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The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase.

Vogel S, Arora T, Wang X, Mendelsohn L, Nichols J, Allen D, Shet AS, Combs CA, Quezado ZMN, Thein SL.

Blood Adv. 2018 Oct 23;2(20):2672-2680. doi: 10.1182/bloodadvances.2018021709.


The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice.

Wang L, Almeida LEF, Kamimura S, van der Meulen JH, Nagaraju K, Quezado M, Wakim P, Quezado ZMN.

Nitric Oxide. 2018 Nov 1;80:70-81. doi: 10.1016/j.niox.2018.08.005. Epub 2018 Aug 14.


The corticosteroid compounds prednisolone and vamorolone do not alter the nociception phenotype and exacerbate liver injury in sickle cell mice.

Almeida LEF, Damsker JM, Albani S, Afsar N, Kamimura S, Pratt D, Kleiner DE, Quezado M, Gordish-Dressman H, Quezado ZMN.

Sci Rep. 2018 Apr 17;8(1):6081. doi: 10.1038/s41598-018-24274-6.


RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.

Khaibullina A, Adjei EA, Afangbedji N, Ivanov A, Kumari N, Almeida LEF, Quezado ZMN, Nekhai S, Jerebtsova M.

Haematologica. 2018 May;103(5):787-798. doi: 10.3324/haematol.2017.180992. Epub 2018 Mar 8.


Patient characteristics affect the response to ketamine and opioids during the treatment of vaso-occlusive episode-related pain in sickle cell disease.

Nobrega R, Sheehy KA, Lippold C, Rice AL, Finkel JC, Quezado ZMN.

Pediatr Res. 2018 Feb;83(2):445-454. doi: 10.1038/pr.2017.197. Epub 2017 Sep 13.


Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide.

Wang L, Wang A, Supplee WW, Koffler K, Cheng Y, Quezado ZMN, Levy RJ.

Data Brief. 2017 Jun 17;13:550-556. doi: 10.1016/j.dib.2017.06.028. eCollection 2017 Aug.


Dexmedetomidine as an adjuvant for perioperative pain management in adolescents undergoing bariatric surgery: An observational cohort study.

Vaughns JD, Martin C, Nelson J, Nadler E, Quezado ZM.

J Pediatr Surg. 2017 Nov;52(11):1787-1790. doi: 10.1016/j.jpedsurg.2017.04.007. Epub 2017 Apr 19.


Subanesthetic ketamine for pain management in hospitalized children, adolescents, and young adults: a single-center cohort study.

Sheehy KA, Lippold C, Rice AL, Nobrega R, Finkel JC, Quezado ZM.

J Pain Res. 2017 Apr 5;10:787-795. doi: 10.2147/JPR.S131156. eCollection 2017.


Blood collection vials and clinically used intravenous fluids contain significant amounts of nitrite.

Almeida LEF, Kamimura S, Nettleton MY, de Souza Batista CM, Walek E, Khaibullina A, Wang L, Quezado ZMN.

Free Radic Biol Med. 2017 Jul;108:533-541. doi: 10.1016/j.freeradbiomed.2017.04.014. Epub 2017 Apr 15.


The Use of Dexmedetomidine in Pediatric Palliative Care: A Preliminary Study.

Burns J, Jackson K, Sheehy KA, Finkel JC, Quezado ZM.

J Palliat Med. 2017 Jul;20(7):779-783. doi: 10.1089/jpm.2016.0419. Epub 2017 Feb 10.


Carbon monoxide incompletely prevents isoflurane-induced defects in murine neurodevelopment.

Wang L, Wang A, Supplee WW, Koffler K, Cheng Y, Quezado ZMN, Levy RJ.

Neurotoxicol Teratol. 2017 May;61:92-103. doi: 10.1016/ Epub 2017 Jan 26.


Nicotinic cholinergic system alterations and nitrous oxide exposure in a mouse model: a hypothesis for the pathobiology of autism spectrum disorder.

Almeida LE, Wang L, Khaibullina A, Quezado ZM.

Psychopharmacology (Berl). 2017 Jan;234(2):317-318. doi: 10.1007/s00213-016-4457-9. Epub 2016 Oct 11. No abstract available.


Altered nocifensive behavior in animal models of autism spectrum disorder: The role of the nicotinic cholinergic system.

Wang L, Almeida LE, Nettleton M, Khaibullina A, Albani S, Kamimura S, Nouraie M, Quezado ZM.

Neuropharmacology. 2016 Dec;111:323-334. doi: 10.1016/j.neuropharm.2016.09.013. Epub 2016 Sep 13.


Subanesthetic ketamine infusions for the treatment of children and adolescents with chronic pain: a longitudinal study.

Sheehy KA, Muller EA, Lippold C, Nouraie M, Finkel JC, Quezado ZM.

BMC Pediatr. 2015 Dec 1;15:198. doi: 10.1186/s12887-015-0515-4.


Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum.

Wang L, Almeida LEF, de Souza Batista CM, Khaibullina A, Xu N, Albani S, Guth KA, Seo JS, Quezado M, Quezado ZMN.

Neurobiol Dis. 2016 Jan;85:60-72. doi: 10.1016/j.nbd.2015.10.004. Epub 2015 Oct 14.


Rapamycin increases fetal hemoglobin and ameliorates the nociception phenotype in sickle cell mice.

Khaibullina A, Almeida LE, Wang L, Kamimura S, Wong EC, Nouraie M, Maric I, Albani S, Finkel J, Quezado ZM.

Blood Cells Mol Dis. 2015 Dec;55(4):363-72. doi: 10.1016/j.bcmd.2015.08.001. Epub 2015 Aug 5.


Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system.

Wang L, Almeida LE, Spornick NA, Kenyon N, Kamimura S, Khaibullina A, Nouraie M, Quezado ZM.

Psychopharmacology (Berl). 2015 Dec;232(23):4303-16. doi: 10.1007/s00213-015-4058-z. Epub 2015 Sep 4.


Dexmedetomidine as an Adjuvant to Analgesic Strategy During Vaso-Occlusive Episodes in Adolescents with Sickle-Cell Disease.

Sheehy KA, Finkel JC, Darbari DS, Guerrera MF, Quezado ZM.

Pain Pract. 2015 Nov;15(8):E90-7. doi: 10.1111/papr.12336. Epub 2015 Jul 23.


Dexmedetomidine ameliorates nocifensive behavior in humanized sickle cell mice.

Calhoun G, Wang L, Almeida LE, Kenyon N, Afsar N, Nouraie M, Finkel JC, Quezado ZM.

Eur J Pharmacol. 2015 May 5;754:125-33. doi: 10.1016/j.ejphar.2015.02.027. Epub 2015 Feb 25.


Validation of a method to directly and specifically measure nitrite in biological matrices.

Almeida LE, Kamimura S, Kenyon N, Khaibullina A, Wang L, de Souza Batista CM, Quezado ZM.

Nitric Oxide. 2015 Feb 15;45:54-64. doi: 10.1016/j.niox.2014.10.008. Epub 2014 Oct 28.


Sickle cell disease in mice is associated with sensitization of sensory nerve fibers.

Kenyon N, Wang L, Spornick N, Khaibullina A, Almeida LE, Cheng Y, Wang J, Guptill V, Finkel JC, Quezado ZM.

Exp Biol Med (Maywood). 2015 Jan;240(1):87-98. doi: 10.1177/1535370214544275. Epub 2014 Jul 28.


Oral cysteamine bitartrate and N-acetylcysteine for patients with infantile neuronal ceroid lipofuscinosis: a pilot study.

Levin SW, Baker EH, Zein WM, Zhang Z, Quezado ZM, Miao N, Gropman A, Griffin KJ, Bianconi S, Chandra G, Khan OI, Caruso RC, Liu A, Mukherjee AB.

Lancet Neurol. 2014 Aug;13(8):777-87. doi: 10.1016/S1474-4422(14)70142-5. Epub 2014 Jul 2.


Altered cerebral protein synthesis in fragile X syndrome: studies in human subjects and knockout mice.

Qin M, Schmidt KC, Zametkin AJ, Bishu S, Horowitz LM, Burlin TV, Xia Z, Huang T, Quezado ZM, Smith CB.

J Cereb Blood Flow Metab. 2013 Apr;33(4):499-507. doi: 10.1038/jcbfm.2012.205. Epub 2013 Jan 9.


In a model of Batten disease, palmitoyl protein thioesterase-1 deficiency is associated with brown adipose tissue and thermoregulation abnormalities.

Khaibullina A, Kenyon N, Guptill V, Quezado MM, Wang L, Koziol D, Wesley R, Moya PR, Zhang Z, Saha A, Mukherjee AB, Quezado ZM.

PLoS One. 2012;7(11):e48733. doi: 10.1371/journal.pone.0048733. Epub 2012 Nov 6.


Dexmedetomidine for patients undergoing diagnostic cardiac procedures: a noninferiority study.

Deutsch N, Finkel JC, Gold K, Cheng YI, Slack MC, Kanter J, Quezado ZM.

Pediatr Cardiol. 2013 Apr;34(4):898-906. doi: 10.1007/s00246-012-0568-1. Epub 2012 Nov 4.


Case report: an unforeseen peril of parental presence during induction of anesthesia.

Johnson YJ, Nickerson M, Quezado ZM.

Anesth Analg. 2012 Dec;115(6):1371-2. doi: 10.1213/ANE.0b013e3182691f74. Epub 2012 Aug 2.


Niemann-pick disease type C: implications for sedation and anesthesia for diagnostic procedures.

Miao N, Lu X, O'Grady NP, Yanjanin N, Porter FD, Quezado ZM.

J Child Neurol. 2012 Dec;27(12):1541-6. doi: 10.1177/0883073812437243. Epub 2012 Feb 28. Review.


TRPV1 antagonists may exacerbate sepsis in aged mice: should we be nervous?

Quezado ZM, Szallasi A.

Cell Cycle. 2012 Feb 15;11(4):647-8. doi: 10.4161/cc.11.4.19280. Epub 2012 Feb 15. No abstract available.


The three isoforms of nitric oxide synthase distinctively affect mouse nocifensive behavior.

Finkel J, Guptill V, Khaibullina A, Spornick N, Vasconcelos O, Liewehr DJ, Steinberg SM, Quezado ZM.

Nitric Oxide. 2012 Feb 15;26(2):81-8. doi: 10.1016/j.niox.2011.12.004. Epub 2011 Dec 17.


Mouse current vocalization threshold measured with a neurospecific nociception assay: the effect of sex, morphine, and isoflurane.

Spornick N, Guptill V, Koziol D, Wesley R, Finkel J, Quezado ZM.

J Neurosci Methods. 2011 Oct 15;201(2):390-8. doi: 10.1016/j.jneumeth.2011.08.011. Epub 2011 Aug 12.


The effect of dexmedetomidine during myringotomy and pressure-equalizing tube placement in children.

Pestieau SR, Quezado ZM, Johnson YJ, Anderson JL, Cheng YI, McCarter RJ, Pena MT, Finkel JC.

Paediatr Anaesth. 2011 Nov;21(11):1128-35. doi: 10.1111/j.1460-9592.2011.03615.x. Epub 2011 May 17.


High-dose dexmedetomidine increases the opioid-free interval and decreases opioid requirement after tonsillectomy in children.

Pestieau SR, Quezado ZM, Johnson YJ, Anderson JL, Cheng YI, McCarter RJ, Choi S, Finkel JC.

Can J Anaesth. 2011 Jun;58(6):540-50. doi: 10.1007/s12630-011-9493-7. Epub 2011 Apr 2.


Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis.

Guptill V, Cui X, Khaibullina A, Keller JM, Spornick N, Mannes A, Iadarola M, Quezado ZM.

Anesthesiology. 2011 May;114(5):1190-9. doi: 10.1097/ALN.0b013e318212515b.


Risks of propofol sedation/anesthesia for imaging studies in pediatric research: eight years of experience in a clinical research center.

Kiringoda R, Thurm AE, Hirschtritt ME, Koziol D, Wesley R, Swedo SE, O'Grady NP, Quezado ZM.

Arch Pediatr Adolesc Med. 2010 Jun;164(6):554-60. doi: 10.1001/archpediatrics.2010.75.


Children with infantile neuronal ceroid lipofuscinosis have an increased risk of hypothermia and bradycardia during anesthesia.

Miao N, Levin SW, Baker EH, Caruso RC, Zhang Z, Gropman A, Koziol D, Wesley R, Mukherjee AB, Quezado ZM.

Anesth Analg. 2009 Aug;109(2):372-8. doi: 10.1213/ane.0b013e3181aa6e95.


Dexmedetomidine and proprofol in complex microlaryngeal surgery in infants.

Quezado ZM, Groblewski JC, Gelfand HJ, Shah RK.

Int J Pediatr Otorhinolaryngol. 2009 Sep;73(9):1311-2. doi: 10.1016/j.ijporl.2009.05.013. Epub 2009 Jun 24.


Cytoreductive surgery and continuous hyperthermic peritoneal perfusion in patients with mesothelioma and peritoneal carcinomatosis: hemodynamic, metabolic, and anesthetic considerations.

Miao N, Pingpank JF, Alexander HR, Royal R, Steinberg SM, Quezado MM, Beresnev T, Quezado ZM.

Ann Surg Oncol. 2009 Feb;16(2):334-44. doi: 10.1245/s10434-008-0253-z. Epub 2008 Dec 3.


Percutaneous hepatic perfusion in patients with metastatic liver cancer: anesthetic, hemodynamic, and metabolic considerations.

Miao N, Pingpank JF, Alexander HR, Steinberg SM, Beresneva T, Quezado ZM.

Ann Surg Oncol. 2008 Mar;15(3):815-23. doi: 10.1245/s10434-007-9781-1. Epub 2008 Jan 8.


Neuronal nitric oxide synthase deficiency decreases survival in bacterial peritonitis and sepsis.

Cui X, Besch V, Khaibullina A, Hergen A, Quezado M, Eichacker P, Quezado ZM.

Intensive Care Med. 2007 Nov;33(11):1993-2003. Epub 2007 Aug 8.


The anesthetic management of children with neonatal-onset multi-system inflammatory disease.

Lauro CF, Goldbach-Mansky R, Schmidt M, Quezado ZM.

Anesth Analg. 2007 Aug;105(2):351-7.


Hypothermia-induced bradycardia in a neonate receiving dexmedetomidine.

Finkel JC, Quezado ZM.

J Clin Anesth. 2007 Jun;19(4):290-2.


Ketamine as an adjuvant for treatment of cancer pain in children and adolescents.

Finkel JC, Pestieau SR, Quezado ZM.

J Pain. 2007 Jun;8(6):515-21. Epub 2007 Apr 16.


Potential outcome factors in subacute combined degeneration: review of observational studies.

Vasconcelos OM, Poehm EH, McCarter RJ, Campbell WW, Quezado ZM.

J Gen Intern Med. 2006 Oct;21(10):1063-8. Review.


Effects of aging on current vocalization threshold in mice measured by a novel nociception assay.

Finkel JC, Besch VG, Hergen A, Kakareka J, Pohida T, Melzer JM, Koziol D, Wesley R, Quezado ZM.

Anesthesiology. 2006 Aug;105(2):360-9.


Anesthesia and airway management of pediatric patients with Smith-Lemli-Opitz syndrome.

Quezado ZM, Veihmeyer J, Schwartz L, Nwokoro NA, Porter FD.

Anesthesiology. 2002 Oct;97(4):1015-9. No abstract available.


Prophylactic granulocyte colony-stimulating factor in the critically ill: carefully balancing the benefits and risks.

Quezado ZM, Eichacker PQ.

Crit Care Med. 2002 Sep;30(9):2162-4. No abstract available.


Inhaled nitric oxide: is systemic host defense at risk?

Cui X, Quezado ZM, Eichacker PQ.

Crit Care Med. 2002 Apr;30(4):945-6. No abstract available.


Continuous venovenous hemofiltration improves arterial oxygenation in endotoxin-induced lung injury in pigs.

Ullrich R, Roeder G, Lorber C, Quezado ZM, Kneifel W, Gasser H, Schlag G, Redl H, Germann P.

Anesthesiology. 2001 Aug;95(2):428-36.


Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice.

Ullrich R, Scherrer-Crosbie M, Bloch KD, Ichinose F, Nakajima H, Picard MH, Zapol WM, Quezado ZM.

Circulation. 2000 Sep 19;102(12):1440-6.


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