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Items: 1 to 50 of 86


Crk proteins transduce FGF signaling to promote lens fiber cell elongation.

Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X.

Elife. 2018 Jan 23;7. pii: e32586. doi: 10.7554/eLife.32586.


A Novel HRAS Mutation Independently Contributes to Left Ventricular Hypertrophy in a Family with a Known MYH7 Mutation.

Sana ME, Quilliam LA, Spitaleri A, Pezzoli L, Marchetti D, Lodrini C, Candiago E, Lincesso AR, Ferrazzi P, Iascone M.

PLoS One. 2016 Dec 21;11(12):e0168501. doi: 10.1371/journal.pone.0168501. eCollection 2016.


Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization.

Wang H, Han X, Bretz CA, Becker S, Gambhir D, Smith GW, Samulski RJ, Wittchen ES, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME.

Mol Ther Methods Clin Dev. 2016 Aug 24;3:16056. doi: 10.1038/mtm.2016.56. eCollection 2016.


Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.

Chrzanowska-Wodnicka M, White GC 2nd, Quilliam LA, Whitehead KJ.

PLoS One. 2015 Dec 29;10(12):e0145689. doi: 10.1371/journal.pone.0145689. eCollection 2015.


Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1.

Birukova AA, Meng F, Tian Y, Meliton A, Sarich N, Quilliam LA, Birukov KG.

Biochim Biophys Acta. 2015 May;1852(5):778-91. doi: 10.1016/j.bbadis.2014.12.016. Epub 2014 Dec 26.


The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.

Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown JH.

J Biol Chem. 2014 Jun 20;289(25):17689-98. doi: 10.1074/jbc.M113.536227. Epub 2014 May 1.


Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization.

Wang H, Jiang Y, Shi D, Quilliam LA, Chrzanowska-Wodnicka M, Wittchen ES, Li DY, Hartnett ME.

FASEB J. 2014 Jan;28(1):265-74. doi: 10.1096/fj.13-240028. Epub 2013 Sep 16.


Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.

Wittchen ES, Nishimura E, McCloskey M, Wang H, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME.

PLoS One. 2013 Sep 10;8(9):e73070. doi: 10.1371/journal.pone.0073070. eCollection 2013.


Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.

Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA.

J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23.


PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.

Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA.

PLoS One. 2013;8(4):e60226. doi: 10.1371/journal.pone.0060226. Epub 2013 Apr 2.


LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap.

Nguyen HB, Babcock JT, Wells CD, Quilliam LA.

Oncogene. 2013 Aug 29;32(35):4100-9. doi: 10.1038/onc.2012.431. Epub 2012 Oct 1.


Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.

Crotzer VL, Matute JD, Arias AA, Zhao H, Quilliam LA, Dinauer MC, Blum JS.

J Immunol. 2012 Oct 15;189(8):3800-4. doi: 10.4049/jimmunol.1103080. Epub 2012 Sep 14.


Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.

Siroky BJ, Yin H, Babcock JT, Lu L, Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F831-44. doi: 10.1152/ajprenal.00441.2011. Epub 2012 Jul 11.


Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.

Jeyaraj SC, Unger NT, Eid AH, Mitra S, Paul El-Dahdah N, Quilliam LA, Flavahan NA, Chotani MA.

Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C499-511. doi: 10.1152/ajpcell.00461.2011. Epub 2012 May 23.


M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.

Castro AF, Campos T, Babcock JT, Armijo ME, Martínez-Conde A, Pincheira R, Quilliam LA.

J Cell Biochem. 2012 Apr;113(4):1253-64. doi: 10.1002/jcb.23458.


PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.

Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, Zhang ZY.

J Biol Chem. 2011 Dec 9;286(49):42316-24. doi: 10.1074/jbc.M111.286302. Epub 2011 Oct 18.


Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.

Kepner EM, Yoder SM, Oh E, Kalwat MA, Wang Z, Quilliam LA, Thurmond DC.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1072-80. doi: 10.1152/ajpendo.00312.2011. Epub 2011 Aug 9.


Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin.

Babcock JT, Quilliam LA.

Curr Drug Targets. 2011 Jul 1;12(8):1223-31. Review.


Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes.

Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC 2nd, Malarkannan S.

J Exp Med. 2010 Aug 30;207(9):1923-38. doi: 10.1084/jem.20100040. Epub 2010 Aug 23.


Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling.

Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS.

Int J Biochem Cell Biol. 2010 Jun;42(6):965-74. doi: 10.1016/j.biocel.2010.02.009. Epub 2010 Feb 23.


Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines.

Woolfrey KM, Srivastava DP, Photowala H, Yamashita M, Barbolina MV, Cahill ME, Xie Z, Jones KA, Quilliam LA, Prakriya M, Penzes P.

Nat Neurosci. 2009 Oct;12(10):1275-84. doi: 10.1038/nn.2386. Epub 2009 Sep 6.


E-cadherin dis-engagement activates the Rap1 GTPase.

Asuri S, Yan J, Paranavitana NC, Quilliam LA.

J Cell Biochem. 2008 Nov 1;105(4):1027-37. doi: 10.1002/jcb.21902.


Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.

Yan J, Li F, Ingram DA, Quilliam LA.

Mol Cell Biol. 2008 Sep;28(18):5803-10. doi: 10.1128/MCB.00393-08. Epub 2008 Jul 14.


Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.

Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson KW 2nd, Paranavitana NC, Peng X, Kim C, Munugalavadla V, Kapur R, Chen H, Shou W, Stone JC, Kaplan MH, Dinauer MC, Durden DL, Quilliam LA.

J Immunol. 2007 Dec 15;179(12):8322-31. Erratum in: J Immunol. 2008 Mar 1;180(5):3612. Munugulavadla, Veerendra [corrected to Munugalavadla, Veerendra].


New insights into the mechanisms of SOS activation.

Quilliam LA.

Sci STKE. 2007 Nov 27;2007(414):pe67.


Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1.

Hong J, Doebele RC, Lingen MW, Quilliam LA, Tang WJ, Rosner MR.

J Biol Chem. 2007 Jul 6;282(27):19781-7. Epub 2007 May 9.


The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.

Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC.

Mol Cell Biol. 2007 Jan;27(1):312-23. Epub 2006 Oct 23.


Specificity and expression of RalGPS as RalGEFs.

Quilliam LA.

Methods Enzymol. 2006;407:108-14.


Characterization of AND-34 function and signaling.

Felekkis K, Quilliam LA, Lerner A.

Methods Enzymol. 2006;407:55-63.


The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane.

Li Y, Asuri S, Rebhun JF, Castro AF, Paranavitana NC, Quilliam LA.

J Biol Chem. 2006 Feb 3;281(5):2506-14. Epub 2005 Nov 29.


Measuring Ras-family GTP levels in vivo--running hot and cold.

Castro AF, Rebhun JF, Quilliam LA.

Methods. 2005 Oct;37(2):190-6. Epub 2005 Nov 8.


AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.

Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A.

Mol Cancer Res. 2005 Jan;3(1):32-41.


Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function.

Wittchen ES, Worthylake RA, Kelly P, Casey PJ, Quilliam LA, Burridge K.

J Biol Chem. 2005 Mar 25;280(12):11675-82. Epub 2005 Jan 20.


Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors.

Arthur WT, Quilliam LA, Cooper JA.

J Cell Biol. 2004 Oct 11;167(1):111-22.


Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.

Castro AF, Rebhun JF, Clark GJ, Quilliam LA.

J Biol Chem. 2003 Aug 29;278(35):32493-6. Epub 2003 Jul 3.


Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.

Riggins RB, Quilliam LA, Bouton AH.

J Biol Chem. 2003 Jul 25;278(30):28264-73. Epub 2003 May 11.


Activation of the Ras superfamily of small GTPases. Workshop on exchange factors.

Zheng Y, Quilliam LA.

EMBO Rep. 2003 May;4(5):463-8. No abstract available.


Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells.

Gu Y, Byrne MC, Paranavitana NC, Aronow B, Siefring JE, D'Souza M, Horton HF, Quilliam LA, Williams DA.

Mol Cell Biol. 2002 Nov;22(21):7645-57.


A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases.

Quilliam LA, Rebhun JF, Castro AF.

Prog Nucleic Acid Res Mol Biol. 2002;71:391-444. Review.


RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia.

Reuther GW, Lambert QT, Rebhun JF, Caligiuri MA, Quilliam LA, Der CJ.

J Biol Chem. 2002 Aug 23;277(34):30508-14. Epub 2002 Mar 5.


Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.

Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, Cheng X.

J Biol Chem. 2002 Mar 29;277(13):11497-504. Epub 2002 Jan 18.


The insert region of RhoA is essential for Rho kinase activation and cellular transformation.

Zong H, Kaibuchi K, Quilliam LA.

Mol Cell Biol. 2001 Aug;21(16):5287-98.


Analyses of M-Ras/R-Ras3 signaling and biology.

Quilliam LA, Rebhun JF, Zong H, Castro AF.

Methods Enzymol. 2001;333:187-202. No abstract available.


Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.

Tsygankova OM, Saavedra A, Rebhun JF, Quilliam LA, Meinkoth JL.

Mol Cell Biol. 2001 Mar;21(6):1921-9.


M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6.

Quilliam LA, Castro AF, Rogers-Graham KS, Martin CB, Der CJ, Bi C.

J Biol Chem. 1999 Aug 20;274(34):23850-7.

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