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Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest.

François B, Cariou A, Clere-Jehl R, Dequin PF, Renon-Carron F, Daix T, Guitton C, Deye N, Legriel S, Plantefève G, Quenot JP, Desachy A, Kamel T, Bedon-Carte S, Diehl JL, Chudeau N, Karam E, Durand-Zaleski I, Giraudeau B, Vignon P, Le Gouge A; CRICS-TRIGGERSEP Network and the ANTHARTIC Study Group.

N Engl J Med. 2019 Nov 7;381(19):1831-1842. doi: 10.1056/NEJMoa1812379.


Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet.

Quenot JP, Dargent A, Large A, Roudaut JB, Andreu P, Barbar S.

Ann Transl Med. 2019 Sep;7(Suppl 6):S181. doi: 10.21037/atm.2019.07.66. No abstract available.


Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm.

Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J; CRICS-TRIGGERSEP Group.

N Engl J Med. 2019 Oct 2. doi: 10.1056/NEJMoa1906661. [Epub ahead of print]


Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial.

Laterre PF, Berry SM, Blemings A, Carlsen JE, François B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windeløv NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brulé N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjølbye AL, Angus DC; SEPSIS-ACT Investigators.

JAMA. 2019 Oct 2. doi: 10.1001/jama.2019.14607. [Epub ahead of print] Erratum in: JAMA. 2019 Oct 15;:.


Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury.

Ehrmann S, Helms J, Joret A, Martin-Lefevre L, Quenot JP, Herbrecht JE, Benzekri-Lefevre D, Robert R, Desachy A, Bellec F, Plantefeve G, Bretagnol A, Dargent A, Lacherade JC, Meziani F, Giraudeau B, Tavernier E, Dequin PF; Clinical research in intensive care and sepsis-Trial group for global evaluation and research in sepsis (CRICS-TRIGGERSEP network).

Ann Intensive Care. 2019 Sep 23;9(1):106. doi: 10.1186/s13613-019-0580-1.


Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients.

Richard JC, Marque S, Gros A, Muller M, Prat G, Beduneau G, Quenot JP, Dellamonica J, Tapponnier R, Soum E, Bitker L, Richecoeur J; REVA research network.

Intensive Care Med. 2019 Nov;45(11):1590-1598. doi: 10.1007/s00134-019-05776-x. Epub 2019 Sep 23.


What are the characteristics that lead physicians to perceive an ICU stay as non-beneficial for the patient?

Quenot JP, Large A, Meunier-Beillard N, Pugliesi PS, Rollet P, Toitot A, Andreu P, Devilliers H, Marchalot A, Ecarnot F, Dargent A, Rigaud JP; INSTINCT study group.

PLoS One. 2019 Sep 6;14(9):e0222039. doi: 10.1371/journal.pone.0222039. eCollection 2019.


Improved quantification of plasma lipopolysaccharide (LPS) burden in sepsis using 3-hydroxy myristate (3HM): a cohort study.

Dargent A, Pais De Barros JP, Ksiazek E, Fournel I, Dusuel A, Rerole AL, Choubley H, Masson D, Lagrost L, Quenot JP.

Intensive Care Med. 2019 Nov;45(11):1678-1680. doi: 10.1007/s00134-019-05749-0. Epub 2019 Aug 26. No abstract available.


"You helped me keep my head above water"-experience of bereavement research after loss of a loved one in the ICU: insights from the ARREVE study.

Laurent A, Reignier J, Le Gouge A, Cottereau A, Adda M, Annane D, Audibert J, Barbier F, Bardou P, Bourcier S, Bourenne J, Boyer A, Brenas F, Das V, Desachy A, Devaquet J, Feissel M, Ganster F, Garrouste-Orgeas M, Grillet G, Guisset O, Hamidfar-Roy R, Hyacinthe AC, Jochmans S, Jourdain M, Lautrette A, Lerolle N, Lesieur O, Lion F, Mateu P, Megarbane B, Merceron S, Mercier E, Messika J, Morin-Longuet P, Philippon-Jouve B, Quenot JP, Renault A, Repesse X, Rigaud JP, Robin S, Roquilly A, Seguin A, Thevenin D, Tirot P, Vinatier I, Azoulay E, Robert R, Kentish-Barnes N.

Intensive Care Med. 2019 Sep;45(9):1252-1261. doi: 10.1007/s00134-019-05722-x. Epub 2019 Aug 12.


High-flow nasal oxygen therapy alone or with non-invasive ventilation in immunocompromised patients admitted to ICU for acute hypoxemic respiratory failure: the randomised multicentre controlled FLORALI-IM protocol.

Coudroy R, Frat JP, Ehrmann S, Pène F, Terzi N, Decavèle M, Prat G, Garret C, Contou D, Bourenne J, Gacouin A, Girault C, Dellamonica J, Malacrino D, Labro G, Quenot JP, Herbland A, Jochmans S, Devaquet J, Benzekri D, Vivier E, Nseir S, Colin G, Thévenin D, Grasselli G, Assefi M, Guerin C, Bougon D, Lherm T, Kouatchet A, Ragot S, Thille AW; and the REVA Network.

BMJ Open. 2019 Aug 10;9(8):e029798. doi: 10.1136/bmjopen-2019-029798.


Corporeal Compression at the Onset of Septic shock (COCOONs): a compression method to reduce fluid balance of septic shock patients.

Dargent A, Large A, Soudry-Faure A, Doise JM, Abdulmalak C, Jonval L, Andreu P, Roudaut JB, Prin S, Charles PE, Payen D, Quenot JP; COCOONs study group.

Sci Rep. 2019 Aug 9;9(1):11566. doi: 10.1038/s41598-019-47939-2.


Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial.

Constantin JM, Jabaudon M, Lefrant JY, Jaber S, Quenot JP, Langeron O, Ferrandière M, Grelon F, Seguin P, Ichai C, Veber B, Souweine B, Uberti T, Lasocki S, Legay F, Leone M, Eisenmann N, Dahyot-Fizelier C, Dupont H, Asehnoune K, Sossou A, Chanques G, Muller L, Bazin JE, Monsel A, Borao L, Garcier JM, Rouby JJ, Pereira B, Futier E; AZUREA Network.

Lancet Respir Med. 2019 Oct;7(10):870-880. doi: 10.1016/S2213-2600(19)30138-9. Epub 2019 Aug 6.


Trisodium citrate 4% versus heparin as a catheter lock for non-tunneled hemodialysis catheters in critically ill patients: a multicenter, randomized clinical trial.

Quenot JP, Helms J, Bourredjem A, Dargent A, Meziani F, Badie J, Blasco G, Piton G, Capellier G, Mezher C, Rebibou JM, Nadji A, Crepin T, Barbar SD, Fleck C, Cransac A, Boulin M, Binquet C, Soudry-Faure A, Bruyère R; VERROU-REA Trial Investigators and the CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis).

Ann Intensive Care. 2019 Jul 1;9(1):75. doi: 10.1186/s13613-019-0553-4.


Effect of fluid balance control in critically ill patients: Design of the stepped wedge trial POINCARE-2.

Agrinier N, Monnier A, Argaud L, Bemer M, Virion JM, Alleyrat C, Charpentier C, Ziegler L, Louis G, Bruel C, Jamme M, Quenot JP, Badie J, Schneider F, Bollaert PE.

Contemp Clin Trials. 2019 Aug;83:109-116. doi: 10.1016/j.cct.2019.06.020. Epub 2019 Jun 29.


Adhering to the procalcitonin algorithm allows antibiotic therapy to be shortened in patients with ventilator-associated pneumonia.

Beye F, Vigneron C, Dargent A, Prin S, Andreu P, Large A, Quenot JP, Bador J, Bruyere R, Charles PE.

J Crit Care. 2019 Oct;53:125-131. doi: 10.1016/j.jcrc.2019.05.022. Epub 2019 May 31.


Antibody Treatment against Angiopoietin-Like 4 Reduces Pulmonary Edema and Injury in Secondary Pneumococcal Pneumonia.

Li L, Foo BJW, Kwok KW, Sakamoto N, Mukae H, Izumikawa K, Mandard S, Quenot JP, Lagrost L, Teh WK, Singh Kohli G, Zhu P, Choi H, Buist ML, Seet JE, Yang L, He F, Kwong Chow VT, Tan NS.

MBio. 2019 Jun 4;10(3). pii: e02469-18. doi: 10.1128/mBio.02469-18.


Remote ischemic conditioning in septic shock (RECO-Sepsis): study protocol for a randomized controlled trial.

Cour M, Buisson M, Klouche K, Bouzgarrou R, Schwebel C, Quenot JP, Zeni F, Beuret P, Ovize M, Argaud L.

Trials. 2019 May 22;20(1):281. doi: 10.1186/s13063-019-3406-4.


Reply to Chousterman et al.: Delaying Renal Replacement Therapy Could Be Harmful in Patients with Acute Brain Injury.

Gaudry S, Quenot JP, Hertig A, Barbar SD, Hajage D, Ricard JD, Dreyfuss D.

Am J Respir Crit Care Med. 2019 Sep 1;200(5):646-647. doi: 10.1164/rccm.201904-0723LE. No abstract available.


Influenza infection and bacteremic pneumococcal pneumonia.

Blot M, Bruyère R, Chavanet P, Dalle F, Piroth L, Quenot JP, Charles PE.

Med Mal Infect. 2019 Sep;49(6):483-484. doi: 10.1016/j.medmal.2019.03.014. Epub 2019 Apr 5. No abstract available.


Factors associated with refusal or acceptance of older patients (≥ 65 years) to provide consent to participate in clinical research in cardiology: a qualitative study.

Ecarnot F, Meunier-Beillard N, Quenot JP, Meneveau N.

Aging Clin Exp Res. 2019 Mar 21. doi: 10.1007/s40520-019-01172-z. [Epub ahead of print]


Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial.

Frat JP, Ricard JD, Quenot JP, Pichon N, Demoule A, Forel JM, Mira JP, Coudroy R, Berquier G, Voisin B, Colin G, Pons B, Danin PE, Devaquet J, Prat G, Clere-Jehl R, Petitpas F, Vivier E, Razazi K, Nay MA, Souday V, Dellamonica J, Argaud L, Ehrmann S, Gibelin A, Girault C, Andreu P, Vignon P, Dangers L, Ragot S, Thille AW; FLORALI-2 study group; REVA network.

Lancet Respir Med. 2019 Apr;7(4):303-312. doi: 10.1016/S2213-2600(19)30048-7. Epub 2019 Mar 18.


Timing of Renal Replacement Therapy for Severe Acute Kidney Injury in Critically Ill Patients.

Gaudry S, Quenot JP, Hertig A, Barbar SD, Hajage D, Ricard JD, Dreyfuss D.

Am J Respir Crit Care Med. 2019 May 1;199(9):1066-1075. doi: 10.1164/rccm.201810-1906CP.


Prophylaxis for stress related gastrointestinal bleeding in the ICU: Should we adjust to each patient's individual risk?

Quenot JP, Dargent A, Barkun A, Bardou M.

Anaesth Crit Care Pain Med. 2019 Apr;38(2):99-101. doi: 10.1016/j.accpm.2019.01.012. Epub 2019 Feb 5. No abstract available.


Tailored multicomponent program for discomfort reduction in critically ill patients may decrease post-traumatic stress disorder in general ICU survivors at 1 year.

Kalfon P, Alessandrini M, Boucekine M, Renoult S, Geantot MA, Deparis-Dusautois S, Berric A, Collange O, Floccard B, Mimoz O, Julien A, Robert R, Audibert J, Renault A, Follin A, Thevenin D, Revel N, Venot M, Patrigeon RG, Signouret T, Fromentin M, Sharshar T, Vigne C, Pottecher J, Levrat Q, Sossou A, Garrouste-Orgeas M, Quenot JP, Boulle C, Azoulay E, Baumstarck K, Auquier P; IPREA-AQVAR Study Group.

Intensive Care Med. 2019 Feb;45(2):223-235. doi: 10.1007/s00134-018-05511-y. Epub 2019 Jan 30.


Timing of Renal-Replacement Therapy in Acute Kidney Injury and Sepsis.

Barbar SD, Dargent A, Quenot JP.

N Engl J Med. 2019 Jan 24;380(4):399. doi: 10.1056/NEJMc1815142. No abstract available.


Renal replacement therapy: Time to give up on early initiation? Yes.

Barbar SD, Gaudry S, Dreyfuss D, Quenot JP.

Anaesth Crit Care Pain Med. 2018 Dec;37(6):501-503. doi: 10.1016/j.accpm.2018.11.008. No abstract available.


Disagreement Between Clinicians and Score in Decision-Making Capacity of Critically Ill Patients.

Bertrand PM, Pereira B, Adda M, Timsit JF, Wolff M, Hilbert G, Gruson D, Garrouste-Orgeas M, Argaud L, Constantin JM, Chabanne R, Quenot JP, Bohe J, Guerin C, Papazian L, Jonquet O, Klouche K, Delahaye A, Riu B, Zieleskiewicz L, Darmon M, Azoulay E, Souweine B, Lautrette A.

Crit Care Med. 2019 Mar;47(3):337-344. doi: 10.1097/CCM.0000000000003550.


Plasma Renin Concentration is Associated With Hemodynamic Deficiency and Adverse Renal Outcome in Septic Shock.

Nguyen M, Denimal D, Dargent A, Guinot PG, Duvillard L, Quenot JP, Bouhemad B.

Shock. 2019 Oct;52(4):e22-e30. doi: 10.1097/SHK.0000000000001285.


Non-readmission decisions in the intensive care unit under French rules: A nationwide survey of practices.

Rigaud JP, Giabicani M, Meunier-Beillard N, Ecarnot F, Beuzelin M, Marchalot A, Dargent A, Quenot JP.

PLoS One. 2018 Oct 18;13(10):e0205689. doi: 10.1371/journal.pone.0205689. eCollection 2018.


Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis.

Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyère R, Lebert C, Bohé J, Badie J, Eraldi JP, Rigaud JP, Levy B, Siami S, Louis G, Bouadma L, Constantin JM, Mercier E, Klouche K, du Cheyron D, Piton G, Annane D, Jaber S, van der Linden T, Blasco G, Mira JP, Schwebel C, Chimot L, Guiot P, Nay MA, Meziani F, Helms J, Roger C, Louart B, Trusson R, Dargent A, Binquet C, Quenot JP; IDEAL-ICU Trial Investigators and the CRICS TRIGGERSEP Network.

N Engl J Med. 2018 Oct 11;379(15):1431-1442. doi: 10.1056/NEJMoa1803213.


End-of-life situations in cardiology: a qualitative study of physicians' and nurses' experience in a large university hospital.

Ecarnot F, Meunier-Beillard N, Seronde MF, Chopard R, Schiele F, Quenot JP, Meneveau N.

BMC Palliat Care. 2018 Oct 5;17(1):112. doi: 10.1186/s12904-018-0366-5.


New-onset atrial fibrillation in ICU: A FROG in the throat.

Guenancia C, Dargent A, Large A, Andreu P, Quenot JP.

Int J Cardiol. 2018 Nov 1;270:189. doi: 10.1016/j.ijcard.2018.06.101. No abstract available.


Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study.

Vuillard C, Pineton de Chambrun M, de Prost N, Guérin C, Schmidt M, Dargent A, Quenot JP, Préau S, Ledoux G, Neuville M, Voiriot G, Fartoukh M, Coudroy R, Dumas G, Maury E, Terzi N, Tandjaoui-Lambiotte Y, Schneider F, Grall M, Guérot E, Larcher R, Ricome S, Le Mao R, Colin G, Guitton C, Zafrani L, Morawiec E, Dubert M, Pajot O, Mentec H, Plantefève G, Contou D.

Ann Intensive Care. 2018 Sep 11;8(1):87. doi: 10.1186/s13613-018-0433-3.


Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction.

Levy B, Clere-Jehl R, Legras A, Morichau-Beauchant T, Leone M, Frederique G, Quenot JP, Kimmoun A, Cariou A, Lassus J, Harjola VP, Meziani F, Louis G, Rossignol P, Duarte K, Girerd N, Mebazaa A, Vignon P; Collaborators.

J Am Coll Cardiol. 2018 Jul 10;72(2):173-182. doi: 10.1016/j.jacc.2018.04.051.


Out of the ICU shifting as a significant workload.

Merdji H, Clere-Jehl R, Dargent A, Andreu P, Large A, Lefebvre F, Schenck M, Helms J, Quenot JP, Meziani F.

Intensive Care Med. 2018 Sep;44(9):1582-1583. doi: 10.1007/s00134-018-5240-7. Epub 2018 Jun 13. No abstract available.


Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening.

Daix T, Guerin E, Tavernier E, Mercier E, Gissot V, Hérault O, Mira JP, Dumas F, Chapuis N, Guitton C, Béné MC, Quenot JP, Tissier C, Guy J, Piton G, Roggy A, Muller G, Legac É, de Prost N, Khellaf M, Wagner-Ballon O, Coudroy R, Dindinaud E, Uhel F, Roussel M, Lafon T, Jeannet R, Vargas F, Fleureau C, Roux M, Allou K, Vignon P, Feuillard J, François B; Septiflux Trial Group.

Chest. 2018 Sep;154(3):617-627. doi: 10.1016/j.chest.2018.03.058. Epub 2018 Apr 26.


How can we best organise communication with patients' families?

Quenot JP, Meunier-Beillard N, Ecarnot F, Dargent A, Rigaud JP.

Anaesth Crit Care Pain Med. 2018 Jun;37(3):187-189. doi: 10.1016/j.accpm.2018.03.003. Epub 2018 Mar 22. No abstract available.


Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.

Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, Cariou A, Forceville X, Schwebel C, Martin C, Timsit JF, Misset B, Ali Benali M, Colin G, Souweine B, Asehnoune K, Mercier E, Chimot L, Charpentier C, François B, Boulain T, Petitpas F, Constantin JM, Dhonneur G, Baudin F, Combes A, Bohé J, Loriferne JF, Amathieu R, Cook F, Slama M, Leroy O, Capellier G, Dargent A, Hissem T, Maxime V, Bellissant E; CRICS-TRIGGERSEP Network.

N Engl J Med. 2018 Mar 1;378(9):809-818. doi: 10.1056/NEJMoa1705716.


What are the ethical dimensions in the profession of intensive care specialist?

Quenot JP, Ecarnot F, Meunier-Beillard N, Dargent A, Eraldi JP, Bougerol F, Large A, Andreu P, Rigaud JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S47. doi: 10.21037/atm.2017.09.34. Review.


What are the ethical questions raised by the integration of intensive care into advance care planning?

Quenot JP, Ecarnot F, Meunier-Beillard N, Dargent A, Large A, Andreu P, Rigaud JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S46. doi: 10.21037/atm.2017.08.08. Review.


Can qualitative research play a role in answering ethical questions in intensive care?

Meunier-Beillard N, Ecarnot F, Rigaud JP, Quenot JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S45. doi: 10.21037/atm.2017.09.33. Review.


What are the ethical aspects surrounding the collegial decisional process in limiting and withdrawing treatment in intensive care?

Quenot JP, Ecarnot F, Meunier-Beillard N, Dargent A, Large A, Andreu P, Rigaud JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S43. doi: 10.21037/atm.2017.04.15. Review.


What are the ethical aspects surrounding intensive care unit admission in patients with cancer?

Rigaud JP, Large A, Meunier-Beillard N, Gélinotte S, Declercq PL, Ecarnot F, Dargent A, Quenot JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S42. doi: 10.21037/atm.2017.12.01. Review.


Ethical challenges involved in obtaining consent for research from patients hospitalized in the intensive care unit.

Ecarnot F, Quenot JP, Besch G, Piton G.

Ann Transl Med. 2017 Dec;5(Suppl 4):S41. doi: 10.21037/atm.2017.04.42.


What are the ethical issues in relation to the role of the family in intensive care?

Quenot JP, Ecarnot F, Meunier-Beillard N, Dargent A, Large A, Andreu P, Rigaud JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S40. doi: 10.21037/atm.2017.04.44. Review.


Intersecting vulnerabilities in professionals and patients in intensive care.

Meunier-Beillard N, Dargent A, Ecarnot F, Rigaud JP, Andreu P, Large A, Quenot JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S39. doi: 10.21037/atm.2017.09.01. Review.


Ethical aspects of admission or non-admission to the intensive care unit.

Rigaud JP, Giabicani M, Beuzelin M, Marchalot A, Ecarnot F, Quenot JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S38. doi: 10.21037/atm.2017.06.53. Review.


Ethical issues in intensive care: more questions than answers.

Quenot JP, Ecarnot F, Rigaud JP.

Ann Transl Med. 2017 Dec;5(Suppl 4):S36. doi: 10.21037/atm.2017.12.04. No abstract available.


Correction to: Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study).

Robert R, Le Gouge A, Kentish-Barnes N, Cottereau A, Giraudeau B, Adda M, Annane D, Audibert J, Barbier F, Bardou P, Bourcier S, Bourenne J, Boyer A, Brenas F, Das V, Desachy A, Devaquet J, Feissel M, Ganster F, Garrouste-Orgeas M, Grillet G, Guisset O, Hamidfar-Roy R, Hyacinthe AC, Jochmans S, Jourdain M, Lautrette A, Lerolle N, Lesieur O, Lion F, Mateu P, Megarbane B, Merceron S, Mercier E, Messika J, Morin-Longuet P, Philippon-Jouve B, Quenot JP, Renault A, Repesse X, Rigaud JP, Robin S, Roquilly A, Seguin A, Thevenin D, Tirot P, Vinatier I, Azoulay E, Reignier J.

Intensive Care Med. 2017 Dec;43(12):1942-1943. doi: 10.1007/s00134-017-4999-2.


Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2).

Reignier J, Boisramé-Helms J, Brisard L, Lascarrou JB, Ait Hssain A, Anguel N, Argaud L, Asehnoune K, Asfar P, Bellec F, Botoc V, Bretagnol A, Bui HN, Canet E, Da Silva D, Darmon M, Das V, Devaquet J, Djibre M, Ganster F, Garrouste-Orgeas M, Gaudry S, Gontier O, Guérin C, Guidet B, Guitton C, Herbrecht JE, Lacherade JC, Letocart P, Martino F, Maxime V, Mercier E, Mira JP, Nseir S, Piton G, Quenot JP, Richecoeur J, Rigaud JP, Robert R, Rolin N, Schwebel C, Sirodot M, Tinturier F, Thévenin D, Giraudeau B, Le Gouge A; NUTRIREA-2 Trial Investigators; Clinical Research in Intensive Care and Sepsis (CRICS) group.

Lancet. 2018 Jan 13;391(10116):133-143. doi: 10.1016/S0140-6736(17)32146-3. Epub 2017 Nov 8.


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