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Mutational landscape differences between young-onset and older-onset breast cancer patients.

Mealey NE, O'Sullivan DE, Pader J, Ruan Y, Wang E, Quan ML, Brenner DR.

BMC Cancer. 2020 Mar 12;20(1):212. doi: 10.1186/s12885-020-6684-z.


The incidence of breast cancer in Canada 1971-2015: trends in screening-eligible and young-onset age groups.

Heer E, Ruan Y, Mealey N, Quan ML, Brenner DR.

Can J Public Health. 2020 Mar 6. doi: 10.17269/s41997-020-00305-6. [Epub ahead of print]


Breast Biopsy During Post-treatment Surveillance of Screen-Detected Breast Cancer Patients Yields High Rates of Benign Findings.

Laws A, Xu Y, Kong S, Brisson AM, Bouchard-Fortier A, Quan ML.

Ann Surg Oncol. 2020 Feb 25. doi: 10.1245/s10434-020-08259-2. [Epub ahead of print]


Neoadjuvant radiotherapy followed by surgery compared with surgery alone in the treatment of retroperitoneal sarcoma: a population-based comparison.

Turner BT, Hampton L, Schiller D, Mack LA, Robertson-More C, Li H, Quan ML, Bouchard-Fortier A.

Curr Oncol. 2019 Dec;26(6):e766-e772. doi: 10.3747/co.26.5185. Epub 2019 Dec 1.


Evaluating A Multidisciplinary Cancer Conference Checklist: Practice Versus Perceptions.

Corter AL, Speller B, McBain K, Wright FC, Quan ML, Kennedy E, Schmocker S, Baxter NN; RUBY Cohort Investigators.

J Multidiscip Healthc. 2019 Nov 1;12:883-891. doi: 10.2147/JMDH.S219854. eCollection 2019.


Effect of a Knowledge-Translation Intervention on Breast Surgeons' Oncofertility Attitudes and Practices.

Warner E, Yee S, Seminsky M, Glass K, Foong S, Kennedy E, Narod S, Quan ML.

Ann Surg Oncol. 2019 Oct 28. doi: 10.1245/s10434-019-07972-x. [Epub ahead of print]


Recommendations to improve patient-centred care for ductal carcinoma in situ: Qualitative focus groups with women.

Nyhof BB, Wright FC, Look Hong NJ, Groot G, Helyer L, Meiers P, Quan ML, Baxter NN, Urquhart R, Warburton R, Gagliardi AR.

Health Expect. 2020 Feb;23(1):106-114. doi: 10.1111/hex.12973. Epub 2019 Sep 18.


Squamous Cell Carcinoma with Regional Metastasis to Axilla or Groin Lymph Nodes: a Multicenter Outcome Analysis.

Pang G, Look Hong NJ, Paull G, Dobransky J, Kupper S, Hurton S, Kagedan DJ, Quan ML, Helyer L, Nessim C, Wright FC.

Ann Surg Oncol. 2019 Dec;26(13):4642-4650. doi: 10.1245/s10434-019-07743-8. Epub 2019 Aug 22.


Same-Day Surgery for Mastectomy Patients in Alberta: A Perioperative Care Pathway and Quality Improvement Initiative.

Keehn AR, Olson DW, Dort JC, Parker S, Anderes S, Headley L, Elwi A, Estey A, Crocker A, Laws A, Quan ML.

Ann Surg Oncol. 2019 Oct;26(10):3354-3360. doi: 10.1245/s10434-019-07568-5. Epub 2019 Jul 24.


Improving Wait Times and Patient Experience Through Implementation of a Provincial Expedited Diagnostic Pathway for BI-RADS 5 Breast Lesions.

Laws A, Crocker A, Dort J, Olson D, Elwi A, Anderes S, Parker S, Estey A, Keehn A, Quan ML.

Ann Surg Oncol. 2019 Oct;26(10):3361-3367. doi: 10.1245/s10434-019-07558-7. Epub 2019 Jul 24.


Generalisability of Common Oncology Clinical Trial Eligibility Criteria in the Real World.

Karim S, Xu Y, Kong S, Abdel-Rahman O, Quan ML, Cheung WY.

Clin Oncol (R Coll Radiol). 2019 Sep;31(9):e160-e166. doi: 10.1016/j.clon.2019.05.003. Epub 2019 May 25.


Chronic Postoperative Opioid Use: A Systematic Review.

Hinther A, Abdel-Rahman O, Cheung WY, Quan ML, Dort JC.

World J Surg. 2019 Sep;43(9):2164-2174. doi: 10.1007/s00268-019-05016-9. Epub 2019 May 9.


Development and validation of case-finding algorithms for recurrence of breast cancer using routinely collected administrative data.

Xu Y, Kong S, Cheung WY, Bouchard-Fortier A, Dort JC, Quan H, Buie EM, McKinnon G, Quan ML.

BMC Cancer. 2019 Mar 8;19(1):210. doi: 10.1186/s12885-019-5432-8.


Taking the pulse of multidisciplinary cancer conferences for breast cancer care in Canada: A stocktake of current practice.

Corter AL, Speller B, Wright FC, Quan ML, Baxter NN.

Breast. 2019 Apr;44:101-107. doi: 10.1016/j.breast.2019.01.007. Epub 2019 Jan 25.


Developing case-finding algorithms for second events of oropharyngeal cancer using administrative data: A population-based validation study.

Xu Y, Kong S, Cheung WY, Quan ML, Nakoneshny SC, Dort JC.

Head Neck. 2019 Jul;41(7):2291-2298. doi: 10.1002/hed.25682. Epub 2019 Feb 1.


Impact of Baseline Cardiovascular Comorbidity on Outcomes in Women With Breast Cancer: A Real-world, Population-based Study.

Abdel-Rahman O, Xu Y, Kong S, Dort J, Quan ML, Karim S, Bouchard-Fortier A, Cho H, Cheung WY.

Clin Breast Cancer. 2019 Apr;19(2):e297-e305. doi: 10.1016/j.clbc.2018.12.005. Epub 2018 Dec 12.


National consensus recommendations on patient-centered care for ductal carcinoma in situ.

Gagliardi AR, Wright FC, Look Hong NJ, Groot G, Helyer L, Meiers P, Quan ML, Urquhart R, Warburton R.

Breast Cancer Res Treat. 2019 Apr;174(3):561-570. doi: 10.1007/s10549-019-05132-z. Epub 2019 Jan 9. Review.


Contralateral prophylactic mastectomy in young women with breast cancer: a population-based analysis of predictive factors and clinical impact.

Bouchard-Fortier A, Baxter NN, Sutradhar R, Fernandes K, Camacho X, Graham P, Quan ML.

Curr Oncol. 2018 Dec;25(6):e562-e568. doi: 10.3747/co.25.4169. Epub 2018 Dec 1.


Scoping clinicians' perspectives on pre-treatment multidisciplinary care for young women with breast cancer.

Corter AL, Quan ML, Wright FL, Kennedy ED, Simunovic MR, Shao J, Baxter NN.

J Multidiscip Healthc. 2018 Oct 9;11:547-555. doi: 10.2147/JMDH.S173735. eCollection 2018.


Does intra-operative margin assessment improve margin status and re-excision rates? A population-based analysis of outcomes in breast-conserving surgery for ductal carcinoma in situ.

Laws A, Brar MS, Bouchard-Fortier A, Leong B, Quan ML.

J Surg Oncol. 2018 Dec;118(7):1205-1211. doi: 10.1002/jso.25248. Epub 2018 Oct 7.


Surgical management of benign phyllodes tumours of the breast: Is wide local excision really necessary?

Qian Y, Quan ML, Ogilvi T, Bouchard-Fortier A.

Can J Surg. 2018 Dec 1;61(6):17617. doi: 10.1503/cjs.017617.


'Driving' Rates Down: A Population-Based Study of Opening New Radiation Therapy Centers on the Use of Mastectomy for Breast Cancer.

Xu Y, Bouchard-Fortier A, Olivotto IA, Cheung WY, Kong S, Kornelsen E, Laws A, Dixon E, Dort JC, Craighead PS, Quan ML.

Ann Surg Oncol. 2018 Oct;25(10):2994-3003. doi: 10.1245/s10434-018-6619-y. Epub 2018 Jul 3.


Factor XIa Inhibitors as New Anticoagulants.

Quan ML, Pinto DJP, Smallheer JM, Ewing WR, Rossi KA, Luettgen JM, Seiffert DA, Wexler RR.

J Med Chem. 2018 Sep 13;61(17):7425-7447. doi: 10.1021/acs.jmedchem.8b00173. Epub 2018 May 18. Review.


Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.

Hu Z, Wang C, Han W, Rossi KA, Bozarth JM, Wu Y, Sheriff S, Myers JE Jr, Luettgen JM, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):987-992. doi: 10.1016/j.bmcl.2018.02.049. Epub 2018 Feb 27.


Patient and provider experiences with active surveillance: A scoping review.

Kim C, Wright FC, Look Hong NJ, Groot G, Helyer L, Meiers P, Quan ML, Urquhart R, Warburton R, Gagliardi AR.

PLoS One. 2018 Feb 5;13(2):e0192097. doi: 10.1371/journal.pone.0192097. eCollection 2018. Review.


Interventions are needed to support patient-provider decision-making for DCIS: a scoping review.

Kim C, Liang L, Wright FC, Hong NJL, Groot G, Helyer L, Meiers P, Quan ML, Urquhart R, Warburton R, Gagliardi AR.

Breast Cancer Res Treat. 2018 Apr;168(3):579-592. doi: 10.1007/s10549-017-4613-x. Epub 2017 Dec 23. Review.


Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).

Pinto DJP, Orwat MJ, Smith LM 2nd, Quan ML, Lam PYS, Rossi KA, Apedo A, Bozarth JM, Wu Y, Zheng JJ, Xin B, Toussaint N, Stetsko P, Gudmundsson O, Maxwell B, Crain EJ, Wong PC, Lou Z, Harper TW, Chacko SA, Myers JE Jr, Sheriff S, Zhang H, Hou X, Mathur A, Seiffert DA, Wexler RR, Luettgen JM, Ewing WR.

J Med Chem. 2017 Dec 14;60(23):9703-9723. doi: 10.1021/acs.jmedchem.7b01171. Epub 2017 Nov 17.


Macrocyclic factor XIa inhibitors.

Wang C, Corte JR, Rossi KA, Bozarth JM, Wu Y, Sheriff S, Myers JE Jr, Luettgen JM, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem Lett. 2017 Sep 1;27(17):4056-4060. doi: 10.1016/j.bmcl.2017.07.048. Epub 2017 Jul 25.


Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.

Corte JR, Yang W, Fang T, Wang Y, Osuna H, Lai A, Ewing WR, Rossi KA, Myers JE Jr, Sheriff S, Lou Z, Zheng JJ, Harper TW, Bozarth JM, Wu Y, Luettgen JM, Seiffert DA, Quan ML, Wexler RR, Lam PYS.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3833-3839. doi: 10.1016/j.bmcl.2017.06.058. Epub 2017 Jun 23.


Indications for Contralateral Prophylactic Mastectomy: A Consensus Statement Using Modified Delphi Methodology.

Wright FC, Look Hong NJ, Quan ML, Beyfuss K, Temple S, Covelli A, Baxter N, Gagliardi AR.

Ann Surg. 2018 Feb;267(2):271-279. doi: 10.1097/SLA.0000000000002309.


Evaluating wait times from screening to breast cancer diagnosis among women undergoing organised assessment vs usual care.

Chiarelli AM, Muradali D, Blackmore KM, Smith CR, Mirea L, Majpruz V, O'Malley FP, Quan ML, Holloway CM.

Br J Cancer. 2017 May 9;116(10):1254-1263. doi: 10.1038/bjc.2017.87. Epub 2017 Mar 30.


Association of Hormone Receptor Expression with Survival in Ovarian Endometrioid Carcinoma: Biological Validation and Clinical Implications.

Rambau P, Kelemen LE, Steed H, Quan ML, Ghatage P, Köbel M.

Int J Mol Sci. 2017 Feb 27;18(3). pii: E515. doi: 10.3390/ijms18030515.


Why Some Mastectomy Patients Opt to Undergo Delayed Breast Reconstruction: Results of a Long-Term Prospective Study.

Metcalfe KA, Semple J, Quan ML, Holloway C, Wright F, Narod S, Hofer S, Bagher S, Zhong T.

Plast Reconstr Surg. 2017 Feb;139(2):267-275. doi: 10.1097/PRS.0000000000002943.


Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.

Corte JR, Fang T, Osuna H, Pinto DJ, Rossi KA, Myers JE Jr, Sheriff S, Lou Z, Zheng JJ, Harper TW, Bozarth JM, Wu Y, Luettgen JM, Seiffert DA, Decicco CP, Wexler RR, Quan ML.

J Med Chem. 2017 Feb 9;60(3):1060-1075. doi: 10.1021/acs.jmedchem.6b01460. Epub 2017 Jan 31.


The effect of surgery type on survival and recurrence in very young women with breast cancer.

Quan ML, Paszat LF, Fernandes KA, Sutradhar R, McCready DR, Rakovitch E, Warner E, Wright FC, Hodgson N, Brackstone M, Baxter NN.

J Surg Oncol. 2017 Feb;115(2):122-130. doi: 10.1002/jso.24489. Epub 2017 Jan 5.


Effect of Multidisciplinary Case Conferences on Physician Decision Making: Breast Diagnostic Rounds.

Foster TJ, Bouchard-Fortier A, Olivotto IA, Quan ML.

Cureus. 2016 Nov 24;8(11):e895. doi: 10.7759/cureus.895.


Attitudes and beliefs about the surgical safety checklist: Just another tick box?

Dharampal N, Cameron C, Dixon E, Ghali W, Quan ML.

Can J Surg. 2016 Aug;59(4):268-75.


Oncofertility Knowledge, Attitudes, and Practices of Canadian Breast Surgeons.

Warner E, Yee S, Kennedy E, Glass K, Foong S, Seminsky M, Quan ML.

Ann Surg Oncol. 2016 Nov;23(12):3850-3859. Epub 2016 Jul 18.


Intraoperative Margin Assessment in Wire-Localized Breast-Conserving Surgery for Invasive Cancer: A Population-Level Comparison of Techniques.

Laws A, Brar MS, Bouchard-Fortier A, Leong B, Quan ML.

Ann Surg Oncol. 2016 Oct;23(10):3290-6. doi: 10.1245/s10434-016-5401-2. Epub 2016 Jul 12.


Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.

Corte JR, Fang T, Pinto DJ, Orwat MJ, Rendina AR, Luettgen JM, Rossi KA, Wei A, Ramamurthy V, Myers JE Jr, Sheriff S, Narayanan R, Harper TW, Zheng JJ, Li YX, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem. 2016 May 15;24(10):2257-72. doi: 10.1016/j.bmc.2016.03.062. Epub 2016 Apr 1.


Breast cancer survival among young women: a review of the role of modifiable lifestyle factors.

Brenner DR, Brockton NT, Kotsopoulos J, Cotterchio M, Boucher BA, Courneya KS, Knight JA, Olivotto IA, Quan ML, Friedenreich CM.

Cancer Causes Control. 2016 Apr;27(4):459-72. doi: 10.1007/s10552-016-0726-5. Epub 2016 Mar 12. Review.


Novel phenylalanine derived diamides as Factor XIa inhibitors.

Smith LM 2nd, Orwat MJ, Hu Z, Han W, Wang C, Rossi KA, Gilligan PJ, Pabbisetty KB, Osuna H, Corte JR, Rendina AR, Luettgen JM, Wong PC, Narayanan R, Harper TW, Bozarth JM, Crain EJ, Wei A, Ramamurthy V, Morin PE, Xin B, Zheng J, Seiffert DA, Quan ML, Lam PYS, Wexler RR, Pinto DJP.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):472-478. doi: 10.1016/j.bmcl.2015.11.089. Epub 2015 Nov 26.


A population-based assessment of melanoma: Does treatment in a regional cancer center make a difference?

Rivard J, Kostaras X, Shea-Budgell M, Chin-Lenn L, Quan ML, McKinnon JG.

J Surg Oncol. 2015 Aug;112(2):173-8. doi: 10.1002/jso.23981.


In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.

Wong PC, Quan ML, Watson CA, Crain EJ, Harpel MR, Rendina AR, Luettgen JM, Wexler RR, Schumacher WA, Seiffert DA.

J Thromb Thrombolysis. 2015 Nov;40(4):416-23. doi: 10.1007/s11239-015-1258-7.


Neoadjuvant Chemotherapy for Breast Cancer, Is Practice Changing? A Population-Based Review of Current Surgical Trends.

Graham PJ, Brar MS, Foster T, McCall M, Bouchard-Fortier A, Temple W, Quan ML.

Ann Surg Oncol. 2015 Oct;22(10):3376-82. doi: 10.1245/s10434-015-4714-x. Epub 2015 Jul 23.


Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety.

Hu Z, Wong PC, Gilligan PJ, Han W, Pabbisetty KB, Bozarth JM, Crain EJ, Harper T, Luettgen JM, Myers JE Jr, Ramamurthy V, Rossi KA, Sheriff S, Watson CA, Wei A, Zheng JJ, Seiffert DA, Wexler RR, Quan ML.

ACS Med Chem Lett. 2015 Apr 8;6(5):590-5. doi: 10.1021/acsmedchemlett.5b00066. eCollection 2015 May 14.


Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.

Pinto DJ, Smallheer JM, Corte JR, Austin EJ, Wang C, Fang T, Smith LM 2nd, Rossi KA, Rendina AR, Bozarth JM, Zhang G, Wei A, Ramamurthy V, Sheriff S, Myers JE Jr, Morin PE, Luettgen JM, Seiffert DA, Quan ML, Wexler RR.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1635-42. doi: 10.1016/j.bmcl.2015.01.028. Epub 2015 Feb 4.


Pyridine and pyridinone-based factor XIa inhibitors.

Corte JR, Fang T, Hangeland JJ, Friends TJ, Rendina AR, Luettgen JM, Bozarth JM, Barbera FA, Rossi KA, Wei A, Ramamurthy V, Morin PE, Seiffert DA, Wexler RR, Quan ML.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):925-30. doi: 10.1016/j.bmcl.2014.12.050. Epub 2014 Dec 31.


A prospective study of mastectomy patients with and without delayed breast reconstruction: long-term psychosocial functioning in the breast cancer survivorship period.

Metcalfe KA, Zhong T, Narod SA, Quan ML, Holloway C, Hofer S, Bagher S, Semple J.

J Surg Oncol. 2015 Mar;111(3):258-64. doi: 10.1002/jso.23829. Epub 2014 Dec 29.


Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.

Hangeland JJ, Friends TJ, Rossi KA, Smallheer JM, Wang C, Sun Z, Corte JR, Fang T, Wong PC, Rendina AR, Barbera FA, Bozarth JM, Luettgen JM, Watson CA, Zhang G, Wei A, Ramamurthy V, Morin PE, Bisacchi GS, Subramaniam S, Arunachalam P, Mathur A, Seiffert DA, Wexler RR, Quan ML.

J Med Chem. 2014 Dec 11;57(23):9915-32. doi: 10.1021/jm5010607. Epub 2014 Dec 2.


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