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Items: 17

1.

Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases.

Marx L, Ríos-Lombardía N, Farnberger JF, Kroutil W, Benítez-Mateos AI, López-Gallego F, Morís F, González-Sabín J, Berglund P.

Adv Synth Catal. 2018 Jun 5;360(11):2157-2165. doi: 10.1002/adsc.201701485. Epub 2018 Feb 28.

2.

Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia.

Puente-Moncada N, Costales P, Antolín I, Núñez LE, Oro P, Hermosilla MA, Pérez-Escuredo J, Ríos-Lombardía N, Sanchez-Sanchez AM, Luño E, Rodríguez C, Martín V, Morís F.

Mol Cancer Ther. 2018 Mar;17(3):614-624. doi: 10.1158/1535-7163.MCT-17-0530. Epub 2018 Jan 16.

3.

Asymmetric Reduction of Prochiral Ketones by Using Self-Sufficient Heterogeneous Biocatalysts Based on NADPH-Dependent Ketoreductases.

Benítez-Mateos AI, San Sebastian E, Ríos-Lombardía N, Morís F, González-Sabín J, López-Gallego F.

Chemistry. 2017 Nov 27;23(66):16843-16852. doi: 10.1002/chem.201703475. Epub 2017 Nov 8.

PMID:
28940802
4.

Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles.

Liardo E, Ríos-Lombardía N, Morís F, González-Sabín J, Rebolledo F.

Org Lett. 2016 Jul 15;18(14):3366-9. doi: 10.1021/acs.orglett.6b01510. Epub 2016 Jun 30.

PMID:
27357900
5.

From a Sequential to a Concurrent Reaction in Aqueous Medium: Ruthenium-Catalyzed Allylic Alcohol Isomerization and Asymmetric Bioreduction.

Ríos-Lombardía N, Vidal C, Liardo E, Morís F, García-Álvarez J, González-Sabín J.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8691-5. doi: 10.1002/anie.201601840. Epub 2016 Jun 3.

PMID:
27258838
6.

Chemoenzymatic one-pot synthesis in an aqueous medium: combination of metal-catalysed allylic alcohol isomerisation-asymmetric bioamination.

Ríos-Lombardía N, Vidal C, Cocina M, Morís F, García-Álvarez J, González-Sabín J.

Chem Commun (Camb). 2015 Jul 11;51(54):10937-40. doi: 10.1039/c5cc03298a.

PMID:
26062926
7.

Analysis of beer volatiles by polymeric imidazolium-solid phase microextraction coatings: Synthesis and characterization of polymeric imidazolium ionic liquids.

González-Álvarez J, Blanco-Gomis D, Arias-Abrodo P, Pello-Palma J, Ríos-Lombardía N, Busto E, Gotor-Fernández V, Gutiérrez-Álvarez MD.

J Chromatogr A. 2013 Aug 30;1305:35-40. doi: 10.1016/j.chroma.2013.07.012. Epub 2013 Jul 7.

PMID:
23891206
8.

Chiral triazolium salts and ionic liquids: from the molecular design vectors to their physical properties through specific supramolecular interactions.

Porcar R, Ríos-Lombardía N, Busto E, Gotor-Fernández V, Montejo-Bernardo J, García-Granda S, Luis SV, Gotor V, Alfonso I, García-Verdugo E.

Chemistry. 2013 Jan 14;19(3):892-904. doi: 10.1002/chem.201202274. Epub 2012 Nov 29.

PMID:
23197418
9.

Polymeric imidazolium ionic liquids as valuable stationary phases in gas chromatography: chemical synthesis and full characterization.

González-Álvarez J, Blanco-Gomis D, Arias-Abrodo P, Díaz-Llorente D, Ríos-Lombardía N, Busto E, Gotor-Fernández V, Gutiérrez-Álvarez MD.

Anal Chim Acta. 2012 Apr 6;721:173-81. doi: 10.1016/j.aca.2012.01.047. Epub 2012 Feb 10.

PMID:
22405317
10.

Characterization of hexacationic imidazolium ionic liquids as effective and highly stable gas chromatography stationary phases.

González-Álvarez J, Blanco-Gomis D, Arias-Abrodo P, Díaz-Llorente D, Ríos-Lombardía N, Busto E, Gotor-Fernández V, Gutiérrez-Álvarez MD.

J Sep Sci. 2012 Jan;35(2):273-9. doi: 10.1002/jssc.201100830. Epub 2011 Dec 9.

PMID:
22162278
11.

Chemoenzymatic asymmetric synthesis of optically active pentane-1,5-diamine fragments by means of lipase-catalyzed desymmetrization transformations.

Ríos-Lombardía N, Busto E, Gotor-Fernández V, Gotor V.

J Org Chem. 2011 Jul 15;76(14):5709-18. doi: 10.1021/jo2007972. Epub 2011 Jun 16.

PMID:
21627134
12.

Complementary lipase-mediated desymmetrization processes of 3-aryl-1,5-disubstituted fragments. Enantiopure synthetic valuable carboxylic acid derivatives.

Ríos-Lombardía N, Gotor-Fernández V, Gotor V.

J Org Chem. 2011 Feb 4;76(3):811-9. doi: 10.1021/jo101962v. Epub 2011 Jan 10.

PMID:
21218800
13.

Evaluation of new ionic liquids as high stability selective stationary phases in gas chromatography.

González Álvarez J, Blanco Gomis D, Arias Abrodo P, Díaz Llorente D, Busto E, Ríos Lombardía N, Gotor Fernández V, Gutiérrez Álvarez MD.

Anal Bioanal Chem. 2011 May;400(5):1209-16. doi: 10.1007/s00216-010-4587-6. Epub 2010 Dec 28.

PMID:
21188580
14.

From salts to ionic liquids by systematic structural modifications: a rational approach towards the efficient modular synthesis of enantiopure imidazolium salts.

Ríos-Lombardía N, Busto E, Gotor-Fernández V, Gotor V, Porcar R, García-Verdugo E, Luis SV, Alfonso I, García-Granda S, Menéndez-Velázquez A.

Chemistry. 2010 Jan 18;16(3):836-47. doi: 10.1002/chem.200901623.

PMID:
19946902
15.

Computational study of the lipase-mediated desymmetrisation of 2-substituted-propane-1,3-diamines.

García-Urdiales E, Busto E, Ríos-Lombardía N, Gotor-Fernández V, Gotor V.

Chembiochem. 2009 Dec 14;10(18):2875-83. doi: 10.1002/cbic.200900412.

PMID:
19885896
16.

Influence of the nucleophile on the Candida antarctica lipase B-catalysed resolution of a chiral acyl donor.

García-Urdiales E, Ríos-Lombardía N, Mangas-Sánchez J, Gotor-Fernández V, Gotor V.

Chembiochem. 2009 Jul 20;10(11):1830-8. doi: 10.1002/cbic.200900204.

PMID:
19575372
17.

Enzymatic desymmetrization of prochiral 2-substituted-1,3-diamines: preparation of valuable nitrogenated compounds.

Ríos-Lombardía N, Busto E, García-Urdiales E, Gotor-Fernández V, Gotor V.

J Org Chem. 2009 Mar 20;74(6):2571-4. doi: 10.1021/jo8025912.

PMID:
19284738

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