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Items: 1 to 50 of 93

1.

A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro.

Lee DE, Alhallak K, Jenkins SV, Vargas I, Greene NP, Quinn KP, Griffin RJ, Dings RPM, Rajaram N.

Sci Rep. 2018 Jun 11;8(1):8815. doi: 10.1038/s41598-018-27262-y.

2.

Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast.

Liu Z, Pouli D, Alonzo CA, Varone A, Karaliota S, Quinn KP, Münger K, Karalis KP, Georgakoudi I.

Sci Adv. 2018 Mar 7;4(3):eaap9302. doi: 10.1126/sciadv.aap9302. eCollection 2018 Mar.

3.

Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease.

Baugh LM, Liu Z, Quinn KP, Osseiran S, Evans CL, Huggins GS, Hinds PW, Black LD, Georgakoudi I.

Nat Biomed Eng. 2017 Nov;1(11):914-924. doi: 10.1038/s41551-017-0152-3. Epub 2017 Nov 6.

4.

Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD.

Kolenc OI, Quinn KP.

Antioxid Redox Signal. 2018 Jan 30. doi: 10.1089/ars.2017.7451. [Epub ahead of print]

PMID:
29268621
5.

Cell derived extracellular matrix fibers synthesized using sacrificial hollow fiber membranes.

Roberts K, Schluns J, Walker A, Jones JD, Quinn KP, Hestekin J, Wolchok JC.

Biomed Mater. 2017 Dec 28;13(1):015023. doi: 10.1088/1748-605X/aa895c.

PMID:
28855424
6.

Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells.

Alhallak K, Jenkins SV, Lee DE, Greene NP, Quinn KP, Griffin RJ, Dings RPM, Rajaram N.

J Biomed Opt. 2017 Jun 1;22(6):60502. doi: 10.1117/1.JBO.22.6.060502.

7.

Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity.

Stuntz E, Gong Y, Sood D, Liaudanskaya V, Pouli D, Quinn KP, Alonzo C, Liu Z, Kaplan DL, Georgakoudi I.

Sci Rep. 2017 Apr 21;7(1):1041. doi: 10.1038/s41598-017-01015-9.

8.

Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110δ as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignancies.

Alfaro J, Pérez de Arce F, Belmar S, Fuentealba G, Avila P, Ureta G, Flores C, Acuña C, Delgado L, Gaete D, Pujala B, Barde A, Nayak AK, Upendra TVR, Patel D, Chauhan S, Sharma VK, Kanno S, Almirez RG, Hung DT, Chakravarty S, Rai R, Bernales S, Quinn KP, Pham SM, McCullagh E.

J Pharmacol Exp Ther. 2017 May;361(2):312-321. doi: 10.1124/jpet.116.238022. Epub 2017 Mar 15.

9.

Nonrelaxing Pelvic Floor Dysfunction Is an Underestimated Complication of Ileal Pouch-Anal Anastomosis.

Quinn KP, Tse CS, Lightner AL, Pendegraft RS, Enders FT, Raffals LE.

Clin Gastroenterol Hepatol. 2017 Aug;15(8):1242-1247. doi: 10.1016/j.cgh.2017.02.024. Epub 2017 Mar 1.

PMID:
28259741
10.

Discovery of pyrazolopyrimidine derivatives as novel inhibitors of ataxia telangiectasia and rad3 related protein (ATR).

Ramachandran SA, Jadhavar PS, Singh MP, Sharma A, Bagle GN, Quinn KP, Wong PY, Protter AA, Rai R, Pham SM, Lindquist JN.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):750-754. doi: 10.1016/j.bmcl.2017.01.045. Epub 2017 Jan 16.

PMID:
28131712
11.

Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ.

Pujala B, Agarwal AK, Middya S, Banerjee M, Surya A, Nayak AK, Gupta A, Khare S, Guguloth R, Randive NA, Shinde BU, Thakur A, Patel DI, Raja M, Green MJ, Alfaro J, Avila P, Pérez de Arce F, Almirez RG, Kanno S, Bernales S, Hung DT, Chakravarty S, McCullagh E, Quinn KP, Rai R, Pham SM.

ACS Med Chem Lett. 2016 Oct 28;7(12):1161-1166. eCollection 2016 Dec 8.

12.

Skin regeneration with all accessory organs following ablation with irreversible electroporation.

Golberg A, Villiger M, Felix Broelsch G, Quinn KP, Albadawi H, Khan S, Watkins MT, Georgakoudi I, Austen WG Jr, Bei M, Bouma BE, Mihm MC Jr, Yarmush ML.

J Tissue Eng Regen Med. 2018 Jan;12(1):98-113. doi: 10.1002/term.2374. Epub 2017 May 23.

13.

Automated quantification of three-dimensional organization of fiber-like structures in biological tissues.

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I.

Biomaterials. 2017 Feb;116:34-47. doi: 10.1016/j.biomaterials.2016.11.041. Epub 2016 Nov 25.

14.

Clinical implications of serial versus isolated biliary fluorescence in situ hybridization (FISH) polysomy in primary sclerosing cholangitis.

Quinn KP, Tabibian JH, Lindor KD.

Scand J Gastroenterol. 2017 Apr;52(4):377-381. doi: 10.1080/00365521.2016.1263681. Epub 2016 Dec 1.

PMID:
27908204
15.

Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis.

Pouli D, Balu M, Alonzo CA, Liu Z, Quinn KP, Rius-Diaz F, Harris RM, Kelly KM, Tromberg BJ, Georgakoudi I.

Sci Transl Med. 2016 Nov 30;8(367):367ra169.

16.

Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism.

Alhallak K, Rebello LG, Muldoon TJ, Quinn KP, Rajaram N.

Biomed Opt Express. 2016 Oct 3;7(11):4364-4374. eCollection 2016 Nov 1.

17.

Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction.

Quinn KP, Sullivan KE, Liu Z, Ballard Z, Siokatas C, Georgakoudi I, Black LD.

Sci Rep. 2016 Nov 7;6:35823. doi: 10.1038/srep35823.

18.

Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.

Jadhavar PS, Ramachandran SA, Riquelme E, Gupta A, Quinn KP, Shivakumar D, Ray S, Zende D, Nayak AK, Miglani SK, Sathe BD, Raja M, Farias O, Alfaro I, Belmar S, Guerrero J, Bernales S, Chakravarty S, Hung DT, Lindquist JN, Rai R.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228. doi: 10.1016/j.bmcl.2016.09.058. Epub 2016 Oct 4.

PMID:
27717544
19.

Preventing Scars after Injury with Partial Irreversible Electroporation.

Golberg A, Villiger M, Khan S, Quinn KP, Lo WC, Bouma BE, Mihm MC Jr, Austen WG Jr, Yarmush ML.

J Invest Dermatol. 2016 Nov;136(11):2297-2304. doi: 10.1016/j.jid.2016.06.620. Epub 2016 Jul 5.

20.

Valve interstitial cell contractile strength and metabolic state are dependent on its shape.

Lam NT, Muldoon TJ, Quinn KP, Rajaram N, Balachandran K.

Integr Biol (Camb). 2016 Oct 10;8(10):1079-1089.

21.

Quantitative differentiation of normal and scarred tissues using second-harmonic generation microscopy.

Yildirim M, Quinn KP, Kobler JB, Zeitels SM, Georgakoudi I, Ben-Yakar A.

Scanning. 2016 Nov;38(6):684-693. doi: 10.1002/sca.21316. Epub 2016 Apr 25.

PMID:
27111090
22.

Age-dependent Characteristics in Women with Breast Cancer: Mastectomy and Reconstructive Trends at an Urban Academic Institution.

Rodby KA, Robinson E, Danielson KK, Quinn KP, Antony AK.

Am Surg. 2016 Mar;82(3):227-35.

PMID:
27099059
23.

Pouchitis Is a Common Complication in Patients With Familial Adenomatous Polyposis Following Ileal Pouch-Anal Anastomosis.

Quinn KP, Lightner AL, Pendegraft RS, Enders FT, Boardman LA, Raffals LE.

Clin Gastroenterol Hepatol. 2016 Sep;14(9):1296-301. doi: 10.1016/j.cgh.2016.04.010. Epub 2016 Apr 13.

PMID:
27085760
24.

Intrapelvic Liver: Massive Hepatomegaly Secondary to Metastatic Malignancy.

Hu RW, Quinn KP, Tabibian JH.

Clin Gastroenterol Hepatol. 2016 Jul;14(7):A37-8. doi: 10.1016/j.cgh.2016.04.003. Epub 2016 Apr 13. No abstract available.

PMID:
27085757
25.

Diabetic Wounds Exhibit Distinct Microstructural and Metabolic Heterogeneity through Label-Free Multiphoton Microscopy.

Quinn KP, Leal EC, Tellechea A, Kafanas A, Auster ME, Veves A, Georgakoudi I.

J Invest Dermatol. 2016 Jan;136(1):342-4. doi: 10.1038/JID.2015.371. No abstract available.

26.

Non-invasive Assessments of Adipose Tissue Metabolism In Vitro.

Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL.

Ann Biomed Eng. 2016 Mar;44(3):725-32. doi: 10.1007/s10439-015-1438-9. Epub 2015 Sep 23. Review.

27.

Evaluating Autologous Lipofilling for Parry-Romberg Syndrome-Associated Defects: A Systematic Literature Review and Case Report.

Rodby KA, Kaptein YE, Roring J, Jacobs RJ, Kang V, Quinn KP, Antony AK.

Cleft Palate Craniofac J. 2016 May;53(3):339-50. doi: 10.1597/14-232. Epub 2015 Aug 21. Review.

PMID:
26295800
28.

Rapid three-dimensional quantification of voxel-wise collagen fiber orientation.

Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto AM, Georgakoudi I.

Biomed Opt Express. 2015 Jun 3;6(7):2294-310. doi: 10.1364/BOE.6.002294. eCollection 2015 Jul 1.

29.

Skin rejuvenation with non-invasive pulsed electric fields.

Golberg A, Khan S, Belov V, Quinn KP, Albadawi H, Felix Broelsch G, Watkins MT, Georgakoudi I, Papisov M, Mihm MC Jr, Austen WG Jr, Yarmush ML.

Sci Rep. 2015 May 12;5:10187. doi: 10.1038/srep10187.

30.

Sixty-Year-Old Man With Acute Epigastric Pain and Increased Serum Lipase Level.

Quinn KP, Tabibian JH, Sweetser S.

Clin Gastroenterol Hepatol. 2015 Sep;13(9):A23-4. doi: 10.1016/j.cgh.2015.05.002. Epub 2015 May 9. No abstract available.

PMID:
25962723
31.

Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures.

Özkucur N, Quinn KP, Pang JC, Du C, Georgakoudi I, Miller E, Levin M, Kaplan DL.

Brain Behav. 2015 Jan;5(1):24-38. doi: 10.1002/brb3.295. Epub 2014 Nov 5.

32.

Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts.

Hayden RS, Fortin JP, Harwood B, Subramanian B, Quinn KP, Georgakoudi I, Kopin AS, Kaplan DL.

Adv Funct Mater. 2014 Jan 29;24(4):472-479.

33.

Equine model for soft-tissue regeneration.

Bellas E, Rollins A, Moreau JE, Lo T, Quinn KP, Fourligas N, Georgakoudi I, Leisk GG, Mazan M, Thane KE, Taeymans O, Hoffman AM, Kaplan DL, Kirker-Head CA.

J Biomed Mater Res B Appl Biomater. 2015 Aug;103(6):1217-1227. doi: 10.1002/jbm.b.33299. Epub 2014 Oct 28.

34.

An automated image processing method to quantify collagen fibre organization within cutaneous scar tissue.

Quinn KP, Golberg A, Broelsch GF, Khan S, Villiger M, Bouma B, Austen WG Jr, Sheridan RL, Mihm MC Jr, Yarmush ML, Georgakoudi I.

Exp Dermatol. 2015 Jan;24(1):78-80. doi: 10.1111/exd.12553. Epub 2014 Nov 11.

35.

Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer development.

Xylas J, Varone A, Quinn KP, Pouli D, McLaughlin-Drubin ME, Thieu HT, Garcia-Moliner ML, House M, Hunter M, Munger K, Georgakoudi I.

Int J Cancer. 2015 Jan 15;136(2):322-32. doi: 10.1002/ijc.28992. Epub 2014 Jun 5.

36.

From single cells to tissues: interactions between the matrix and human breast cells in real time.

Barnes C, Speroni L, Quinn KP, Montevil M, Saetzler K, Bode-Animashaun G, McKerr G, Georgakoudi I, Downes CS, Sonnenschein C, Howard CV, Soto AM.

PLoS One. 2014 Apr 1;9(4):e93325. doi: 10.1371/journal.pone.0093325. eCollection 2014.

37.

Endogenous two-photon fluorescence imaging elucidates metabolic changes related to enhanced glycolysis and glutamine consumption in precancerous epithelial tissues.

Varone A, Xylas J, Quinn KP, Pouli D, Sridharan G, McLaughlin-Drubin ME, Alonzo C, Lee K, Münger K, Georgakoudi I.

Cancer Res. 2014 Jun 1;74(11):3067-75. doi: 10.1158/0008-5472.CAN-13-2713. Epub 2014 Mar 31.

38.

Quantitative characterization of mineralized silk film remodeling during long-term osteoblast-osteoclast co-culture.

Hayden RS, Quinn KP, Alonzo CA, Georgakoudi I, Kaplan DL.

Biomaterials. 2014 Apr;35(12):3794-802. doi: 10.1016/j.biomaterials.2014.01.034. Epub 2014 Jan 29.

39.

Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells.

Sullivan KE, Quinn KP, Tang KM, Georgakoudi I, Black LD 3rd.

Stem Cell Res Ther. 2014 Jan 24;5(1):14. doi: 10.1186/scrt403.

40.

Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation.

Quinn KP, Sridharan GV, Hayden RS, Kaplan DL, Lee K, Georgakoudi I.

Sci Rep. 2013 Dec 5;3:3432. doi: 10.1038/srep03432.

41.

Autocorrelation method for fractal analysis in nonrectangular image domains.

MacDonald DH, Hunter M, Quinn KP, Georgakoudi I.

Opt Lett. 2013 Nov 1;38(21):4477-9. doi: 10.1364/OL.38.004477.

PMID:
24177123
42.

Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro.

Williams C, Quinn KP, Georgakoudi I, Black LD 3rd.

Acta Biomater. 2014 Jan;10(1):194-204. doi: 10.1016/j.actbio.2013.08.037. Epub 2013 Sep 6.

43.

Non-invasive monitoring of cell metabolism and lipid production in 3D engineered human adipose tissues using label-free multiphoton microscopy.

Chang T, Zimmerley MS, Quinn KP, Lamarre-Jouenne I, Kaplan DL, Beaurepaire E, Georgakoudi I.

Biomaterials. 2013 Nov;34(34):8607-16. doi: 10.1016/j.biomaterials.2013.07.066. Epub 2013 Aug 9.

44.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.

Ng RA, Sun M, Bowers S, Hom RK, Probst GD, John V, Fang LY, Maillard M, Gailunas A, Brogley L, Neitz RJ, Tung JS, Pleiss MA, Konradi AW, Sham HL, Dappen MS, Adler M, Yao N, Zmolek W, Nakamura D, Quinn KP, Sauer JM, Bova MP, Ruslim L, Artis DR, Yednock TA.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4674-9. doi: 10.1016/j.bmcl.2013.06.006. Epub 2013 Jun 11.

PMID:
23856050
45.

Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry.

Erve JC, Gauby S, Maynard JW Jr, Svensson MA, Tonn G, Quinn KP.

Chem Res Toxicol. 2013 Jun 17;26(6):926-36. doi: 10.1021/tx4001144. Epub 2013 May 30.

PMID:
23721565
46.

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.

Probst G, Aubele DL, Bowers S, Dressen D, Garofalo AW, Hom RK, Konradi AW, Marugg JL, Mattson MN, Neitzel ML, Semko CM, Sham HL, Smith J, Sun M, Truong AP, Ye XM, Xu YZ, Dappen MS, Jagodzinski JJ, Keim PS, Peterson B, Latimer LH, Quincy D, Wu J, Goldbach E, Ness DK, Quinn KP, Sauer JM, Wong K, Zhang H, Zmolek W, Brigham EF, Kholodenko D, Hu K, Kwong GT, Lee M, Liao A, Motter RN, Sacayon P, Santiago P, Willits C, Bard F, Bova MP, Hemphill SS, Nguyen L, Ruslim L, Tanaka K, Tanaka P, Wallace W, Yednock TA, Basi GS.

J Med Chem. 2013 Jul 11;56(13):5261-74. doi: 10.1021/jm301741t. Epub 2013 Jun 20.

PMID:
23713656
47.

Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model.

Speroni L, Whitt GS, Xylas J, Quinn KP, Jondeau-Cabaton A, Barnes C, Georgakoudi I, Sonnenschein C, Soto AM.

Tissue Eng Part C Methods. 2014 Jan;20(1):42-51. doi: 10.1089/ten.TEC.2013.0054. Epub 2013 Jun 25.

48.

Rapid quantification of pixel-wise fiber orientation data in micrographs.

Quinn KP, Georgakoudi I.

J Biomed Opt. 2013 Apr;18(4):046003. doi: 10.1117/1.JBO.18.4.046003.

49.

Triazolopyridazine LRRK2 kinase inhibitors.

Franzini M, Ye XM, Adler M, Aubele DL, Garofalo AW, Gauby S, Goldbach E, Probst GD, Quinn KP, Santiago P, Sham HL, Tam D, Truong A, Ren Z.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):1967-73. doi: 10.1016/j.bmcl.2013.02.043. Epub 2013 Feb 14.

PMID:
23454015
50.

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.

Garofalo AW, Adler M, Aubele DL, Brigham EF, Chian D, Franzini M, Goldbach E, Kwong GT, Motter R, Probst GD, Quinn KP, Ruslim L, Sham HL, Tam D, Tanaka P, Truong AP, Ye XM, Ren Z.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):1974-7. doi: 10.1016/j.bmcl.2013.02.041. Epub 2013 Feb 15.

PMID:
23453068

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