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Items: 1 to 50 of 71

1.

Cat flu: Broad spectrum polymeric antivirals.

Synowiec A, Gryniuk I, Pachota M, Strzelec Ł, Roman O, Kłysik-Trzciańska K, Zając M, Drebot I, Gula K, Andruchowicz A, Rajfur Z, Szczubiałka K, Nowakowska M, Pyrc K.

Antiviral Res. 2019 Jul 17;170:104563. doi: 10.1016/j.antiviral.2019.104563. [Epub ahead of print]

PMID:
31325462
2.

Membrane protein of HCoV-NL63 is responsible for interaction with the adhesion receptor.

Naskalska A, Dabrowska A, Szczepanski A, Milewska A, Jasik KP, Pyrc K.

J Virol. 2019 Jul 17. pii: JVI.00355-19. doi: 10.1128/JVI.00355-19. [Epub ahead of print]

PMID:
31315999
3.

Highly Effective and Safe Polymeric Inhibitors of Herpes Simplex Virus in Vitro and in Vivo.

Pachota M, Kłysik-Trzciańska K, Synowiec A, Yukioka S, Yusa SI, Zając M, Zawilinska B, Dzieciątkowski T, Szczubialka K, Pyrc K, Nowakowska M.

ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26745-26752. doi: 10.1021/acsami.9b10302. Epub 2019 Jul 19.

PMID:
31287654
4.

Detection of legal highs in the urine of methadone-treated patient by LC-MS.

Labuz K, Adamowicz P, Kała M, Pyrc K, Reszke E, Mielczarek P, Silberring J, Smoluch M.

Basic Clin Pharmacol Toxicol. 2019 Sep;125(3):253-258. doi: 10.1111/bcpt.13270. Epub 2019 Jun 26. Review.

PMID:
31188528
5.

Zika virus: mapping and reprogramming the entry.

Owczarek K, Chykunova Y, Jassoy C, Maksym B, Rajfur Z, Pyrc K.

Cell Commun Signal. 2019 May 3;17(1):41. doi: 10.1186/s12964-019-0349-z.

6.

Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors.

Szczepanski A, Owczarek K, Bzowska M, Gula K, Drebot I, Ochman M, Maksym B, Rajfur Z, Mitchell JA, Pyrc K.

Viruses. 2019 Apr 5;11(4). pii: E328. doi: 10.3390/v11040328.

7.

Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human metapneumovirus.

Ciejka J, Botwina P, Nowakowska M, Szczubiałka K, Pyrc K.

PLoS One. 2019 Mar 28;14(3):e0214646. doi: 10.1371/journal.pone.0214646. eCollection 2019.

8.

Phosphonate inhibitors of West Nile virus NS2B/NS3 protease.

Skoreński M, Milewska A, Pyrć K, Sieńczyk M, Oleksyszyn J.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):8-14. doi: 10.1080/14756366.2018.1506772.

9.

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease.

Gruba N, Martinez JIR, Grzywa R, Wysocka M, Skoreński M, Dabrowska A, Łęcka M, Suder P, Sieńczyk M, Pyrc K, Lesner A.

ACS Med Chem Lett. 2018 Aug 28;9(10):1025-1029. doi: 10.1021/acsmedchemlett.8b00316. eCollection 2018 Oct 11.

PMID:
30344911
10.

Novel coronavirus-like particles targeting cells lining the respiratory tract.

Naskalska A, Dabrowska A, Nowak P, Szczepanski A, Jasik K, Milewska A, Ochman M, Zeglen S, Rajfur Z, Pyrc K.

PLoS One. 2018 Sep 5;13(9):e0203489. doi: 10.1371/journal.pone.0203489. eCollection 2018.

11.

Bacterial Infections During Hospital Stay and Their Impact on Mortality After Lung Transplantation: A Single-Center Study.

Wojarski J, Ochman M, Medrala W, Kulaczkowska Z, Karolak W, Maruszewski M, Urlik M, Wozniak-Grygiel E, Sioła M, Latos M, Biniszkiewicz P, Pyrc K, Zeglen S.

Transplant Proc. 2018 Sep;50(7):2064-2069. doi: 10.1016/j.transproceed.2017.11.080. Epub 2018 Mar 13.

PMID:
30177110
12.

Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients.

Wojarski J, Ochman M, Latos M, Biniszkiewicz P, Karolak W, Woźniak-Grygiel E, Maruszewski M, Urlik M, Mędrala W, Kułaczkowska Z, Pyrc K, Żegleń S.

Transplant Proc. 2018 Sep;50(7):2053-2058. doi: 10.1016/j.transproceed.2017.12.059. Epub 2018 Mar 13.

PMID:
30177108
13.

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.

Szczepanski A, Owczarek K, Milewska A, Baster Z, Rajfur Z, Mitchell JA, Pyrc K.

Vet Res. 2018 Jul 3;49(1):55. doi: 10.1186/s13567-018-0551-9.

14.

Early events during human coronavirus OC43 entry to the cell.

Owczarek K, Szczepanski A, Milewska A, Baster Z, Rajfur Z, Sarna M, Pyrc K.

Sci Rep. 2018 May 8;8(1):7124. doi: 10.1038/s41598-018-25640-0.

15.

APOBEC3-mediated restriction of RNA virus replication.

Milewska A, Kindler E, Vkovski P, Zeglen S, Ochman M, Thiel V, Rajfur Z, Pyrc K.

Sci Rep. 2018 Apr 13;8(1):5960. doi: 10.1038/s41598-018-24448-2.

16.

Entry of Human Coronavirus NL63 into the Cell.

Milewska A, Nowak P, Owczarek K, Szczepanski A, Zarebski M, Hoang A, Berniak K, Wojarski J, Zeglen S, Baster Z, Rajfur Z, Pyrc K.

J Virol. 2018 Jan 17;92(3). pii: e01933-17. doi: 10.1128/JVI.01933-17. Print 2018 Feb 1.

17.

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.

Skalniak L, Zak KM, Guzik K, Magiera K, Musielak B, Pachota M, Szelazek B, Kocik J, Grudnik P, Tomala M, Krzanik S, Pyrc K, Dömling A, Dubin G, Holak TA.

Oncotarget. 2017 Aug 7;8(42):72167-72181. doi: 10.18632/oncotarget.20050. eCollection 2017 Sep 22.

18.

Inhibition of Herpes Simplex Viruses by Cationic Dextran Derivatives.

Pachota M, Klysik K, Synowiec A, Ciejka J, Szczubiałka K, Pyrć K, Nowakowska M.

J Med Chem. 2017 Oct 26;60(20):8620-8630. doi: 10.1021/acs.jmedchem.7b01189. Epub 2017 Oct 6.

PMID:
28956914
19.

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs in the Porphyromonas gingivalis CRISPR-Cas I-C System.

Burmistrz M, Rodriguez Martinez JI, Krochmal D, Staniec D, Pyrc K.

J Bacteriol. 2017 Oct 31;199(23). pii: e00275-17. doi: 10.1128/JB.00275-17. Print 2017 Dec 1.

20.

Novel peptidyl α-aminoalkylphosphonates as inhibitors of hepatitis C virus NS3/4A protease.

Skoreński M, Pachota M, Pyrć K, Sieńczyk M, Oleksyszyn J.

Antiviral Res. 2017 Aug;144:286-298. doi: 10.1016/j.antiviral.2017.06.020. Epub 2017 Jun 30.

PMID:
28673801
21.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.

22.

Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses.

Ciejka J, Wolski K, Nowakowska M, Pyrc K, Szczubiałka K.

Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:735-742. doi: 10.1016/j.msec.2017.03.047. Epub 2017 Mar 6.

PMID:
28482585
23.

Structural Characterization of Human Coronavirus NL63 N Protein.

Szelazek B, Kabala W, Kus K, Zdzalik M, Twarda-Clapa A, Golik P, Burmistrz M, Florek D, Wladyka B, Pyrc K, Dubin G.

J Virol. 2017 May 12;91(11). pii: e02503-16. doi: 10.1128/JVI.02503-16. Print 2017 Jun 1.

24.

Substrate profiling of Zika virus NS2B-NS3 protease.

Gruba N, Rodriguez Martinez JI, Grzywa R, Wysocka M, Skoreński M, Burmistrz M, Łęcka M, Lesner A, Sieńczyk M, Pyrć K.

FEBS Lett. 2016 Oct;590(20):3459-3468. doi: 10.1002/1873-3468.12443. Epub 2016 Oct 18.

25.

Type III CRISPR complexes from Thermus thermophilus.

Szychowska M, Siwek W, Pawolski D, Kazrani AA, Pyrc K, Bochtler M.

Acta Biochim Pol. 2016;63(2):377-86. doi: 10.18388/abp.2016_1261. Epub 2016 Jun 14.

26.

HTCC: Broad Range Inhibitor of Coronavirus Entry.

Milewska A, Kaminski K, Ciejka J, Kosowicz K, Zeglen S, Wojarski J, Nowakowska M, Szczubiałka K, Pyrc K.

PLoS One. 2016 Jun 1;11(6):e0156552. doi: 10.1371/journal.pone.0156552. eCollection 2016.

27.

Novel Polyanions Inhibiting Replication of Influenza Viruses.

Ciejka J, Milewska A, Wytrwal M, Wojarski J, Golda A, Ochman M, Nowakowska M, Szczubialka K, Pyrc K.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):1955-66. doi: 10.1128/AAC.02183-15. Print 2016 Apr.

28.

CRISPR-Cas Systems in Prokaryotes.

Burmistrz M, Pyrć K.

Pol J Microbiol. 2015;64(3):193-202. Review.

29.

Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis.

Benedyk M, Mydel PM, Delaleu N, Płaza K, Gawron K, Milewska A, Maresz K, Koziel J, Pyrc K, Potempa J.

J Innate Immun. 2016;8(2):185-98. doi: 10.1159/000441724. Epub 2015 Nov 28.

30.

Virus Like Particles as Immunogens and Universal Nanocarriers.

Naskalska A, Pyrć K.

Pol J Microbiol. 2015;64(1):3-13. Review.

31.

Functional Analysis of Porphyromonas gingivalis W83 CRISPR-Cas Systems.

Burmistrz M, Dudek B, Staniec D, Rodriguez Martinez JI, Bochtler M, Potempa J, Pyrc K.

J Bacteriol. 2015 Aug;197(16):2631-41. doi: 10.1128/JB.00261-15. Epub 2015 May 26.

32.

Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme.

Huang X, Dong W, Milewska A, Golda A, Qi Y, Zhu QK, Marasco WA, Baric RS, Sims AC, Pyrc K, Li W, Sui J.

J Virol. 2015 Jul;89(14):7202-13. doi: 10.1128/JVI.00854-15. Epub 2015 Apr 29.

33.

The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps.

Zabieglo K, Majewski P, Majchrzak-Gorecka M, Wlodarczyk A, Grygier B, Zegar A, Kapinska-Mrowiecka M, Naskalska A, Pyrc K, Dubin A, Wahl SM, Cichy J.

J Leukoc Biol. 2015 Jul;98(1):99-106. doi: 10.1189/jlb.4AB1114-543R. Epub 2015 Apr 27.

34.

The nucleocapsid protein of human coronavirus NL63.

Zuwała K, Golda A, Kabala W, Burmistrz M, Zdzalik M, Nowak P, Kedracka-Krok S, Zarebski M, Dobrucki J, Florek D, Zeglen S, Wojarski J, Potempa J, Dubin G, Pyrc K.

PLoS One. 2015 Feb 20;10(2):e0117833. doi: 10.1371/journal.pone.0117833. eCollection 2015.

35.

Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.

Milewska A, Zarebski M, Nowak P, Stozek K, Potempa J, Pyrc K.

J Virol. 2014 Nov;88(22):13221-30. doi: 10.1128/JVI.02078-14. Epub 2014 Sep 3.

36.

In vitro testing the potential of a novel chimeric IgG variant for inhibiting collagen fibrils formation in recurrent hereditary gingival fibromatosis: chimeric antibody in a gingival model.

Gawron K, Lazarz-Bartyzel K, Lazarz M, Steplewska K, Pyrc K, Potempa J, Chomyszyn-Gajewska M.

J Physiol Pharmacol. 2014 Aug;65(4):585-91.

37.

Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis.

Koziel J, Bryzek D, Sroka A, Maresz K, Glowczyk I, Bielecka E, Kantyka T, Pyrć K, Svoboda P, Pohl J, Potempa J.

J Immunol. 2014 Jun 1;192(11):5363-72. doi: 10.4049/jimmunol.1303062. Epub 2014 Apr 25.

38.

Stability of infectious human coronavirus NL63.

Florek D, Burmistrz M, Potempa J, Pyrc K.

J Virol Methods. 2014 Sep 1;205:87-90. doi: 10.1016/j.jviromet.2014.04.001. Epub 2014 Apr 18.

PMID:
24747590
39.

Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD).

Maresz KJ, Hellvard A, Sroka A, Adamowicz K, Bielecka E, Koziel J, Gawron K, Mizgalska D, Marcinska KA, Benedyk M, Pyrc K, Quirke AM, Jonsson R, Alzabin S, Venables PJ, Nguyen KA, Mydel P, Potempa J.

PLoS Pathog. 2013 Sep;9(9):e1003627. doi: 10.1371/journal.ppat.1003627. Epub 2013 Sep 12.

40.

Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung.

Kantyka T, Pyrc K, Gruca M, Smagur J, Plaza K, Guzik K, Zeglen S, Ochman M, Potempa J.

J Innate Immun. 2013;5(3):251-60. doi: 10.1159/000345417. Epub 2012 Dec 11.

41.

HexaPrime: a novel method for detection of coronaviruses.

Pyrc K, Stożek K, Galan W, Potempa J.

J Virol Methods. 2013 Mar;188(1-2):29-36. doi: 10.1016/j.jviromet.2012.11.039. Epub 2012 Dec 7.

PMID:
23219933
42.

Novel polymeric inhibitors of HCoV-NL63.

Milewska A, Ciejka J, Kaminski K, Karewicz A, Bielska D, Zeglen S, Karolak W, Nowakowska M, Potempa J, Bosch BJ, Pyrc K, Szczubialka K.

Antiviral Res. 2013 Feb;97(2):112-21. doi: 10.1016/j.antiviral.2012.11.006. Epub 2012 Nov 29.

PMID:
23201315
43.

Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage.

Pyrc K, Milewska A, Kantyka T, Sroka A, Maresz K, Kozieł J, Nguyen KA, Enghild JJ, Knudsen AD, Potempa J.

Infect Immun. 2013 Jan;81(1):55-64. doi: 10.1128/IAI.00830-12. Epub 2012 Oct 22.

44.
45.

Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63.

Dijkman R, Jebbink MF, Deijs M, Milewska A, Pyrc K, Buelow E, van der Bijl A, van der Hoek L.

J Gen Virol. 2012 Sep;93(Pt 9):1924-9. doi: 10.1099/vir.0.043919-0. Epub 2012 Jun 20.

PMID:
22718567
46.

Use of sensitive, broad-spectrum molecular assays and human airway epithelium cultures for detection of respiratory pathogens.

Pyrc K, Stożek K, Wojcik K, Gawron K, Zeglen S, Karolak W, Wojarski J, Ochman M, Hubalewska-Mazgaj M, Bochenek G, Sanak M, Zembala M, Szczeklik A, Potempa J.

PLoS One. 2012;7(3):e32582. doi: 10.1371/journal.pone.0032582. Epub 2012 Mar 5.

47.

Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro.

Pyrc K, Strzyz P, Milewska A, Golda A, Schildgen O, Potempa J.

J Gen Virol. 2011 Oct;92(Pt 10):2324-32. doi: 10.1099/vir.0.032094-0. Epub 2011 Jun 29.

PMID:
21715599
48.

Development of loop-mediated isothermal amplification assay for detection of human coronavirus-NL63.

Pyrc K, Milewska A, Potempa J.

J Virol Methods. 2011 Jul;175(1):133-6. doi: 10.1016/j.jviromet.2011.04.024. Epub 2011 Apr 27.

PMID:
21545810
49.

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells.

Golda A, Malek N, Dudek B, Zeglen S, Wojarski J, Ochman M, Kucewicz E, Zembala M, Potempa J, Pyrc K.

J Gen Virol. 2011 Jun;92(Pt 6):1358-68. doi: 10.1099/vir.0.028381-0. Epub 2011 Feb 16.

50.

Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures.

Pyrc K, Sims AC, Dijkman R, Jebbink M, Long C, Deming D, Donaldson E, Vabret A, Baric R, van der Hoek L, Pickles R.

J Virol. 2010 Nov;84(21):11255-63. doi: 10.1128/JVI.00947-10. Epub 2010 Aug 18.

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