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Items: 10


Potencies of vitamin D analogs, 1α-hydroxyvitamin D3 , 1α-hydroxyvitamin D2 and 25-hydroxyvitamin D3 , in lowering cholesterol in hypercholesterolemic mice in vivo.

Quach HP, Dzekic T, Bukuroshi P, Pang KS.

Biopharm Drug Dispos. 2018 Apr;39(4):196-204. doi: 10.1002/bdd.2126.


Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.

Quach HP, Noh K, Hoi SY, Bruinsma A, Groothuis GMM, Li AP, Chow ECY, Pang KS.

Biopharm Drug Dispos. 2018 Feb;39(2):99-115. doi: 10.1002/bdd.2118. Epub 2018 Jan 30.


Highlighting Vitamin D Receptor-Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling.

Yang QJ, Bukuroshi P, Quach HP, Chow ECY, Pang KS.

Drug Metab Dispos. 2018 Jan;46(1):75-87. doi: 10.1124/dmd.117.077271. Epub 2017 Oct 30.


Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

Chow EC, Quach HP, Zhang Y, Wang JZ, Evans DC, Li AP, Silva J, Tirona RG, Lai Y, Pang KS.

J Pharmacol Exp Ther. 2017 Jan;360(1):174-191. Epub 2016 Oct 27.


Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.

Chow EC, Wang JZ, Quach HP, Tang H, Evans DC, Li AP, Silva J, Pang KS.

Drug Metab Dispos. 2016 Sep;44(9):1524-35. doi: 10.1124/dmd.116.070060. Epub 2016 Jun 24.


Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice.

Ramakrishnan V, Yang QJ, Quach HP, Cao Y, Chow EC, Mager DE, Pang KS.

Drug Metab Dispos. 2016 Feb;44(2):189-208. doi: 10.1124/dmd.115.067033. Epub 2015 Nov 19.


PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.

Quach HP, Yang QJ, Chow EC, Mager DE, Hoi SY, Pang KS.

Br J Pharmacol. 2015 Jul;172(14):3611-26. doi: 10.1111/bph.13153. Epub 2015 May 15.


Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.

Kim YC, Kim IB, Noh CK, Quach HP, Yoon IS, Chow ECY, Kim M, Jin HE, Cho KH, Chung SJ, Pang KS, Maeng HJ.

J Pharm Sci. 2014 Nov;103(11):3793-3805. doi: 10.1002/jps.24195. Epub 2014 Sep 29.


Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS.

Gastroenterology. 2014 Apr;146(4):1048-59. doi: 10.1053/j.gastro.2013.12.027. Epub 2013 Dec 21.


Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.

Chow EC, Quach HP, Vieth R, Pang KS.

Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E977-89. doi: 10.1152/ajpendo.00489.2012. Epub 2013 Mar 12.

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