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Items: 46


NF-κB RelA is required for hepatoprotection during pneumonia and sepsis.

Kim Y, Allen E, Baird LA, Symer EM, Korkmaz FT, Na E, Odom CV, Jones MR, Mizgerd JP, Traber KE, Quinton LJ.

Infect Immun. 2019 Jun 3. pii: IAI.00132-19. doi: 10.1128/IAI.00132-19. [Epub ahead of print]


C-rac-king the Code of Smoke-induced Pneumonia Susceptibility.

Quinton LJ.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1246-1248. doi: 10.1164/rccm.201807-1217ED. No abstract available.


Integrative Physiology of Pneumonia.

Quinton LJ, Walkey AJ, Mizgerd JP.

Physiol Rev. 2018 Jul 1;98(3):1417-1464. doi: 10.1152/physrev.00032.2017. Review.


Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN.

Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10. doi: 10.1016/j.stem.2017.08.014. Epub 2017 Sep 28.


Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells.

Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR.

J Clin Invest. 2017 Oct 2;127(10):3866-3876. doi: 10.1172/JCI94639. Epub 2017 Sep 18.


The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.

Kozlowski E, Wasserman GA, Morgan M, O'Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR.

PLoS One. 2017 Jun 30;12(6):e0179797. doi: 10.1371/journal.pone.0179797. eCollection 2017.


Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia.

Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L548-L558. doi: 10.1152/ajplung.00482.2016. Epub 2017 May 18.


Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia.

Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP.

Mucosal Immunol. 2018 Jan;11(1):220-235. doi: 10.1038/mi.2017.43. Epub 2017 May 17.


Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity.

Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP.

J Infect Dis. 2017 Aug 15;216(4):425-435. doi: 10.1093/infdis/jix159.


Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia.

Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):407-18. doi: 10.1165/rcmb.2015-0261OC.


Activation of Hepatic STAT3 Maintains Pulmonary Defense during Endotoxemia.

Hilliard KL, Allen E, Traber KE, Kim Y, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ.

Infect Immun. 2015 Oct;83(10):4015-27. doi: 10.1128/IAI.00464-15. Epub 2015 Jul 27.


Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia.

Traber KE, Hilliard KL, Allen E, Wasserman GA, Yamamoto K, Jones MR, Mizgerd JP, Quinton LJ.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):479-88. doi: 10.1165/rcmb.2014-0342OC.


The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia.

Hilliard KL, Allen E, Traber KE, Yamamoto K, Stauffer NM, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):378-90. doi: 10.1165/rcmb.2014-0195OC.


Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection.

Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR.

PLoS One. 2014 Oct 9;9(10):e109072. doi: 10.1371/journal.pone.0109072. eCollection 2014.


Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling.

Quinton LJ, Mizgerd JP.

Annu Rev Physiol. 2015;77:407-30. doi: 10.1146/annurev-physiol-021014-071937. Epub 2014 Aug 13. Review.


Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands.

Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF.

Front Pharmacol. 2014 Feb 6;5:8. doi: 10.3389/fphar.2014.00008. eCollection 2014.


Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia.

Yamamoto K, Ahyi AN, Pepper-Cunningham ZA, Ferrari JD, Wilson AA, Jones MR, Quinton LJ, Mizgerd JP.

Am J Respir Cell Mol Biol. 2014 Feb;50(2):253-62. doi: 10.1165/rcmb.2013-0114OC.


Roles of STAT3 in protein secretion pathways during the acute-phase response.

Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP.

Infect Immun. 2013 May;81(5):1644-53. doi: 10.1128/IAI.01332-12. Epub 2013 Mar 4.


Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.

Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP.

PLoS Genet. 2012;8(11):e1003105. doi: 10.1371/journal.pgen.1003105. Epub 2012 Nov 29.


Evaluating the NET influence of inflammation on pneumonia biology.

Quinton LJ.

Am J Respir Crit Care Med. 2012 Nov 15;186(10):943-4. doi: 10.1164/rccm.201209-1702ED. No abstract available.


Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia.

Yamamoto K, Ferrari JD, Cao Y, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP.

J Immunol. 2012 Sep 1;189(5):2450-9. doi: 10.4049/jimmunol.1200634. Epub 2012 Jul 27.


Leukemia inhibitory factor signaling is required for lung protection during pneumonia.

Quinton LJ, Mizgerd JP, Hilliard KL, Jones MR, Kwon CY, Allen E.

J Immunol. 2012 Jun 15;188(12):6300-8. doi: 10.4049/jimmunol.1200256. Epub 2012 May 11.


Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice.

Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP.

J Clin Invest. 2012 May;122(5):1758-63. doi: 10.1172/JCI59408. Epub 2012 Apr 2.


GM-CSF: a double dose of protection during pneumonia.

Quinton LJ.

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 1;302(5):L445-6. doi: 10.1152/ajplung.00022.2012. Epub 2012 Jan 20. No abstract available.


Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity.

Blahna MT, Jones MR, Quinton LJ, Matsuura KY, Mizgerd JP.

J Biol Chem. 2011 Dec 9;286(49):42381-9. doi: 10.1074/jbc.M111.259689. Epub 2011 Oct 17.


Differential flux of macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant from the lung after intrapulmonary delivery.

Zamjahn JB, Quinton LJ, Mack JC, Frevert CW, Nelson S, Bagby GJ.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L568-74. doi: 10.1152/ajplung.00340.2010. Epub 2011 Jul 8.


Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia.

Pittet LA, Quinton LJ, Yamamoto K, Robson BE, Ferrari JD, Algül H, Schmid RM, Mizgerd JP.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):573-81. doi: 10.1165/rcmb.2010-0210OC. Epub 2011 Jan 7.


NF-κB and STAT3 signaling hubs for lung innate immunity.

Quinton LJ, Mizgerd JP.

Cell Tissue Res. 2011 Jan;343(1):153-65. doi: 10.1007/s00441-010-1044-y. Epub 2010 Sep 25. Review.


Zcchc11-dependent uridylation of microRNA directs cytokine expression.

Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP.

Nat Cell Biol. 2009 Sep;11(9):1157-63. doi: 10.1038/ncb1931. Epub 2009 Aug 23.


Mechanisms of the hepatic acute-phase response during bacterial pneumonia.

Quinton LJ, Jones MR, Robson BE, Mizgerd JP.

Infect Immun. 2009 Jun;77(6):2417-26. doi: 10.1128/IAI.01300-08. Epub 2009 Mar 16.


The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide.

Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd JP, Zhang P, Nelson S.

Shock. 2009 Feb;31(2):212-7. doi: 10.1097/SHK.0b013e31817c0d7d.


Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia.

Quinton LJ, Jones MR, Robson BE, Simms BT, Whitsett JA, Mizgerd JP.

Am J Respir Cell Mol Biol. 2008 Jun;38(6):699-706. doi: 10.1165/rcmb.2007-0365OC. Epub 2008 Jan 10.


Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide.

Happel KI, Rudner X, Quinton LJ, Movassaghi JL, Clark C, Odden AR, Zhang P, Bagby GJ, Nelson S, Shellito JE.

Alcohol. 2007 Aug;41(5):325-33.


Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice.

Johnston RA, Mizgerd JP, Flynt L, Quinton LJ, Williams ES, Shore SA.

Am J Respir Cell Mol Biol. 2007 Oct;37(4):477-84. Epub 2007 Jun 15.


Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia.

Quinton LJ, Jones MR, Simms BT, Kogan MS, Robson BE, Skerrett SJ, Mizgerd JP.

J Immunol. 2007 Feb 1;178(3):1896-903.


Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide.

Krishnamurthy VM, Quinton LJ, Estroff LA, Metallo SJ, Isaacs JM, Mizgerd JP, Whitesides GM.

Biomaterials. 2006 Jul;27(19):3663-74. Epub 2006 Mar 9.


Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia.

Jones MR, Quinton LJ, Simms BT, Lupa MM, Kogan MS, Mizgerd JP.

J Infect Dis. 2006 Feb 1;193(3):360-9. Epub 2005 Dec 27.


Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae.

Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK.

J Exp Med. 2005 Sep 19;202(6):761-9. Epub 2005 Sep 12.


Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment.

Quinton LJ, Nelson S, Zhang P, Happel KI, Gamble L, Bagby GJ.

Alcohol Clin Exp Res. 2005 Jul;29(7):1198-205.


Chemokine receptor 5 and its ligands in the immune response to murine tuberculosis.

Badewa AP, Quinton LJ, Shellito JE, Mason CM.

Tuberculosis (Edinb). 2005 May;85(3):185-95.


The granulopoietic cytokine response and enhancement of granulopoiesis in mice during endotoxemia.

Zhang P, Quinton LJ, Gamble L, Bagby GJ, Summer WR, Nelson S.

Shock. 2005 Apr;23(4):344-52.


Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation.

Shahbazian LM, Quinton LJ, Bagby GJ, Nelson S, Wang G, Zhang P.

Crit Care Med. 2004 Aug;32(8):1740-6.


Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment.

Quinton LJ, Nelson S, Zhang P, Boé DM, Happel KI, Pan W, Bagby GJ.

Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L465-72. Epub 2003 Nov 14.


Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection.

Happel KI, Zheng M, Young E, Quinton LJ, Lockhart E, Ramsay AJ, Shellito JE, Schurr JR, Bagby GJ, Nelson S, Kolls JK.

J Immunol. 2003 May 1;170(9):4432-6.


Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge.

Zhang P, Quinton LJ, Bagby GJ, Summer WR, Nelson S.

J Infect Dis. 2003 Jan 1;187(1):62-9. Epub 2002 Dec 13.


The granulocyte colony-stimulating factor response after intrapulmonary and systemic bacterial challenges.

Quinton LJ, Nelson S, Boé DM, Zhang P, Zhong Q, Kolls JK, Bagby GJ.

J Infect Dis. 2002 May 15;185(10):1476-82. Epub 2002 Apr 30.


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