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NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.

Marín-Aguilar F, Lechuga-Vieco AV, Alcocer-Gómez E, Castejón-Vega B, Lucas J, Garrido C, Peralta-Garcia A, Pérez-Pulido AJ, Varela-López A, Quiles JL, Ryffel B, Flores I, Bullón P, Ruiz-Cabello J, Cordero MD.

Aging Cell. 2019 Oct 18:e13050. doi: 10.1111/acel.13050. [Epub ahead of print]


Heart Histopathology and Mitochondrial Ultrastructure in Aged Rats Fed for 24 Months on Different Unsaturated Fats (Virgin Olive Oil, Sunflower Oil or Fish Oil) and Affected by Different Longevity.

Navarro-Hortal MD, Ramírez-Tortosa CL, Varela-López A, Romero-Márquez JM, Ochoa JJ, Ramírez-Tortosa M, Forbes-Hernández TY, Granados-Principal S, Battino M, Quiles JL.

Nutrients. 2019 Oct 7;11(10). pii: E2390. doi: 10.3390/nu11102390.


[Food policies to prevent obesity and the main non-transmissible diseases in Spain: where there's a will there's a way].

Royo-Bordonada MÁ, Rodríguez-Artalejo F, Bes-Rastrollo M, Fernández-Escobar C, González CA, Rivas F, Martínez-González MÁ, Quiles J, Bueno-Cavanillas A, Navarrete-Muñoz EM, Navarro C, López-García E, Romaguera D, Morales Suárez-Varela M, Vioque J; en nombre del Grupo de Nutrición de la Sociedad Española de Epidemiología.

Gac Sanit. 2019 Oct 1. pii: S0213-9111(19)30153-0. doi: 10.1016/j.gaceta.2019.05.009. [Epub ahead of print] Spanish.


An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients.

Varela-López A, Battino M, Navarro-Hortal MD, Giampieri F, Forbes-Hernández TY, Romero-Márquez JM, Collado R, Quiles JL.

Food Chem Toxicol. 2019 Sep 29;134:110834. doi: 10.1016/j.fct.2019.110834. [Epub ahead of print] Review.


The Paradox of Coenzyme Q10 in Aging.

Díaz-Casado ME, Quiles JL, Barriocanal-Casado E, González-García P, Battino M, López LC, Varela-López A.

Nutrients. 2019 Sep 14;11(9). pii: E2221. doi: 10.3390/nu11092221. Review.


Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer.

Ramirez-Tortosa C, Sanchez A, Perez-Ramirez C, Quiles JL, Robles-Almazan M, Pulido-Moran M, Sanchez-Rovira P, Ramirez-Tortosa M.

Antioxidants (Basel). 2019 Sep 11;8(9). pii: E393. doi: 10.3390/antiox8090393.


Protective effects of raspberry on the oxidative damage in HepG2 cells through Keap1/Nrf2-dependent signaling pathway.

Chen L, Li K, Liu Q, Quiles JL, Filosa R, Kamal MA, Wang F, Kai G, Zou X, Teng H, Xiao J.

Food Chem Toxicol. 2019 Nov;133:110781. doi: 10.1016/j.fct.2019.110781. Epub 2019 Aug 26.


Modulation of CAT-2B-Mediated l-Arginine Uptake and Nitric Oxide Biosynthesis in HCT116 Cell Line Through Biological Activity of 4'-Geranyloxyferulic Acid Extract from Quinoa Seeds.

Franceschelli S, Gatta DMP, Pesce M, Ferrone A, Quiles JL, Genovese S, Epifano F, Fiorito S, Taddeo VA, Patruno A, Grilli A, Felaco M, Speranza L.

Int J Mol Sci. 2019 Jul 2;20(13). pii: E3262. doi: 10.3390/ijms20133262.


Industrial-Scale Decontamination Procedure Effects on the Content of Acaricides, Heavy Metals and Antioxidant Capacity of Beeswax.

Navarro-Hortal MD, Orantes-Bermejo FJ, Sánchez-González C, Varela-López A, Giampieri F, Torres Fernández-Piñar C, Serra-Bonvehí J, Forbes-Hernández TY, Reboredo-Rodríguez P, Llopis J, Aranda P, Battino M, Quiles JL.

Molecules. 2019 Apr 17;24(8). pii: E1518. doi: 10.3390/molecules24081518.


Longevity and cause of death in male Wistar rats fed lifelong diets based on virgin olive oil, sunflower oil or fish oil.

Ramirez-Tortosa CL, Varela-López A, Navarro-Hortal MD, Ramos-Pleguezuelos FM, Márquez-Lobo B, Ramirez-Tortosa MC, Ochoa JJ, Battino M, Quiles JL.

J Gerontol A Biol Sci Med Sci. 2019 Apr 6. pii: glz091. doi: 10.1093/gerona/glz091. [Epub ahead of print]


Development of an Antifungal and Antimycotoxigenic Device Containing Allyl Isothiocyanate for Silo Fumigation.

Quiles JM, Nazareth TM, Luz C, Luciano FB, Mañes J, Meca G.

Toxins (Basel). 2019 Mar 1;11(3). pii: E137. doi: 10.3390/toxins11030137.


Shelf life extension of mozzarella cheese contaminated with Penicillium spp. using the antifungal compound ɛ-polylysine.

Luz C, Torrijos R, Quiles JM, Mañes J, Meca G.

Food Sci Technol Int. 2019 Jun;25(4):295-302. doi: 10.1177/1082013218823136. Epub 2019 Jan 12.


Relevance of functional foods in the Mediterranean diet: the role of olive oil, berries and honey in the prevention of cancer and cardiovascular diseases.

Battino M, Forbes-Hernández TY, Gasparrini M, Afrin S, Cianciosi D, Zhang J, Manna PP, Reboredo-Rodríguez P, Varela Lopez A, Quiles JL, Mezzetti B, Bompadre S, Xiao J, Giampieri F.

Crit Rev Food Sci Nutr. 2019;59(6):893-920. doi: 10.1080/10408398.2018.1526165. Epub 2018 Nov 13.


Beeswax by-Products Efficiently Counteract the Oxidative Damage Induced by an Oxidant Agent in Human Dermal Fibroblasts.

Giampieri F, Gasparrini M, Forbes-Hernández TY, Manna PP, Zhang J, Reboredo-Rodríguez P, Cianciosi D, Quiles JL, Torres Fernández-Piñar C, Orantes-Bermejo FJ, Bompadre S, Afrin S, Battino M.

Int J Mol Sci. 2018 Sep 19;19(9). pii: E2842. doi: 10.3390/ijms19092842.


Phenolic Compounds in Honey and Their Associated Health Benefits: A Review.

Cianciosi D, Forbes-Hernández TY, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna PP, Zhang J, Bravo Lamas L, Martínez Flórez S, Agudo Toyos P, Quiles JL, Giampieri F, Battino M.

Molecules. 2018 Sep 11;23(9). pii: E2322. doi: 10.3390/molecules23092322. Review.


Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells.

Rodríguez-Hernández MA, González R, de la Rosa ÁJ, Gallego P, Ordóñez R, Navarro-Villarán E, Contreras L, Rodríguez-Arribas M, González-Gallego J, Álamo-Martínez JM, Marín-Gómez LM, Del Campo JA, Quiles JL, Fuentes JM, de la Cruz J, Mauriz JL, Padillo FJ, Muntané J.

J Cell Physiol. 2018 Jan;234(1):692-708. doi: 10.1002/jcp.26855. Epub 2018 Aug 21.


Targeting molecular pathways in cancer stem cells by natural bioactive compounds.

Cianciosi D, Varela-Lopez A, Forbes-Hernandez TY, Gasparrini M, Afrin S, Reboredo-Rodriguez P, Zhang J, Quiles JL, Nabavi SF, Battino M, Giampieri F.

Pharmacol Res. 2018 Sep;135:150-165. doi: 10.1016/j.phrs.2018.08.006. Epub 2018 Aug 10. Review.


Phenolic Compounds Isolated from Olive Oil as Nutraceutical Tools for the Prevention and Management of Cancer and Cardiovascular Diseases.

Reboredo-Rodríguez P, Varela-López A, Forbes-Hernández TY, Gasparrini M, Afrin S, Cianciosi D, Zhang J, Manna PP, Bompadre S, Quiles JL, Battino M, Giampieri F.

Int J Mol Sci. 2018 Aug 6;19(8). pii: E2305. doi: 10.3390/ijms19082305. Review.


Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability.

Afrin S, Giampieri F, Forbes-Hernández TY, Gasparrini M, Amici A, Cianciosi D, Quiles JL, Battino M.

Free Radic Biol Med. 2018 Oct;126:41-54. doi: 10.1016/j.freeradbiomed.2018.07.014. Epub 2018 Jul 26.


Aflatoxins and A. flavus Reduction in Loaf Bread through the Use of Natural Ingredients.

Quiles JM, Torrijos R, Luciano FB, Mañes J, Meca G.

Molecules. 2018 Jul 4;23(7). pii: E1638. doi: 10.3390/molecules23071638.


Autophagy in Human Health and Disease: Novel Therapeutic Opportunities.

Giampieri F, Afrin S, Forbes-Hernandez TY, Gasparrini M, Cianciosi D, Reboredo-Rodriguez P, Varela-Lopez A, Quiles JL, Battino M.

Antioxid Redox Signal. 2019 Feb 1;30(4):577-634. doi: 10.1089/ars.2017.7234. Epub 2018 Aug 10.


Prognosis and lipid profile improvement by a specialized outpatient clinic for acute coronary syndrome patients.

Cordero A, Bertomeu-González V, Moreno-Arribas J, Castillo J, Quiles J, Bertomeu-Martinez V.

Atherosclerosis. 2018 Aug;275:28-34. doi: 10.1016/j.atherosclerosis.2018.05.026. Epub 2018 May 21.


Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance.

Varela-López A, Navarro-Hortal MD, Giampieri F, Bullón P, Battino M, Quiles JL.

Molecules. 2018 May 20;23(5). pii: E1226. doi: 10.3390/molecules23051226. Review.


The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle.

Afrin S, Giampieri F, Gasparrini M, Forbes-Hernández TY, Cianciosi D, Reboredo-Rodriguez P, Amici A, Quiles JL, Battino M.

Food Funct. 2018 Apr 25;9(4):2145-2157. doi: 10.1039/c8fo00164b.


The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability.

Afrin S, Giampieri F, Gasparrini M, Forbes-Hernández TY, Cianciosi D, Reboredo-Rodriguez P, Manna PP, Zhang J, Quiles JL, Battino M.

Food Funct. 2018 Apr 25;9(4):2158-2170. doi: 10.1039/c8fo00165k.


Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer.

El-Azem N, Pulido-Moran M, Ramirez-Tortosa CL, Quiles JL, Cara FE, Sanchez-Rovira P, Granados-Principal S, Ramirez-Tortosa M.

Eur J Nutr. 2019 Apr;58(3):1203-1211. doi: 10.1007/s00394-018-1638-9. Epub 2018 Feb 21.


Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast.

Gasparrini M, Giampieri F, Forbes-Hernandez TY, Afrin S, Cianciosi D, Reboredo-Rodriguez P, Varela-Lopez A, Zhang J, Quiles JL, Mezzetti B, Bompadre S, Battino M.

Food Chem Toxicol. 2018 Apr;114:128-140. doi: 10.1016/j.fct.2018.02.038. Epub 2018 Feb 16.


Hydroxytyrosol: Bioavailability, toxicity, and clinical applications.

Robles-Almazan M, Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Rodriguez-Garcia C, Quiles JL, Ramirez-Tortosa M.

Food Res Int. 2018 Mar;105:654-667. doi: 10.1016/j.foodres.2017.11.053. Epub 2017 Nov 21. Review.


Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment.

Bullón P, Castejón-Vega B, Román-Malo L, Jimenez-Guerrero MP, Cotán D, Forbes-Hernandez TY, Varela-López A, Pérez-Pulido AJ, Giampieri F, Quiles JL, Battino M, Sánchez-Alcázar JA, Cordero MD.

J Allergy Clin Immunol. 2018 Oct;142(4):1131-1143.e7. doi: 10.1016/j.jaci.2018.01.018. Epub 2018 Feb 2.


Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?

Giampieri F, Quiles JL, Orantes-Bermejo FJ, Gasparrini M, Forbes-Hernandez TY, Sánchez-González C, Llopis J, Rivas-García L, Afrin S, Varela-López A, Cianciosi D, Reboredo-Rodriguez P, Fernández-Piñar CT, Iglesias RC, Ruiz R, Aparicio S, Crespo J, Dzul Lopez L, Xiao J, Battino M.

Food Chem Toxicol. 2018 Feb;112:126-133. doi: 10.1016/j.fct.2017.12.041. Epub 2017 Dec 25.


Effect of α-tocopherol megadoses on hematologic parameters and antioxidant capacity of rats in an ultraendurance probe.

Clemente-Suárez VJ, Mielgo-Ayuso J, Quiles JL, Varela-Lopez A, Aranda P.

Physiol Int. 2017 Dec 1;104(4):291-300. doi: 10.1556/2060.104.2017.4.2.


NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.

Pavillard LE, Cañadas-Lozano D, Alcocer-Gómez E, Marín-Aguilar F, Pereira S, Robertson AAB, Muntané J, Ryffel B, Cooper MA, Quiles JL, Bullón P, Ruiz-Cabello J, Cordero MD.

Oncotarget. 2017 Sep 8;8(59):99740-99756. doi: 10.18632/oncotarget.20763. eCollection 2017 Nov 21.


Gene pathways associated with mitochondrial function, oxidative stress and telomere length are differentially expressed in the liver of rats fed lifelong on virgin olive, sunflower or fish oils.

Varela-Lopez A, Pérez-López MP, Ramirez-Tortosa CL, Battino M, Granados-Principal S, Ramirez-Tortosa MDC, Ochoa JJ, Vera-Ramirez L, Giampieri F, Quiles JL.

J Nutr Biochem. 2018 Feb;52:36-44. doi: 10.1016/j.jnutbio.2017.09.007. Epub 2017 Sep 20.


Biomonitoring of mercury in hair of breastfeeding mothers living in the Valencian Region (Spain). Levels and predictors of exposure.

Yusà V, Pérez R, Suelves T, Corpas-Burgos F, Gormáz M, Dualde P, Coscolla C, Quiles J, Roca M, Vento M.

Chemosphere. 2017 Nov;187:106-113. doi: 10.1016/j.chemosphere.2017.08.100. Epub 2017 Aug 20.


The protective effect of acerola (Malpighia emarginata) against oxidative damage in human dermal fibroblasts through the improvement of antioxidant enzyme activity and mitochondrial functionality.

Alvarez-Suarez JM, Giampieri F, Gasparrini M, Mazzoni L, Santos-Buelga C, González-Paramás AM, Forbes-Hernández TY, Afrin S, Páez-Watson T, Quiles JL, Battino M.

Food Funct. 2017 Sep 20;8(9):3250-3258. doi: 10.1039/c7fo00859g.


Identification of transcriptome signature for myocardial reductive stress.

Quiles JM, Narasimhan M, Mosbruger T, Shanmugam G, Crossman D, Rajasekaran NS.

Redox Biol. 2017 Oct;13:568-580. doi: 10.1016/j.redox.2017.07.013. Epub 2017 Jul 24.


Data on body weight and liver functionality in aged rats fed an enriched strawberry diet.

Giampieri F, Alvarez-Suarez JM, Gasparrini M, Forbes-Hernandez TY, Afrin S, Rubini C, Zizzi A, Quiles JL, Mezzetti B, Battino M.

Data Brief. 2017 Jun 16;13:432-436. doi: 10.1016/j.dib.2017.06.021. eCollection 2017 Aug.


Fumigation of Brazil nuts with allyl isothiocyanate to inhibit the growth of Aspergillus parasiticus and aflatoxin production.

Lopes LF, Bordin K, de Lara GH, Saladino F, Quiles JM, Meca G, Luciano FB.

J Sci Food Agric. 2018 Jan;98(2):792-798. doi: 10.1002/jsfa.8527. Epub 2017 Aug 12.


Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice.

Quiles JM, Narasimhan M, Shanmugam G, Milash B, Hoidal JR, Rajasekaran NS.

BMC Genomics. 2017 Jul 3;18(1):509. doi: 10.1186/s12864-017-3875-3. No abstract available.


Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation.

Varela-López A, Ochoa JJ, Llamas-Elvira JM, López-Frías M, Planells E, Speranza L, Battino M, Quiles JL.

Int J Mol Sci. 2017 Jun 29;18(7). pii: E1397. doi: 10.3390/ijms18071397.


Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation.

Forbes-Hernández TY, Giampieri F, Gasparrini M, Afrin S, Mazzoni L, Cordero MD, Mezzetti B, Quiles JL, Battino M.

Nutrients. 2017 Jun 16;9(6). pii: E621. doi: 10.3390/nu9060621.


The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases.

Giampieri F, Forbes-Hernandez TY, Gasparrini M, Afrin S, Cianciosi D, Reboredo-Rodriguez P, Varela-Lopez A, Quiles JL, Mezzetti B, Battino M.

Ann N Y Acad Sci. 2017 Jun;1398(1):62-71. doi: 10.1111/nyas.13373. Epub 2017 Jun 15. Review.


Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage.

Gasparrini M, Forbes-Hernandez TY, Afrin S, Reboredo-Rodriguez P, Cianciosi D, Mezzetti B, Quiles JL, Bompadre S, Battino M, Giampieri F.

Nutrients. 2017 Jun 14;9(6). pii: E605. doi: 10.3390/nu9060605.


Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells.

Forbes-Hernández TY, Gasparrini M, Afrin S, Cianciosi D, González-Paramás AM, Santos-Buelga C, Mezzetti B, Quiles JL, Battino M, Giampieri F, Bompadre S.

Int J Mol Sci. 2017 May 28;18(6). pii: E1149. doi: 10.3390/ijms18061149.


Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade.

Giampieri F, Alvarez-Suarez JM, Cordero MD, Gasparrini M, Forbes-Hernandez TY, Afrin S, Santos-Buelga C, González-Paramás AM, Astolfi P, Rubini C, Zizzi A, Tulipani S, Quiles JL, Mezzetti B, Battino M.

Food Chem. 2017 Nov 1;234:464-471. doi: 10.1016/j.foodchem.2017.05.017. Epub 2017 May 6.


Exercise reduced pentraxin 3 levels produced by endotoxin-stimulated human peripheral blood mononuclear cells in obese individuals.

Slusher AL, Shibata Y, Whitehurst M, Maharaj A, Quiles JM, Huang CJ.

Exp Biol Med (Maywood). 2017 Jun;242(12):1279-1286. doi: 10.1177/1535370217706963. Epub 2017 Apr 25.


Biological Effect of Licochalcone C on the Regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO Signaling Pathways in H9c2 Cells in Response to LPS Stimulation.

Franceschelli S, Pesce M, Ferrone A, Gatta DM, Patruno A, Lutiis MA, Quiles JL, Grilli A, Felaco M, Speranza L.

Int J Mol Sci. 2017 Mar 23;18(4). pii: E690. doi: 10.3390/ijms18040690.


Strawberry-Tree Honey Induces Growth Inhibition of Human Colon Cancer Cells and Increases ROS Generation: A Comparison with Manuka Honey.

Afrin S, Forbes-Hernandez TY, Gasparrini M, Bompadre S, Quiles JL, Sanna G, Spano N, Giampieri F, Battino M.

Int J Mol Sci. 2017 Mar 11;18(3). pii: E613. doi: 10.3390/ijms18030613.


A Cross-sectional Study on Evidence-Based Nursing Practice in the Contemporary Hospital Setting: Implications for Nurses in Professional Development.

Rose Bovino L, Aquila AM, Bartos S, McCurry T, Cunningham CE, Lane T, Rogucki N, DosSantos J, Moody D, Mealia-Ospina K, Pust-Marcone J, Quiles J.

J Nurses Prof Dev. 2017 Mar/Apr;33(2):64-69. doi: 10.1097/NND.0000000000000339.


Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition.

Varela-López A, Ochoa JJ, Llamas-Elvira JM, López-Frías M, Planells E, Ramirez-Tortosa M, Ramirez-Tortosa CL, Giampieri F, Battino M, Quiles JL.

Nutrients. 2017 Feb 22;9(2). pii: E176. doi: 10.3390/nu9020176.

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