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Items: 1 to 50 of 150

1.

Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering.

Abdallah II, van Merkerk R, Klumpenaar E, Quax WJ.

Sci Rep. 2018 Jul 2;8(1):9961. doi: 10.1038/s41598-018-28177-4.

2.

PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection.

Utari PD, Setroikromo R, Melgert BN, Quax WJ.

Front Cell Infect Microbiol. 2018 Apr 26;8:119. doi: 10.3389/fcimb.2018.00119. eCollection 2018.

3.

Cytotoxic Deoxypodophyllotoxin Can Be Extracted in High Purity from Anthriscus sylvestris Roots by Supercritical Carbon Dioxide.

Seegers CLC, Tepper PG, Setroikromo R, Quax WJ.

Planta Med. 2018 May;84(8):544-550. doi: 10.1055/s-0043-123938. Epub 2017 Dec 18.

PMID:
29253908
4.

Deciphering Physiological Functions of AHL Quorum Quenching Acylases.

Utari PD, Vogel J, Quax WJ.

Front Microbiol. 2017 Jun 19;8:1123. doi: 10.3389/fmicb.2017.01123. eCollection 2017. Review.

5.

Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis.

Wang Y, van Assen AHG, Reis CR, Setroikromo R, van Merkerk R, Boersma YL, Cool RH, Quax WJ.

FEBS J. 2017 Aug;284(15):2501-2512. doi: 10.1111/febs.14142. Epub 2017 Jul 7.

6.

Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells.

Arabpour M, Cool RH, Faber KN, Quax WJ, Haisma HJ.

J Drug Target. 2017 Apr;25(4):360-369. doi: 10.1080/1061186X.2016.1262867. Epub 2016 Dec 28.

PMID:
27885847
7.

Insights into the Three-Dimensional Structure of Amorpha-4,11-diene Synthase and Probing of Plasticity Residues.

Abdallah II, Czepnik M, van Merkerk R, Quax WJ.

J Nat Prod. 2016 Oct 28;79(10):2455-2463. Epub 2016 Sep 27.

PMID:
27673334
8.

Complete Genome Sequence of Bacillus subtilis subsp. subtilis Strain ∆6.

Reuß DR, Thürmer A, Daniel R, Quax WJ, Stülke J.

Genome Announc. 2016 Jul 28;4(4). pii: e00759-16. doi: 10.1128/genomeA.00759-16.

9.

Quantitative antibody-free LC-MS/MS analysis of sTRAIL in sputum and saliva at the sub-ng/mL level.

Wilffert D, Donzelli R, Asselman A, Hermans J, Govorukhina N, Ten Hacken NH, Quax WJ, van de Merbel NC, Bischoff R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:205-210. doi: 10.1016/j.jchromb.2016.04.041. Epub 2016 Apr 26.

PMID:
27250581
10.

Highly sensitive antibody-free μLC-MS/MS quantification of rhTRAIL in serum.

Wilffert D, Asselman A, Donzelli R, Hermans J, Govorukhina N, Quax WJ, van de Merbel NC, Bischoff R.

Bioanalysis. 2016 May;8(9):881-90. doi: 10.4155/bio.16.30. Epub 2016 Apr 13.

PMID:
27072193
11.

Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases.

van der Meer JY, Poddar H, Baas BJ, Miao Y, Rahimi M, Kunzendorf A, van Merkerk R, Tepper PG, Geertsema EM, Thunnissen AM, Quax WJ, Poelarends GJ.

Nat Commun. 2016 Mar 8;7:10911. doi: 10.1038/ncomms10911.

12.

High-Throughput Screening in Protein Engineering: Recent Advances and Future Perspectives.

Wójcik M, Telzerow A, Quax WJ, Boersma YL.

Int J Mol Sci. 2015 Oct 20;16(10):24918-45. doi: 10.3390/ijms161024918. Review.

13.

Metabolic engineering of Bacillus subtilis for terpenoid production.

Guan Z, Xue D, Abdallah II, Dijkshoorn L, Setroikromo R, Lv G, Quax WJ.

Appl Microbiol Biotechnol. 2015 Nov;99(22):9395-406. doi: 10.1007/s00253-015-6950-1. Epub 2015 Sep 15. Review.

14.

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, Correa de Sampaio P, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E.

Oncogene. 2016 Mar 10;35(10):1261-70. doi: 10.1038/onc.2015.180. Epub 2015 Jun 8.

PMID:
26050621
15.

Enhanced C30 carotenoid production in Bacillus subtilis by systematic overexpression of MEP pathway genes.

Xue D, Abdallah II, de Haan IE, Sibbald MJ, Quax WJ.

Appl Microbiol Biotechnol. 2015 Jul;99(14):5907-15. doi: 10.1007/s00253-015-6531-3. Epub 2015 Apr 9.

16.

Engineering Escherichia coli for methanol conversion.

Müller JEN, Meyer F, Litsanov B, Kiefer P, Potthoff E, Heux S, Quax WJ, Wendisch VF, Brautaset T, Portais JC, Vorholt JA.

Metab Eng. 2015 Mar;28:190-201. doi: 10.1016/j.ymben.2014.12.008. Epub 2015 Jan 14.

PMID:
25596507
17.

DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.

Yu R, Albarenque SM, Cool RH, Quax WJ, Mohr A, Zwacka RM.

Cancer Biol Ther. 2014;15(12):1658-66. doi: 10.4161/15384047.2014.972183.

18.

The TAK1-NF-κB axis as therapeutic target for AML.

Bosman MC, Schepers H, Jaques J, Brouwers-Vos AZ, Quax WJ, Schuringa JJ, Vellenga E.

Blood. 2014 Nov 13;124(20):3130-40. doi: 10.1182/blood-2014-04-569780. Epub 2014 Oct 6.

19.

Two death-inducing human TRAIL receptors to target in cancer: similar or distinct regulation and function?

van Roosmalen IA, Quax WJ, Kruyt FA.

Biochem Pharmacol. 2014 Oct 15;91(4):447-56. doi: 10.1016/j.bcp.2014.08.010. Epub 2014 Aug 20. Review.

PMID:
25150214
20.

Deinococcus radiodurans can interfere with quorum sensing by producing an AHL-acylase and an AHL-lactonase.

Koch G, Nadal-Jimenez P, Cool RH, Quax WJ.

FEMS Microbiol Lett. 2014 Jul;356(1):62-70. doi: 10.1111/1574-6968.12479. Epub 2014 Jun 26.

21.

Assessing Pseudomonas virulence with nonmammalian host: Galleria mellonella.

Koch G, Nadal-Jimenez P, Cool RH, Quax WJ.

Methods Mol Biol. 2014;1149:681-8. doi: 10.1007/978-1-4939-0473-0_52.

PMID:
24818942
22.

PvdP is a tyrosinase that drives maturation of the pyoverdine chromophore in Pseudomonas aeruginosa.

Nadal-Jimenez P, Koch G, Reis CR, Muntendam R, Raj H, Jeronimus-Stratingh CM, Cool RH, Quax WJ.

J Bacteriol. 2014 Jul;196(14):2681-90. doi: 10.1128/JB.01376-13. Epub 2014 May 9.

23.

Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ.

Koch G, Nadal-Jimenez P, Reis CR, Muntendam R, Bokhove M, Melillo E, Dijkstra BW, Cool RH, Quax WJ.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1568-73. doi: 10.1073/pnas.1311263111. Epub 2014 Jan 13.

24.

Crystal structures of two Bacillus carboxylesterases with different enantioselectivities.

Rozeboom HJ, Godinho LF, Nardini M, Quax WJ, Dijkstra BW.

Biochim Biophys Acta. 2014 Mar;1844(3):567-75. doi: 10.1016/j.bbapap.2014.01.003. Epub 2014 Jan 11.

25.

Erratum to: the ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma.

van Roosmalen IA, Reis CR, Setroikromo R, Yuvaraj S, Joseph JV, Tepper PG, Kruyt FA, Quax WJ.

Springerplus. 2014 Dec 15;3:738. doi: 10.1186/2193-1801-3-738. eCollection 2014.

26.

The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma.

van Roosmalen IAM, Reis CR, Setroikromo R, Yuvaraj S, Joseph JV, Tepper PG, Kruyt FAE, Quax WJ.

Springerplus. 2014 Sep 1;3:495. doi: 10.1186/2193-1801-3-495. eCollection 2014. Erratum in: Springerplus. 2014;3:738.

27.
28.

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL.

Meijer A, Kruyt FA, van der Zee AG, Hollema H, Le P, ten Hoor KA, Groothuis GM, Quax WJ, de Vries EG, de Jong S.

Br J Cancer. 2013 Nov 12;109(10):2685-95. doi: 10.1038/bjc.2013.636. Epub 2013 Oct 17.

29.

Antibody-free LC-MS/MS quantification of rhTRAIL in human and mouse serum.

Wilffert D, Reis CR, Hermans J, Govorukhina N, Tomar T, de Jong S, Quax WJ, van de Merbel NC, Bischoff R.

Anal Chem. 2013 Nov 19;85(22):10754-60. doi: 10.1021/ac4017902. Epub 2013 Nov 1.

PMID:
24125577
30.

Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.

Papaioannou E, Utari PD, Quax WJ.

Int J Mol Sci. 2013 Sep 23;14(9):19309-40. doi: 10.3390/ijms140919309. Review.

31.

Kinetic resolution and stereoselective synthesis of 3-substituted aspartic acids by using engineered methylaspartate ammonia lyases.

Raj H, Szymanski W, de Villiers J, Puthan Veetil V, Quax WJ, Shimamoto K, Janssen DB, Feringa BL, Poelarends GJ.

Chemistry. 2013 Aug 19;19(34):11148-52. doi: 10.1002/chem.201301832. Epub 2013 Jul 12.

PMID:
23852946
32.

Caenorhabditis elegans reveals novel Pseudomonas aeruginosa virulence mechanism.

Utari PD, Quax WJ.

Trends Microbiol. 2013 Jul;21(7):315-6. doi: 10.1016/j.tim.2013.04.006. Epub 2013 May 14.

PMID:
23684150
33.

Bortezomib sensitivity of acute myeloid leukemia CD34(+) cells can be enhanced by targeting the persisting activity of NF-κB and the accumulation of MCL-1.

Bosman MC, Schuringa JJ, Quax WJ, Vellenga E.

Exp Hematol. 2013 Jun;41(6):530-538.e1. doi: 10.1016/j.exphem.2013.02.002. Epub 2013 Feb 13.

PMID:
23416210
34.

Production of α-cuprenene in Xanthophyllomyces dendrorhous: a step closer to a potent terpene biofactory.

Melillo E, Setroikromo R, Quax WJ, Kayser O.

Microb Cell Fact. 2013 Feb 5;12:13. doi: 10.1186/1475-2859-12-13.

35.

Development of a dry, stable and inhalable acyl-homoserine-lactone-acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections.

Wahjudi M, Murugappan S, van Merkerk R, Eissens AC, Visser MR, Hinrichs WL, Quax WJ.

Eur J Pharm Sci. 2013 Mar 12;48(4-5):637-43. doi: 10.1016/j.ejps.2012.12.015. Epub 2012 Dec 28.

PMID:
23277289
36.

An unexpected promiscuous activity of 4-oxalocrotonate tautomerase: the cis-trans isomerisation of nitrostyrene.

Zandvoort E, Geertsema EM, Baas BJ, Quax WJ, Poelarends GJ.

Chembiochem. 2012 Sep 3;13(13):1869-73. doi: 10.1002/cbic.201200371. Epub 2012 Jul 31.

PMID:
22851288
37.

Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells.

Azijli K, Yuvaraj S, Peppelenbosch MP, Würdinger T, Dekker H, Joore J, van Dijk E, Quax WJ, Peters GJ, de Jong S, Kruyt FA.

J Cell Sci. 2012 Oct 1;125(Pt 19):4651-61. doi: 10.1242/jcs.109587. Epub 2012 Jul 13.

38.

Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous.

Melillo E, Muntendam R, Quax WJ, Kayser O.

J Biotechnol. 2012 Oct 31;161(3):302-7. doi: 10.1016/j.jbiotec.2012.05.024. Epub 2012 Jul 4.

PMID:
22771888
39.

In vitro regeneration of wild chervil (Anthriscus sylvestris L.).

Hendrawati O, Hille J, Woerdenbag HJ, Quax WJ, Kayser O.

In Vitro Cell Dev Biol Plant. 2012 Jun;48(3):355-361. Epub 2011 Oct 25.

40.

Enhancement of the promiscuous aldolase and dehydration activities of 4-oxalocrotonate tautomerase by protein engineering.

Zandvoort E, Geertsema EM, Quax WJ, Poelarends GJ.

Chembiochem. 2012 Jun 18;13(9):1274-7. doi: 10.1002/cbic.201200225. Epub 2012 May 21.

PMID:
22615135
41.

Dehalogenation of an anthropogenic compound by an engineered variant of the mouse cytokine macrophage migration inhibitory factor.

Wasiel AA, Baas BJ, Zandvoort E, Quax WJ, Poelarends GJ.

Chembiochem. 2012 Jun 18;13(9):1270-3. doi: 10.1002/cbic.201200153. Epub 2012 May 21.

PMID:
22615048
42.

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids.

Raj H, Szymański W, de Villiers J, Rozeboom HJ, Veetil VP, Reis CR, de Villiers M, Dekker FJ, de Wildeman S, Quax WJ, Thunnissen AM, Feringa BL, Janssen DB, Poelarends GJ.

Nat Chem. 2012 Apr 29;4(6):478-84. doi: 10.1038/nchem.1338.

PMID:
22614383
43.

The multiple signaling systems regulating virulence in Pseudomonas aeruginosa.

Jimenez PN, Koch G, Thompson JA, Xavier KB, Cool RH, Quax WJ.

Microbiol Mol Biol Rev. 2012 Mar;76(1):46-65. doi: 10.1128/MMBR.05007-11. Review.

44.

Lipase A gene transcription in Pseudomonas alcaligenes is under control of RNA polymerase σ54 and response regulator LipR.

Krzeslak J, Papaioannou E, van Merkerk R, Paal KA, Bischoff R, Cool RH, Quax WJ.

FEMS Microbiol Lett. 2012 Apr;329(2):146-53. doi: 10.1111/j.1574-6968.2012.02516.x. Epub 2012 Feb 24.

45.

Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis.

Godinho LF, Reis CR, Rozeboom HJ, Dekker FJ, Dijkstra BW, Poelarends GJ, Quax WJ.

J Biotechnol. 2012 Mar 31;158(1-2):36-43. doi: 10.1016/j.jbiotec.2011.12.026. Epub 2012 Jan 12.

PMID:
22248594
46.

Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL.

Szegezdi E, van der Sloot AM, Mahalingam D, O'Leary L, Cool RH, Muñoz IG, Montoya G, Quax WJ, de Jong S, Samali A, Serrano L.

Mol Cell Proteomics. 2012 Mar;11(3):M111.013730. doi: 10.1074/mcp.M111.013730. Epub 2012 Jan 2.

47.

Bridging between organocatalysis and biocatalysis: asymmetric addition of acetaldehyde to β-nitrostyrenes catalyzed by a promiscuous proline-based tautomerase.

Zandvoort E, Geertsema EM, Baas BJ, Quax WJ, Poelarends GJ.

Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1240-3. doi: 10.1002/anie.201107404. Epub 2011 Dec 21. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6035.

PMID:
22190406
48.

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans.

Raj H, Puthan Veetil V, Szymanski W, Dekker FJ, Quax WJ, Feringa BL, Janssen DB, Poelarends GJ.

Appl Microbiol Biotechnol. 2012 Apr;94(2):385-97. doi: 10.1007/s00253-011-3615-6. Epub 2011 Oct 18.

49.

Functional analysis of the sortase YhcS in Bacillus subtilis.

Fasehee H, Westers H, Bolhuis A, Antelmann H, Hecker M, Quax WJ, Mirlohi AF, van Dijl JM, Ahmadian G.

Proteomics. 2011 Oct;11(19):3905-13. doi: 10.1002/pmic.201100174. Epub 2011 Aug 31.

PMID:
21800427
50.

Discovery of an Escherichia coli esterase with high activity and enantioselectivity toward 1,2-O-isopropylideneglycerol esters.

Godinho LF, Reis CR, Tepper PG, Poelarends GJ, Quax WJ.

Appl Environ Microbiol. 2011 Sep;77(17):6094-9. doi: 10.1128/AEM.05122-11. Epub 2011 Jul 15.

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