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Items: 1 to 50 of 58

1.

Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma.

Lackner C, Quagliata L, Cross W, Ribi S, Heinimann K, Paradiso V, Quintavalle C, Kovacova M, Baumhoer D, Piscuoglio S, Terracciano L, Kovac M.

Sci Rep. 2019 Mar 14;9(1):4611. doi: 10.1038/s41598-019-40843-9.

2.

Cetuximab monotherapy and cetuximab plus capecitabine as first-line treatment in older patients with RAS- and BRAF wild-type metastatic colorectal cancer. Results of the multicenter phase II trial SAKK 41/10.

Kienle DL, Dietrich D, Ribi K, Wicki A, Quagliata L, Winterhalder RC, Koeberle D, Horber D, Bastian S, Kueng M, Saletti P, Helbling D, Baertschi D, Lugli A, Bernhard J, Andrieu C, von Moos R.

J Geriatr Oncol. 2019 Mar;10(2):304-310. doi: 10.1016/j.jgo.2018.11.011. Epub 2018 Dec 14.

PMID:
30559073
3.

A scalable solution for tumor mutational burden from formalin-fixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load Assay.

Chaudhary R, Quagliata L, Martin JP, Alborelli I, Cyanam D, Mittal V, Tom W, Au-Young J, Sadis S, Hyland F.

Transl Lung Cancer Res. 2018 Dec;7(6):616-630. doi: 10.21037/tlcr.2018.08.01.

4.

SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics.

Singer F, Irmisch A, Toussaint NC, Grob L, Singer J, Thurnherr T, Beerenwinkel N, Levesque MP, Dummer R, Quagliata L, Rothschild SI, Wicki A, Beisel C, Stekhoven DJ.

BMC Med Inform Decis Mak. 2018 Oct 29;18(1):89. doi: 10.1186/s12911-018-0680-0.

5.

Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening.

Paradiso V, Garofoli A, Tosti N, Lanzafame M, Perrina V, Quagliata L, Matter MS, Wieland S, Heim MH, Piscuoglio S, Ng CKY, Terracciano LM.

J Mol Diagn. 2018 Nov;20(6):836-848. doi: 10.1016/j.jmoldx.2018.07.003. Epub 2018 Aug 22.

PMID:
30142445
6.

Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations.

Castro-Giner F, Gkountela S, Donato C, Alborelli I, Quagliata L, Ng CKY, Piscuoglio S, Aceto N.

Diagnostics (Basel). 2018 May 9;8(2). pii: E31. doi: 10.3390/diagnostics8020031. Review.

7.

The protein histidine phosphatase LHPP is a tumour suppressor.

Hindupur SK, Colombi M, Fuhs SR, Matter MS, Guri Y, Adam K, Cornu M, Piscuoglio S, Ng CKY, Betz C, Liko D, Quagliata L, Moes S, Jenoe P, Terracciano LM, Heim MH, Hunter T, Hall MN.

Nature. 2018 Mar 29;555(7698):678-682. doi: 10.1038/nature26140. Epub 2018 Mar 21.

8.

Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study.

Ng CKY, Di Costanzo GG, Tosti N, Paradiso V, Coto-Llerena M, Roscigno G, Perrina V, Quintavalle C, Boldanova T, Wieland S, Marino-Marsilia G, Lanzafame M, Quagliata L, Condorelli G, Matter MS, Tortora R, Heim MH, Terracciano LM, Piscuoglio S.

Ann Oncol. 2018 May 1;29(5):1286-1291. doi: 10.1093/annonc/mdy083.

PMID:
29509837
9.

Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma.

Kancherla V, Abdullazade S, Matter MS, Lanzafame M, Quagliata L, Roma G, Hoshida Y, Terracciano LM, Ng CKY, Piscuoglio S.

Front Genet. 2018 Feb 2;9:2. doi: 10.3389/fgene.2018.00002. eCollection 2018.

10.

TGFβ counteracts LYVE-1-mediated induction of lymphangiogenesis by small hyaluronan oligosaccharides.

Bauer J, Rothley M, Schmaus A, Quagliata L, Ehret M, Biskup M, Orian-Rousseau V, Jackson DG, Pettis RJ, Harvey A, Bräse S, Thiele W, Sleeman JP.

J Mol Med (Berl). 2018 Feb;96(2):199-209. doi: 10.1007/s00109-017-1615-4. Epub 2017 Dec 27.

PMID:
29282520
11.

Donor-derived, metastatic urothelial cancer after kidney transplantation associated with a potentially oncogenic BK polyomavirus.

Müller DC, Rämö M, Naegele K, Ribi S, Wetterauer C, Perrina V, Quagliata L, Vlajnic T, Ruiz C, Balitzki B, Grobholz R, Gosert R, Ajuh ET, Hirsch HH, Bubendorf L, Rentsch CA.

J Pathol. 2018 Mar;244(3):265-270. doi: 10.1002/path.5012. Epub 2018 Feb 1.

PMID:
29205775
12.

Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.

Quintavalle C, Hindupur SK, Quagliata L, Pallante P, Nigro C, Condorelli G, Andersen JB, Tagscherer KE, Roth W, Beguinot F, Heim MH, Ng CKY, Piscuoglio S, Matter MS.

Cell Death Dis. 2017 Oct 26;8(10):e3138. doi: 10.1038/cddis.2017.512.

13.

High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models.

Quagliata L, Quintavalle C, Lanzafame M, Matter MS, Novello C, di Tommaso L, Pressiani T, Rimassa L, Tornillo L, Roncalli M, Cillo C, Pallante P, Piscuoglio S, Ng CK, Terracciano LM.

Lab Invest. 2018 Jan;98(1):95-105. doi: 10.1038/labinvest.2017.107. Epub 2017 Oct 16.

14.

Ex-vivo assessment of drug response on breast cancer primary tissue with preserved microenvironments.

Muraro MG, Muenst S, Mele V, Quagliata L, Iezzi G, Tzankov A, Weber WP, Spagnoli GC, Soysal SD.

Oncoimmunology. 2017 May 30;6(7):e1331798. doi: 10.1080/2162402X.2017.1331798. eCollection 2017.

15.

High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy.

Quintavalle C, Burmeister K, Piscuoglio S, Quagliata L, Karamitopoulou E, Sepe R, Fusco A, Terracciano LM, Andersen JB, Pallante P, Matter MS.

Mol Carcinog. 2017 Sep;56(9):2146-2157. doi: 10.1002/mc.22671. Epub 2017 May 17.

PMID:
28467612
16.

Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes.

Burmeister K, Quagliata L, Andreozzi M, Eppenberger-Castori S, Matter MS, Perrina V, Grobholz R, Jochum W, Horber D, Moosmann P, Lehmann F, Köberle D, Ng CK, Piscuoglio S, Tornillo L, Terracciano LM.

PLoS One. 2017 Apr 12;12(4):e0175563. doi: 10.1371/journal.pone.0175563. eCollection 2017.

17.

Down-regulation of hepatocyte nuclear factor-4α and defective zonation in livers expressing mutant Z α1-antitrypsin.

Piccolo P, Annunziata P, Soria LR, Attanasio S, Barbato A, Castello R, Carissimo A, Quagliata L, Terracciano LM, Brunetti-Pierri N.

Hepatology. 2017 Jul;66(1):124-135. doi: 10.1002/hep.29160. Epub 2017 May 27.

PMID:
28295475
18.

Liver damage and senescence increases in patients developing hepatocellular carcinoma.

Rey S, Quintavalle C, Burmeister K, Calabrese D, Schlageter M, Quagliata L, Cathomas G, Diebold J, Molinolo A, Heim MH, Terracciano LM, Matter MS.

J Gastroenterol Hepatol. 2017 Aug;32(8):1480-1486. doi: 10.1111/jgh.13717.

PMID:
28052383
19.

Syrosingopine sensitizes cancer cells to killing by metformin.

Benjamin D, Colombi M, Hindupur SK, Betz C, Lane HA, El-Shemerly MY, Lu M, Quagliata L, Terracciano L, Moes S, Sharpe T, Wodnar-Filipowicz A, Moroni C, Hall MN.

Sci Adv. 2016 Dec 23;2(12):e1601756. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec.

20.

HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models.

Andreozzi M, Quintavalle C, Benz D, Quagliata L, Matter M, Calabrese D, Tosti N, Ruiz C, Trapani F, Tornillo L, Fusco A, Heim MH, Ng CK, Pallante P, Terracciano LM, Piscuoglio S.

Neoplasia. 2016 Dec;18(12):724-731. doi: 10.1016/j.neo.2016.10.002. Epub 2016 Nov 14.

21.

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.

Carotenuto P, Fassan M, Pandolfo R, Lampis A, Vicentini C, Cascione L, Paulus-Hock V, Boulter L, Guest R, Quagliata L, Hahne JC, Ridgway R, Jamieson T, Athineos D, Veronese A, Visone R, Murgia C, Ferrari G, Guzzardo V, Evans TRJ, MacLeod M, Feng GJ, Dale T, Negrini M, Forbes SJ, Terracciano L, Scarpa A, Patel T, Valeri N, Workman P, Sansom O, Braconi C.

Gut. 2017 Jul;66(7):1268-1277. doi: 10.1136/gutjnl-2016-312278. Epub 2016 Sep 12.

22.

Gene expression analysis of biopsy samples reveals critical limitations of transcriptome-based molecular classifications of hepatocellular carcinoma.

Makowska Z, Boldanova T, Adametz D, Quagliata L, Vogt JE, Dill MT, Matter MS, Roth V, Terracciano L, Heim MH.

J Pathol Clin Res. 2016 Feb 5;2(2):80-92. doi: 10.1002/cjp2.37. eCollection 2016 Apr.

23.

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T.

Hepatology. 2016 Oct;64(4):1217-31. doi: 10.1002/hep.28723. Epub 2016 Aug 11.

PMID:
27396433
24.

Promoter-Associated RNAs Regulate HSPC152 Gene Expression in Malignant Melanoma.

Bonen H, Kol N, Shomron N, Leibowitz-Amit R, Quagliata L, Lorber T, Sidi Y, Avni D.

Noncoding RNA. 2016 Jun 30;2(3). pii: E7. doi: 10.3390/ncrna2030007.

25.

Clinicopathological Features and Metastatic Pattern of Hepatocellular Carcinoma: An Autopsy Study of 398 Patients.

Schlageter M, Quagliata L, Matter M, Perrina V, Tornillo L, Terracciano L.

Pathobiology. 2016;83(6):301-7. doi: 10.1159/000446245. Epub 2016 Jun 18.

26.

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis.

Kowalik MA, Guzzo G, Morandi A, Perra A, Menegon S, Masgras I, Trevisan E, Angioni MM, Fornari F, Quagliata L, Ledda-Columbano GM, Gramantieri L, Terracciano L, Giordano S, Chiarugi P, Rasola A, Columbano A.

Oncotarget. 2016 May 31;7(22):32375-93. doi: 10.18632/oncotarget.8632.

27.

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.

Matter MS, Marquardt JU, Andersen JB, Quintavalle C, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata L, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwalder M, Factor VM, Thorgeirsson SS.

Hepatology. 2016 Jun;63(6):1888-99. doi: 10.1002/hep.28487. Epub 2016 Mar 15.

28.

Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression.

Crea F, Quagliata L, Michael A, Liu HH, Frumento P, Azad AA, Xue H, Pikor L, Watahiki A, Morant R, Eppenberger-Castori S, Wang Y, Parolia A, Lennox KA, Lam WL, Gleave M, Chi KN, Pandha H, Wang Y, Helgason CD.

Mol Oncol. 2016 May;10(5):693-703. doi: 10.1016/j.molonc.2015.12.010. Epub 2015 Dec 22.

29.

Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.

Dazert E, Colombi M, Boldanova T, Moes S, Adametz D, Quagliata L, Roth V, Terracciano L, Heim MH, Jenoe P, Hall MN.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1381-6. doi: 10.1073/pnas.1523434113. Epub 2016 Jan 19.

30.

The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival.

Mattu S, Fornari F, Quagliata L, Perra A, Angioni MM, Petrelli A, Menegon S, Morandi A, Chiarugi P, Ledda-Columbano GM, Gramantieri L, Terracciano L, Giordano S, Columbano A.

J Hepatol. 2016 Apr;64(4):891-8. doi: 10.1016/j.jhep.2015.11.029. Epub 2015 Nov 30.

PMID:
26658681
31.

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention.

Witzigmann D, Quagliata L, Schenk SH, Quintavalle C, Terracciano LM, Huwyler J.

Hepatol Res. 2016 Jun;46(7):686-96. doi: 10.1111/hepr.12599. Epub 2015 Oct 29.

PMID:
26422581
32.

A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer.

Seibert JK, Quagliata L, Quintavalle C, Hammond TG, Terracciano L, Odermatt A.

Cancer Med. 2015 Nov;4(11):1717-29. doi: 10.1002/cam4.517. Epub 2015 Aug 26.

33.

HMGA1 overexpression is associated with a particular subset of human breast carcinomas.

Sepe R, Piscuoglio S, Quintavalle C, Perrina V, Quagliata L, Formisano U, Terracciano LM, Fusco A, Pallante P.

J Clin Pathol. 2016 Feb;69(2):117-21. doi: 10.1136/jclinpath-2015-202907. Epub 2015 Aug 6.

PMID:
26251519
34.

Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α).

Svensson K, Schnyder S, Albert V, Cardel B, Quagliata L, Terracciano LM, Handschin C.

J Biol Chem. 2015 Jun 26;290(26):16059-76. doi: 10.1074/jbc.M114.590653. Epub 2015 May 18.

35.

Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis.

Zavattari P, Perra A, Menegon S, Kowalik MA, Petrelli A, Angioni MM, Follenzi A, Quagliata L, Ledda-Columbano GM, Terracciano L, Giordano S, Columbano A.

Hepatology. 2015 Sep;62(3):851-62. doi: 10.1002/hep.27790. Epub 2015 Apr 22.

PMID:
25783764
36.

Liver Diseases and Long Non-Coding RNAs: New Insight and Perspective.

Quagliata L, Terracciano LM.

Front Med (Lausanne). 2014 Oct 17;1:35. doi: 10.3389/fmed.2014.00035. eCollection 2014. Review.

37.

Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation.

Hefetz-Sela S, Stein I, Klieger Y, Porat R, Sade-Feldman M, Zreik F, Nagler A, Pappo O, Quagliata L, Dazert E, Eferl R, Terracciano L, Wagner EF, Ben-Neriah Y, Baniyash M, Pikarsky E.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17582-7. doi: 10.1073/pnas.1409700111. Epub 2014 Nov 24.

38.

Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model.

Rothweiler S, Dill MT, Terracciano L, Makowska Z, Quagliata L, Hlushchuk R, Djonov V, Heim MH, Semela D.

Lab Invest. 2015 Mar;95(3):351-62. doi: 10.1038/labinvest.2014.141. Epub 2014 Nov 24.

39.

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.

Cornu M, Oppliger W, Albert V, Robitaille AM, Trapani F, Quagliata L, Fuhrer T, Sauer U, Terracciano L, Hall MN.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11592-9. doi: 10.1073/pnas.1412047111. Epub 2014 Jul 31.

40.

Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences.

Arabi L, Gsponer JR, Smida J, Nathrath M, Perrina V, Jundt G, Ruiz C, Quagliata L, Baumhoer D.

Genes Cancer. 2014 Apr;5(1-2):56-63.

41.

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.

Lepore M, Kalinichenko A, Colone A, Paleja B, Singhal A, Tschumi A, Lee B, Poidinger M, Zolezzi F, Quagliata L, Sander P, Newell E, Bertoletti A, Terracciano L, De Libero G, Mori L.

Nat Commun. 2014 May 15;5:3866. doi: 10.1038/ncomms4866. Erratum in: Nat Commun. 2014;5:4493. Kalinicenko, Artem [corrected to Kalinichenko, Artem].

PMID:
24832684
42.

Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.

Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E.

Cancer Discov. 2014 Jun;4(6):730-43. doi: 10.1158/2159-8290.CD-13-0782. Epub 2014 Mar 31.

43.

Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer.

Crea F, Watahiki A, Quagliata L, Xue H, Pikor L, Parolia A, Wang Y, Lin D, Lam WL, Farrar WL, Isogai T, Morant R, Castori-Eppenberger S, Chi KN, Wang Y, Helgason CD.

Oncotarget. 2014 Feb 15;5(3):764-74.

44.

A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.

Hansen MT, Forst B, Cremers N, Quagliata L, Ambartsumian N, Grum-Schwensen B, Klingelhöfer J, Abdul-Al A, Herrmann P, Osterland M, Stein U, Nielsen GH, Scherer PE, Lukanidin E, Sleeman JP, Grigorian M.

Oncogene. 2015 Jan 22;34(4):424-35. doi: 10.1038/onc.2013.568. Epub 2014 Jan 27.

PMID:
24469032
45.

Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model.

Quagliata L, Klusmeier S, Cremers N, Pytowski B, Harvey A, Pettis RJ, Thiele W, Sleeman JP.

Clin Exp Metastasis. 2014 Mar;31(3):351-65. doi: 10.1007/s10585-013-9633-2. Epub 2013 Dec 31.

PMID:
24379135
46.

Identification of New Players in Hepatocarcinogenesis: Limits and Opportunities of Using Tissue Microarray (TMA).

Quagliata L, Schlageter M, Quintavalle C, Tornillo L, Terracciano LM.

Microarrays (Basel). 2014 Apr 15;3(2):91-102. doi: 10.3390/microarrays3020091. Review.

47.

SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules.

Quagliata L, Andreozzi M, Kovac M, Tornillo L, Makowska Z, Moretti F, Heim MH, Heinimann K, Piscuoglio S, Terracciano LM.

Eur J Cancer. 2014 Mar;50(4):731-8. doi: 10.1016/j.ejca.2013.11.018. Epub 2013 Dec 3.

PMID:
24315626
48.

Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.

Quagliata L, Matter MS, Piscuoglio S, Arabi L, Ruiz C, Procino A, Kovac M, Moretti F, Makowska Z, Boldanova T, Andersen JB, Hämmerle M, Tornillo L, Heim MH, Diederichs S, Cillo C, Terracciano LM.

Hepatology. 2014 Mar;59(3):911-23. doi: 10.1002/hep.26740. Epub 2014 Jan 28.

49.

VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities.

Andreozzi M, Quagliata L, Gsponer JR, Ruiz C, Vuaroqueaux V, Eppenberger-Castori S, Tornillo L, Terracciano LM.

Angiogenesis. 2014 Jul;17(3):519-27. doi: 10.1007/s10456-013-9396-z. Epub 2013 Oct 11.

PMID:
24114200
50.

Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats.

Thiele W, Rothley M, Teller N, Jung N, Bulat B, Plaumann D, Vanderheiden S, Schmaus A, Cremers N, Göppert B, Dimmler A, Eschbach V, Quagliata L, Thaler S, Marko D, Bräse S, Sleeman JP.

Carcinogenesis. 2013 Dec;34(12):2804-13. doi: 10.1093/carcin/bgt291. Epub 2013 Aug 23.

PMID:
23975834

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