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Items: 1 to 50 of 128

1.

Portfolio Analysis of Research Grants in Data Science Funded by the National Heart, Lung, and Blood Institute.

Li H, Miller M, Burke C, Danthi NS, Charette M, Gan W, Qasba P, Wei GS, Goff DC Jr, Luo XJ.

Circ Genom Precis Med. 2019 Nov 21. doi: 10.1161/CIRCGEN.119.002746. [Epub ahead of print]

PMID:
31752505
2.

Correction to Glycans of Antibodies as a Specific Site for Drug Conjugation Using Glycosyltransferases.

Qasba PK.

Bioconjug Chem. 2016 Jan 20;27(1):264. doi: 10.1021/acs.bioconjchem.5b00658. Epub 2015 Dec 14. No abstract available.

PMID:
26653670
3.

Glycans of Antibodies as a Specific Site for Drug Conjugation Using Glycosyltransferases.

Qasba PK.

Bioconjug Chem. 2015 Nov 18;26(11):2170-5. doi: 10.1021/acs.bioconjchem.5b00173. Epub 2015 Jun 23. Erratum in: Bioconjug Chem. 2016 Jan 20;27(1):264.

PMID:
26065635
4.

Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar.

Zhu Z, Ramakrishnan B, Li J, Wang Y, Feng Y, Prabakaran P, Colantonio S, Dyba MA, Qasba PK, Dimitrov DS.

MAbs. 2014;6(5):1190-200. doi: 10.4161/mabs.29889. Epub 2014 Oct 30.

5.

A systems approach to blood disorders.

Qasba P.

Adv Exp Med Biol. 2014;844:395-9. doi: 10.1007/978-1-4939-2095-2_19. Review.

PMID:
25480652
6.

NHLBI support of systems biology.

Qasba P, Larkin J.

Front Physiol. 2013 Nov 15;4:299. doi: 10.3389/fphys.2013.00299. eCollection 2013.

7.

Crystal structures of β-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding.

Tsutsui Y, Ramakrishnan B, Qasba PK.

J Biol Chem. 2013 Nov 1;288(44):31963-70. doi: 10.1074/jbc.M113.509984. Epub 2013 Sep 19.

8.

Investigations on β1,4-galactosyltransferase I using 6-sulfo-GlcNAc as an acceptor sugar substrate.

Ramakrishnan B, Moncrief AJ, Davis TA, Holland LA, Qasba PK.

Glycoconj J. 2013 Dec;30(9):835-42. doi: 10.1007/s10719-013-9488-4. Epub 2013 Aug 13.

PMID:
23942731
9.

In vitro folding of β-1,4galactosyltransferase and polypeptide-α-N-acetylgalactosaminyltransferase from the inclusion bodies.

Ramakrishnan B, Qasba PK.

Methods Mol Biol. 2013;1022:321-33. doi: 10.1007/978-1-62703-465-4_24.

PMID:
23765672
10.

Use of novel mutant galactosyltransferase for the bioconjugation of terminal N-acetylglucosamine (GlcNAc) residues on live cell surface.

Mercer N, Ramakrishnan B, Boeggeman E, Verdi L, Qasba PK.

Bioconjug Chem. 2013 Jan 16;24(1):144-52. doi: 10.1021/bc300542z. Epub 2013 Jan 3.

11.

Binding of N-acetylglucosamine (GlcNAc) β1-6-branched oligosaccharide acceptors to β4-galactosyltransferase I reveals a new ligand binding mode.

Ramakrishnan B, Boeggeman E, Qasba PK.

J Biol Chem. 2012 Aug 17;287(34):28666-74. doi: 10.1074/jbc.M112.373514. Epub 2012 Jun 27.

12.

Gene therapy for Fanconi anemia: one step closer to the clinic.

Tolar J, Becker PS, Clapp DW, Hanenberg H, de Heredia CD, Kiem HP, Navarro S, Qasba P, Rio P, Schmidt M, Sevilla J, Verhoeyen E, Thrasher AJ, Bueren J.

Hum Gene Ther. 2012 Feb;23(2):141-4. doi: 10.1089/hum.2011.237. No abstract available.

13.

Applications of site-specific labeling to study HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid.

Mercer N, Ramakrishnan B, Boeggeman E, Qasba PK.

PLoS One. 2011;6(10):e26093. doi: 10.1371/journal.pone.0026093. Epub 2011 Oct 10.

14.

The N-acetyl-binding pocket of N-acetylglucosaminyltransferases also accommodates a sugar analog with a chemical handle at C2.

Pasek M, Ramakrishnan B, Boeggeman E, Mercer N, Dulcey AE, Griffiths GL, Qasba PK.

Glycobiology. 2012 Mar;22(3):379-88. doi: 10.1093/glycob/cwr110. Epub 2011 Aug 25.

15.

Bioconjugation using mutant glycosyltransferases for the site-specific labeling of biomolecules with sugars carrying chemical handles.

Ramakrishnan B, Boeggeman E, Pasek M, Qasba PK.

Methods Mol Biol. 2011;751:281-96. doi: 10.1007/978-1-61779-151-2_17.

PMID:
21674337
18.

Crystal structure of the catalytic domain of Drosophila beta1,4-Galactosyltransferase-7.

Ramakrishnan B, Qasba PK.

J Biol Chem. 2010 May 14;285(20):15619-26. doi: 10.1074/jbc.M109.099564. Epub 2010 Mar 17.

19.

Galectin-1 as a fusion partner for the production of soluble and folded human beta-1,4-galactosyltransferase-T7 in E. coli.

Pasek M, Boeggeman E, Ramakrishnan B, Qasba PK.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):679-84. doi: 10.1016/j.bbrc.2010.03.051. Epub 2010 Mar 11.

20.

Multiple site-specific in vitro labeling of single-chain antibody.

Ramakrishnan B, Boeggeman E, Manzoni M, Zhu Z, Loomis K, Puri A, Dimitrov DS, Qasba PK.

Bioconjug Chem. 2009 Jul;20(7):1383-9. doi: 10.1021/bc900149r.

21.

Site specific conjugation of fluoroprobes to the remodeled Fc N-glycans of monoclonal antibodies using mutant glycosyltransferases: application for cell surface antigen detection.

Boeggeman E, Ramakrishnan B, Pasek M, Manzoni M, Puri A, Loomis KH, Waybright TJ, Qasba PK.

Bioconjug Chem. 2009 Jun;20(6):1228-36. doi: 10.1021/bc900103p.

22.

Bioconjugation and detection of lactosamine moiety using alpha1,3-galactosyltransferase mutants that transfer C2-modified galactose with a chemical handle.

Pasek M, Ramakrishnan B, Boeggeman E, Manzoni M, Waybright TJ, Qasba PK.

Bioconjug Chem. 2009 Mar 18;20(3):608-18. doi: 10.1021/bc800534r.

23.

Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.

Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK, Esko JD.

J Biol Chem. 2009 Feb 20;284(8):4952-9. doi: 10.1074/jbc.M805782200. Epub 2008 Dec 23.

24.

Iterative cluster-NMA: A tool for generating conformational transitions in proteins.

Schuyler AD, Jernigan RL, Qasba PK, Ramakrishnan B, Chirikjian GS.

Proteins. 2009 Feb 15;74(3):760-76. doi: 10.1002/prot.22200.

25.

Site-specific linking of biomolecules via glycan residues using glycosyltransferases.

Qasba PK, Boeggeman E, Ramakrishnan B.

Biotechnol Prog. 2008 May-Jun;24(3):520-6. doi: 10.1021/bp0704034. Epub 2008 Apr 22. Review.

26.

Structure and function of beta -1,4-galactosyltransferase.

Qasba PK, Ramakrishnan B, Boeggeman E.

Curr Drug Targets. 2008 Apr;9(4):292-309. Review.

27.

Applications of glycosyltransferases in the site-specific conjugation of biomolecules and the development of a targeted drug delivery system and contrast agents for MRI.

Ramakrishnan B, Boeggeman E, Qasba PK.

Expert Opin Drug Deliv. 2008 Feb;5(2):149-53. doi: 10.1517/17425247.5.2.149. Review.

28.

Novel method for in vitro O-glycosylation of proteins: application for bioconjugation.

Ramakrishnan B, Boeggeman E, Qasba PK.

Bioconjug Chem. 2007 Nov-Dec;18(6):1912-8. Epub 2007 Oct 23.

PMID:
17953440
29.

Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method.

Boeggeman E, Ramakrishnan B, Kilgore C, Khidekel N, Hsieh-Wilson LC, Simpson JT, Qasba PK.

Bioconjug Chem. 2007 May-Jun;18(3):806-14. Epub 2007 Mar 20.

30.

Letter to the Glyco-Forum: catalytic domains of glycosyltransferases with 'add-on' domains.

Qasba PK, Ramakrishnan B.

Glycobiology. 2007 May;17(5):7G-9G. Epub 2007 Feb 5. No abstract available.

PMID:
17283039
31.

Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment.

Heare T, Alp NJ, Priestman DA, Kulkarni AB, Qasba P, Butters TD, Dwek RA, Clarke K, Channon KM, Platt FM.

J Inherit Metab Dis. 2007 Feb;30(1):79-87. Epub 2006 Dec 25.

PMID:
17189993
32.

Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates.

Ramakrishnan B, Qasba PK.

J Mol Biol. 2007 Jan 19;365(3):570-6. Epub 2006 Oct 14.

33.

Critical resources for gene therapy in Heart, Lung, and Blood Diseases Working Group.

Woo SL, Skarlatos SI, Joyce MM, Croxton TL, Qasba P; Heart, Lung, and Blood Diseases Working Group.

Mol Ther. 2006 Apr;13(4):641-3. No abstract available.

34.
35.

Critical Resources for Gene Therapy in Heart, Lung, and Blood Diseases Working Group.

Woo SL, Skarlatos SI, Joyce MM, Croxton TL, Qasba P.

Mol Ther. 2006 Apr;13(4):641-643. doi: 10.1016/j.ymthe.2005.12.007. Epub 2006 Feb 2. No abstract available.

PMID:
28189018
36.

Structural snapshots of beta-1,4-galactosyltransferase-I along the kinetic pathway.

Ramakrishnan B, Ramasamy V, Qasba PK.

J Mol Biol. 2006 Apr 14;357(5):1619-33. Epub 2006 Feb 9.

PMID:
16497331
37.
38.

Mutation of arginine 228 to lysine enhances the glucosyltransferase activity of bovine beta-1,4-galactosyltransferase I.

Ramakrishnan B, Boeggeman E, Qasba PK.

Biochemistry. 2005 Mar 8;44(9):3202-10.

PMID:
15736931
39.

Substrate-induced conformational changes in glycosyltransferases.

Qasba PK, Ramakrishnan B, Boeggeman E.

Trends Biochem Sci. 2005 Jan;30(1):53-62. Review.

PMID:
15653326
40.

Structure and catalytic cycle of beta-1,4-galactosyltransferase.

Ramakrishnan B, Boeggeman E, Ramasamy V, Qasba PK.

Curr Opin Struct Biol. 2004 Oct;14(5):593-600. Review.

PMID:
15465321
42.

A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications.

Khidekel N, Arndt S, Lamarre-Vincent N, Lippert A, Poulin-Kerstien KG, Ramakrishnan B, Qasba PK, Hsieh-Wilson LC.

J Am Chem Soc. 2003 Dec 31;125(52):16162-3.

PMID:
14692737
43.

HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro.

D'Costa J, Harvey-White J, Qasba P, Limaye A, Kaneski CR, Davis-Warren A, Brady RO, Bankiewicz KS, Major EO, Arya SK.

J Med Virol. 2003 Oct;71(2):173-82.

PMID:
12938190
44.

The role of tryptophan 314 in the conformational changes of beta1,4-galactosyltransferase-I.

Ramasamy V, Ramakrishnan B, Boeggeman E, Qasba PK.

J Mol Biol. 2003 Aug 29;331(5):1065-76.

PMID:
12927542
47.

Interdependence of backbone flexibility, residue conservation, and enzyme function: a case study on beta1,4-galactosyltransferase-I.

Gunasekaran K, Ma B, Ramakrishnan B, Qasba PK, Nussinov R.

Biochemistry. 2003 Apr 8;42(13):3674-87.

PMID:
12667057
48.

Long-term correction of globotriaosylceramide storage in Fabry mice by recombinant adeno-associated virus-mediated gene transfer.

Park J, Murray GJ, Limaye A, Quirk JM, Gelderman MP, Brady RO, Qasba P.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3450-4. Epub 2003 Mar 6.

49.

Studies on the metal binding sites in the catalytic domain of beta1,4-galactosyltransferase.

Boeggeman E, Qasba PK.

Glycobiology. 2002 Jul;12(7):395-407.

PMID:
12122021
50.

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