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Items: 1 to 50 of 141

1.

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function.

Hurcombe JA, Lay AC, Ni L, Barrington AF, Woodgett JR, Quaggin SE, Welsh GI, Coward RJ.

FASEB Bioadv. 2019 Aug;1(8):498-510. doi: 10.1096/fba.2019-00011. Epub 2019 Jul 1.

PMID:
31825015
2.

Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.

Thomson BR, Carota IA, Souma T, Soman S, Vestweber D, Quaggin SE.

Elife. 2019 Oct 17;8. pii: e48474. doi: 10.7554/eLife.48474.

3.

Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Cinà DP, Ketela T, Brown KR, Chandrashekhar M, Mero P, Li C, Onay T, Fu Y, Han Z, Saleem M, Moffat J, Quaggin SE.

Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1593-F1604. doi: 10.1152/ajprenal.00195.2019. Epub 2019 Sep 30.

PMID:
31566424
4.

Genetic Deletion of Emp2 Does Not Cause Proteinuric Kidney Disease in Mice.

Donnan MD, Scott RP, Onay T, Tarjus A, Onay UV, Quaggin SE.

Front Med (Lausanne). 2019 Aug 27;6:189. doi: 10.3389/fmed.2019.00189. eCollection 2019.

5.

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium.

Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M.

J Exp Med. 2019 Aug 5;216(8):1874-1890. doi: 10.1084/jem.20182151. Epub 2019 Jun 13.

PMID:
31196980
6.

Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system.

Zhang Y, Guo H, Kim SB, Wu Y, Ostojich D, Park SH, Wang X, Weng Z, Li R, Bandodkar AJ, Sekine Y, Choi J, Xu S, Quaggin S, Ghaffari R, Rogers JA.

Lab Chip. 2019 Apr 23;19(9):1545-1555. doi: 10.1039/c9lc00103d.

PMID:
30912557
7.

Targeting VE-PTP phosphatase protects the kidney from diabetic injury.

Carota IA, Kenig-Kozlovsky Y, Onay T, Scott R, Thomson BR, Souma T, Bartlett CS, Li Y, Procissi D, Ramirez V, Yamaguchi S, Tarjus A, Tanna CE, Li C, Eremina V, Vestweber D, Oladipupo SS, Breyer MD, Quaggin SE.

J Exp Med. 2019 Apr 1;216(4):936-949. doi: 10.1084/jem.20180009. Epub 2019 Mar 18.

8.

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Hurcombe JA, Hartley P, Lay AC, Ni L, Bedford JJ, Leader JP, Singh S, Murphy A, Scudamore CL, Marquez E, Barrington AF, Pinto V, Marchetti M, Wong LF, Uney J, Saleem MA, Mathieson PW, Patel S, Walker RJ, Woodgett JR, Quaggin SE, Welsh GI, Coward RJM.

Nat Commun. 2019 Jan 24;10(1):403. doi: 10.1038/s41467-018-08235-1.

9.

Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development.

Ide S, Finer G, Maezawa Y, Onay T, Souma T, Scott R, Ide K, Akimoto Y, Li C, Ye M, Zhao X, Baba Y, Minamizuka T, Jin J, Takemoto M, Yokote K, Quaggin SE.

J Am Soc Nephrol. 2018 Dec;29(12):2795-2808. doi: 10.1681/ASN.2017121278. Epub 2018 Oct 30.

10.

Morphological Analysis of Schlemm's Canal in Mice.

Thomson BR, Quaggin SE.

Methods Mol Biol. 2018;1846:153-160. doi: 10.1007/978-1-4939-8712-2_10.

11.

Selective permeability of mouse blood-aqueous barrier as determined by 15N-heavy isotope tracing and mass spectrometry.

Liu P, Thomson BR, Khalatyan N, Feng L, Liu X, Savas JN, Quaggin SE, Jin J.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9032-9037. doi: 10.1073/pnas.1807982115. Epub 2018 Aug 20.

12.

Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation.

Liu P, Wysocki J, Souma T, Ye M, Ramirez V, Zhou B, Wilsbacher LD, Quaggin SE, Batlle D, Jin J.

Kidney Int. 2018 Jul;94(1):114-125. doi: 10.1016/j.kint.2018.01.029. Epub 2018 Apr 22.

PMID:
29691064
13.

Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures.

Kuppe C, Rohlfs W, Grepl M, Schulte K, Veron D, Elger M, Sanden SK, Saritas T, Andrae J, Betsholtz C, Trautwein C, Hausmann R, Quaggin S, Bachmann S, Kriz W, Tufro A, Floege J, Moeller MJ.

Nephrol Dial Transplant. 2018 Sep 1;33(9):1514-1525. doi: 10.1093/ndt/gfy057.

14.

Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.

Jampol LM, Glassman AR, Liu D, Aiello LP, Bressler NM, Duh EJ, Quaggin S, Wells JA, Wykoff CC; Diabetic Retinopathy Clinical Research Network.

Ophthalmology. 2018 Jul;125(7):1054-1063. doi: 10.1016/j.ophtha.2018.01.019. Epub 2018 Mar 7.

15.

Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility.

Laursen SB, Finsen S, Marcussen N, Quaggin SE, Hansen PBL, Dimke H.

PLoS One. 2018 Feb 21;13(2):e0193032. doi: 10.1371/journal.pone.0193032. eCollection 2018.

16.

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling.

Farber G, Hurtado R, Loh S, Monette S, Mtui J, Kopan R, Quaggin S, Meyer-Schwesinger C, Herzlinger D, Scott RP, Blobel CP.

Angiogenesis. 2018 May;21(2):335-347. doi: 10.1007/s10456-018-9599-4. Epub 2018 Feb 3.

17.

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.

Souma T, Thomson BR, Heinen S, Carota IA, Yamaguchi S, Onay T, Liu P, Ghosh AK, Li C, Eremina V, Hong YK, Economides AN, Vestweber D, Peters KG, Jin J, Quaggin SE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1298-1303. doi: 10.1073/pnas.1714446115. Epub 2018 Jan 22.

18.

Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor.

Daly C, Qian X, Castanaro C, Pasnikowski E, Jiang X, Thomson BR, Quaggin SE, Papadopoulos N, Wei Y, Rudge JS, Thurston G, Yancopoulos GD, Davis S.

Sci Rep. 2018 Jan 11;8(1):505. doi: 10.1038/s41598-017-18912-8.

19.

Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice.

Loganathan K, Salem Said E, Winterrowd E, Orebrand M, He L, Vanlandewijck M, Betsholtz C, Quaggin SE, Jeansson M.

PLoS One. 2018 Jan 2;13(1):e0189433. doi: 10.1371/journal.pone.0189433. eCollection 2018.

20.

Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels.

Kenig-Kozlovsky Y, Scott RP, Onay T, Carota IA, Thomson BR, Gil HJ, Ramirez V, Yamaguchi S, Tanna CE, Heinen S, Wu C, Stan RV, Klein JD, Sands JM, Oliver G, Quaggin SE.

J Am Soc Nephrol. 2018 Apr;29(4):1097-1107. doi: 10.1681/ASN.2017090962. Epub 2017 Dec 13.

21.

Angiopoietin-1 is required for Schlemm's canal development in mice and humans.

Thomson BR, Souma T, Tompson SW, Onay T, Kizhatil K, Siggs OM, Feng L, Whisenhunt KN, Yanovitch TL, Kalaydjieva L, Azmanov DN, Finzi S, Tanna CE, Hewitt AW, Mackey DA, Bradfield YS, Souzeau E, Javadiyan S, Wiggs JL, Pasutto F, Liu X, John SW, Craig JE, Jin J, Young TL, Quaggin SE.

J Clin Invest. 2017 Dec 1;127(12):4421-4436. doi: 10.1172/JCI95545. Epub 2017 Nov 6.

22.

Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model.

Xu Q, Junttila S, Scherer A, Giri KR, Kivelä O, Skovorodkin I, Röning J, Quaggin SE, Marti HP, Shan J, Samoylenko A, Vainio SJ.

Dis Model Mech. 2017 Dec 19;10(12):1503-1515. doi: 10.1242/dmm.028332.

23.

ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies.

Martin CE, Petersen KA, Aoudjit L, Tilak M, Eremina V, Hardy WR, Quaggin SE, Takano T, Jones N.

J Am Soc Nephrol. 2018 Jan;29(1):92-103. doi: 10.1681/ASN.2017030285. Epub 2017 Oct 10.

24.

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis.

Rai R, Verma SK, Kim D, Ramirez V, Lux E, Li C, Sahoo S, Wilsbacher LD, Vaughan DE, Quaggin SE, Ghosh AK.

Epigenetics. 2017;12(11):1004-1013. doi: 10.1080/15592294.2017.1370173. Epub 2017 Dec 6.

25.

Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis.

Kong KH, Oh HJ, Lim BJ, Kim M, Han KH, Choi YH, Kwon K, Nam BY, Park KS, Park JT, Han SH, Yoo TH, Lee S, Kim SJ, Kang DH, Choi KB, Eremina V, Quaggin SE, Ryu DR, Kang SW.

Sci Rep. 2017 Sep 12;7(1):11351. doi: 10.1038/s41598-017-11829-2.

26.

Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1.

Bartlett CS, Scott RP, Carota IA, Wnuk ML, Kanwar YS, Miner JH, Quaggin SE.

Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1232-F1242. doi: 10.1152/ajprenal.00311.2017. Epub 2017 Aug 23.

27.

Angiopoietin-1 deficiency increases tumor metastasis in mice.

Michael IP, Orebrand M, Lima M, Pereira B, Volpert O, Quaggin SE, Jeansson M.

BMC Cancer. 2017 Aug 11;17(1):539. doi: 10.1186/s12885-017-3531-y.

28.

SuPAR and FSGS: is the jury still out?

Gallon L, Quaggin SE.

Nat Rev Nephrol. 2017 Sep;13(9):593. doi: 10.1038/nrneph.2017.109. Epub 2017 Jul 31. No abstract available.

PMID:
28757636
29.

Glomerular disease: A suPAR kidney connection found in the bone marrow.

Gallon L, Quaggin SE.

Nat Rev Nephrol. 2017 May;13(5):263-264. doi: 10.1038/nrneph.2017.29. Epub 2017 Mar 13. No abstract available.

30.

Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI.

Dutta RK, Kondeti VK, Sharma I, Chandel NS, Quaggin SE, Kanwar YS.

J Am Soc Nephrol. 2017 May;28(5):1421-1436. doi: 10.1681/ASN.2016070744. Epub 2016 Nov 28.

31.

A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes.

Kindt F, Hammer E, Kemnitz S, Blumenthal A, Klemm P, Schlüter R, Quaggin SE, van den Brandt J, Fuellen G, Völker U, Endlich K, Endlich N.

Br J Pharmacol. 2017 Jan;174(2):163-176. doi: 10.1111/bph.13667. Epub 2016 Dec 20.

32.

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.

33.

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.

Souma T, Tompson SW, Thomson BR, Siggs OM, Kizhatil K, Yamaguchi S, Feng L, Limviphuvadh V, Whisenhunt KN, Maurer-Stroh S, Yanovitch TL, Kalaydjieva L, Azmanov DN, Finzi S, Mauri L, Javadiyan S, Souzeau E, Zhou T, Hewitt AW, Kloss B, Burdon KP, Mackey DA, Allen KF, Ruddle JB, Lim SH, Rozen S, Tran-Viet KN, Liu X, John S, Wiggs JL, Pasutto F, Craig JE, Jin J, Quaggin SE, Young TL.

J Clin Invest. 2016 Jul 1;126(7):2575-87. doi: 10.1172/JCI85830. Epub 2016 Jun 6.

34.

CD146(+) cells are essential for kidney vasculature development.

Halt KJ, Pärssinen HE, Junttila SM, Saarela U, Sims-Lucas S, Koivunen P, Myllyharju J, Quaggin S, Skovorodkin IN, Vainio SJ.

Kidney Int. 2016 Aug;90(2):311-324. doi: 10.1016/j.kint.2016.02.021. Epub 2016 Apr 18.

35.

Vascular Growth Factors and Glomerular Disease.

Bartlett CS, Jeansson M, Quaggin SE.

Annu Rev Physiol. 2016;78:437-61. doi: 10.1146/annurev-physiol-021115-105412. Review.

36.

Nephrin Tyrosine Phosphorylation Is Required to Stabilize and Restore Podocyte Foot Process Architecture.

New LA, Martin CE, Scott RP, Platt MJ, Keyvani Chahi A, Stringer CD, Lu P, Samborska B, Eremina V, Takano T, Simpson JA, Quaggin SE, Jones N.

J Am Soc Nephrol. 2016 Aug;27(8):2422-35. doi: 10.1681/ASN.2015091048. Epub 2016 Jan 22.

37.

Kindling the Kidney.

Quaggin SE.

N Engl J Med. 2016 Jan 21;374(3):281-3. doi: 10.1056/NEJMcibr1514351.

38.

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy.

Jha JC, Thallas-Bonke V, Banal C, Gray SP, Chow BS, Ramm G, Quaggin SE, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

Diabetologia. 2016 Feb;59(2):379-89. doi: 10.1007/s00125-015-3796-0. Epub 2015 Oct 28.

39.

Therapies on the Horizon for Diabetic Kidney Disease.

Khan SS, Quaggin SE.

Curr Diab Rep. 2015 Dec;15(12):111. doi: 10.1007/s11892-015-0685-3. Review.

40.

ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization.

Daniel E, Onwukwe GU, Wierenga RK, Quaggin SE, Vainio SJ, Krause M.

BMC Bioinformatics. 2015 Sep 21;16:303. doi: 10.1186/s12859-015-0743-5.

41.

Review series: The cell biology of renal filtration.

Scott RP, Quaggin SE.

J Cell Biol. 2015 Apr 27;209(2):199-210. doi: 10.1083/jcb.201410017. Review.

42.

Crosstalk in glomerular injury and repair.

Dimke H, Maezawa Y, Quaggin SE.

Curr Opin Nephrol Hypertens. 2015 May;24(3):231-8. doi: 10.1097/MNH.0000000000000117. Review.

43.

Signaling during Kidney Development.

Krause M, Rak-Raszewska A, Pietilä I, Quaggin SE, Vainio S.

Cells. 2015 Apr 10;4(2):112-32. doi: 10.3390/cells4020112. Review.

44.

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy.

Shah A, Xia L, Masson EA, Gui C, Momen A, Shikatani EA, Husain M, Quaggin S, John R, Fantus IG.

J Am Soc Nephrol. 2015 Dec;26(12):2963-77. doi: 10.1681/ASN.2014050528. Epub 2015 Apr 8.

45.

Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary.

Naillat F, Yan W, Karjalainen R, Liakhovitskaia A, Samoylenko A, Xu Q, Sun Z, Shen B, Medvinsky A, Quaggin S, Vainio SJ.

Exp Cell Res. 2015 Mar 15;332(2):163-78. doi: 10.1016/j.yexcr.2015.01.010. Epub 2015 Jan 30.

46.

Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney.

Dimke H, Sparks MA, Thomson BR, Frische S, Coffman TM, Quaggin SE.

J Am Soc Nephrol. 2015 May;26(5):1027-38. doi: 10.1681/ASN.2014010060. Epub 2014 Nov 10.

47.

A lymphatic defect causes ocular hypertension and glaucoma in mice.

Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE.

J Clin Invest. 2014 Oct;124(10):4320-4. doi: 10.1172/JCI77162. Epub 2014 Sep 9.

48.

Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS.

Maezawa Y, Onay T, Scott RP, Keir LS, Dimke H, Li C, Eremina V, Maezawa Y, Jeansson M, Shan J, Binnie M, Lewin M, Ghosh A, Miner JH, Vainio SJ, Quaggin SE.

J Am Soc Nephrol. 2014 Nov;25(11):2459-70. doi: 10.1681/ASN.2013121307. Epub 2014 Jun 5.

49.

The glomerulus: the sphere of influence.

Pollak MR, Quaggin SE, Hoenig MP, Dworkin LD.

Clin J Am Soc Nephrol. 2014 Aug 7;9(8):1461-9. doi: 10.2215/CJN.09400913. Epub 2014 May 29. Review.

50.

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7090-5. doi: 10.1073/pnas.1321942111. Epub 2014 Apr 28.

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