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Best matches for Rådmark O[au]:

Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: kinetics of the reaction and stereochemistry of the product. Haeggström J et al. Biochim Biophys Acta. (1988)

Cloning of the cDNA for human 12-lipoxygenase. Izumi T et al. Proc Natl Acad Sci U S A. (1990)

Properties of leukotriene A4-hydrolase. Rådmark O et al. Adv Prostaglandin Thromboxane Leukot Res. (1990)

Search results

Items: 1 to 50 of 177

1.

Exosomes and cells from lung cancer pleural exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1.

Lukic A, Wahlund CJE, Gómez C, Brodin D, Samuelsson B, Wheelock CE, Gabrielsson S, Rådmark O.

Cancer Lett. 2019 Mar 1;444:1-8. doi: 10.1016/j.canlet.2018.11.033. Epub 2018 Dec 1.

PMID:
30508568
2.

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.

Pace S, Pergola C, Dehm F, Rossi A, Gerstmeier J, Troisi F, Pein H, Schaible AM, Weinigel C, Rummler S, Northoff H, Laufer S, Maier TJ, Rådmark O, Samuelsson B, Koeberle A, Sautebin L, Werz O.

J Clin Invest. 2017 Aug 1;127(8):3167-3176. doi: 10.1172/JCI92885. Epub 2017 Jul 24.

3.

GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures.

Lukic A, Larssen P, Fauland A, Samuelsson B, Wheelock CE, Gabrielsson S, Radmark O.

FASEB J. 2017 Oct;31(10):4370-4381. doi: 10.1096/fj.201700319R. Epub 2017 Jun 21.

PMID:
28637652
4.

Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase.

Mittal M, Hasan M, Balagunaseelan N, Fauland A, Wheelock C, Rådmark O, Haeggström JZ, Rinaldo-Matthis A.

Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):2099-2111. doi: 10.1016/j.bbagen.2017.05.015. Epub 2017 May 19.

PMID:
28528958
5.

Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia.

Yektaei-Karin E, Zovko A, Nilsson A, Näsman-Glaser B, Kanter L, Rådmark O, Wallvik J, Ekblom M, Dolinska M, Qian H, Stenke L.

Leuk Lymphoma. 2017 Aug;58(8):1903-1913. doi: 10.1080/10428194.2016.1262029. Epub 2016 Dec 8.

PMID:
27931141
6.

Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules.

Martinez-Bravo MJ, Wahlund CJ, Qazi KR, Moulder R, Lukic A, Rådmark O, Lahesmaa R, Grunewald J, Eklund A, Gabrielsson S.

J Allergy Clin Immunol. 2017 Apr;139(4):1186-1194. doi: 10.1016/j.jaci.2016.05.051. Epub 2016 Aug 23.

PMID:
27566455
7.

Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways.

Dietz K, de Los Reyes Jiménez M, Gollwitzer ES, Chaker AM, Zissler UM, Rådmark OP, Baarsma HA, Königshoff M, Schmidt-Weber CB, Marsland BJ, Esser-von Bieren J.

J Allergy Clin Immunol. 2017 Apr;139(4):1343-1354.e6. doi: 10.1016/j.jaci.2016.07.014. Epub 2016 Aug 20.

PMID:
27554815
8.

Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.

Lukic A, Ji J, Idborg H, Samuelsson B, Palmberg L, Gabrielsson S, Rådmark O.

J Lipid Res. 2016 Sep;57(9):1659-69. doi: 10.1194/jlr.M066910. Epub 2016 Jul 19.

9.

Kinetic investigation of human 5-lipoxygenase with arachidonic acid.

Mittal M, Kumar RB, Balagunaseelan N, Hamberg M, Jegerschöld C, Rådmark O, Haeggström JZ, Rinaldo-Matthis A.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3547-51. doi: 10.1016/j.bmcl.2016.06.025. Epub 2016 Jun 11.

PMID:
27363940
10.

Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.

Terzuoli E, Donnini S, Finetti F, Nesi G, Villari D, Hanaka H, Radmark O, Giachetti A, Ziche M.

Oncotarget. 2016 Jul 12;7(28):44350-44364. doi: 10.18632/oncotarget.10051.

11.

Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs.

Kumar RB, Zhu L, Idborg H, Rådmark O, Jakobsson PJ, Rinaldo-Matthis A, Hebert H, Jegerschöld C.

PLoS One. 2016 Mar 24;11(3):e0152116. doi: 10.1371/journal.pone.0152116. eCollection 2016.

12.

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes.

Gerstmeier J, Weinigel C, Rummler S, Rådmark O, Werz O, Garscha U.

FASEB J. 2016 Jan;30(1):276-85. doi: 10.1096/fj.15-278010. Epub 2015 Sep 22.

PMID:
26396238
13.

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.

Lehmann C, Homann J, Ball AK, Blöcher R, Kleinschmidt TK, Basavarajappa D, Angioni C, Ferreirós N, Häfner AK, Rådmark O, Proschak E, Haeggström JZ, Geisslinger G, Parnham MJ, Steinhilber D, Kahnt AS.

FASEB J. 2015 Dec;29(12):5029-43. doi: 10.1096/fj.15-275487. Epub 2015 Aug 19.

PMID:
26289316
14.

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

Mahshid Y, Markoutsa S, Dincbas-Renqvist V, Sürün D, Christensson B, Sander B, Björkholm M, Sorg BL, Rådmark O, Claesson HE.

Prostaglandins Leukot Essent Fatty Acids. 2015 Sep;100:33-40. doi: 10.1016/j.plefa.2015.06.003. Epub 2015 Jun 24.

PMID:
26210919
15.

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.

Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, Radmark O, Ziche M, Donnini S.

Endocr Relat Cancer. 2015 Aug;22(4):665-78. doi: 10.1530/ERC-15-0277. Epub 2015 Jun 25.

16.

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M.

Nat Cell Biol. 2014 Dec;16(12):1180-91. doi: 10.1038/ncb3064. Epub 2014 Nov 17.

17.

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease.

Rådmark O, Werz O, Steinhilber D, Samuelsson B.

Biochim Biophys Acta. 2015 Apr;1851(4):331-9. doi: 10.1016/j.bbalip.2014.08.012. Epub 2014 Aug 22. Review.

PMID:
25152163
18.

Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase.

Schröder M, Häfner AK, Hofmann B, Rådmark O, Tumulka F, Abele R, Dötsch V, Steinhilber D.

Biochim Biophys Acta. 2014 Oct;1842(10):1538-47. doi: 10.1016/j.bbalip.2014.07.022. Epub 2014 Aug 8.

PMID:
25107828
19.

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis.

Basavarajappa D, Wan M, Lukic A, Steinhilber D, Samuelsson B, Rådmark O.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11371-6. doi: 10.1073/pnas.1410983111. Epub 2014 Jul 17.

20.

In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis.

Rossi A, Pergola C, Pace S, Rådmark O, Werz O, Sautebin L.

Pharmacol Res. 2014 Sep;87:1-7. doi: 10.1016/j.phrs.2014.05.011. Epub 2014 Jun 2.

PMID:
24892983
21.

A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity.

Rakonjac Ryge M, Tanabe M, Provost P, Persson B, Chen X, Funk CD, Rinaldo-Matthis A, Hofmann B, Steinhilber D, Watanabe T, Samuelsson B, Rådmark O.

Arch Biochem Biophys. 2014 Mar 1;545:179-85. doi: 10.1016/j.abb.2014.01.017. Epub 2014 Jan 28.

PMID:
24480307
22.

Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.

Sha W, Olesch C, Hanaka H, Rådmark O, Weigert A, Brüne B.

Int J Cancer. 2013 Oct 1;133(7):1578-88. doi: 10.1002/ijc.28181. Epub 2013 Apr 22.

23.

Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis.

Loell I, Alemo Munters L, Pandya J, Zong M, Alexanderson H, Fasth AE, Ståhl Hallengren C, Rådmark O, Lundberg IE, Jakobsson PJ, Korotkova M.

Ann Rheum Dis. 2013 Feb;72(2):293-9. doi: 10.1136/annrheumdis-2012-201294. Epub 2012 Jun 26.

PMID:
22736094
24.

Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma.

Torregrosa Paredes P, Esser J, Admyre C, Nord M, Rahman QK, Lukic A, Rådmark O, Grönneberg R, Grunewald J, Eklund A, Scheynius A, Gabrielsson S.

Allergy. 2012 Jul;67(7):911-9. doi: 10.1111/j.1398-9995.2012.02835.x. Epub 2012 May 23.

PMID:
22620679
25.

EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.

Donnini S, Finetti F, Terzuoli E, Giachetti A, Iñiguez MA, Hanaka H, Fresno M, Rådmark O, Ziche M.

Oncogene. 2012 Jul 19;31(29):3457-66. doi: 10.1038/onc.2011.503. Epub 2011 Nov 14.

PMID:
22081067
26.

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes.

Pergola C, Rogge A, Dodt G, Northoff H, Weinigel C, Barz D, Rådmark O, Sautebin L, Werz O.

FASEB J. 2011 Oct;25(10):3377-87. doi: 10.1096/fj.11-182758. Epub 2011 Jun 21.

PMID:
21693622
27.

Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors.

Esser J, Gehrmann U, Salvado MD, Wetterholm A, Haeggström JZ, Samuelsson B, Gabrielsson S, Scheynius A, Rådmark O.

FASEB J. 2011 Apr;25(4):1417-27. doi: 10.1096/fj.10-175828. Epub 2011 Jan 12.

PMID:
21228223
28.

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.

Conrad M, Sandin A, Förster H, Seiler A, Frijhoff J, Dagnell M, Bornkamm GW, Rådmark O, Hooft van Huijsduijnen R, Aspenström P, Böhmer F, Ostman A.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15774-9. doi: 10.1073/pnas.1007909107. Epub 2010 Aug 23.

29.

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration.

Esser J, Gehrmann U, D'Alexandri FL, Hidalgo-Estévez AM, Wheelock CE, Scheynius A, Gabrielsson S, Rådmark O.

J Allergy Clin Immunol. 2010 Nov;126(5):1032-40, 1040.e1-4. doi: 10.1016/j.jaci.2010.06.039. Epub 2010 Aug 21.

PMID:
20728205
30.

Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.

Rådmark O, Samuelsson B.

J Intern Med. 2010 Jul;268(1):5-14. doi: 10.1111/j.1365-2796.2010.02246.x. Epub 2010 Apr 28. Review.

31.

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.

Rådmark O, Samuelsson B.

Biochem Biophys Res Commun. 2010 May 21;396(1):105-10. doi: 10.1016/j.bbrc.2010.02.173. Review.

PMID:
20494120
32.

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

Hanaka H, Pawelzik SC, Johnsen JI, Rakonjac M, Terawaki K, Rasmuson A, Sveinbjörnsson B, Schumacher MC, Hamberg M, Samuelsson B, Jakobsson PJ, Kogner P, Rådmark O.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18757-62. doi: 10.1073/pnas.0910218106. Epub 2009 Oct 21.

33.

Calcitriol upregulates open chromatin and elongation markers at functional vitamin D response elements in the distal part of the 5-lipoxygenase gene.

Stoffers KL, Sorg BL, Seuter S, Rau O, Rådmark O, Steinhilber D.

J Mol Biol. 2010 Jan 29;395(4):884-96. doi: 10.1016/j.jmb.2009.10.022. Epub 2009 Oct 24.

PMID:
19837082
34.

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

Esser J, Rakonjac M, Hofmann B, Fischer L, Provost P, Schneider G, Steinhilber D, Samuelsson B, Rådmark O.

Biochem J. 2009 Dec 14;425(1):265-74. doi: 10.1042/BJ20090856.

PMID:
19807693
35.

Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.

Katryniok C, Schnur N, Gillis A, von Knethen A, Sorg BL, Looijenga L, Rådmark O, Steinhilber D.

Biochim Biophys Acta. 2010 Jan;1801(1):49-57. doi: 10.1016/j.bbalip.2009.09.003. Epub 2009 Sep 23.

PMID:
19781662
36.

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, Hoffmann M, Hoernig C, Fischer L, Steinhilber D, Franke L, Schneider G, Rådmark O, Sautebin L, Werz O.

Cell Mol Life Sci. 2009 Aug;66(16):2759-71. doi: 10.1007/s00018-009-0078-3. Epub 2009 Jul 5.

PMID:
19579006
37.

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.

Gheorghe KR, Korotkova M, Catrina AI, Backman L, af Klint E, Claesson HE, Rådmark O, Jakobsson PJ.

Arthritis Res Ther. 2009;11(3):R83. doi: 10.1186/ar2717. Epub 2009 Jun 4.

38.

[Dicer interacts with Wig-1 protein].

Huang J, Wang HB, Yao L, Zheng XM, Radmark O.

Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Oct;41(5):376-82. Chinese.

PMID:
19127773
39.

ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma.

Pergola C, Dodt G, Rossi A, Neunhoeffer E, Lawrenz B, Northoff H, Samuelsson B, Rådmark O, Sautebin L, Werz O.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19881-6. doi: 10.1073/pnas.0809120105. Epub 2008 Dec 8.

40.

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

Dincbas-Renqvist V, Pépin G, Rakonjac M, Plante I, Ouellet DL, Hermansson A, Goulet I, Doucet J, Samuelsson B, Rådmark O, Provost P.

Biochim Biophys Acta. 2009 Feb;1789(2):99-108. doi: 10.1016/j.bbagrm.2008.10.002. Epub 2008 Oct 28.

41.

5-Lipoxygenase: mechanisms of regulation.

Rådmark O, Samuelsson B.

J Lipid Res. 2009 Apr;50 Suppl:S40-5. doi: 10.1194/jlr.R800062-JLR200. Epub 2008 Nov 5.

42.

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M.

Cell Metab. 2008 Sep;8(3):237-48. doi: 10.1016/j.cmet.2008.07.005.

43.

The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes.

Schnur N, Seuter S, Katryniok C, Rådmark O, Steinhilber D.

Biochim Biophys Acta. 2007 Oct;1771(10):1271-82. Epub 2007 Aug 17.

PMID:
17894944
44.

5-Lipoxygenase: regulation of expression and enzyme activity.

Rådmark O, Werz O, Steinhilber D, Samuelsson B.

Trends Biochem Sci. 2007 Jul;32(7):332-41. Epub 2007 Jun 18. Review.

PMID:
17576065
45.

Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene.

Seuter S, Väisänen S, Rådmark O, Carlberg C, Steinhilber D.

Biochim Biophys Acta. 2007 Jul;1771(7):864-72. Epub 2007 Apr 19.

PMID:
17500032
46.

5-lipoxygenase: regulation and possible involvement in atherosclerosis.

Rådmark O, Samuelsson B.

Prostaglandins Other Lipid Mediat. 2007 May;83(3):162-74. Epub 2007 Jan 25. Review.

PMID:
17481551
47.

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.

Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13150-5. Epub 2006 Aug 21.

48.

Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site.

Sorg BL, Klan N, Seuter S, Dishart D, Rådmark O, Habenicht A, Carlberg C, Werz O, Steinhilber D.

Biochim Biophys Acta. 2006 Jul;1761(7):686-97. Epub 2006 Apr 26.

PMID:
16750418
49.

Arachidonic acid is a physiological activator of the ryanodine receptor in pancreatic beta-cells.

Woolcott OO, Gustafsson AJ, Dzabic M, Pierro C, Tedeschi P, Sandgren J, Bari MR, Nguyen KH, Bianchi M, Rakonjac M, Rådmark O, Ostenson CG, Islam MS.

Cell Calcium. 2006 Jun;39(6):529-37. Epub 2006 Apr 18.

PMID:
16620964
50.

GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.

Dishart D, Schnur N, Klan N, Werz O, Steinhilber D, Samuelsson B, Rådmark O.

Biochim Biophys Acta. 2005 Dec 30;1738(1-3):37-47. Epub 2005 Dec 27.

PMID:
16413224

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