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Items: 28


A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.

Saunders LR, Bankovich AJ, Anderson WC, Aujay MA, Bheddah S, Black K, Desai R, Escarpe PA, Hampl J, Laysang A, Liu D, Lopez-Molina J, Milton M, Park A, Pysz MA, Shao H, Slingerland B, Torgov M, Williams SA, Foord O, Howard P, Jassem J, Badzio A, Czapiewski P, Harpole DH, Dowlati A, Massion PP, Travis WD, Pietanza MC, Poirier JT, Rudin CM, Stull RA, Dylla SJ.

Sci Transl Med. 2015 Aug 26;7(302):302ra136. doi: 10.1126/scitranslmed.aac9459.


Initiation and characterization of small cell lung cancer patient-derived xenografts from ultrasound-guided transbronchial needle aspirates.

Anderson WC, Boyd MB, Aguilar J, Pickell B, Laysang A, Pysz MA, Bheddah S, Ramoth J, Slingerland BC, Dylla SJ, Rubio ER.

PLoS One. 2015 May 8;10(5):e0125255. doi: 10.1371/journal.pone.0125255. eCollection 2015.


Vascular endothelial growth factor receptor type 2-targeted contrast-enhanced US of pancreatic cancer neovasculature in a genetically engineered mouse model: potential for earlier detection.

Pysz MA, Machtaler SB, Seeley ES, Lee JJ, Brentnall TA, Rosenberg J, Tranquart F, Willmann JK.

Radiology. 2015 Mar;274(3):790-9. doi: 10.1148/radiol.14140568. Epub 2014 Oct 14.


Differential regulation of cyclin D1 expression by protein kinase C α and ϵ signaling in intestinal epithelial cells.

Pysz MA, Hao F, Hizli AA, Lum MA, Swetzig WM, Black AR, Black JD.

J Biol Chem. 2014 Aug 8;289(32):22268-83. doi: 10.1074/jbc.M114.571554. Epub 2014 Jun 9.


Ultrasound molecular imaging in a human CD276 expression-modulated murine ovarian cancer model.

Lutz AM, Bachawal SV, Drescher CW, Pysz MA, Willmann JK, Gambhir SS.

Clin Cancer Res. 2014 Mar 1;20(5):1313-22. doi: 10.1158/1078-0432.CCR-13-1642. Epub 2014 Jan 3.


Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiency.

Panje CM, Wang DS, Pysz MA, Paulmurugan R, Ren Y, Tranquart F, Tian L, Willmann JK.

Theranostics. 2012;2(11):1078-91. doi: 10.7150/thno.4240. Epub 2012 Nov 8.


Fast microbubble dwell-time based ultrasonic molecular imaging approach for quantification and monitoring of angiogenesis in cancer.

Pysz MA, Guracar I, Tian L, Willmann JK.

Quant Imaging Med Surg. 2012 Jun;2(2):68-80. Epub 2012 Jun 15.


Cationic versus neutral microbubbles for ultrasound-mediated gene delivery in cancer.

Wang DS, Panje C, Pysz MA, Paulmurugan R, Rosenberg J, Gambhir SS, Schneider M, Willmann JK.

Radiology. 2012 Sep;264(3):721-32. doi: 10.1148/radiol.12112368. Epub 2012 Jun 21.


β-Catenin regulates hepatic mitochondrial function and energy balance in mice.

Lehwald N, Tao GZ, Jang KY, Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG.

Gastroenterology. 2012 Sep;143(3):754-764. doi: 10.1053/j.gastro.2012.05.048. Epub 2012 Jun 7.


Quantitative assessment of tumor angiogenesis using real-time motion-compensated contrast-enhanced ultrasound imaging.

Pysz MA, Guracar I, Foygel K, Tian L, Willmann JK.

Angiogenesis. 2012 Sep;15(3):433-42. doi: 10.1007/s10456-012-9271-3. Epub 2012 Apr 26.


Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer.

Kimura RH, Teed R, Hackel BJ, Pysz MA, Chuang CZ, Sathirachinda A, Willmann JK, Gambhir SS.

Clin Cancer Res. 2012 Feb 1;18(3):839-49. doi: 10.1158/1078-0432.CCR-11-1116. Epub 2011 Dec 15.


Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium.

Hao F, Pysz MA, Curry KJ, Haas KN, Seedhouse SJ, Black AR, Black JD.

J Biol Chem. 2011 May 20;286(20):18104-17. doi: 10.1074/jbc.M110.208488. Epub 2011 Mar 18.


Targeted contrast-enhanced ultrasound: an emerging technology in abdominal and pelvic imaging.

Pysz MA, Willmann JK.

Gastroenterology. 2011 Mar;140(3):785-90. doi: 10.1053/j.gastro.2011.01.027. Epub 2011 Jan 18. Review. No abstract available.


Assessment and monitoring tumor vascularity with contrast-enhanced ultrasound maximum intensity persistence imaging.

Pysz MA, Foygel K, Panje CM, Needles A, Tian L, Willmann JK.

Invest Radiol. 2011 Mar;46(3):187-95. doi: 10.1097/RLI.0b013e3181f9202d.


Molecular ultrasound assessment of tumor angiogenesis.

Deshpande N, Pysz MA, Willmann JK.

Angiogenesis. 2010 Jun;13(2):175-88. doi: 10.1007/s10456-010-9175-z. Epub 2010 Jun 12. Review.


Molecular imaging: current status and emerging strategies.

Pysz MA, Gambhir SS, Willmann JK.

Clin Radiol. 2010 Jul;65(7):500-16. doi: 10.1016/j.crad.2010.03.011. Review.


Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55).

Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JK.

Radiology. 2010 Aug;256(2):519-27. doi: 10.1148/radiol.10091858. Epub 2010 Jun 1.


PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.

Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen KP, Robine S, Velcich A, Augenlicht LH, Black AR, Black JD.

Exp Cell Res. 2009 May 1;315(8):1415-28. doi: 10.1016/j.yexcr.2009.02.002. Epub 2009 Feb 14.


Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells.

Hizli AA, Black AR, Pysz MA, Black JD.

J Biol Chem. 2006 May 26;281(21):14596-603. Epub 2006 Mar 23.


Genome-wide transcriptional variation within and between steady states for continuous growth of the hyperthermophile Thermotoga Maritima.

Shockley KR, Scott KL, Pysz MA, Conners SB, Johnson MR, Montero CI, Wolfinger RD, Kelly RM.

Appl Environ Microbiol. 2005 Sep;71(9):5572-6.


Transcriptional analysis of biofilm formation processes in the anaerobic, hyperthermophilic bacterium Thermotoga maritima.

Pysz MA, Conners SB, Montero CI, Shockley KR, Johnson MR, Ward DE, Kelly RM.

Appl Environ Microbiol. 2004 Oct;70(10):6098-112.


Functional genomics-based studies of the microbial ecology of hyperthermophilic micro-organisms.

Johnson MR, Montero CI, Conners SB, Shockley KR, Pysz MA, Kelly RM.

Biochem Soc Trans. 2004 Apr;32(Pt 2):188-92. Review.


Transcriptional analysis of dynamic heat-shock response by the hyperthermophilic bacterium Thermotoga maritima.

Pysz MA, Ward DE, Shockley KR, Montero CI, Conners SB, Johnson MR, Kelly RM.

Extremophiles. 2004 Jun;8(3):209-17. Epub 2004 Feb 27.


Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells.

Clark JA, Black AR, Leontieva OV, Frey MR, Pysz MA, Kunneva L, Woloszynska-Read A, Roy D, Black JD.

J Biol Chem. 2004 Mar 5;279(10):9233-47. Epub 2003 Dec 11.


Growth of hyperthermophilic archaeon Pyrococcus furiosus on chitin involves two family 18 chitinases.

Gao J, Bauer MW, Shockley KR, Pysz MA, Kelly RM.

Appl Environ Microbiol. 2003 Jun;69(6):3119-28.


Rheology of protein gels synthesized through a combined enzymatic and heat treatment method.

Burke MD, Ha SY, Pysz MA, Khan SA.

Int J Biol Macromol. 2002 Dec 20;31(1-3):37-44.


Continuous cultivation of hyperthermophiles.

Pysz MA, Rinker KD, Shockley KR, Kelly RM.

Methods Enzymol. 2001;330:31-40. No abstract available.


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