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Items: 26

1.

An LC/MS based method to quantify DNA adduct in tumor and organ tissues.

Li C, Dong L, Kamali A, Sugimoto H, Abdul-Hadi K, Chen S, Abu-Yousif A, Qian MG.

Anal Biochem. 2019 Mar 1;568:1-6. doi: 10.1016/j.ab.2018.12.014. Epub 2018 Dec 21.

PMID:
30579655
2.

Perspectives on potentiating immunocapture-LC-MS for the bioanalysis of biotherapeutics and biomarkers.

Sugimoto H, Wei D, Dong L, Ghosh D, Chen S, Qian MG.

Bioanalysis. 2018 Oct 1;10(20):1679-1690. doi: 10.4155/bio-2018-0205. Epub 2018 Oct 29.

PMID:
30371100
3.

Immunocapture-LC/MS-Based Target Engagement Measurement in Tumor Plasma Membrane.

Sugimoto H, Ghosh D, Chen S, Smith MD, Abu-Yousif AO, Qian MG.

Anal Chem. 2018 Nov 20;90(22):13564-13571. doi: 10.1021/acs.analchem.8b03726. Epub 2018 Nov 9.

PMID:
30371057
4.

A Two-Step Immunocapture LC/MS/MS Assay for Plasma Stability and Payload Migration Assessment of Cysteine-Maleimide-Based Antibody Drug Conjugates.

Dong L, Li C, Locuson C, Chen S, Qian MG.

Anal Chem. 2018 May 15;90(10):5989-5994. doi: 10.1021/acs.analchem.8b00694. Epub 2018 Apr 24.

PMID:
29688004
5.

Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models.

Kogiso M, Qi L, Braun FK, Injac SG, Zhang L, Du Y, Zhang H, Lin FY, Zhao S, Lindsay H, Su JM, Baxter PA, Adesina AM, Liao D, Qian MG, Berg S, Muscal JA, Li XN.

Clin Cancer Res. 2018 May 1;24(9):2159-2170. doi: 10.1158/1078-0432.CCR-17-2256. Epub 2018 Feb 20.

6.

Rapid quantification of a cleavable antibody-conjugated drug by liquid chromatography/tandem mass spectrometry with microwave-assisted enzymatic cleavage.

Xu L, Packer LE, Qian MG, Wu JT.

J Pharm Biomed Anal. 2016 Sep 5;128:226-235. doi: 10.1016/j.jpba.2016.05.043. Epub 2016 May 24.

PMID:
27281578
7.

Pharmacokinetics of ixazomib, an oral proteasome inhibitor, in solid tumour patients with moderate or severe hepatic impairment.

Gupta N, Hanley MJ, Venkatakrishnan K, Perez R, Norris RE, Nemunaitis J, Yang H, Qian MG, Falchook G, Labotka R, Fu S.

Br J Clin Pharmacol. 2016 Sep;82(3):728-38. doi: 10.1111/bcp.12991. Epub 2016 May 29.

8.

Automated non-stepwise preparation of bioanalytical calibration standards and quality controls using an ultra-low volume digitizing liquid dispenser.

Liao D, Chen S, Paton M, Qian MG.

Rapid Commun Mass Spectrom. 2014 Jun 15;28(11):1215-20. doi: 10.1002/rcm.6894.

PMID:
24760562
9.

A novel dynamic flush method to reduce column-related carryover.

Chen S, Zhang J, Liao D, Qian MG.

J Chromatogr Sci. 2014 Sep;52(8):950-3. doi: 10.1093/chromsci/bmt111. Epub 2013 Jul 30.

PMID:
23899466
10.

Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target.

Patel AV, Eaves D, Jessen WJ, Rizvi TA, Ecsedy JA, Qian MG, Aronow BJ, Perentesis JP, Serra E, Cripe TP, Miller SJ, Ratner N.

Clin Cancer Res. 2012 Sep 15;18(18):5020-30. doi: 10.1158/1078-0432.CCR-12-1072. Epub 2012 Jul 18.

11.

MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma.

Shi JQ, Lasky K, Shinde V, Stringer B, Qian MG, Liao D, Liu R, Driscoll D, Nestor MT, Amidon BS, Rao Y, Duffey MO, Manfredi MG, Vos TJ, D' Amore N, Hyer ML.

Mol Cancer Ther. 2012 Sep;11(9):2045-53. doi: 10.1158/1535-7163.MCT-11-1036. Epub 2012 May 18.

12.

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).

Duffey MO, Vos TJ, Adams R, Alley J, Anthony J, Barrett C, Bharathan I, Bowman D, Bump NJ, Chau R, Cullis C, Driscoll DL, Elder A, Forsyth N, Frazer J, Guo J, Guo L, Hyer ML, Janowick D, Kulkarni B, Lai SJ, Lasky K, Li G, Li J, Liao D, Little J, Peng B, Qian MG, Reynolds DJ, Rezaei M, Scott MP, Sells TB, Shinde V, Shi QJ, Sintchak MD, Soucy F, Sprott KT, Stroud SG, Nestor M, Visiers I, Weatherhead G, Ye Y, D'Amore N.

J Med Chem. 2012 Jan 12;55(1):197-208. doi: 10.1021/jm2011172. Epub 2011 Dec 5.

PMID:
22070629
13.

Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist.

Lu C, Balani SK, Qian MG, Prakash SR, Ducray PS, von Moltke LL.

J Pharmacol Exp Ther. 2010 Feb;332(2):562-8. doi: 10.1124/jpet.109.161893. Epub 2009 Nov 4.

PMID:
19889796
14.

Determination of drug plasma protein binding by solid phase microextraction.

Musteata FM, Pawliszyn J, Qian MG, Wu JT, Miwa GT.

J Pharm Sci. 2006 Aug;95(8):1712-22.

PMID:
16795010
15.

Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry.

Balani SK, Nagaraja NV, Qian MG, Costa AO, Daniels JS, Yang H, Shimoga PR, Wu JT, Gan LS, Lee FW, Miwa GT.

Drug Metab Dispos. 2006 Mar;34(3):384-8. Epub 2005 Dec 2.

PMID:
16326814
16.
17.

On-line analysis by capillary separations interfaced to an ion trap storage/reflectron time-of-flight mass spectrometer.

Wu JT, Qian MG, Li MX, Zheng K, Huang P, Lubman DM.

J Chromatogr A. 1998 Jan 23;794(1-2):377-89. Review.

PMID:
9491563
20.
21.

Procedures for tandem mass spectrometry on an ion trap storage/reflectron time-of-flight mass spectrometer.

Qian MG, Lubman DM.

Rapid Commun Mass Spectrom. 1996;10(15):1911-20.

PMID:
9004527
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