Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 163

1.

Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers.

Bergey CM, Lopez M, Harrison GF, Patin E, Cohen JA, Quintana-Murci L, Barreiro LB, Perry GH.

Proc Natl Acad Sci U S A. 2018 Nov 9. pii: 201812135. doi: 10.1073/pnas.1812135115. [Epub ahead of print]

PMID:
30413626
2.

Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array.

McEwen LM, Jones MJ, Lin DTS, Edgar RD, Husquin LT, MacIsaac JL, Ramadori KE, Morin AM, Rider CF, Carlsten C, Quintana-Murci L, Horvath S, Kobor MS.

Clin Epigenetics. 2018 Oct 16;10(1):123. doi: 10.1186/s13148-018-0556-2.

3.

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus.

Clave E, Araujo IL, Alanio C, Patin E, Bergstedt J, Urrutia A, Lopez-Lastra S, Li Y, Charbit B, MacPherson CR, Hasan M, Melo-Lima BL, Douay C, Saut N, Germain M, Trégouët DA, Morange PE, Fontes M, Duffy D, Di Santo JP, Quintana-Murci L, Albert ML, Toubert A; Milieu Intérieur Consortium.

Sci Transl Med. 2018 Sep 5;10(457). pii: eaao2966. doi: 10.1126/scitranslmed.aao2966.

PMID:
30185651
4.

The demographic and adaptive history of central African hunter-gatherers and farmers.

Patin E, Quintana-Murci L.

Curr Opin Genet Dev. 2018 Aug 10;53:90-97. doi: 10.1016/j.gde.2018.07.008. [Epub ahead of print] Review.

PMID:
30103089
5.

Host and viral genetic diversity can help explain mortality during the 1918-21 influenza pandemic in the Pacific region.

Tarantola A, Horwood P, Richard V, Quintana-Murci L.

Lancet Infect Dis. 2018 Aug;18(8):833-834. doi: 10.1016/S1473-3099(18)30408-0. No abstract available.

PMID:
30064670
6.

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.

Scepanovic P, Alanio C, Hammer C, Hodel F, Bergstedt J, Patin E, Thorball CW, Chaturvedi N, Charbit B, Abel L, Quintana-Murci L, Duffy D, Albert ML, Fellay J; Milieu Intérieur Consortium.

Genome Med. 2018 Jul 27;10(1):59. doi: 10.1186/s13073-018-0568-8.

7.

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

Patin E, Hasan M, Bergstedt J, Rouilly V, Libri V, Urrutia A, Alanio C, Scepanovic P, Hammer C, Jönsson F, Beitz B, Quach H, Lim YW, Hunkapiller J, Zepeda M, Green C, Piasecka B, Leloup C, Rogge L, Huetz F, Peguillet I, Lantz O, Fontes M, Di Santo JP, Thomas S, Fellay J, Duffy D, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium.

Nat Immunol. 2018 Jun;19(6):645. doi: 10.1038/s41590-018-0105-3.

PMID:
29725081
8.

IRF4 haploinsufficiency in a family with Whipple's disease.

Guérin A, Kerner G, Marr N, Markle JG, Fenollar F, Wong N, Boughorbel S, Avery DT, Ma CS, Bougarn S, Bouaziz M, Béziat V, Della Mina E, Oleaga-Quintas C, Lazarov T, Worley L, Nguyen T, Patin E, Deswarte C, Martinez-Barricarte R, Boucherit S, Ayral X, Edouard S, Boisson-Dupuis S, Rattina V, Bigio B, Vogt G, Geissmann F, Quintana-Murci L, Chaussabel D, Tangye SG, Raoult D, Abel L, Bustamante J, Casanova JL.

Elife. 2018 Mar 14;7. pii: e32340. doi: 10.7554/eLife.32340.

9.

The demographic history and mutational load of African hunter-gatherers and farmers.

Lopez M, Kousathanas A, Quach H, Harmant C, Mouguiama-Daouda P, Hombert JM, Froment A, Perry GH, Barreiro LB, Verdu P, Patin E, Quintana-Murci L.

Nat Ecol Evol. 2018 Apr;2(4):721-730. doi: 10.1038/s41559-018-0496-4. Epub 2018 Mar 12.

PMID:
29531345
10.

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

Patin E, Hasan M, Bergstedt J, Rouilly V, Libri V, Urrutia A, Alanio C, Scepanovic P, Hammer C, Jönsson F, Beitz B, Quach H, Lim YW, Hunkapiller J, Zepeda M, Green C, Piasecka B, Leloup C, Rogge L, Huetz F, Peguillet I, Lantz O, Fontes M, Di Santo JP, Thomas S, Fellay J, Duffy D, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium.

Nat Immunol. 2018 Mar;19(3):302-314. doi: 10.1038/s41590-018-0049-7. Epub 2018 Feb 23. Erratum in: Nat Immunol. 2018 May 3;:.

PMID:
29476184
11.

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.

Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E488-E497. doi: 10.1073/pnas.1714765115. Epub 2017 Dec 27.

12.

miR-222 isoforms are differentially regulated by type-I interferon.

Nejad C, Pillman KA, Siddle KJ, Pépin G, Änkö ML, McCoy CE, Beilharz TH, Quintana-Murci L, Goodall GJ, Bracken CP, Gantier MP.

RNA. 2018 Mar;24(3):332-341. doi: 10.1261/rna.064550.117. Epub 2017 Dec 20.

PMID:
29263133
13.

The Genetic Legacy of the Indian Ocean Slave Trade: Recent Admixture and Post-admixture Selection in the Makranis of Pakistan.

Laso-Jadart R, Harmant C, Quach H, Zidane N, Tyler-Smith C, Mehdi Q, Ayub Q, Quintana-Murci L, Patin E.

Am J Hum Genet. 2017 Dec 7;101(6):977-984. doi: 10.1016/j.ajhg.2017.09.025. Epub 2017 Nov 9.

14.

Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity.

Bisiaux A, Boussier J, Duffy D, Quintana-Murci L, Fontes M, Albert ML; Milieu Intérieur Consortium.

Front Immunol. 2017 Jul 13;8:796. doi: 10.3389/fimmu.2017.00796. eCollection 2017.

15.

Trends in DNA Methylation with Age Replicate Across Diverse Human Populations.

Gopalan S, Carja O, Fagny M, Patin E, Myrick JW, McEwen LM, Mah SM, Kobor MS, Froment A, Feldman MW, Quintana-Murci L, Henn BM.

Genetics. 2017 Jul;206(3):1659-1674. doi: 10.1534/genetics.116.195594. Epub 2017 May 22.

16.

Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America.

Patin E, Lopez M, Grollemund R, Verdu P, Harmant C, Quach H, Laval G, Perry GH, Barreiro LB, Froment A, Heyer E, Massougbodji A, Fortes-Lima C, Migot-Nabias F, Bellis G, Dugoujon JM, Pereira JB, Fernandes V, Pereira L, Van der Veen L, Mouguiama-Daouda P, Bustamante CD, Hombert JM, Quintana-Murci L.

Science. 2017 May 5;356(6337):543-546. doi: 10.1126/science.aal1988.

PMID:
28473590
17.

Living in an adaptive world: Genomic dissection of the genus Homo and its immune response.

Quach H, Quintana-Murci L.

J Exp Med. 2017 Apr 3;214(4):877-894. doi: 10.1084/jem.20161942. Epub 2017 Mar 28. Review.

18.

[Innate immunity and human diseases: from archaic introgression to natural selection].

Deschamps M, Quintana-Murci L.

Med Sci (Paris). 2016 Dec;32(12):1079-1086. doi: 10.1051/medsci/20163212011. Epub 2017 Jan 3. Review. French.

19.

Understanding rare and common diseases in the context of human evolution.

Quintana-Murci L.

Genome Biol. 2016 Nov 7;17(1):225. Review.

20.

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

Wang Y, Ma CS, Ling Y, Bousfiha A, Camcioglu Y, Jacquot S, Payne K, Crestani E, Roncagalli R, Belkadi A, Kerner G, Lorenzo L, Deswarte C, Chrabieh M, Patin E, Vincent QB, Müller-Fleckenstein I, Fleckenstein B, Ailal F, Quintana-Murci L, Fraitag S, Alyanakian MA, Leruez-Ville M, Picard C, Puel A, Bustamante J, Boisson-Dupuis S, Malissen M, Malissen B, Abel L, Hovnanian A, Notarangelo LD, Jouanguy E, Tangye SG, Béziat V, Casanova JL.

J Exp Med. 2016 Oct 17;213(11):2413-2435. Epub 2016 Sep 19.

21.

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

Quach H, Rotival M, Pothlichet J, Loh YE, Dannemann M, Zidane N, Laval G, Patin E, Harmant C, Lopez M, Deschamps M, Naffakh N, Duffy D, Coen A, Leroux-Roels G, Clément F, Boland A, Deleuze JF, Kelso J, Albert ML, Quintana-Murci L.

Cell. 2016 Oct 20;167(3):643-656.e17. doi: 10.1016/j.cell.2016.09.024.

22.

Might Interspecific Interactions between Pathogens Drive Host Evolution? The Case of Plasmodium Species and Duffy-Negativity in Human Populations.

Roche B, Rougeron V, Quintana-Murci L, Renaud F, Abbate JL, Prugnolle F.

Trends Parasitol. 2017 Jan;33(1):21-29. doi: 10.1016/j.pt.2016.09.010. Epub 2016 Oct 17. Review.

PMID:
27765439
23.

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.

Urrutia A, Duffy D, Rouilly V, Posseme C, Djebali R, Illanes G, Libri V, Albaud B, Gentien D, Piasecka B, Hasan M, Fontes M, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium.

Cell Rep. 2016 Sep 6;16(10):2777-2791. doi: 10.1016/j.celrep.2016.08.011. Epub 2016 Aug 25.

24.

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.

Horvath S, Gurven M, Levine ME, Trumble BC, Kaplan H, Allayee H, Ritz BR, Chen B, Lu AT, Rickabaugh TM, Jamieson BD, Sun D, Li S, Chen W, Quintana-Murci L, Fagny M, Kobor MS, Tsao PS, Reiner AP, Edlefsen KL, Absher D, Assimes TL.

Genome Biol. 2016 Aug 11;17(1):171. doi: 10.1186/s13059-016-1030-0.

25.

Genetic and epigenetic variation of human populations: An adaptive tale.

Quintana-Murci L.

C R Biol. 2016 Jul-Aug;339(7-8):278-83. doi: 10.1016/j.crvi.2016.04.005. Epub 2016 May 13. Review.

26.

The mutation significance cutoff: gene-level thresholds for variant predictions.

Itan Y, Shang L, Boisson B, Ciancanelli MJ, Markle JG, Martinez-Barricarte R, Scott E, Shah I, Stenson PD, Gleeson J, Cooper DN, Quintana-Murci L, Zhang SY, Abel L, Casanova JL.

Nat Methods. 2016 Feb;13(2):109-10. doi: 10.1038/nmeth.3739. No abstract available.

27.

Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.

Deschamps M, Laval G, Fagny M, Itan Y, Abel L, Casanova JL, Patin E, Quintana-Murci L.

Am J Hum Genet. 2016 Jan 7;98(1):5-21. doi: 10.1016/j.ajhg.2015.11.014.

28.

The epigenomic landscape of African rainforest hunter-gatherers and farmers.

Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L.

Nat Commun. 2015 Nov 30;6:10047. doi: 10.1038/ncomms10047.

29.

The human gene damage index as a gene-level approach to prioritizing exome variants.

Itan Y, Shang L, Boisson B, Patin E, Bolze A, Moncada-Vélez M, Scott E, Ciancanelli MJ, Lafaille FG, Markle JG, Martinez-Barricarte R, de Jong SJ, Kong XF, Nitschke P, Belkadi A, Bustamante J, Puel A, Boisson-Dupuis S, Stenson PD, Gleeson JG, Cooper DN, Quintana-Murci L, Claverie JM, Zhang SY, Abel L, Casanova JL.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13615-20. doi: 10.1073/pnas.1518646112. Epub 2015 Oct 19.

30.

Origins, admixture and founder lineages in European Roma.

Martínez-Cruz B, Mendizabal I, Harmant C, de Pablo R, Ioana M, Angelicheva D, Kouvatsi A, Makukh H, Netea MG, Pamjav H, Zalán A, Tournev I, Marushiakova E, Popov V, Bertranpetit J, Kalaydjieva L, Quintana-Murci L, Comas D.

Eur J Hum Genet. 2016 Jun;24(6):937-43. doi: 10.1038/ejhg.2015.201. Epub 2015 Sep 16.

31.

bacterial infection drives the expression dynamics of microRNAs and their isomiRs.

Siddle KJ, Tailleux L, Deschamps M, Loh YH, Deluen C, Gicquel B, Antoniewski C, Barreiro LB, Farinelli L, Quintana-Murci L.

PLoS Genet. 2015 Mar 20;11(3):e1005064. doi: 10.1371/journal.pgen.1005064. eCollection 2015 Mar. Erratum in: PLoS Genet. 2015 Jun;11(6):e1005321.

32.

Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations.

Balaresque P, Poulet N, Cussat-Blanc S, Gerard P, Quintana-Murci L, Heyer E, Jobling MA.

Eur J Hum Genet. 2015 Oct;23(10):1413-22. doi: 10.1038/ejhg.2014.285. Epub 2015 Jan 14.

33.

Automated flow cytometric analysis across large numbers of samples and cell types.

Chen X, Hasan M, Libri V, Urrutia A, Beitz B, Rouilly V, Duffy D, Patin É, Chalmond B, Rogge L, Quintana-Murci L, Albert ML, Schwikowski B; Milieu Intérieur Consortium.

Clin Immunol. 2015 Apr;157(2):249-60. doi: 10.1016/j.clim.2014.12.009. Epub 2015 Jan 7.

34.

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.

Hasan M, Beitz B, Rouilly V, Libri V, Urrutia A, Duffy D, Cassard L, Di Santo JP, Mottez E, Quintana-Murci L, Albert ML, Rogge L; Milieu Intérieur Consortium.

Clin Immunol. 2015 Apr;157(2):261-76. doi: 10.1016/j.clim.2014.12.008. Epub 2015 Jan 6.

35.

The Milieu Intérieur study - an integrative approach for study of human immunological variance.

Thomas S, Rouilly V, Patin E, Alanio C, Dubois A, Delval C, Marquier LG, Fauchoux N, Sayegrih S, Vray M, Duffy D, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium.

Clin Immunol. 2015 Apr;157(2):277-93. doi: 10.1016/j.clim.2014.12.004. Epub 2015 Jan 3.

36.

Editorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology.

Barreiro LB, Quintana-Murci L.

Curr Opin Immunol. 2014 Oct;30:v-vii. doi: 10.1016/j.coi.2014.09.003. Epub 2014 Sep 17. No abstract available.

PMID:
25240536
37.

Preserving immune diversity through ancient inheritance and admixture.

Ségurel L, Quintana-Murci L.

Curr Opin Immunol. 2014 Oct;30:79-84. doi: 10.1016/j.coi.2014.08.002. Epub 2014 Sep 3. Review.

PMID:
25190608
38.

The Red Queen's long race: human adaptation to pathogen pressure.

Siddle KJ, Quintana-Murci L.

Curr Opin Genet Dev. 2014 Dec;29:31-8. doi: 10.1016/j.gde.2014.07.004. Epub 2014 Aug 24. Review.

PMID:
25170983
39.

Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.

Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3596-603. doi: 10.1073/pnas.1402875111. Epub 2014 Aug 18.

40.

Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.

Fagny M, Patin E, Enard D, Barreiro LB, Quintana-Murci L, Laval G.

Mol Biol Evol. 2014 Jul;31(7):1850-68. doi: 10.1093/molbev/msu118. Epub 2014 Apr 1.

PMID:
24694833
41.

HGCS: an online tool for prioritizing disease-causing gene variants by biological distance.

Itan Y, Mazel M, Mazel B, Abhyankar A, Nitschke P, Quintana-Murci L, Boisson-Dupuis S, Boisson B, Abel L, Zhang SY, Casanova JL.

BMC Genomics. 2014 Apr 3;15:256. doi: 10.1186/1471-2164-15-256.

42.

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

Duffy D, Rouilly V, Libri V, Hasan M, Beitz B, David M, Urrutia A, Bisiaux A, Labrie ST, Dubois A, Boneca IG, Delval C, Thomas S, Rogge L, Schmolz M, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium.

Immunity. 2014 Mar 20;40(3):436-50. doi: 10.1016/j.immuni.2014.03.002.

43.

The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.

Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L.

Nat Commun. 2014;5:3163. doi: 10.1038/ncomms4163.

PMID:
24495941
44.

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.

Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L.

Genome Res. 2014 May;24(5):850-9. doi: 10.1101/gr.161471.113. Epub 2014 Jan 30.

45.

Immunology taught by human genetics.

Casanova JL, Abel L, Quintana-Murci L.

Cold Spring Harb Symp Quant Biol. 2013;78:157-72. doi: 10.1101/sqb.2013.78.019968. Epub 2013 Oct 3. Review.

PMID:
24092470
46.

Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming.

Aimé C, Laval G, Patin E, Verdu P, Ségurel L, Chaix R, Hegay T, Quintana-Murci L, Heyer E, Austerlitz F.

Mol Biol Evol. 2013 Dec;30(12):2629-44. doi: 10.1093/molbev/mst156. Epub 2013 Sep 24.

PMID:
24063884
47.

Sequencing Y chromosomes resolves discrepancy in time to common ancestor of males versus females.

Poznik GD, Henn BM, Yee MC, Sliwerska E, Euskirchen GM, Lin AA, Snyder M, Quintana-Murci L, Kidd JM, Underhill PA, Bustamante CD.

Science. 2013 Aug 2;341(6145):562-5. doi: 10.1126/science.1237619.

48.

Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.

Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci L.

Hum Mol Genet. 2013 Dec 1;22(23):4829-40. doi: 10.1093/hmg/ddt335. Epub 2013 Jul 12.

49.

The impact of natural selection on health and disease: uses of the population genetics approach in humans.

Vasseur E, Quintana-Murci L.

Evol Appl. 2013 Jun;6(4):596-607. doi: 10.1111/eva.12045. Epub 2013 Jan 21.

50.

Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata.

Boattini A, Martinez-Cruz B, Sarno S, Harmant C, Useli A, Sanz P, Yang-Yao D, Manry J, Ciani G, Luiselli D, Quintana-Murci L, Comas D, Pettener D; Genographic Consortium.

PLoS One. 2013 May 29;8(5):e65441. doi: 10.1371/journal.pone.0065441. Print 2013.

Supplemental Content

Loading ...
Support Center