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Items: 43

1.

Brain macrophages harbor latent, infectious simian immunodeficiency virus.

Abreu C, Shirk EN, Queen SE, Beck SE, Mangus LM, Pate KAM, Mankowski JL, Gama L, Clements JE.

AIDS. 2019 Dec 1;33 Suppl 2:S181-S188. doi: 10.1097/QAD.0000000000002269.

PMID:
31789817
2.

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques.

Abreu CM, Veenhuis RT, Avalos CR, Graham S, Parrilla DR, Ferreira EA, Queen SE, Shirk EN, Bullock BT, Li M, Metcalf Pate KA, Beck SE, Mangus LM, Mankowski JL, Mac Gabhann F, O'Connor SL, Gama L, Clements JE.

mBio. 2019 Aug 20;10(4). pii: e01659-19. doi: 10.1128/mBio.01659-19.

3.

Infectious Virus Persists in CD4+ T Cells and Macrophages in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques.

Abreu CM, Veenhuis RT, Avalos CR, Graham S, Queen SE, Shirk EN, Bullock BT, Li M, Metcalf Pate KA, Beck SE, Mangus LM, Mankowski JL, Clements JE, Gama L.

J Virol. 2019 Jul 17;93(15). pii: e00065-19. doi: 10.1128/JVI.00065-19. Print 2019 Aug 1.

4.

SIV-Induced Immune Activation and Metabolic Alterations in the Dorsal Root Ganglia During Acute Infection.

Mangus LM, Weinberg RL, Knight AC, Queen SE, Adams RJ, Mankowski JL.

J Neuropathol Exp Neurol. 2019 Jan 1;78(1):78-87. doi: 10.1093/jnen/nly111.

5.

A Quantitative Approach to SIV Functional Latency in Brain Macrophages.

Abreu C, Shirk EN, Queen SE, Mankowski JL, Gama L, Clements JE.

J Neuroimmune Pharmacol. 2019 Mar;14(1):23-32. doi: 10.1007/s11481-018-9803-8. Epub 2018 Aug 30. Review.

PMID:
30167896
6.

SIV Latency in Macrophages in the CNS.

Gama L, Abreu C, Shirk EN, Queen SE, Beck SE, Metcalf Pate KA, Bullock BT, Zink MC, Mankowski JL, Clements JE.

Curr Top Microbiol Immunol. 2018;417:111-130. doi: 10.1007/82_2018_89. Review.

7.

Increased Microglial CSF1R Expression in the SIV/Macaque Model of HIV CNS Disease.

Knight AC, Brill SA, Queen SE, Tarwater PM, Mankowski JL.

J Neuropathol Exp Neurol. 2018 Mar 1;77(3):199-206. doi: 10.1093/jnen/nlx115.

8.

Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy.

Mangus LM, Beck SE, Queen SE, Brill SA, Shirk EN, Metcalf Pate KA, Muth DC, Adams RJ, Gama L, Clements JE, Mankowski JL.

Am J Pathol. 2018 Jan;188(1):125-134. doi: 10.1016/j.ajpath.2017.08.035. Epub 2017 Dec 8.

9.

An SIV/macaque model targeted to study HIV-associated neurocognitive disorders.

Beck SE, Queen SE, Metcalf Pate KA, Mangus LM, Abreu CM, Gama L, Witwer KW, Adams RJ, Zink MC, Clements JE, Mankowski JL.

J Neurovirol. 2018 Apr;24(2):204-212. doi: 10.1007/s13365-017-0582-4. Epub 2017 Oct 3. Review.

10.

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir.

Avalos CR, Abreu CM, Queen SE, Li M, Price S, Shirk EN, Engle EL, Forsyth E, Bullock BT, Mac Gabhann F, Wietgrefe SW, Haase AT, Zink MC, Mankowski JL, Clements JE, Gama L.

mBio. 2017 Aug 15;8(4). pii: e01186-17. doi: 10.1128/mBio.01186-17.

11.

Marked Enteropathy in an Accelerated Macaque Model of AIDS.

Croteau JD, Engle EL, Queen SE, Shirk EN, Zink MC.

Am J Pathol. 2017 Mar;187(3):589-604. doi: 10.1016/j.ajpath.2016.10.019. Epub 2017 Jan 3.

12.

Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection.

Williams DW, Engle EL, Shirk EN, Queen SE, Gama L, Mankowski JL, Zink MC, Clements JE.

Am J Pathol. 2016 Aug;186(8):2068-2087. doi: 10.1016/j.ajpath.2016.03.019. Epub 2016 Jun 18.

13.

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques.

Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE.

J Virol. 2016 May 27;90(12):5643-5656. doi: 10.1128/JVI.00290-16. Print 2016 Jun 15.

14.

Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control.

Beck SE, Queen SE, Viscidi R, Johnson D, Kent SJ, Adams RJ, Tarwater PM, Mankowski JL.

J Neurovirol. 2016 Aug;22(4):498-507. doi: 10.1007/s13365-015-0420-5. Epub 2016 Jan 4.

15.

Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy.

Dorsey JL, Mangus LM, Hauer P, Ebenezer GJ, Queen SE, Laast VA, Adams RJ, Mankowski JL.

J Neuropathol Exp Neurol. 2015 Nov;74(11):1053-60. doi: 10.1097/NEN.0000000000000249.

16.

A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads.

Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN.

J Infect Dis. 2015 Nov 1;212(9):1387-96. doi: 10.1093/infdis/jiv230. Epub 2015 Apr 15.

17.

Paving the path to HIV neurotherapy: Predicting SIV CNS disease.

Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL.

Eur J Pharmacol. 2015 Jul 15;759:303-12. doi: 10.1016/j.ejphar.2015.03.018. Epub 2015 Mar 24. Review.

18.

Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques.

Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL.

J Neurovirol. 2015 Apr;21(2):148-58. doi: 10.1007/s13365-015-0313-7. Epub 2015 Feb 12.

PMID:
25672885
19.

Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus-infected macaques.

Mangus LM, Dorsey JL, Laast VA, Hauer P, Queen SE, Adams RJ, McArthur JC, Mankowski JL.

J Neuropathol Exp Neurol. 2015 Jan;74(1):38-47. doi: 10.1097/NEN.0000000000000148.

20.

Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease.

Meulendyke KA, Queen SE, Engle EL, Shirk EN, Liu J, Steiner JP, Nath A, Tarwater PM, Graham DR, Mankowski JL, Zink MC.

J Neurovirol. 2014 Dec;20(6):591-602. doi: 10.1007/s13365-014-0283-1. Epub 2014 Sep 17.

21.

Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage.

Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL.

Am J Pathol. 2014 Jun;184(6):1652-9. doi: 10.1016/j.ajpath.2014.02.009. Epub 2014 May 12.

22.

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.

Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL.

J Am Heart Assoc. 2014 Apr 2;3(2):e000874. doi: 10.1161/JAHA.114.000874.

23.

TGFβ-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection.

Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL.

J Acquir Immune Defic Syndr. 2014 Apr 15;65(5):510-6. doi: 10.1097/QAI.0000000000000048.

24.

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain.

Kelly KM, Beck SE, Metcalf Pate KA, Queen SE, Dorsey JL, Adams RJ, Avery LB, Hubbard W, Tarwater PM, Mankowski JL.

AIDS. 2013 Nov 28;27(18):F21-8. doi: 10.1097/QAD.0000000000000074.

25.

14-3-3 Protein in CSF reflects SIV-mediated pre-synaptic damage.

Helke KL, Queen SE, Mankowski JL.

Curr HIV Res. 2013 Jun;11(4):281-7.

PMID:
24016180
26.

Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques.

Metcalf Pate KA, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL.

J Infect Dis. 2013 Sep;208(6):874-83. doi: 10.1093/infdis/jit278. Epub 2013 Jul 11.

28.

Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection.

Gama L, Shirk EN, Russell JN, Carvalho KI, Li M, Queen SE, Kalil J, Zink MC, Clements JE, Kallas EG.

J Leukoc Biol. 2012 May;91(5):803-16. doi: 10.1189/jlb.1111579. Epub 2012 Feb 24.

29.

Diastolic dysfunction is associated with myocardial viral load in simian immunodeficiency virus-infected macaques.

Kelly KM, Tarwater PM, Karper JM, Bedja D, Queen SE, Tunin RS, Adams RJ, Kass DA, Mankowski JL.

AIDS. 2012 Apr 24;26(7):815-23. doi: 10.1097/QAD.0b013e3283518f01.

PMID:
22301409
30.

Replication-competent simian immunodeficiency virus (SIV) Gag escape mutations archived in latent reservoirs during antiretroviral treatment of SIV-infected macaques.

Queen SE, Mears BM, Kelly KM, Dorsey JL, Liao Z, Dinoso JB, Gama L, Adams RJ, Zink MC, Clements JE, Kent SJ, Mankowski JL.

J Virol. 2011 Sep;85(17):9167-75. doi: 10.1128/JVI.00366-11. Epub 2011 Jun 29.

31.

Initiation of HAART during acute simian immunodeficiency virus infection rapidly controls virus replication in the CNS by enhancing immune activity and preserving protective immune responses.

Graham DR, Gama L, Queen SE, Li M, Brice AK, Kelly KM, Mankowski JL, Clements JE, Zink MC.

J Neurovirol. 2011 Feb;17(1):120-30. doi: 10.1007/s13365-010-0005-2. Epub 2010 Dec 7.

32.

Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA.

Zink MC, Brice AK, Kelly KM, Queen SE, Gama L, Li M, Adams RJ, Bartizal C, Varrone J, Rabi SA, Graham DR, Tarwater PM, Mankowski JL, Clements JE.

J Infect Dis. 2010 Jul 1;202(1):161-70. doi: 10.1086/653213.

33.

HIV and SIV induce alterations in CNS CaMKII expression and activation: a potential mechanism for cognitive impairment.

Gupta RG, Kelly KM, Helke KL, Queen SE, Karper JM, Dorsey JL, Brice AK, Adams RJ, Tarwater PM, Kolson DL, Mankowski JL.

Am J Pathol. 2010 Jun;176(6):2776-84. doi: 10.2353/ajpath.2010.090809. Epub 2010 Apr 9.

34.

Coordinated regulation of SIV replication and immune responses in the CNS.

Witwer KW, Gama L, Li M, Bartizal CM, Queen SE, Varrone JJ, Brice AK, Graham DR, Tarwater PM, Mankowski JL, Zink MC, Clements JE.

PLoS One. 2009 Dec 17;4(12):e8129. doi: 10.1371/journal.pone.0008129.

35.

Natural host genetic resistance to lentiviral CNS disease: a neuroprotective MHC class I allele in SIV-infected macaques.

Mankowski JL, Queen SE, Fernandez CS, Tarwater PM, Karper JM, Adams RJ, Kent SJ.

PLoS One. 2008;3(11):e3603. doi: 10.1371/journal.pone.0003603. Epub 2008 Nov 3.

36.

Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal ganglia.

Laast VA, Pardo CA, Tarwater PM, Queen SE, Reinhart TA, Ghosh M, Adams RJ, Zink MC, Mankowski JL.

J Neuropathol Exp Neurol. 2007 Jan;66(1):26-34.

PMID:
17204934
37.

Platelet decline: an early predictive hematologic marker of simian immunodeficiency virus central nervous system disease.

Wachtman LM, Tarwater PM, Queen SE, Adams RJ, Mankowski JL.

J Neurovirol. 2006 Feb;12(1):25-33.

PMID:
16595371
38.

14-3-3 protein in CSF: an early predictor of SIV CNS disease.

Helke KL, Queen SE, Tarwater PM, Turchan-Cholewo J, Nath A, Zink MC, Irani DN, Mankowski JL.

J Neuropathol Exp Neurol. 2005 Mar;64(3):202-8.

PMID:
15804051
39.

Cerebrospinal fluid markers that predict SIV CNS disease.

Mankowski JL, Queen SE, Clements JE, Zink MC.

J Neuroimmunol. 2004 Dec;157(1-2):66-70.

PMID:
15579282
40.

Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis.

Mankowski JL, Queen SE, Tarwater PJ, Adams RJ, Guilarte TR.

J Neurovirol. 2003 Feb;9(1):94-100.

PMID:
12587072
41.

Accumulation of beta-amyloid precursor protein in axons correlates with CNS expression of SIV gp41.

Mankowski JL, Queen SE, Tarwater PM, Fox KJ, Perry VH.

J Neuropathol Exp Neurol. 2002 Jan;61(1):85-90.

PMID:
11829347
42.

Alterations in blood-brain barrier glucose transport in SIV-infected macaques.

Mankowski JL, Queen SE, Kirstein LM, Spelman JP, Laterra J, Simpson IA, Adams RJ, Clements JE, Zink MC.

J Neurovirol. 1999 Dec;5(6):695-702.

PMID:
10602410
43.

Sleep reduction in night-shift workers: is it sleep deprivation or a sleep disturbance disorder?

Mahan RP, Carvalhais AB, Queen SE.

Percept Mot Skills. 1990 Jun;70(3 Pt 1):723-30.

PMID:
2377404

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