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Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance.

Li Y, Liu J, Gao L, Liu Y, Meng F, Li X, Qin FX.

Immunol Lett. 2019 Mar 15. pii: S0165-2478(18)30388-2. doi: 10.1016/j.imlet.2019.03.006. [Epub ahead of print]


Inhibition of Influenza A Virus Replication by TRIM14 via Its Multifaceted Protein-Protein Interaction With NP.

Wu X, Wang J, Wang S, Wu F, Chen Z, Li C, Cheng G, Qin FX.

Front Microbiol. 2019 Feb 26;10:344. doi: 10.3389/fmicb.2019.00344. eCollection 2019.


Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.

Tong Y, Zhou L, Yang L, Guo P, Cao Y, Qin FX, Liu J.

EBioMedicine. 2019 Jan;39:132-144. doi: 10.1016/j.ebiom.2018.11.062. Epub 2018 Dec 7.


Identification of TRIM14 as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx.

Tan G, Xu F, Song H, Yuan Y, Xiao Q, Ma F, Qin FX, Cheng G.

Front Immunol. 2018 Aug 13;9:1872. doi: 10.3389/fimmu.2018.01872. eCollection 2018.


CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade.

Chen L, Diao L, Yang Y, Yi X, Rodriguez BL, Li Y, Villalobos PA, Cascone T, Liu X, Tan L, Lorenzi PL, Huang A, Zhao Q, Peng D, Fradette JJ, Peng DH, Ungewiss C, Roybal J, Tong P, Oba J, Skoulidis F, Peng W, Carter BW, Gay CM, Fan Y, Class CA, Zhu J, Rodriguez-Canales J, Kawakami M, Byers LA, Woodman SE, Papadimitrakopoulou VA, Dmitrovsky E, Wang J, Ullrich SE, Wistuba II, Heymach JV, Qin FX, Gibbons DL.

Cancer Discov. 2018 Sep;8(9):1156-1175. doi: 10.1158/2159-8290.CD-17-1033. Epub 2018 Jul 16.


seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment From Mouse RNA-Seq Data.

Chen Z, Quan L, Huang A, Zhao Q, Yuan Y, Yuan X, Shen Q, Shang J, Ben Y, Qin FX, Wu A.

Front Immunol. 2018 Jun 5;9:1286. doi: 10.3389/fimmu.2018.01286. eCollection 2018.


Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses.

Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin FX, Cui J.

Sci Adv. 2018 May 2;4(5):eaar2824. doi: 10.1126/sciadv.aar2824. eCollection 2018 May.


Magnetic graphene enabled tunable microwave absorber via thermal control.

Quan L, Qin FX, Li YH, Estevez D, Fu GJ, Wang H, Peng HX.

Nanotechnology. 2018 Jun 15;29(24):245706. doi: 10.1088/1361-6528/aabaae. Epub 2018 Mar 29.


STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells.

Liu Y, Lv J, Liu J, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX, Huang B.

J Clin Invest. 2018 Mar 1;128(3):1057-1073. doi: 10.1172/JCI96329. Epub 2018 Feb 12.


Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice.

Li C, Zhu X, Ji X, Quanquin N, Deng YQ, Tian M, Aliyari R, Zuo X, Yuan L, Afridi SK, Li XF, Jung JU, Nielsen-Saines K, Qin FX, Qin CF, Xu Z, Cheng G.

EBioMedicine. 2017 Oct;24:189-194. doi: 10.1016/j.ebiom.2017.09.034. Epub 2017 Sep 28.


Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells.

Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin X, Chen D, Li Y, Zhang S, Xie HQ, Zhao B, Zhao T, Lu J, Hu ZW, Cao X, Qin FX, Huang B.

Nat Commun. 2017 May 10;8:15207. doi: 10.1038/ncomms15207.


Corrigendum: Inference of immune cell composition on the expression profiles of mouse tissue.

Chen Z, Huang A, Sun J, Jiang T, Qin FX, Wu A.

Sci Rep. 2017 Mar 24;7:45416. doi: 10.1038/srep45416. No abstract available.


25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.

Li C, Deng YQ, Wang S, Ma F, Aliyari R, Huang XY, Zhang NN, Watanabe M, Dong HL, Liu P, Li XF, Ye Q, Tian M, Hong S, Fan J, Zhao H, Li L, Vishlaghi N, Buth JE, Au C, Liu Y, Lu N, Du P, Qin FX, Zhang B, Gong D, Dai X, Sun R, Novitch BG, Xu Z, Qin CF, Cheng G.

Immunity. 2017 Mar 21;46(3):446-456. doi: 10.1016/j.immuni.2017.02.012. Epub 2017 Mar 14.


Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets.

Wang L, Liu SY, Chen HW, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, Liang Y, Jiang T, Modlin R, Bloom BR, Li Q, Deng JC, Zhou P, Qin FX, Cheng G.

Cell Host Microbe. 2017 Mar 8;21(3):334-343. doi: 10.1016/j.chom.2017.02.007.


A human programmed death-ligand 1-expressing mouse tumor model for evaluating the therapeutic efficacy of anti-human PD-L1 antibodies.

Huang A, Peng D, Guo H, Ben Y, Zuo X, Wu F, Yang X, Teng F, Li Z, Qian X, Qin FX.

Sci Rep. 2017 Feb 16;7:42687. doi: 10.1038/srep42687.


Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication.

Tan G, Xiao Q, Song H, Ma F, Xu F, Peng D, Li N, Wang X, Niu J, Gao P, Qin FX, Cheng G.

Cell Mol Immunol. 2018 Mar;15(3):272-281. doi: 10.1038/cmi.2016.67. Epub 2017 Feb 13.


Inference of immune cell composition on the expression profiles of mouse tissue.

Chen Z, Huang A, Sun J, Jiang T, Qin FX, Wu A.

Sci Rep. 2017 Jan 13;7:40508. doi: 10.1038/srep40508. Erratum in: Sci Rep. 2017 Mar 24;7:45416.


Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System.

Li C, Wang Z, Cao Y, Wang L, Ji J, Chen Z, Deng T, Jiang T, Cheng G, Qin FX.

J Virol. 2017 Feb 14;91(5). pii: e02282-16. doi: 10.1128/JVI.02282-16. Print 2017 Mar 1.


Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.

Chen L, Yi X, Goswami S, Ahn YH, Roybal JD, Yang Y, Diao L, Peng D, Peng D, Fradette JJ, Wang J, Byers LA, Kurie JM, Ullrich SE, Qin FX, Gibbons DL.

Oncoimmunology. 2016 Sep 26;5(11):e1234570. doi: 10.1080/2162402X.2016.1234570. eCollection 2016.


A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation.

Peng D, Wang Z, Huang A, Zhao Y, Qin FX.

J Immunol. 2017 Jan 15;198(2):808-819. doi: 10.4049/jimmunol.1601009. Epub 2016 Dec 12.


TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein.

Wang S, Chen Y, Li C, Wu Y, Guo L, Peng C, Huang Y, Cheng G, Qin FX.

Sci Rep. 2016 Aug 31;6:32336. doi: 10.1038/srep32336.


Isotetrandrine ameliorates tert-butyl hydroperoxide-induced oxidative stress through upregulation of heme oxygenase-1 expression.

Wang L, Ci X, Lv H, Wang X, Qin FX, Cheng G.

Exp Biol Med (Maywood). 2016 Aug;241(14):1568-76. doi: 10.1177/1535370216647122. Epub 2016 May 2.


[Chemical speciations of heavy metals and their risk assessment in agricultural soils in a coal mining area from Xingren County, Guizhou Province, China.]

Pang WP, Qin FX, Lyu YC, Li YJ, Li G, Li XL.

Ying Yong Sheng Tai Xue Bao. 2016 May;27(5):1468-1478. doi: 10.13287/j.1001-9332.201605.009. Chinese.


Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System.

Wang Z, Ji J, Peng D, Ma F, Cheng G, Qin FX.

J Immunol. 2016 May 15;196(10):4322-30. doi: 10.4049/jimmunol.1502458. Epub 2016 Apr 4.


Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase.

Wang L, Wu A, Wang YE, Quanquin N, Li C, Wang J, Chen HW, Liu S, Liu P, Zhang H, Qin FX, Jiang T, Cheng G.

J Virol. 2015 Dec 30;90(6):2938-47. doi: 10.1128/JVI.02400-15.


New targets for controlling Ebola virus disease.

Qin FX, Jiang CY, Jiang T, Cheng G.

Natl Sci Rev. 2015 Sep;2(3):266-267. Epub 2015 Jul 17. No abstract available.


The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression.

Chen L, Heymach JV, Qin FX, Gibbons DL.

Oncoimmunology. 2015 Feb 3;4(5):e1002731. eCollection 2015 May.


The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells.

Ci X, Lv H, Wang L, Wang X, Peng L, Qin FX, Cheng G.

Chem Biol Interact. 2015 Sep 5;239:192-9. doi: 10.1016/j.cbi.2015.06.032. Epub 2015 Jun 22.


Network of co-mutations in Ebola virus genome predicts the disease lethality.

Deng L, Liu M, Hua S, Peng Y, Wu A, Qin FX, Cheng G, Jiang T.

Cell Res. 2015 Jun;25(6):753-6. doi: 10.1038/cr.2015.54. Epub 2015 May 15. No abstract available.


Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.

Chen Y, Wang S, Yi Z, Tian H, Aliyari R, Li Y, Chen G, Liu P, Zhong J, Chen X, Du P, Su L, Qin FX, Deng H, Cheng G.

Sci Rep. 2014 Dec 3;4:7242. doi: 10.1038/srep07242.


Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein.

Li C, Wu A, Peng Y, Wang J, Guo Y, Chen Z, Zhang H, Wang Y, Dong J, Wang L, Qin FX, Cheng G, Deng T, Jiang T.

Sci Rep. 2014 Nov 26;4:7192. doi: 10.1038/srep07192.


Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.

Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, Zhang X, Yi X, Dwyer D, Lin W, Diao L, Wang J, Roybal J, Patel M, Ungewiss C, Peng D, Antonia S, Mediavilla-Varela M, Robertson G, Suraokar M, Welsh JW, Erez B, Wistuba II, Chen L, Peng D, Wang S, Ullrich SE, Heymach JV, Kurie JM, Qin FX.

Nat Commun. 2014 Oct 28;5:5241. doi: 10.1038/ncomms6241.


Adsorptive removal of dibenzothiophene from model fuels over one-pot synthesized PTA@MIL-101(Cr) hybrid material.

Jia SY, Zhang YF, Liu Y, Qin FX, Ren HT, Wu SH.

J Hazard Mater. 2013 Nov 15;262:589-97. doi: 10.1016/j.jhazmat.2013.08.056. Epub 2013 Aug 28.


cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis.

Zhang Y, Jin H, Li L, Qin FX, Wen Z.

Blood. 2011 Oct 13;118(15):4093-101. doi: 10.1182/blood-2011-03-342501. Epub 2011 Aug 19.


Monoclonal antibodies against nucleophosmin mutants: potentials for the detection of acute myeloid leukemia.

Tan S, Zhang L, Zhong XM, Yang ZL, Zhao LY, Gao YJ, Shao HY, Qin FX, Chen XC, Zhang HJ, Chen H, Wang L.

Int J Med Sci. 2011;8(4):309-14. Epub 2011 May 17.


Knockdown of NPM1 by RNA interference inhibits cells proliferation and induces apoptosis in leukemic cell line.

Qin FX, Shao HY, Chen XC, Tan S, Zhang HJ, Miao ZY, Wang L, Hui-Chen, Zhang L.

Int J Med Sci. 2011 Apr 20;8(4):287-94.


Nucleophosmin gene mutations promote NIH3T3 cell migration and invasion through CXCR4 and MMPs.

Shao HY, Miao ZY, Hui-Chen, Qin FX, Chen XC, Tan S, Zhang HJ, Wang L, Gao YJ, Yang ZL, Zhang L.

Exp Mol Pathol. 2011 Feb;90(1):38-44. doi: 10.1016/j.yexmp.2010.11.009. Epub 2010 Nov 28.


Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.

Kastner L, Dwyer D, Qin FX.

J Immunol. 2010 Nov 15;185(10):5778-86. doi: 10.4049/jimmunol.0901948. Epub 2010 Oct 6.


Increased integrity of circulating cell-free DNA in plasma of patients with acute leukemia.

Gao YJ, He YJ, Yang ZL, Shao HY, Zuo Y, Bai Y, Chen H, Chen XC, Qin FX, Tan S, Wang J, Wang L, Zhang L.

Clin Chem Lab Med. 2010 Nov;48(11):1651-6. doi: 10.1515/CCLM.2010.311. Epub 2010 Sep 13.


Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus.

Román E, Shino H, Qin FX, Liu YJ.

J Immunol. 2010 Oct 1;185(7):3819-23. doi: 10.4049/jimmunol.0900665. Epub 2010 Aug 27.


Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5.

Shimizu S, Kamata M, Kittipongdaja P, Chen KN, Kim S, Pang S, Boyer J, Qin FX, An DS, Chen IS.

Genet Vaccines Ther. 2009 Jun 10;7:8. doi: 10.1186/1479-0556-7-8.


Distinct biological roles for the notch ligands Jagged-1 and Jagged-2.

Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM.

J Biol Chem. 2009 Jun 26;284(26):17766-74. doi: 10.1074/jbc.M109.003111. Epub 2009 Apr 27.


Dynamic behavior and function of Foxp3+ regulatory T cells in tumor bearing host.

Qin FX.

Cell Mol Immunol. 2009 Feb;6(1):3-13. doi: 10.1038/cmi.2009.2. Review.


Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery.

Ito T, Hanabuchi S, Wang YH, Park WR, Arima K, Bover L, Qin FX, Gilliet M, Liu YJ.

Immunity. 2008 Jun;28(6):870-80. doi: 10.1016/j.immuni.2008.03.018. Epub 2008 May 29.


[Determination of trace lead in Chinese medicinal materials by GFAAS with PdCl2 as a matrix modifier].

Qin FX, Zhang MS, Hu JW, Huang XF, Zhang D.

Guang Pu Xue Yu Guang Pu Fen Xi. 2007 Oct;27(10):2123-6. Chinese.


Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells.

Wei J, Duramad O, Perng OA, Reiner SL, Liu YJ, Qin FX.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18169-74. Epub 2007 Oct 31.


Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.

An DS, Donahue RE, Kamata M, Poon B, Metzger M, Mao SH, Bonifacino A, Krouse AE, Darlix JL, Baltimore D, Qin FX, Chen IS.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13110-5. Epub 2007 Aug 1.


SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.

Wang F, Nguyen M, Qin FX, Tong Q.

Aging Cell. 2007 Aug;6(4):505-14. Epub 2007 May 23.


OX40 ligand shuts down IL-10-producing regulatory T cells.

Ito T, Wang YH, Duramad O, Hanabuchi S, Perng OA, Gilliet M, Qin FX, Liu YJ.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13138-43. Epub 2006 Aug 21.


Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

An DS, Qin FX, Auyeung VC, Mao SH, Kung SK, Baltimore D, Chen IS.

Mol Ther. 2006 Oct;14(4):494-504. Epub 2006 Jul 17.

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