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Items: 26


l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo.

Lange SM, McKell MC, Schmidt SM, Zhao J, Crowther RR, Green LC, Bricker RL, Arnett E, Köhler SE, Schlesinger LS, Setchell KDR, Qualls JE.

J Immunol. 2019 Mar 15;202(6):1747-1754. doi: 10.4049/jimmunol.1801569. Epub 2019 Feb 1.


l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung.

Lange SM, McKell MC, Schmidt SM, Hossfeld AP, Chaturvedi V, Kinder JM, McAlees JW, Lewkowich IP, Way SS, Turner J, Qualls JE.

Front Immunol. 2017 Nov 16;8:1561. doi: 10.3389/fimmu.2017.01561. eCollection 2017.


CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.

Bertaux-Skeirik N, Wunderlich M, Teal E, Chakrabarti J, Biesiada J, Mahe M, Sundaram N, Gabre J, Hawkins J, Jian G, Engevik AC, Yang L, Wang J, Goldenring JR, Qualls JE, Medvedovic M, Helmrath MA, Diwan T, Mulloy JC, Zavros Y.

J Pathol. 2017 Aug;242(4):463-475. doi: 10.1002/path.4918.


T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.

Van de Velde LA, Subramanian C, Smith AM, Barron L, Qualls JE, Neale G, Alfonso-Pecchio A, Jackowski S, Rock CO, Wynn TA, Murray PJ.

J Biol Chem. 2017 Jan 6;292(1):15-30. doi: 10.1074/jbc.M116.766238. Epub 2016 Nov 30.


T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.

Marigo I, Zilio S, Desantis G, Mlecnik B, Agnellini AH, Ugel S, Sasso MS, Qualls JE, Kratochvill F, Zanovello P, Molon B, Ries CH, Runza V, Hoves S, Bilocq AM, Bindea G, Mazza EM, Bicciato S, Galon J, Murray PJ, Bronte V.

Cancer Cell. 2016 Oct 10;30(4):651. doi: 10.1016/j.ccell.2016.09.009. No abstract available.


T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.

Marigo I, Zilio S, Desantis G, Mlecnik B, Agnellini AHR, Ugel S, Sasso MS, Qualls JE, Kratochvill F, Zanovello P, Molon B, Ries CH, Runza V, Hoves S, Bilocq AM, Bindea G, Mazza EMC, Bicciato S, Galon J, Murray PJ, Bronte V.

Cancer Cell. 2016 Sep 12;30(3):377-390. doi: 10.1016/j.ccell.2016.08.004. Erratum in: Cancer Cell. 2016 Oct 10;30(4):651.


Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration.

Qualls JE, Murray PJ.

Semin Immunopathol. 2016 Mar;38(2):139-52. doi: 10.1007/s00281-015-0534-0. Epub 2015 Oct 21. Review.


TNF Counterbalances the Emergence of M2 Tumor Macrophages.

Kratochvill F, Neale G, Haverkamp JM, Van de Velde LA, Smith AM, Kawauchi D, McEvoy J, Roussel MF, Dyer MA, Qualls JE, Murray PJ.

Cell Rep. 2015 Sep 22;12(11):1902-14. doi: 10.1016/j.celrep.2015.08.033. Epub 2015 Sep 10.


Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity.

Rapovy SM, Zhao J, Bricker RL, Schmidt SM, Setchell KD, Qualls JE.

J Immunol. 2015 Oct 1;195(7):3293-300. doi: 10.4049/jimmunol.1500800. Epub 2015 Aug 26.


Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.

Kratochvill F, Gratz N, Qualls JE, Van De Velde LA, Chi H, Kovarik P, Murray PJ.

Cancer Res. 2015 Aug 1;75(15):3054-64. doi: 10.1158/0008-5472.CAN-15-0205. Epub 2015 Jul 16.


Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

Haverkamp JM, Smith AM, Weinlich R, Dillon CP, Qualls JE, Neale G, Koss B, Kim Y, Bronte V, Herold MJ, Green DR, Opferman JT, Murray PJ.

Immunity. 2014 Dec 18;41(6):947-59. doi: 10.1016/j.immuni.2014.10.020. Epub 2014 Dec 11.


Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.

Duque-Correa MA, Kühl AA, Rodriguez PC, Zedler U, Schommer-Leitner S, Rao M, Weiner J 3rd, Hurwitz R, Qualls JE, Kosmiadi GA, Murray PJ, Kaufmann SH, Reece ST.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4024-32. doi: 10.1073/pnas.1408839111. Epub 2014 Sep 8.


Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection.

Elahi S, Ertelt JM, Kinder JM, Jiang TT, Zhang X, Xin L, Chaturvedi V, Strong BS, Qualls JE, Steinbrecher KA, Kalfa TA, Shaaban AF, Way SS.

Nature. 2013 Dec 5;504(7478):158-62. doi: 10.1038/nature12675. Epub 2013 Nov 6.


Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

Barron L, Smith AM, El Kasmi KC, Qualls JE, Huang X, Cheever A, Borthwick LA, Wilson MS, Murray PJ, Wynn TA.

PLoS One. 2013 Apr 24;8(4):e61961. doi: 10.1371/journal.pone.0061961. Print 2013.


Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.

Qualls JE, Subramanian C, Rafi W, Smith AM, Balouzian L, DeFreitas AA, Shirey KA, Reutterer B, Kernbauer E, Stockinger S, Decker T, Miyairi I, Vogel SN, Salgame P, Rock CO, Murray PJ.

Cell Host Microbe. 2012 Sep 13;12(3):313-23. doi: 10.1016/j.chom.2012.07.012.


A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.

Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ.

J Biol Chem. 2011 Jul 1;286(26):23582-90. doi: 10.1074/jbc.M111.249235. Epub 2011 May 12.


Tumor macrophages protective and pathogenic roles in cancer development.

Qualls JE, Murray PJ.

Curr Top Dev Biol. 2011;94:309-28. doi: 10.1016/B978-0-12-380916-2.00010-3. Review.


Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling.

Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ.

Sci Signal. 2010 Aug 17;3(135):ra62. doi: 10.1126/scisignal.2000955.


A double agent in cancer: stopping macrophages wounds tumors.

Qualls JE, Murray PJ.

Nat Med. 2010 Aug;16(8):863-4. doi: 10.1038/nm0810-863. No abstract available.


IL-10 inhibits miR-155 induction by toll-like receptors.

McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA.

J Biol Chem. 2010 Jul 2;285(27):20492-8. doi: 10.1074/jbc.M110.102111. Epub 2010 Apr 30.


Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.

El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, König T, Schleicher U, Koo MS, Kaplan G, Fitzgerald KA, Tuomanen EI, Orme IM, Kanneganti TD, Bogdan C, Wynn TA, Murray PJ.

Nat Immunol. 2008 Dec;9(12):1399-406. doi: 10.1038/ni.1671. Epub 2008 Nov 2.


Suppression of experimental colitis in mice by CD11c+ dendritic cells.

Qualls JE, Tuna H, Kaplan AM, Cohen DA.

Inflamm Bowel Dis. 2009 Feb;15(2):236-47. doi: 10.1002/ibd.20733.


Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2.

Moreira LO, Smith AM, DeFreitas AA, Qualls JE, El Kasmi KC, Murray PJ.

Vaccine. 2008 Oct 29;26(46):5808-13. doi: 10.1016/j.vaccine.2008.08.038. Epub 2008 Sep 27.


CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells.

Dasu T, Qualls JE, Tuna H, Raman C, Cohen DA, Bondada S.

Immunol Lett. 2008 Aug 15;119(1-2):103-13. doi: 10.1016/j.imlet.2008.05.008. Epub 2008 Jun 23.


Suppression of experimental colitis by intestinal mononuclear phagocytes.

Qualls JE, Kaplan AM, van Rooijen N, Cohen DA.

J Leukoc Biol. 2006 Oct;80(4):802-15. Epub 2006 Aug 3.


Host-guest scale of left-handed polyproline II helix formation.

Rucker AL, Pager CT, Campbell MN, Qualls JE, Creamer TP.

Proteins. 2003 Oct 1;53(1):68-75.


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