Rödel C, Fokas E; German Rectal Cancer Study Group.

Int J Cancer. 2019 Oct 15;145(8):2282-2291. doi: 10.1002/ijc.32274. Epub 2019 Apr 2.

PMID:
30868576
6.

Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability.

Raab M, Sanhaji M, Zhou S, Rödel F, El-Balat A, Becker S, Strebhardt K.

Neoplasia. 2019 Apr;21(4):363-375. doi: 10.1016/j.neo.2019.01.007. Epub 2019 Mar 7.

7.

Merkel Cell Polyoma Viral Load and Intratumoral CD8+ Lymphocyte Infiltration Predict Overall Survival in Patients With Merkel Cell Carcinoma.

von der Grün J, Winkelmann R, Meissner M, Wieland U, Silling S, Martin D, Fokas E, Rödel C, Rödel F, Balermpas P.

Front Oncol. 2019 Jan 24;9:20. doi: 10.3389/fonc.2019.00020. eCollection 2019.

8.

Modulation of radiation sensitivity and antitumor immunity by viral pathogenic factors: Implications for radio-immunotherapy.

Rödel F, Martin D, Balermpas P, Wieland U, Winkelmann R, Riekmann T, Falk S, Rödel C, Fokas E.

Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):126-137. doi: 10.1016/j.bbcan.2018.12.006. Epub 2018 Dec 31. Review.

PMID:
30605716
9.

Is it time to redefine the role of low-dose radiotherapy for benign disease?

Montero A, Sabater S, Rödel F, Gaipl US, Ott OJ, Seegenschmiedt MH, Arenas M.

Ann Rheum Dis. 2018 Dec 21. pii: annrheumdis-2018-214873. doi: 10.1136/annrheumdis-2018-214873. [Epub ahead of print] No abstract available.

PMID:
30578294
10.

Low-dose radiotherapy: Mayday, mayday. We've been hit!

Ott OJ, Micke O, Mücke R, Niewald M, Rödel F, Schäfer U, Seegenschmiedt MH, Arenas M, Frey B, Gaipl US; German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD).

Strahlenther Onkol. 2019 Apr;195(4):285-288. doi: 10.1007/s00066-018-1412-1. Epub 2018 Dec 18. No abstract available.

PMID:
30564845
11.

Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib.

Hehlgans S, Booms P, Güllülü Ö, Sader R, Rödel C, Balermpas P, Rödel F, Ghanaati S.

Int J Mol Sci. 2018 Aug 23;19(9). pii: E2485. doi: 10.3390/ijms19092485.

12.

Ionizing radiation reduces the capacity of activated macrophages to induce T-cell proliferation, but does not trigger dendritic cell-mediated non-targeted effects.

Wunderlich R, Rühle PF, Deloch L, Rödel F, Fietkau R, Gaipl US, Frey B.

Int J Radiat Biol. 2019 Jan;95(1):33-43. doi: 10.1080/09553002.2018.1490037. Epub 2018 Aug 21.

PMID:
29912595
13.

Ionizing Radiation Induces Morphological Changes and Immunological Modulation of Jurkat Cells.

Voos P, Fuck S, Weipert F, Babel L, Tandl D, Meckel T, Hehlgans S, Fournier C, Moroni A, Rödel F, Thiel G.

Front Immunol. 2018 Apr 30;9:922. doi: 10.3389/fimmu.2018.00922. eCollection 2018.

14.

Anal squamous cell carcinoma - State of the art management and future perspectives.

Martin D, Balermpas P, Winkelmann R, Rödel F, Rödel C, Fokas E.

Cancer Treat Rev. 2018 Apr;65:11-21. doi: 10.1016/j.ctrv.2018.02.001. Epub 2018 Feb 22. Review.

PMID:
29494827
15.

Differential effects of α-catenin on the invasion and radiochemosensitivity of human colorectal cancer cells.

Förster S, Hehlgans S, Rödel F, Otto B, Cordes N.

Int J Oncol. 2018 Apr;52(4):1117-1128. doi: 10.3892/ijo.2018.4279. Epub 2018 Feb 21.

16.

Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

Stangl S, Tontcheva N, Sievert W, Shevtsov M, Niu M, Schmid TE, Pigorsch S, Combs SE, Haller B, Balermpas P, Rödel F, Rödel C, Fokas E, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Stuschke M, Grosu AL, Abdollahi A, Debus J, Belka C, Maihöfer C, Mönnich D, Zips D, Multhoff G.

Int J Cancer. 2018 May 1;142(9):1911-1925. doi: 10.1002/ijc.31213. Epub 2017 Dec 23.

17.

Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy.

Rödel F, Steinhäuser K, Kreis NN, Friemel A, Martin D, Wieland U, Rave-Fränk M, Balermpas P, Fokas E, Louwen F, Rödel C, Yuan J.

Radiother Oncol. 2018 Feb;126(2):214-221. doi: 10.1016/j.radonc.2017.10.028. Epub 2017 Nov 6.

PMID:
29122359
18.

Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer.

Martin D, Rödel F, Winkelmann R, Balermpas P, Rödel C, Fokas E.

Front Immunol. 2017 Sep 29;8:1225. doi: 10.3389/fimmu.2017.01225. eCollection 2017.

19.

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma.

Wagner J, Pfannenstiel V, Waldmann A, Bergs JWJ, Brill B, Huenecke S, Klingebiel T, Rödel F, Buchholz CJ, Wels WS, Bader P, Ullrich E.

Front Immunol. 2017 Jun 12;8:676. doi: 10.3389/fimmu.2017.00676. eCollection 2017.

20.

Measuring Leukocyte Adhesion to (Primary) Endothelial Cells after Photon and Charged Particle Exposure with a Dedicated Laminar Flow Chamber.

Erbeldinger N, Rapp F, Ktitareva S, Wendel P, Bothe AS, Dettmering T, Durante M, Friedrich T, Bertulat B, Meyer S, Cardoso MC, Hehlgans S, Rödel F, Fournier C.

Front Immunol. 2017 Jun 1;8:627. doi: 10.3389/fimmu.2017.00627. eCollection 2017.

21.

Erratum to: Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters.

Yildirim M, Müller von der Grün J, Winkelmann R, Fokas E, Rödel F, Ackermann H, Rödel C, Balermpas P.

Strahlenther Onkol. 2017 Aug;193(8):682. doi: 10.1007/s00066-017-1155-4. No abstract available.

PMID:
28540428
22.

Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases.

Rödel F, Fournier C, Wiedemann J, Merz F, Gaipl US, Frey B, Keilholz L, Seegenschmiedt MH, Rödel C, Hehlgans S.

Front Immunol. 2017 May 3;8:519. doi: 10.3389/fimmu.2017.00519. eCollection 2017. Review.

23.

The immune microenvironment and HPV in anal cancer: Rationale to complement chemoradiation with immunotherapy.

Martin D, Rödel F, Balermpas P, Rödel C, Fokas E.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):221-230. doi: 10.1016/j.bbcan.2017.05.001. Epub 2017 May 10. Review.

PMID:
28501560
24.

The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

Balermpas P, Rödel F, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Sak A, Stuschke M, Gkika E, Grosu AL, Abdollahi A, Debus J, Stangl S, Ganswindt U, Belka C, Pigorsch S, Multhoff G, Combs SE, Welz S, Zips D, Lim SY, Rödel C, Fokas E; DKTK-ROG.

Int J Cancer. 2017 Aug 1;141(3):594-603. doi: 10.1002/ijc.30770. Epub 2017 May 19.

25.

Human papilloma virus load and PD-1/PD-L1, CD8+ and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy.

Balermpas P, Martin D, Wieland U, Rave-Fränk M, Strebhardt K, Rödel C, Fokas E, Rödel F.

Oncoimmunology. 2017 Feb 6;6(3):e1288331. doi: 10.1080/2162402X.2017.1288331. eCollection 2017.

26.

Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors.

Frey B, Rückert M, Weber J, Mayr X, Derer A, Lotter M, Bert C, Rödel F, Fietkau R, Gaipl US.

Front Immunol. 2017 Mar 8;8:231. doi: 10.3389/fimmu.2017.00231. eCollection 2017.

27.

Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2.

Badawi A, Hehlgans S, Pfeilschifter J, Rödel F, Eberhardt W.

Cancer Lett. 2017 May 1;393:103-112. doi: 10.1016/j.canlet.2017.02.010. Epub 2017 Feb 20.

PMID:
28219770
28.

Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis.

Yildirim M, Müller von der Grün J, Winkelmann R, Fokas E, Rödel F, Ackermann H, Rödel C, Balermpas P.

Strahlenther Onkol. 2017 Apr;193(4):305-314. doi: 10.1007/s00066-017-1102-4. Epub 2017 Jan 31. Erratum in: Strahlenther Onkol. 2017 Aug;193(8):682.

PMID:
28144684
29.

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.

Antonietti P, Linder B, Hehlgans S, Mildenberger IC, Burger MC, Fulda S, Steinbach JP, Gessler F, Rödel F, Mittelbronn M, Kögel D.

Mol Cancer Ther. 2017 Jan;16(1):156-168. doi: 10.1158/1535-7163.MCT-16-0262. Epub 2016 Oct 24.

30.

Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance.

Voges Y, Michaelis M, Rothweiler F, Schaller T, Schneider C, Politt K, Mernberger M, Nist A, Stiewe T, Wass MN, Rödel F, Cinatl J.

Cell Death Dis. 2016 Oct 13;7(10):e2410. doi: 10.1038/cddis.2016.257.

31.

Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.

Rödel F, Martin D, Helmke C, Balermpas P, Fokas E, Wieland U, Rave-Fränk M, Kitz J, Matthess Y, Raab M, Strebhardt K, Rödel C.

Oncotarget. 2016 Aug 16;7(33):53339-53349. doi: 10.18632/oncotarget.10801.

32.

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.

Helmke C, Raab M, Rödel F, Matthess Y, Oellerich T, Mandal R, Sanhaji M, Urlaub H, Rödel C, Becker S, Strebhardt K.

Cell Res. 2016 Aug;26(8):914-34. doi: 10.1038/cr.2016.78. Epub 2016 Jun 21.

33.

The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis.

Hehlgans S, Oppermann J, Reichert S, Fulda S, Rödel C, Rödel F.

Radiat Oncol. 2015 Sep 17;10:198. doi: 10.1186/s13014-015-0507-4.

34.

Erratum to: Re-irradiation with cetuximab or cisplatin-based chemotherapy for recurrent squamous cell carcinoma of the head and neck.

Dornoff N, Weiß C, Rödel F, Wagenblast J, Ghanaati S, Nateghian A, Rödel C, Balermpas P.

Strahlenther Onkol. 2015 Sep;191(9):763-4. doi: 10.1007/s00066-015-0882-7. No abstract available.

PMID:
26238802
35.

CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG).

Balermpas P, Rödel F, Rödel C, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Gkika E, Stuschke M, Avlar M, Grosu AL, Abdollahi A, Debus J, Bayer C, Stangl S, Belka C, Pigorsch S, Multhoff G, Combs SE, Mönnich D, Zips D, Fokas E.

Int J Cancer. 2016 Jan 1;138(1):171-81. doi: 10.1002/ijc.29683. Epub 2015 Jul 30.

36.

The role of recent nanotechnology in enhancing the efficacy of radiation therapy.

Bergs JW, Wacker MG, Hehlgans S, Piiper A, Multhoff G, Rödel C, Rödel F.

Biochim Biophys Acta. 2015 Aug;1856(1):130-43. doi: 10.1016/j.bbcan.2015.06.008. Epub 2015 Jul 2. Review.

PMID:
26142869
37.

DEGRO practical guidelines for radiotherapy of non-malignant disorders: Part I: physical principles, radiobiological mechanisms, and radiogenic risk.

Reichl B, Block A, Schäfer U, Bert C, Müller R, Jung H, Rödel F; German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD).

Strahlenther Onkol. 2015 Sep;191(9):701-9. doi: 10.1007/s00066-015-0865-8. Epub 2015 Jun 28.

PMID:
26117368
38.

Drug-Resistant Urothelial Cancer Cell Lines Display Diverse Sensitivity Profiles to Potential Second-Line Therapeutics.

Vallo S, Michaelis M, Rothweiler F, Bartsch G, Gust KM, Limbart DM, Rödel F, Wezel F, Haferkamp A, Cinatl J Jr.

Transl Oncol. 2015 Jun;8(3):210-6. doi: 10.1016/j.tranon.2015.04.002.

39.

Study of the anti-inflammatory effects of low-dose radiation: The contribution of biphasic regulation of the antioxidative system in endothelial cells.

Large M, Hehlgans S, Reichert S, Gaipl US, Fournier C, Rödel C, Weiss C, Rödel F.

Strahlenther Onkol. 2015 Sep;191(9):742-9. doi: 10.1007/s00066-015-0848-9. Epub 2015 Jun 8.

PMID:
26051282
40.

Re-irradiation with cetuximab or cisplatin-based chemotherapy for recurrent squamous cell carcinoma of the head and neck.

Dornoff N, Weiß C, Rödel F, Wagenblast J, Ghanaati S, Atefeh N, Rödel C, Balermpas P.

Strahlenther Onkol. 2015 Aug;191(8):656-64. doi: 10.1007/s00066-015-0854-y. Epub 2015 May 25. Erratum in: Strahlenther Onkol. 2015 Sep;191(9):763-4.

PMID:
26004121
41.

Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.

Specht HM, Ahrens N, Blankenstein C, Duell T, Fietkau R, Gaipl US, Günther C, Gunther S, Habl G, Hautmann H, Hautmann M, Huber RM, Molls M, Offner R, Rödel C, Rödel F, Schütz M, Combs SE, Multhoff G.

Front Immunol. 2015 Apr 15;6:162. doi: 10.3389/fimmu.2015.00162. eCollection 2015. Review.

42.

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases.

Frey B, Hehlgans S, Rödel F, Gaipl US.

Cancer Lett. 2015 Nov 28;368(2):230-7. doi: 10.1016/j.canlet.2015.04.010. Epub 2015 Apr 14. Review.

PMID:
25888451
43.

Irradiation with X-rays phase-advances the molecular clockwork in liver, adrenal gland and pancreas.

Müller MH, Rödel F, Rüb U, Korf HW.

Chronobiol Int. 2015 Feb;32(1):27-36. doi: 10.3109/07420528.2014.949735. Epub 2014 Aug 20.

PMID:
25140390
44.

Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences.

Balermpas P, Rödel F, Liberz R, Oppermann J, Wagenblast J, Ghanaati S, Harter PN, Mittelbronn M, Weiss C, Rödel C, Fokas E.

Br J Cancer. 2014 Oct 14;111(8):1509-18. doi: 10.1038/bjc.2014.446. Epub 2014 Aug 5.

45.

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy.

Gaipl US, Multhoff G, Scheithauer H, Lauber K, Hehlgans S, Frey B, Rödel F.

Immunotherapy. 2014;6(5):597-610. doi: 10.2217/imt.14.38. Review.

PMID:
24896628
46.

Human papillomavirus DNA load and p16INK4a expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy.

Rödel F, Wieland U, Fraunholz I, Kitz J, Rave-Fränk M, Wolff HA, Weiss C, Wirtz R, Balermpas P, Fokas E, Rödel C.

Int J Cancer. 2015 Jan 15;136(2):278-88. doi: 10.1002/ijc.28979. Epub 2014 May 27.

47.

Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells.

Heylmann D, Rödel F, Kindler T, Kaina B.

Biochim Biophys Acta. 2014 Aug;1846(1):121-9. doi: 10.1016/j.bbcan.2014.04.009. Epub 2014 May 4. Review.

PMID:
24797212
48.
49.

Tumor-infiltrating lymphocytes favor the response to chemoradiotherapy of head and neck cancer.

Balermpas P, Rödel F, Weiss C, Rödel C, Fokas E.

Oncoimmunology. 2014 Jan 1;3(1):e27403.

50.

A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species.

Large M, Reichert S, Hehlgans S, Fournier C, Rödel C, Rödel F.

Radiat Oncol. 2014 Mar 22;9:80. doi: 10.1186/1748-717X-9-80.

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