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CD3+ Macrophages Deliver Proinflammatory Cytokines by a CD3- and Transmembrane TNF-Dependent Pathway and Are Increased at the BCG-Infection Site.

Rodriguez-Cruz A, Vesin D, Ramon-Luing L, Zuñiga J, Quesniaux VFJ, Ryffel B, Lascurain R, Garcia I, Chávez-Galán L.

Front Immunol. 2019 Nov 7;10:2550. doi: 10.3389/fimmu.2019.02550. eCollection 2019.


Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice.

Nascimento M, Gombault A, Lacerda-Queiroz N, Panek C, Savigny F, Sbeity M, Bourinet M, Le Bert M, Riteau N, Ryffel B, Quesniaux VFJ, Couillin I.

Sci Rep. 2019 Oct 16;9(1):14848. doi: 10.1038/s41598-019-51427-y.


Acute Respiratory Barrier Disruption by Ozone Exposure in Mice.

Sokolowska M, Quesniaux VFJ, Akdis CA, Chung KF, Ryffel B, Togbe D.

Front Immunol. 2019 Sep 13;10:2169. doi: 10.3389/fimmu.2019.02169. eCollection 2019. Review.


Self-DNA Sensing in Lung Inflammatory Diseases.

Benmerzoug S, Ryffel B, Togbe D, Quesniaux VFJ.

Trends Immunol. 2019 Aug;40(8):719-734. doi: 10.1016/ Epub 2019 Jun 28. Review.


Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring.

Darby MG, Chetty A, Mrjden D, Rolot M, Smith K, Mackowiak C, Sedda D, Nyangahu D, Jaspan H, Toellner KM, Waisman A, Quesniaux V, Ryffel B, Cunningham AF, Dewals BG, Brombacher F, Horsnell WGC.

Sci Adv. 2019 May 29;5(5):eaav3058. doi: 10.1126/sciadv.aav3058. eCollection 2019 May.


Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity.

Benmerzoug S, Bounab B, Rose S, Gosset D, Biet F, Cochard T, Xavier A, Rouxel N, Fauconnier L, Horsnell WGC, Ryffel B, Togbe D, Quesniaux VFJ.

Cell Rep. 2019 May 28;27(9):2649-2664.e5. doi: 10.1016/j.celrep.2019.04.110.


Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection.

Chavez-Galan L, Vesin D, Blaser G, Uysal H, Benmerzoug S, Rose S, Ryffel B, Quesniaux VFJ, Garcia I.

Sci Rep. 2019 Mar 28;9(1):5297. doi: 10.1038/s41598-019-41629-9.


STING-dependent sensing of self-DNA drives silica-induced lung inflammation.

Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, Mollet L, Le Bert M, Lambers C, Geleff S, Roth M, Fauconnier L, Sedda D, Carvalho C, Perche O, Laurenceau D, Ryffel B, Apetoh L, Kiziltunc A, Uslu H, Albez FS, Akgun M, Togbe D, Quesniaux VFJ.

Nat Commun. 2018 Dec 6;9(1):5226. doi: 10.1038/s41467-018-07425-1.


Correction: Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation.

Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld JC, Iovanna J, Huber S, Chamaillard M, Quesniaux VFJ, Sokol H, Ryffel B.

Mucosal Immunol. 2019 Jan;12(1):290. doi: 10.1038/s41385-018-0112-6.


Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice.

Feat-Vetel J, Larrigaldie V, Meyer-Dilhet G, Herzine A, Mougin C, Laugeray A, Gefflaut T, Richard O, Quesniaux V, Montécot-Dubourg C, Mortaud S.

Neurotoxicology. 2018 Dec;69:152-163. doi: 10.1016/j.neuro.2018.10.001. Epub 2018 Oct 10.


Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose.

Araujo AM, Antunes MM, Mattos MS, Diniz AB, Alvarenga DM, Nakagaki BN, Carvalho É, Lacerda VAS, Carvalho-Gontijo R, Goulart J, Mafra K, Freitas-Lopes MA, Oliveira HMC, Dutra CM, David BA, Mendes Silva A, Quesniaux V, Ryffel B, Oliveira SC, Barber GN, Mansur DS, Cunha TM, Rezende RM, Oliveira AG, Menezes GB.

Cells. 2018 Jul 27;7(8). pii: E88. doi: 10.3390/cells7080088.


The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice.

Secher T, Maillet I, Mackowiak C, Le Bérichel J, Philippeau A, Panek C, Boury M, Oswald E, Saoudi A, Erard F, Le Bert M, Quesniaux V, Couturier-Maillard A, Ryffel B.

Sci Rep. 2018 Jul 26;8(1):11245. doi: 10.1038/s41598-018-29689-9.


The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin.

Fanny M, Nascimento M, Baron L, Schricke C, Maillet I, Akbal M, Riteau N, Le Bert M, Quesniaux V, Ryffel B, Gombault A, Même S, Même W, Couillin I.

Front Immunol. 2018 Jun 25;9:1476. doi: 10.3389/fimmu.2018.01476. eCollection 2018.


Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy.

Uysal H, Chavez-Galan L, Vesin D, Blaser G, Benkhoucha M, Ryffel B, Quesniaux VFJ, Garcia I.

Int J Mol Sci. 2018 Jul 4;19(7). pii: E1959. doi: 10.3390/ijms19071959.


G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation.

Dalloul Z, Chenuet P, Dalloul I, Boyer F, Aldigier JC, Laffleur B, El Makhour Y, Ryffel B, Quesniaux VFJ, Togbé D, Mergny JL, Cook-Moreau J, Cogné M.

J Allergy Clin Immunol. 2018 Oct;142(4):1352-1355. doi: 10.1016/j.jaci.2018.06.011. Epub 2018 Jun 20. No abstract available.


GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection.

Benmerzoug S, Marinho FV, Rose S, Mackowiak C, Gosset D, Sedda D, Poisson E, Uyttenhove C, Van Snick J, Jacobs M, Garcia I, Ryffel B, Quesniaux VFJ.

Sci Rep. 2018 Jun 5;8(1):8652. doi: 10.1038/s41598-018-26984-3.


Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation.

Michaudel C, Maillet I, Fauconnier L, Quesniaux V, Chung KF, Wiegman C, Peter D, Ryffel B.

Front Immunol. 2018 May 7;9:916. doi: 10.3389/fimmu.2018.00916. eCollection 2018.


The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection.

Marinho FV, Benmerzoug S, Rose S, Campos PC, Marques JT, Báfica A, Barber G, Ryffel B, Oliveira SC, Quesniaux VFJ.

J Innate Immun. 2018;10(3):239-252. doi: 10.1159/000488952. Epub 2018 May 23.


Cell iron status influences macrophage polarization.

Agoro R, Taleb M, Quesniaux VFJ, Mura C.

PLoS One. 2018 May 17;13(5):e0196921. doi: 10.1371/journal.pone.0196921. eCollection 2018.


Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation.

Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld JC, Iovanna J, Huber S, Chamaillard M, Quesniaux V, Sokol H, Chamaillard M, Ryffel B.

Mucosal Immunol. 2018 Jul;11(4):1181-1190. doi: 10.1038/s41385-018-0005-8. Epub 2018 May 4. Erratum in: Mucosal Immunol. 2019 Jan;12(1):290.


MyD88 as a therapeutic target for inflammatory lung diseases.

Di Padova F, Quesniaux VFJ, Ryffel B.

Expert Opin Ther Targets. 2018 May;22(5):401-408. doi: 10.1080/14728222.2018.1464139. Epub 2018 Apr 20. Review.


Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33.

Michaudel C, Mackowiak C, Maillet I, Fauconnier L, Akdis CA, Sokolowska M, Dreher A, Tan HT, Quesniaux VF, Ryffel B, Togbe D.

J Allergy Clin Immunol. 2018 Sep;142(3):942-958. doi: 10.1016/j.jaci.2017.11.044. Epub 2018 Jan 10.


Tumor Necrosis Factor-Alpha Targeting Can Protect against Arthritis with Low Sensitization to Infection.

Belmellat N, Semerano L, Segueni N, Damotte D, Decker P, Ryffel B, Quesniaux V, Boissier MC, Assier E.

Front Immunol. 2017 Nov 14;8:1533. doi: 10.3389/fimmu.2017.01533. eCollection 2017.


Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis.

Palomo J, Quesniaux VFJ, Togbe D, Reverchon F, Ryffel B.

Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12502. Review.


IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation.

Antunes MM, Araújo AM, Diniz AB, Pereira RVS, Alvarenga DM, David BA, Rocha RM, Lopes MAF, Marchesi SC, Nakagaki BN, Carvalho É, Marques PE, Ryffel B, Quesniaux V, Guabiraba Brito R, Filho JCA, Cara DC, Rezende RM, Menezes GB.

Inflamm Res. 2018 Jan;67(1):77-88. doi: 10.1007/s00011-017-1098-3. Epub 2017 Oct 14.


Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.

Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, Mauny P, Lory R, Uttenhove C, van Snick J, Iwakura Y, di Padova F, Quesniaux V, Togbe D, Ryffel B.

Clin Sci (Lond). 2017 Oct 12;131(20):2533-2548. doi: 10.1042/CS20171034. Print 2017 Oct 15.


An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection.

Agoro R, Benmerzoug S, Rose S, Bouyer M, Gozzelino R, Garcia I, Ryffel B, Quesniaux VFJ, Mura C.

J Infect Dis. 2017 Oct 17;216(7):907-918. doi: 10.1093/infdis/jix366.


Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy.

Chavez-Galan L, Vesin D, Uysal H, Blaser G, Benkhoucha M, Ryffel B, Quesniaux VFJ, Garcia I.

Front Immunol. 2017 Aug 25;8:999. doi: 10.3389/fimmu.2017.00999. eCollection 2017.


Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury.

Dos Santos JC, Grund LZ, Seibert CS, Marques EE, Soares AB, Quesniaux VF, Ryffel B, Lopes-Ferreira M, Lima C.

Sci Rep. 2017 Aug 11;7(1):7912. doi: 10.1038/s41598-017-08395-y.


The Emerging Roles of STING in Bacterial Infections.

Marinho FV, Benmerzoug S, Oliveira SC, Ryffel B, Quesniaux VFJ.

Trends Microbiol. 2017 Nov;25(11):906-918. doi: 10.1016/j.tim.2017.05.008. Epub 2017 Jun 15. Review.


IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria.

Reverchon F, Mortaud S, Sivoyon M, Maillet I, Laugeray A, Palomo J, Montécot C, Herzine A, Meme S, Meme W, Erard F, Ryffel B, Menuet A, Quesniaux VFJ.

PLoS Pathog. 2017 Apr 27;13(4):e1006322. doi: 10.1371/journal.ppat.1006322. eCollection 2017 Apr.


Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells.

Li C, Maillet I, Mackowiak C, Viala C, Di Padova F, Li M, Togbe D, Quesniaux V, Lai Y, Ryffel B.

Cell Death Dis. 2017 Apr 6;8(4):e2735. doi: 10.1038/cddis.2017.90.


Bioengineered 3D Models for Studying Human Cell-Tuberculosis Interactions.

Benmerzoug S, Quesniaux VFJ.

Trends Microbiol. 2017 Apr;25(4):245-246. doi: 10.1016/j.tim.2017.02.009. Epub 2017 Mar 8.


Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis.

Hsu NJ, Francisco NM, Keeton R, Allie N, Quesniaux VF, Ryffel B, Jacobs M.

Front Immunol. 2017 Feb 23;8:180. doi: 10.3389/fimmu.2017.00180. eCollection 2017.


Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells.

Tan Z, Liu Q, Jiang R, Lv L, Shoto SS, Maillet I, Quesniaux V, Tang J, Zhang W, Sun B, Ryffel B.

Cell Mol Immunol. 2018 Apr;15(4):388-398. doi: 10.1038/cmi.2016.63. Epub 2017 Feb 13.


Neutrophils releasing IL-17A into NETs are essential to plasma cell differentiation in inflamed tissue dependent on IL-1R.

Grund LZ, Novaski I, Quesniaux VF, Ryffel B, Lopes-Ferreira M, Lima C.

Autoimmunity. 2017 Mar;50(2):86-101. doi: 10.1080/08916934.2016.1261834. Epub 2016 Dec 23.


Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation.

Dambuza IM, Keeton R, Hsu NJ, Allie N, Quesniaux VF, Ryffel B, Jacobs M.

Sci Rep. 2016 Dec 20;6:39499. doi: 10.1038/srep39499.


Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization.

Segueni N, Tritto E, Bourigault ML, Rose S, Erard F, Le Bert M, Jacobs M, Di Padova F, Stiehl DP, Moulin P, Brees D, Chibout SD, Ryffel B, Kammüller M, Quesniaux VF.

Sci Rep. 2016 Nov 17;6:36923. doi: 10.1038/srep36923.


IL-1R1-MyD88 axis elicits papain-induced lung inflammation.

Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall ED, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A.

Eur J Immunol. 2016 Nov;46(11):2531-2541. doi: 10.1002/eji.201646366. Epub 2016 Sep 22.


Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen.

Madouri F, Chenuet P, Beuraud C, Fauconnier L, Marchiol T, Rouxel N, Ledru A, Gallerand M, Lombardi V, Mascarell L, Marquant Q, Apetoh L, Erard F, Le Bert M, Trovero F, Quesniaux VFJ, Ryffel B, Togbe D.

J Allergy Clin Immunol. 2017 May;139(5):1650-1666. doi: 10.1016/j.jaci.2016.08.044. Epub 2016 Oct 14.


Perinatal Exposure to Glufosinate Ammonium Herbicide Impairs Neurogenesis and Neuroblast Migration through Cytoskeleton Destabilization.

Herzine A, Laugeray A, Feat J, Menuet A, Quesniaux V, Richard O, Pichon J, Montécot-Dubourg C, Perche O, Mortaud S.

Front Cell Neurosci. 2016 Aug 9;10:191. doi: 10.3389/fncel.2016.00191. eCollection 2016.


Glufosinate aerogenic exposure induces glutamate and IL-1 receptor dependent lung inflammation.

Maillet I, Perche O, Pâris A, Richard O, Gombault A, Herzine A, Pichon J, Huaux F, Mortaud S, Ryffel B, Quesniaux VF, Montécot-Dubourg C.

Clin Sci (Lond). 2016 Nov 1;130(21):1939-54. doi: 10.1042/CS20160530. Epub 2016 Aug 22.


Tumor Necrosis Factor and Its Receptors Are Crucial to Control Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection in a Murine Model.

Chavez-Galan L, Vesin D, Segueni N, Prasad P, Buser-Llinares R, Blaser G, Pache JC, Ryffel B, Quesniaux VF, Garcia I.

Am J Pathol. 2016 Sep;186(9):2364-77. doi: 10.1016/j.ajpath.2016.05.015. Epub 2016 Jul 25.


Inflammasome, IL-1 and inflammation in ozone-induced lung injury.

Michaudel C, Couturier-Maillard A, Chenuet P, Maillet I, Mura C, Couillin I, Gombault A, Quesniaux VF, Huaux F, Ryffel B.

Am J Clin Exp Immunol. 2016 Mar 23;5(1):33-40. eCollection 2016. Review.


Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection.

Segueni N, Benmerzoug S, Rose S, Gauthier A, Bourigault ML, Reverchon F, Philippeau A, Erard F, Le Bert M, Bouscayrol H, Wachter T, Garcia I, Kollias G, Jacobs M, Ryffel B, Quesniaux VF.

Sci Rep. 2016 Mar 2;6:22454. doi: 10.1038/srep22454.


Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain.

Zarpelon AC, Rodrigues FC, Lopes AH, Souza GR, Carvalho TT, Pinto LG, Xu D, Ferreira SH, Alves-Filho JC, McInnes IB, Ryffel B, Quesniaux VF, Reverchon F, Mortaud S, Menuet A, Liew FY, Cunha FQ, Cunha TM, Verri WA Jr.

FASEB J. 2016 Jan;30(1):54-65. doi: 10.1096/fj.14-267146. Epub 2015 Aug 26.


Control of Mycobacterial Infections in Mice Expressing Human Tumor Necrosis Factor (TNF) but Not Mouse TNF.

Olleros ML, Chavez-Galan L, Segueni N, Bourigault ML, Vesin D, Kruglov AA, Drutskaya MS, Bisig R, Ehlers S, Aly S, Walter K, Kuprash DV, Chouchkova M, Kozlov SV, Erard F, Ryffel B, Quesniaux VF, Nedospasov SA, Garcia I.

Infect Immun. 2015 Sep;83(9):3612-23. doi: 10.1128/IAI.00743-15. Epub 2015 Jun 29.


TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis.

Francisco NM, Hsu NJ, Keeton R, Randall P, Sebesho B, Allie N, Govender D, Quesniaux V, Ryffel B, Kellaway L, Jacobs M.

J Neuroinflammation. 2015 Jun 26;12:125. doi: 10.1186/s12974-015-0345-1.


Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection.

Segueni N, Vigne S, Palmer G, Bourigault ML, Olleros ML, Vesin D, Garcia I, Ryffel B, Quesniaux VF, Gabay C.

PLoS One. 2015 May 7;10(5):e0126058. doi: 10.1371/journal.pone.0126058. eCollection 2015.


Mycobacterium tuberculosis infection of the 'non-classical immune cell'.

Randall PJ, Hsu NJ, Quesniaux V, Ryffel B, Jacobs M.

Immunol Cell Biol. 2015 Oct;93(9):789-95. doi: 10.1038/icb.2015.43. Epub 2015 Mar 24. Review.


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