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Items: 45


Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1.

Khanna R, Moutal A, White KA, Chefdeville A, Negrao de Assis P, Cai S, Swier VJ, Bellampalli SS, Giunta MD, Darbro BW, Quelle DE, Sieren JC, Wallace MR, Rogers CS, Meyerholz DK, Weimer JM.

Pain. 2019 Nov;160(11):2473-2486. doi: 10.1097/j.pain.0000000000001648.


RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth.

Umesalma S, Kaemmer CA, Kohlmeyer JL, Letney B, Schab AM, Reilly JA, Sheehy RM, Hagen J, Tiwari N, Zhan F, Leidinger MR, O'Dorisio TM, Dillon J, Merrill RA, Meyerholz DK, Perl AL, Brown BJ, Braun TA, Scott AT, Ginader T, Taghiyev AF, Zamba GK, Howe JR, Strack S, Bellizzi AM, Narla G, Darbro BW, Quelle FW, Quelle DE.

J Clin Invest. 2019 Mar 4;130:1641-1653. doi: 10.1172/JCI123049. eCollection 2019 Mar 4.


Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations.

Meng X, Yang S, Li Y, Li Y, Devor EJ, Bi J, Wang X, Umesalma S, Quelle DE, Thiel WH, Thiel KW, Leslie KK.

Dis Markers. 2018 Dec 17;2018:3810108. doi: 10.1155/2018/3810108. eCollection 2018.


Radiomic biomarkers informative of cancerous transformation in neurofibromatosis-1 plexiform tumors.

Uthoff J, De Stefano FA, Panzer K, Darbro BW, Sato TS, Khanna R, Quelle DE, Meyerholz DK, Weimer J, Sieren JC.

J Neuroradiol. 2019 May;46(3):179-185. doi: 10.1016/j.neurad.2018.05.006. Epub 2018 Jun 27.


A porcine model of neurofibromatosis type 1 that mimics the human disease.

White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, Dodd RD, Panzer K, Tang AH, Darbro BW, Moutal A, Cai S, Li W, Bellampalli SS, Khanna R, Rogers CS, Sieren JC, Quelle DE, Weimer JM.

JCI Insight. 2018 Jun 21;3(12). pii: 120402. doi: 10.1172/jci.insight.120402. eCollection 2018 Jun 21.


Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models.

Meyerholz DK, Ofori-Amanfo GK, Leidinger MR, Goeken JA, Khanna R, Sieren JC, Darbro BW, Quelle DE, Weimer JM.

J Histochem Cytochem. 2017 Oct;65(10):607-618. doi: 10.1369/0022155417729357. Epub 2017 Aug 28.


Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells.

Pardo M, Yu L, Shen S, Tate P, Bode D, Letney BL, Quelle DE, Skarnes W, Choudhary JS.

Sci Rep. 2017 Aug 15;7(1):8157. doi: 10.1038/s41598-017-08456-2.


NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma.

Hao M, Franqui-Machin R, Xu H, Shaughnessy J Jr, Barlogie B, Roodman D, Quelle DE, Janz S, Tomasson MH, Sanderson RD, Qiu L, Frech I, Tricot G, Zhan F.

Leukemia. 2017 Jul;31(7):1648-1650. doi: 10.1038/leu.2017.115. Epub 2017 Apr 12. No abstract available.


p53 Acetylation: Regulation and Consequences.

Reed SM, Quelle DE.

Cancers (Basel). 2014 Dec 23;7(1):30-69. doi: 10.3390/cancers7010030. Review.


NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.

Reed SM, Hagen J, Muniz VP, Rosean TR, Borcherding N, Sciegienka S, Goeken JA, Naumann PW, Zhang W, Tompkins VS, Janz S, Meyerholz DK, Quelle DE.

PLoS One. 2014 Nov 13;9(11):e112126. doi: 10.1371/journal.pone.0112126. eCollection 2014.


RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner.

Hagen J, Muniz VP, Falls KC, Reed SM, Taghiyev AF, Quelle FW, Gourronc FA, Klingelhutz AJ, Major HJ, Askeland RW, Sherman SK, O'Dorisio TM, Bellizzi AM, Howe JR, Darbro BW, Quelle DE.

Cancer Res. 2014 Nov 15;74(22):6661-70. doi: 10.1158/0008-5472.CAN-13-3742. Epub 2014 Oct 1.


Development and translational imaging of a TP53 porcine tumorigenesis model.

Sieren JC, Meyerholz DK, Wang XJ, Davis BT, Newell JD Jr, Hammond E, Rohret JA, Rohret FA, Struzynski JT, Goeken JA, Naumann PW, Leidinger MR, Taghiyev A, Van Rheeden R, Hagen J, Darbro BW, Quelle DE, Rogers CS.

J Clin Invest. 2014 Sep;124(9):4052-66. doi: 10.1172/JCI75447. Epub 2014 Aug 8.


ARF sees Pdgfrβ through the miR.

Reed SM, Quelle FW, Quelle DE.

Cell Cycle. 2014;13(10):1520-1. doi: 10.4161/cc.28900. Epub 2014 Apr 22. No abstract available.


Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53.

Reed SM, Hagen J, Tompkins VS, Thies K, Quelle FW, Quelle DE.

Cell Cycle. 2014;13(8):1288-98. doi: 10.4161/cc.28202. Epub 2014 Feb 19.


RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts.

Zhang X, Hagen J, Muniz VP, Smith T, Coombs GS, Eischen CM, Mackie DI, Roman DL, Van Rheeden R, Darbro B, Tompkins VS, Quelle DE.

PLoS One. 2013 Nov 25;8(11):e80228. doi: 10.1371/journal.pone.0080228. eCollection 2013.


RABL6A Promotes Oxaliplatin Resistance in Tumor Cells and Is a New Marker of Survival for Resected Pancreatic Ductal Adenocarcinoma Patients.

Muniz VP, Askeland RW, Zhang X, Reed SM, Tompkins VS, Hagen J, McDowell BD, Button A, Smith BJ, Weydert JA, Mezhir JJ, Quelle DE.

Genes Cancer. 2013 Jul;4(7-8):273-84. doi: 10.1177/1947601913501074.


RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.

Huang J, Stewart A, Maity B, Hagen J, Fagan RL, Yang J, Quelle DE, Brenner C, Fisher RA.

Oncogene. 2014 Jul 3;33(27):3604-11. doi: 10.1038/onc.2013.324. Epub 2013 Sep 2.


The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.

Muniz VP, Barnes JM, Paliwal S, Zhang X, Tang X, Chen S, Zamba KD, Cullen JJ, Meyerholz DK, Meyers S, Davis JN, Grossman SR, Henry MD, Quelle DE.

Mol Cancer Res. 2011 Jul;9(7):867-77. doi: 10.1158/1541-7786.MCR-10-0475. Epub 2011 Jun 2.


Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities.

di Tommaso A, Hagen J, Tompkins V, Muniz V, Dudakovic A, Kitzis A, Ladeveze V, Quelle DE.

Exp Cell Res. 2009 Apr 15;315(7):1326-35. doi: 10.1016/j.yexcr.2009.01.010. Epub 2009 Jan 27.


Generation and characterization of monoclonal antibodies to NIAM: a nuclear interactor of ARF and Mdm2.

Hagen J, Tompkins V, Dudakovic A, Weydert JA, Quelle DE.

Hybridoma (Larchmt). 2008 Jun;27(3):159-66. doi: 10.1089/hyb.2007.0533.


Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells.

Groskreutz DJ, Monick MM, Yarovinsky TO, Powers LS, Quelle DE, Varga SM, Look DC, Hunninghake GW.

J Immunol. 2007 Sep 1;179(5):2741-7.


A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, Ladeveze V, Domann FE, Eischen CM, Quelle DE.

J Biol Chem. 2007 Jan 12;282(2):1322-33. Epub 2006 Nov 16.


Identification of novel ARF binding proteins by two-hybrid screening.

Tompkins V, Hagen J, Zediak VP, Quelle DE.

Cell Cycle. 2006 Mar;5(6):641-6. Epub 2006 Mar 15.


Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.

Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG, Kaiser S, Aronow BJ, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, Quelle DE, Watson MA, Perry A, Gutmann DH, Ratner N.

Cancer Res. 2006 Mar 1;66(5):2584-91.


ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.

Datta A, Sen J, Hagen J, Korgaonkar CK, Caffrey M, Quelle DE, Hughes DE, Ackerson TJ, Costa RH, Raychaudhuri P.

Mol Cell Biol. 2005 Sep;25(18):8024-36.


Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function.

Korgaonkar C, Hagen J, Tompkins V, Frazier AA, Allamargot C, Quelle FW, Quelle DE.

Mol Cell Biol. 2005 Feb;25(4):1258-71.


Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways.

Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE.

Mol Cancer Res. 2003 Jan;1(3):195-206.


The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

Linggi B, Müller-Tidow C, van de Locht L, Hu M, Nip J, Serve H, Berdel WE, van der Reijden B, Quelle DE, Rowley JD, Cleveland J, Jansen JH, Pandolfi PP, Hiebert SW.

Nat Med. 2002 Jul;8(7):743-50. Epub 2002 Jun 24.


ARF function does not require p53 stabilization or Mdm2 relocalization.

Korgaonkar C, Zhao L, Modestou M, Quelle DE.

Mol Cell Biol. 2002 Jan;22(1):196-206.


The alternative reading frame tumor suppressor inhibits growth through p21-dependent and p21-independent pathways.

Modestou M, Puig-Antich V, Korgaonkar C, Eapen A, Quelle DE.

Cancer Res. 2001 Apr 1;61(7):3145-50.


Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ.

Cell. 1997 Nov 28;91(5):649-59.


Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors.

Linardopoulos S, Street AJ, Quelle DE, Parry D, Peters G, Sherr CJ, Balmain A.

Cancer Res. 1995 Nov 15;55(22):5168-72.


Cloning and characterization of murine p16INK4a and p15INK4b genes.

Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ, Serrano M.

Oncogene. 1995 Aug 17;11(4):635-45.


D-type cyclin-dependent kinase activity in mammalian cells.

Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY.

Mol Cell Biol. 1994 Mar;14(3):2066-76.


D-type cyclins and their cyclin-dependent kinases: G1 phase integrators of the mitogenic response.

Sherr CJ, Kato J, Quelle DE, Matsuoka M, Roussel MF.

Cold Spring Harb Symp Quant Biol. 1994;59:11-9. Review. No abstract available.


Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

Quelle DE, Ashmun RA, Shurtleff SA, Kato JY, Bar-Sagi D, Roussel MF, Sherr CJ.

Genes Dev. 1993 Aug;7(8):1559-71.


Phosphorylatable and epitope-tagged human erythropoietins: utility and purification of native baculovirus-derived forms.

Quelle DE, Lynch KJ, Burkert-Smith RE, Weiss S, Whitford W, Wojchowski DM.

Protein Expr Purif. 1992 Dec;3(6):461-9.


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