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Items: 1 to 50 of 138

1.

Myeloid cells in the central nervous system: So similar, yet so different.

Quintana FJ.

Sci Immunol. 2019 Feb 8;4(32). pii: eaaw2841. doi: 10.1126/sciimmunol.aaw2841. Epub 2019 Feb 8. Review.

PMID:
30737356
2.

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease.

Rothhammer V, Quintana FJ.

Nat Rev Immunol. 2019 Feb 4. doi: 10.1038/s41577-019-0125-8. [Epub ahead of print] Review.

PMID:
30718831
3.

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.

Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ.

Cell. 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17.

PMID:
30661753
4.

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.

Starossom SC, Campo Garcia J, Woelfle T, Romero-Suarez S, Olah M, Watanabe F, Cao L, Yeste A, Tukker JJ, Quintana FJ, Imitola J, Witzel F, Schmitz D, Morkel M, Paul F, Infante-Duarte C, Khoury SJ.

Nat Commun. 2019 Jan 15;10(1):217. doi: 10.1038/s41467-018-08140-7.

5.

Astrocytes play a crucial role in the formation and evolution of MS lesions-Commentary.

Quintana FJ.

Mult Scler. 2018 Aug 23:1352458518796693. doi: 10.1177/1352458518796693. [Epub ahead of print] No abstract available.

PMID:
30136890
6.

HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease.

Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS.

J Autoimmun. 2018 Nov;94:122-133. doi: 10.1016/j.jaut.2018.07.022. Epub 2018 Aug 8.

PMID:
30098863
7.

Effects of Systolic Blood Pressure on Brain Integrity in Multiple Sclerosis.

Dossi DE, Chaves H, Heck ES, Rodriguez Murúa S, Ventrice F, Bakshi R, Quintana FJ, Correale J, Farez MF.

Front Neurol. 2018 Jun 25;9:487. doi: 10.3389/fneur.2018.00487. eCollection 2018.

8.

Microglial control of astrocytes in response to microbial metabolites.

Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ.

Nature. 2018 May;557(7707):724-728. doi: 10.1038/s41586-018-0119-x. Epub 2018 May 16.

PMID:
29769726
9.

Detection of aryl hydrocarbon receptor agonists in human samples.

Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ.

Sci Rep. 2018 Mar 21;8(1):4970. doi: 10.1038/s41598-018-23323-4.

10.

Regulation of Astrocyte Functions in Multiple Sclerosis.

Wheeler MA, Quintana FJ.

Cold Spring Harb Perspect Med. 2019 Jan 2;9(1). pii: a029009. doi: 10.1101/cshperspect.a029009. Review.

PMID:
29358321
11.

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor.

Gutiérrez-Vázquez C, Quintana FJ.

Immunity. 2018 Jan 16;48(1):19-33. doi: 10.1016/j.immuni.2017.12.012. Review.

12.

Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist.

Dolciami D, Gargaro M, Cerra B, Scalisi G, Bagnoli L, Servillo G, Fazia MAD, Puccetti P, Quintana FJ, Fallarino F, Macchiarulo A.

ChemMedChem. 2018 Feb 6;13(3):270-279. doi: 10.1002/cmdc.201700669. Epub 2018 Jan 23.

PMID:
29266750
13.

Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.

Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM.

J Neurochem. 2018 Jan;144(2):128-138. doi: 10.1111/jnc.14243. Epub 2017 Nov 21.

14.

A gut feeling about multiple sclerosis.

Quintana FJ, Prinz M.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10528-10529. doi: 10.1073/pnas.1714260114. Epub 2017 Sep 25. No abstract available.

15.

Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation.

Quintana FJ.

J Clin Invest. 2017 Aug 1;127(8):2897-2899. doi: 10.1172/JCI95769. Epub 2017 Jul 24.

16.

IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.

Nirschl CJ, Suárez-Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, Chau D, Rezaee M, Kim TG, Huang R, Fuentes-Duculan J, Song-Zhao GX, Gulati N, Lowes MA, King SL, Quintana FJ, Lee YS, Krueger JG, Sarin KY, Yoon CH, Garraway L, Regev A, Shalek AK, Troyanskaya O, Anandasabapathy N.

Cell. 2017 Jun 29;170(1):127-141.e15. doi: 10.1016/j.cell.2017.06.016.

17.

Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS.

Rothhammer V, Borucki DM, Garcia Sanchez MI, Mazzola MA, Hemond CC, Regev K, Paul A, Kivisäkk P, Bakshi R, Izquierdo G, Weiner HL, Quintana FJ.

Neurol Neuroimmunol Neuroinflamm. 2017 Jun 16;4(4):e359. doi: 10.1212/NXI.0000000000000359. eCollection 2017 Jul.

18.

Control of immune-mediated pathology via the aryl hydrocarbon receptor.

Wheeler MA, Rothhammer V, Quintana FJ.

J Biol Chem. 2017 Jul 28;292(30):12383-12389. doi: 10.1074/jbc.R116.767723. Epub 2017 Jun 14. Review.

19.

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.

Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC.

JCI Insight. 2017 May 4;2(9). pii: 92791. doi: 10.1172/jci.insight.92791. [Epub ahead of print]

20.

Role of AHR and HIF-1α in Glioblastoma Metabolism.

Gabriely G, Wheeler MA, Takenaka MC, Quintana FJ.

Trends Endocrinol Metab. 2017 Jun;28(6):428-436. doi: 10.1016/j.tem.2017.02.009. Epub 2017 Mar 16. Review.

21.

Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation.

Rothhammer V, Kenison JE, Tjon E, Takenaka MC, de Lima KA, Borucki DM, Chao CC, Wilz A, Blain M, Healy L, Antel J, Quintana FJ.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2012-2017. doi: 10.1073/pnas.1615413114. Epub 2017 Feb 6.

22.

Sample size requirements for one-year treatment effects using deep gray matter volume from 3T MRI in progressive forms of multiple sclerosis.

Kim G, Chu R, Yousuf F, Tauhid S, Stazzone L, Houtchens MK, Stankiewicz JM, Severson C, Kimbrough D, Quintana FJ, Chitnis T, Weiner HL, Healy BC, Bakshi R.

Int J Neurosci. 2017 Nov;127(11):971-980. doi: 10.1080/00207454.2017.1283313. Epub 2017 Feb 2.

PMID:
28100092
23.

Dendritic cells in autoimmunity, infections, and cancer.

Quintana FJ.

Semin Immunopathol. 2017 Feb;39(2):97-98. doi: 10.1007/s00281-016-0618-5. Epub 2017 Jan 16. No abstract available.

24.

Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation.

Quintana FJ.

Nat Immunol. 2016 Dec 16;18(1):8-10. doi: 10.1038/ni.3637. No abstract available.

PMID:
27984572
25.

Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.

Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB.

Gastroenterology. 2016 Dec;151(6):1100-1104. doi: 10.1053/j.gastro.2016.08.055. Epub 2016 Sep 28.

26.

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.

Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ.

Cell Rep. 2016 Oct 25;17(5):1318-1329. doi: 10.1016/j.celrep.2016.09.082.

27.

Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain.

Kuhn C, Rezende RM, da Cunha AP, Valette F, Quintana FJ, Chatenoud L, Weiner HL.

J Autoimmun. 2017 Jan;76:115-122. doi: 10.1016/j.jaut.2016.10.001. Epub 2016 Oct 10.

PMID:
27745778
28.

Environmental control of autoimmune inflammation in the central nervous system.

Rothhammer V, Quintana FJ.

Curr Opin Immunol. 2016 Dec;43:46-53. doi: 10.1016/j.coi.2016.09.002. Epub 2016 Oct 4. Review.

29.

Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes.

Poutiainen P, Jaronen M, Quintana FJ, Brownell AL.

Front Mol Neurosci. 2016 Sep 15;9:85. eCollection 2016. Review.

30.

Tolerogenic dendritic cells.

Takenaka MC, Quintana FJ.

Semin Immunopathol. 2017 Feb;39(2):113-120. doi: 10.1007/s00281-016-0587-8. Epub 2016 Sep 19. Review.

31.

Anti-inflammatory effects of melatonin in multiple sclerosis.

Farez MF, Calandri IL, Correale J, Quintana FJ.

Bioessays. 2016 Oct;38(10):1016-26. doi: 10.1002/bies.201600018. Epub 2016 Aug 26. Review.

PMID:
27561251
32.

Alterations of the human gut microbiome in multiple sclerosis.

Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL.

Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015.

33.

Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.

Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ.

Sci Signal. 2016 Jun 21;9(433):ra61. doi: 10.1126/scisignal.aad0612.

PMID:
27330188
34.

Science Signaling Podcast for 21 June 2016: Nanoparticles to treat type 1 diabetes.

Quintana FJ, VanHook AM.

Sci Signal. 2016 Jun 21;9(433):c15. doi: 10.1126/scisignal.aag2900.

PMID:
27330187
35.

Purinergic Signaling as a Regulator of Th17 Cell Plasticity.

Fernández D, Flores-Santibáñez F, Neira J, Osorio-Barrios F, Tejón G, Nuñez S, Hidalgo Y, Fuenzalida MJ, Meza D, Ureta G, Lladser A, Pacheco R, Acuña-Castillo C, Guixé V, Quintana FJ, Bono MR, Rosemblatt M, Sauma D.

PLoS One. 2016 Jun 20;11(6):e0157889. doi: 10.1371/journal.pone.0157889. eCollection 2016.

36.

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.

Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçınkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B.

Cell. 2016 Jun 30;166(1):88-101. doi: 10.1016/j.cell.2016.05.034. Epub 2016 Jun 9.

37.

IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation.

Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL.

Brain. 2016 Jul;139(Pt 7):1939-57. doi: 10.1093/brain/aww113. Epub 2016 May 31.

38.

Regulation of the T Cell Response by CD39.

Takenaka MC, Robson S, Quintana FJ.

Trends Immunol. 2016 Jul;37(7):427-439. doi: 10.1016/j.it.2016.04.009. Epub 2016 May 25. Review.

39.

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.

Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ.

Nat Med. 2016 Jun;22(6):586-97. doi: 10.1038/nm.4106. Epub 2016 May 9.

40.

System-wide Analysis of the T Cell Response.

Covacu R, Philip H, Jaronen M, Almeida J, Kenison JE, Darko S, Chao CC, Yaari G, Louzoun Y, Carmel L, Douek DC, Efroni S, Quintana FJ.

Cell Rep. 2016 Mar 22;14(11):2733-44. doi: 10.1016/j.celrep.2016.02.056. Epub 2016 Mar 10.

41.

Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis.

Bakshi R, Yeste A, Patel B, Tauhid S, Tummala S, Rahbari R, Chu R, Regev K, Kivisäkk P, Weiner HL, Quintana FJ.

Neurol Neuroimmunol Neuroinflamm. 2016 Jan 27;3(2):e200. doi: 10.1212/NXI.0000000000000200. eCollection 2016 Apr.

42.

Achieving Tolerance with Perforin-Secreting Dendritic Cells.

Takenaka MC, Quintana FJ.

Trends Mol Med. 2016 Jan;22(1):3-4. doi: 10.1016/j.molmed.2015.11.008. Epub 2015 Dec 12.

43.

The 'Omics' of Amyotrophic Lateral Sclerosis.

Caballero-Hernandez D, Toscano MG, Cejudo-Guillen M, Garcia-Martin ML, Lopez S, Franco JM, Quintana FJ, Roodveldt C, Pozo D.

Trends Mol Med. 2016 Jan;22(1):53-67. doi: 10.1016/j.molmed.2015.11.001. Epub 2015 Dec 13. Review.

PMID:
26691296
44.

Norepinephrine Controls Effector T Cell Differentiation through β2-Adrenergic Receptor-Mediated Inhibition of NF-κB and AP-1 in Dendritic Cells.

Takenaka MC, Araujo LP, Maricato JT, Nascimento VM, Guereschi MG, Rezende RM, Quintana FJ, Basso AS.

J Immunol. 2016 Jan 15;196(2):637-44. doi: 10.4049/jimmunol.1501206. Epub 2015 Dec 11.

45.

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.

Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J.

Cell. 2015 Sep 10;162(6):1338-52. doi: 10.1016/j.cell.2015.08.025.

46.

Role of astrocytes and microglia in central nervous system inflammation. Introduction.

Rothhammer V, Quintana FJ.

Semin Immunopathol. 2015 Nov;37(6):575-6. doi: 10.1007/s00281-015-0521-5. Epub 2015 Aug 13. No abstract available.

47.

Control of autoimmune CNS inflammation by astrocytes.

Rothhammer V, Quintana FJ.

Semin Immunopathol. 2015 Nov;37(6):625-38. doi: 10.1007/s00281-015-0515-3. Epub 2015 Jul 30. Review.

48.

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.

Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ.

Nat Med. 2015 Jun;21(6):638-46. doi: 10.1038/nm.3868. Epub 2015 May 25.

49.

[The microprobes of antigens for studying of autoimmune diseases].

Yeste A, Quintana FJ.

Klin Lab Diagn. 2014 Nov;59(11):10-7. Russian. No abstract available.

PMID:
25850238
50.

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB.

Blood. 2015 Jun 18;125(25):3886-95. doi: 10.1182/blood-2014-12-618363. Epub 2015 Apr 1.

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