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Items: 1 to 50 of 619

1.

cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia.

Wang H, Xu J, Lazarovici P, Quirion R, Zheng W.

Front Mol Neurosci. 2018 Aug 30;11:255. doi: 10.3389/fnmol.2018.00255. eCollection 2018. Review.

2.

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.

Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J.

Curr Biol. 2018 Apr 2;28(7):1079-1089.e4. doi: 10.1016/j.cub.2018.02.047. Epub 2018 Mar 22.

PMID:
29576474
3.

Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer's Disease.

Mahar I, Albuquerque MS, Mondragon-Rodriguez S, Cavanagh C, Davoli MA, Chabot JG, Williams S, Mechawar N, Quirion R, Krantic S.

Front Aging Neurosci. 2017 Jan 19;8:327. doi: 10.3389/fnagi.2016.00327. eCollection 2016.

4.

Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway.

Liao R, Yan F, Zeng Z, Farhan M, Little P, Quirion R, Srivastava LK, Zheng W.

Mol Neurobiol. 2017 Nov;54(9):6931-6943. doi: 10.1007/s12035-016-0211-x. Epub 2016 Oct 24.

PMID:
27774572
5.

Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model.

Cavanagh C, Tse YC, Nguyen HB, Krantic S, Breitner JC, Quirion R, Wong TP.

Neurobiol Aging. 2016 Nov;47:41-49. doi: 10.1016/j.neurobiolaging.2016.07.009. Epub 2016 Jul 25.

6.

The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway.

Zeng Z, Wang X, Bhardwaj SK, Zhou X, Little PJ, Quirion R, Srivastava LK, Zheng W.

Mol Neurobiol. 2017 Jul;54(5):3395-3406. doi: 10.1007/s12035-016-9904-4. Epub 2016 May 13.

PMID:
27173157
7.

High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.

Bouvier DS, Jones EV, Quesseveur G, Davoli MA, A Ferreira T, Quirion R, Mechawar N, Murai KK.

Sci Rep. 2016 Apr 19;6:24544. doi: 10.1038/srep24544.

8.

Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways.

Zeng Z, Wang H, Shang F, Zhou L, Little PJ, Quirion R, Zheng W.

Psychopharmacology (Berl). 2016 Mar;233(5):785-94. doi: 10.1007/s00213-015-4168-7. Epub 2015 Dec 2.

PMID:
26626328
9.

Forkhead box O transcription factors as possible mediators in the development of major depression.

Wang H, Quirion R, Little PJ, Cheng Y, Feng ZP, Sun HS, Xu J, Zheng W.

Neuropharmacology. 2015 Dec;99:527-37. doi: 10.1016/j.neuropharm.2015.08.020. Epub 2015 Aug 14. Review.

PMID:
26279492
10.

Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages.

Colby-Milley J, Cavanagh C, Jego S, Breitner JC, Quirion R, Adamantidis A.

PLoS One. 2015 Jun 15;10(6):e0130177. doi: 10.1371/journal.pone.0130177. eCollection 2015.

11.

Immunohistochemical distribution of neuropeptide Y, peptide YY, pancreatic polypeptide-like immunoreactivity and their receptors in the epidermal skin of healthy women.

Dumont Y, Bastianetto S, Duranton A, Breton L, Quirion R.

Peptides. 2015 Aug;70:7-16. doi: 10.1016/j.peptides.2015.05.002. Epub 2015 May 19.

PMID:
26002416
12.

Signaling pathways relevant to cognition-enhancing drug targets.

Ménard C, Gaudreau P, Quirion R.

Handb Exp Pharmacol. 2015;228:59-98. doi: 10.1007/978-3-319-16522-6_3. Review.

PMID:
25977080
13.

Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease.

Albuquerque MS, Mahar I, Davoli MA, Chabot JG, Mechawar N, Quirion R, Krantic S.

Front Aging Neurosci. 2015 Mar 24;7:30. doi: 10.3389/fnagi.2015.00030. eCollection 2015.

14.

Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models.

Ménard C, Quirion R, Vigneault E, Bouchard S, Ferland G, El Mestikawy S, Gaudreau P.

Neurobiol Aging. 2015 Mar;36(3):1471-82. doi: 10.1016/j.neurobiolaging.2014.11.013. Epub 2014 Nov 26.

15.

Proceedings of the 2013 CINP summit: innovative partnerships to accelerate CNS drug discovery for improved patient care.

Phillips AG, Hongaard-Andersen P, Moscicki RA, Sahakian B, Quirion R, Krishnan KR, Race T.

Int J Neuropsychopharmacol. 2014 Dec 25;18(3). pii: pyu100. doi: 10.1093/ijnp/pyu100. Review.

16.

Neuropeptide Y pathways in anxiety-related disorders.

Dumont Y, Quirion R.

Biol Psychiatry. 2014 Dec 1;76(11):834-5. doi: 10.1016/j.biopsych.2014.09.015. Epub 2014 Nov 4. No abstract available.

PMID:
25439997
17.

Securing the future of drug discovery for central nervous system disorders.

Andersen PH, Moscicki R, Sahakian B, Quirion R, Krishnan R, Race T, Phillips A; 2013 CINP Summit Group.

Nat Rev Drug Discov. 2014 Dec;13(12):871-2. doi: 10.1038/nrd4489.

PMID:
25435203
18.

Neuroprotective action of resveratrol.

Bastianetto S, Ménard C, Quirion R.

Biochim Biophys Acta. 2015 Jun;1852(6):1195-201. doi: 10.1016/j.bbadis.2014.09.011. Epub 2014 Oct 2. Review.

19.

The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.

Yu W, Bonnet M, Farso M, Ma K, Chabot JG, Martin E, Torriglia A, Guan Z, McLaurin J, Quirion R, Krantic S.

BMC Neurosci. 2014 Jun 10;15:73. doi: 10.1186/1471-2202-15-73.

20.

Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging.

Ménard C, Quirion R, Bouchard S, Ferland G, Gaudreau P.

Front Aging Neurosci. 2014 May 7;6:81. doi: 10.3389/fnagi.2014.00081. eCollection 2014.

21.

Targeting cell surface trafficking of pain-facilitating receptors to treat chronic pain conditions.

Ma W, Quirion R.

Expert Opin Ther Targets. 2014 Apr;18(4):459-72. doi: 10.1517/14728222.2014.887683. Epub 2014 Feb 10. Review.

PMID:
24512266
22.

Involvement of adrenomedullin in the attenuation of acute morphine-induced analgesia in rats.

Wang D, Huo Y, Quirion R, Hong Y.

Peptides. 2014 Apr;54:67-70. doi: 10.1016/j.peptides.2014.01.009. Epub 2014 Jan 24.

PMID:
24468549
23.

Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma.

Menard C, Bastianetto S, Quirion R.

Front Cell Neurosci. 2013 Dec 26;7:281. doi: 10.3389/fncel.2013.00281. eCollection 2013.

24.

Possible role of dynorphins in Alzheimer's disease and age-related cognitive deficits.

Ménard C, Herzog H, Schwarzer C, Quirion R.

Neurodegener Dis. 2014;13(2-3):82-5. doi: 10.1159/000353848. Epub 2013 Aug 22.

PMID:
23970097
25.

Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms.

Jiang J, Wang D, Zhou X, Huo Y, Chen T, Hu F, Quirion R, Hong Y.

Br J Pharmacol. 2013 Nov;170(5):1027-40. doi: 10.1111/bph.12326.

26.

Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging.

Ménard C, Tse YC, Cavanagh C, Chabot JG, Herzog H, Schwarzer C, Wong TP, Quirion R.

J Neurosci. 2013 Jul 31;33(31):12792-804. doi: 10.1523/JNEUROSCI.0290-13.2013.

27.

Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice.

Shukla M, Quirion R, Ma W.

Neuroscience. 2013 Oct 10;250:92-101. doi: 10.1016/j.neuroscience.2013.06.064. Epub 2013 Jul 11.

PMID:
23850592
28.

Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer's disease.

Goutagny R, Gu N, Cavanagh C, Jackson J, Chabot JG, Quirion R, Krantic S, Williams S.

Eur J Neurosci. 2013 Jun;37(12):1896-902. doi: 10.1111/ejn.12233.

PMID:
23773058
29.

βCTF-correlated burst of hippocampal TNFα occurs at a very early, pre-plaque stage in the TgCRND8 mouse model of Alzheimer's disease.

Cavanagh C, Colby-Milley J, Bouvier D, Farso M, Chabot JG, Quirion R, Krantic S.

J Alzheimers Dis. 2013;36(2):233-8. doi: 10.3233/JAD-122131.

PMID:
23579326
30.

Immune marker CD68 correlates with cognitive impairment in normally aged rats.

Farso M, Ménard C, Colby-Milley J, Quirion R.

Neurobiol Aging. 2013 Aug;34(8):1971-6. doi: 10.1016/j.neurobiolaging.2013.02.008. Epub 2013 Mar 21.

PMID:
23523271
31.

Aging and long-term caloric restriction regulate neuropeptide Y receptor subtype densities in the rat brain.

Veyrat-Durebex C, Quirion R, Ferland G, Dumont Y, Gaudreau P.

Neuropeptides. 2013 Jun;47(3):163-9. doi: 10.1016/j.npep.2013.01.001. Epub 2013 Feb 12.

PMID:
23410741
32.

Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat.

Morales-Medina JC, Juarez I, Venancio-García E, Cabrera SN, Menard C, Yu W, Flores G, Mechawar N, Quirion R.

Neuroscience. 2013 Apr 16;236:233-43. doi: 10.1016/j.neuroscience.2013.01.037. Epub 2013 Jan 26.

PMID:
23357118
33.

Mood and memory-associated behaviors in neuropeptide Y5 knockout mice.

Ito M, Dumont Y, Quirion R.

Neuropeptides. 2013 Apr;47(2):75-84. doi: 10.1016/j.npep.2012.10.009. Epub 2012 Dec 4.

PMID:
23218957
34.

Chronic administration of the Y2 receptor antagonist, JNJ-31020028, induced anti-depressant like-behaviors in olfactory bulbectomized rat.

Morales-Medina JC, Dumont Y, Bonaventure P, Quirion R.

Neuropeptides. 2012 Dec;46(6):329-34. doi: 10.1016/j.npep.2012.09.009. Epub 2012 Oct 25.

PMID:
23103057
35.

Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain.

Ménard C, Quirion R.

Front Pharmacol. 2012 Oct 12;3:182. doi: 10.3389/fphar.2012.00182. eCollection 2012.

36.

Glutamate attenuates IGF-1 receptor tyrosine phosphorylation in mouse brain: possible significance in ischemic brain damage.

Sun C, Meng Q, Zhang L, Wang H, Quirion R, Zheng W.

Neurosci Res. 2012 Dec;74(3-4):290-7. doi: 10.1016/j.neures.2012.10.001. Epub 2012 Oct 22.

PMID:
23085572
37.

Involvement of PKA-dependent upregulation of nNOS-CGRP in adrenomedullin-initiated mechanistic pathway underlying CFA-induced response in rats.

Wang D, Ruan L, Hong Y, Chabot JG, Quirion R.

Exp Neurol. 2013 Jan;239:111-9. doi: 10.1016/j.expneurol.2012.10.006. Epub 2012 Oct 12.

PMID:
23063906
38.

The possible role of the Akt signaling pathway in schizophrenia.

Zheng W, Wang H, Zeng Z, Lin J, Little PJ, Srivastava LK, Quirion R.

Brain Res. 2012 Aug 27;1470:145-58. doi: 10.1016/j.brainres.2012.06.032. Epub 2012 Jul 4. Review.

PMID:
22771711
39.

The selective neuropeptide Y Y5 agonist [cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP differently modulates emotional processes and body weight in the rat.

Morales-Medina JC, Dominguez-Lopez S, Gobbi G, Beck-Sickinger AG, Quirion R.

Behav Brain Res. 2012 Aug 1;233(2):298-304. doi: 10.1016/j.bbr.2012.05.015. Epub 2012 May 19.

PMID:
22613731
40.

Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells.

Wang H, Zhang Q, Zhang L, Little PJ, Xie X, Meng Q, Ren Y, Zhou L, Gao G, Quirion R, Zheng W.

Neurosci Lett. 2012 May 10;516(1):105-9. doi: 10.1016/j.neulet.2012.03.068. Epub 2012 Apr 2.

PMID:
22490886
41.

Forkhead family transcription factor FoxO and neural differentiation.

Wen Q, Wang H, Little PJ, Quirion R, Zheng W.

Neurogenetics. 2012 May;13(2):105-13. doi: 10.1007/s10048-012-0320-2. Epub 2012 Mar 28. Review.

PMID:
22453702
42.

Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway.

Efthimiadi L, Farso M, Quirion R, Krantic S.

Neurodegener Dis. 2012;10(1-4):80-91. doi: 10.1159/000335911. Epub 2012 Feb 17.

PMID:
22354185
43.

Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT(2A) receptor antagonist ketanserin in rats.

Wang D, Chen T, Gao Y, Quirion R, Hong Y.

Pharmacol Biochem Behav. 2012 May;101(3):379-86. doi: 10.1016/j.pbb.2012.02.004. Epub 2012 Feb 9.

PMID:
22342663
44.

Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways.

Ménard C, Quirion R.

PLoS One. 2012;7(1):e28666. doi: 10.1371/journal.pone.0028666. Epub 2012 Jan 6.

45.

Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model.

Krantic S, Isorce N, Mechawar N, Davoli MA, Vignault E, Albuquerque M, Chabot JG, Moyse E, Chauvin JP, Aubert I, McLaurin J, Quirion R.

J Alzheimers Dis. 2012;29(2):293-308. doi: 10.3233/JAD-2011-110830.

PMID:
22232004
46.

Clozapine administration reverses behavioral, neuronal, and nitric oxide disturbances in the neonatal ventral hippocampus rat.

Bringas ME, Morales-Medina JC, Flores-Vivaldo Y, Negrete-Diaz JV, Aguilar-Alonso P, León-Chávez BA, Lazcano-Ortiz Z, Monroy E, Rodríguez-Moreno A, Quirion R, Flores G.

Neuropharmacology. 2012 Mar;62(4):1848-57. doi: 10.1016/j.neuropharm.2011.12.008. Epub 2011 Dec 17.

PMID:
22207157
47.

WITHDRAWN: Glutamate Attenuates IGF-1 Receptor Signaling via NR2B containing NMDA Receptors 3 and neuronal Nitric Oxide Synthase.

Han C, Quirion R, Zheng W.

Biochem Biophys Res Commun. 2011 Oct 6. [Epub ahead of print]

PMID:
22001275
48.

On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats.

Wang Z, Chabot JG, Quirion R.

Mol Pain. 2011 Sep 21;7:68. doi: 10.1186/1744-8069-7-68.

49.

α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling.

Yu W, Mechawar N, Krantic S, Quirion R.

J Neurochem. 2011 Nov;119(4):848-58. doi: 10.1111/j.1471-4159.2011.07466.x. Epub 2011 Oct 3.

50.

Role of neuropeptide Y Y₁ and Y₂ receptors on behavioral despair in a rat model of depression with co-morbid anxiety.

Morales-Medina JC, Dumont Y, Benoit CE, Bastianetto S, Flores G, Fournier A, Quirion R.

Neuropharmacology. 2012 Jan;62(1):200-8. doi: 10.1016/j.neuropharm.2011.06.030. Epub 2011 Jul 23.

PMID:
21803058

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