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Items: 38

1.

Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases.

Poplawski T, Pytel D, Dziadek J, Majsterek I.

Oxid Med Cell Longev. 2019 Apr 7;2019:6949347. doi: 10.1155/2019/6949347. eCollection 2019. No abstract available.

2.

Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.

Rozpędek W, Pytel D, Popławski T, Walczak A, Gradzik K, Wawrzynkiewicz A, Wojtczak R, Mucha B, Diehl JA, Majsterek I.

Curr Alzheimer Res. 2019;16(3):209-218. doi: 10.2174/1567205016666190228121157.

PMID:
30819079
3.
4.

Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells.

Kowalczyk T, Sitarek P, Skała E, Toma M, Wielanek M, Pytel D, Wieczfińska J, Szemraj J, Śliwiński T.

Cytotechnology. 2019 Feb;71(1):165-180. doi: 10.1007/s10616-018-0274-9. Epub 2019 Jan 4.

5.

Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk.

Mucha B, Pytel D, Markiewicz L, Cuchra M, Szymczak I, Przybylowska-Sygut K, Dziki A, Majsterek I, Dziki L.

Clin Colorectal Cancer. 2018 Jun;17(2):e435-e441. doi: 10.1016/j.clcc.2016.10.001. Epub 2017 Jan 10.

PMID:
29793654
6.

Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment.

Rozpędek W, Pytel D, Nowak-Zduńczyk A, Lewko D, Wojtczak R, Diehl JA, Majsterek I.

Curr Med Chem. 2019;26(8):1425-1445. doi: 10.2174/0929867325666180117102233.

PMID:
29345572
7.

Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract.

Skała E, Kowalczyk T, Toma M, Szemraj J, Radek M, Pytel D, Wieczfinska J, Wysokińska H, Śliwiński T, Sitarek P.

Mol Cell Biochem. 2018 Aug;445(1-2):89-97. doi: 10.1007/s11010-017-3254-z. Epub 2017 Dec 14.

PMID:
29238899
8.

Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.

Rozpędek W, Pytel D, Dziki Ł, Nowak A, Dziki A, Diehl JA, Majsterek I.

Pol Przegl Chir. 2017 Jun 30;89(3):7-10.

9.

Molecular Basis of Human Diseases and Targeted Therapy Based on Small-Molecule Inhibitors of ER Stress-Induced Signaling Pathways.

Rozpedek W, Nowak A, Pytel D, Diehl JA, Majsterek I.

Curr Mol Med. 2017;17(2):118-132. doi: 10.2174/1566524017666170306122643. Review.

PMID:
28266275
10.

Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition.

Sitarek P, Rijo P, Garcia C, Skała E, Kalemba D, Białas AJ, Szemraj J, Pytel D, Toma M, Wysokińska H, Śliwiński T.

Oxid Med Cell Longev. 2017;2017:7384061. doi: 10.1155/2017/7384061. Epub 2017 Jan 16.

11.

The Essential Oils of Rhaponticum carthamoides Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities.

Skała E, Rijo P, Garcia C, Sitarek P, Kalemba D, Toma M, Szemraj J, Pytel D, Wysokińska H, Śliwiński T.

Oxid Med Cell Longev. 2016;2016:8505384. doi: 10.1155/2016/8505384. Epub 2016 Dec 18.

12.

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.

Pytel D, Gao Y, Mackiewicz K, Katlinskaya YV, Staschke KA, Paredes MC, Yoshida A, Qie S, Zhang G, Chajewski OS, Wu L, Majsterek I, Herlyn M, Fuchs SY, Diehl JA.

PLoS Genet. 2016 Dec 15;12(12):e1006518. doi: 10.1371/journal.pgen.1006518. eCollection 2016 Dec.

13.

The role of base excision repair in pathogenesis of breast cancer in the Polish population.

Cuchra M, Mucha B, Markiewicz L, Przybylowska-Sygut K, Pytel D, Jeziorski A, Kordek R, Majsterek I.

Mol Carcinog. 2016 Dec;55(12):1899-1914. doi: 10.1002/mc.22436. Epub 2015 Nov 19.

PMID:
27870262
14.

[Small molecule inhibitors of PERK-dependent signaling pathway as a novel, therapeutic molecular strategy in Alzheimer's disease treatment].

Rozpędek W, Pytel D, Diehl JA, Majsterek I.

Pol Merkur Lekarski. 2016 Jul 29;41(241):5-10. Review. Polish.

PMID:
27734813
15.

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.

Rozpedek W, Pytel D, Mucha B, Leszczynska H, Diehl JA, Majsterek I.

Curr Mol Med. 2016;16(6):533-44. Review.

16.

[The role of the adaptive stress response in the pathogenesis of neurodegenerative diseases, cancer and diabetes mellitus type 2].

Rozpędek W, Markiewicz Ł, Diehl JA, Pytel D, Majsterek I.

Pol Merkur Lekarski. 2015 Dec;39(234):393-7. Review. Polish.

PMID:
26802695
17.

Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease.

Rozpedek W, Markiewicz L, Diehl JA, Pytel D, Majsterek I.

Curr Med Chem. 2015;22(27):3169-84. Review.

18.

Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients.

Markiewicz L, Pytel D, Mucha B, Szymanek K, Szaflik J, Szaflik JP, Majsterek I.

Biomed Res Int. 2015;2015:812503. doi: 10.1155/2015/812503. Epub 2015 May 11.

19.

The role of base excision repair in the development of primary open angle glaucoma in the Polish population.

Cuchra M, Markiewicz L, Mucha B, Pytel D, Szymanek K, Szemraj J, Szaflik J, Szaflik JP, Majsterek I.

Mutat Res. 2015 Aug;778:26-40. doi: 10.1016/j.mrfmmm.2015.05.003. Epub 2015 May 19.

PMID:
26056729
20.

Tumor progression and the different faces of the PERK kinase.

Pytel D, Majsterek I, Diehl JA.

Oncogene. 2016 Mar 10;35(10):1207-15. doi: 10.1038/onc.2015.178. Epub 2015 Jun 1. Review.

21.

Analysis of the expression and polymorphism of APOE, HSP, BDNF, and GRIN2B genes associated with the neurodegeneration process in the pathogenesis of primary open angle glaucoma.

Nowak A, Majsterek I, Przybyłowska-Sygut K, Pytel D, Szymanek K, Szaflik J, Szaflik JP.

Biomed Res Int. 2015;2015:258281. doi: 10.1155/2015/258281. Epub 2015 Mar 29.

22.

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.

Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA.

J Biomol Screen. 2014 Aug;19(7):1024-34. doi: 10.1177/1087057114525853. Epub 2014 Mar 5.

23.

The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.

Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA.

Sci Signal. 2013 Nov 26;6(303):ra102. doi: 10.1126/scisignal.2004373.

24.

The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.

Lee EK, Lian Z, D'Andrea K, Letrero R, Sheng W, Liu S, Diehl JN, Pytel D, Barbash O, Schuchter L, Amaravaradi R, Xu X, Herlyn M, Nathanson KL, Diehl JA.

Mol Cell Biol. 2013 Nov;33(22):4422-33. doi: 10.1128/MCB.00706-13. Epub 2013 Sep 9.

25.

UPR-inducible miRNAs contribute to stressful situations.

Chitnis N, Pytel D, Diehl JA.

Trends Biochem Sci. 2013 Sep;38(9):447-52. doi: 10.1016/j.tibs.2013.06.012. Epub 2013 Jul 29. Review.

26.

BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.

Slupianek A, Falinski R, Znojek P, Stoklosa T, Flis S, Doneddu V, Pytel D, Synowiec E, Blasiak J, Bellacosa A, Skorski T.

Leukemia. 2013 Mar;27(3):629-34. doi: 10.1038/leu.2012.294. Epub 2012 Oct 9.

27.

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA.

Mol Cell. 2012 Nov 9;48(3):353-64. doi: 10.1016/j.molcel.2012.08.025. Epub 2012 Sep 27.

28.

PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA.

Mol Cell Biol. 2012 Jun;32(12):2268-78. doi: 10.1128/MCB.00063-12. Epub 2012 Apr 9.

29.

BCR/ABL stimulates WRN to promote survival and genomic instability.

Slupianek A, Poplawski T, Jozwiakowski SK, Cramer K, Pytel D, Stoczynska E, Nowicki MO, Blasiak J, Skorski T.

Cancer Res. 2011 Feb 1;71(3):842-51. doi: 10.1158/0008-5472.CAN-10-1066. Epub 2010 Dec 1.

30.

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.

Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA.

Oncogene. 2010 Jul 8;29(27):3881-95. doi: 10.1038/onc.2010.153. Epub 2010 May 10.

31.

DNA damage and repair of head and neck cancer cells after radio- and chemotherapy.

Rusin P, Walczak A, Zwierzchlejska A, Olszewski J, Morawiec-Bajda A, Kaczmarczyk D, Kusmierczyk K, Garncarek P, Pytel D, Sliwinński T, Majsterek I.

Z Naturforsch C. 2009 Jul-Aug;64(7-8):601-10.

PMID:
19791515
32.

Tyrosine kinase blockers: new hope for successful cancer therapy.

Pytel D, Sliwinski T, Poplawski T, Ferriola D, Majsterek I.

Anticancer Agents Med Chem. 2009 Jan;9(1):66-76. Review.

PMID:
19149483
33.

[Uracil-DNA glycosylases].

Pytel D, Słupianek A, Ksiazek D, Skórski T, Błasiak J.

Postepy Biochem. 2008;54(4):362-70. Review. Polish.

PMID:
19248582
34.

[The role of oncogenic tyrosine kinases in the cellular response to anticancer therapy].

Słupianek A, Pytel D, Majsterek I.

Postepy Hig Med Dosw (Online). 2007 Dec 14;61:819-27. Polish.

35.

Imatinib (STI571) inhibits DNA repair in human leukemia oncogenic tyrosine kinase-expressing cells.

Majsterek I, Arabski M, Czechowska A, Pytel D, Morawiec Z, Morawiec-Bajda A, Blasiak J.

Z Naturforsch C. 2006 Nov-Dec;61(11-12):896-902.

PMID:
17294703
36.

Comparative study of DNA damage, cell cycle and apoptosis in human K562 and CCRF-CEM leukemia cells: role of BCR/ABL in therapeutic resistance.

Pytel D, Wysocki T, Majsterek I.

Comp Biochem Physiol C Toxicol Pharmacol. 2006 Sep;144(1):85-92. Epub 2006 Jun 29.

PMID:
16904383
37.

Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair.

Majsterek I, Sliwinski T, Poplawski T, Pytel D, Kowalski M, Slupianek A, Skorski T, Blasiak J.

Mutat Res. 2006 Jan 31;603(1):74-82. Epub 2006 Jan 4.

PMID:
16388976
38.

[Tyrosine kinases. New target of anticancer therapy].

Majsterek I, Pytel D, Błasiak J.

Postepy Biochem. 2005;51(3):251-60. Review. Polish.

PMID:
16381169

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