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Items: 1 to 50 of 269

1.

Total Synthesis of Natural Hyacinthacine C5 and Six Related Hyacinthacine C5 Epimers.

Carroll AW, Savaspun K, Willis AC, Hoshino M, Kato A, Pyne SG.

J Org Chem. 2018 May 18;83(10):5558-5576. doi: 10.1021/acs.joc.8b00585. Epub 2018 May 3.

PMID:
29701065
2.

Sphingosine Kinases as Druggable Targets.

Pyne S, Adams DR, Pyne NJ.

Handb Exp Pharmacol. 2018 Feb 20. doi: 10.1007/164_2018_96. [Epub ahead of print]

PMID:
29460151
3.

Barriers and enablers to adoption of intrauterine device as a contraceptive method: A multi-stakeholder perspective.

Mishra N, Panda M, Pyne S, Srinivas N, Pati S, Pati S.

J Family Med Prim Care. 2017 Jul-Sep;6(3):616-621. doi: 10.4103/2249-4863.222028.

4.

Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots.

Cheenpracha S, Boapun P, Limtharakul Née Ritthiwigrom T, Laphookhieo S, Pyne SG.

Nat Prod Res. 2017 Nov 24:1-7. doi: 10.1080/14786419.2017.1408108. [Epub ahead of print]

PMID:
29172699
5.

Ca2+/nuclear factor of activated T cells signaling is enriched in early-onset rectal tumors devoid of canonical Wnt activation.

Kumar R, Raman R, Kotapalli V, Gowrishankar S, Pyne S, Pollack JR, Bashyam MD.

J Mol Med (Berl). 2018 Feb;96(2):135-146. doi: 10.1007/s00109-017-1607-4. Epub 2017 Nov 9.

PMID:
29124284
6.

Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species.

Phetsang S, Panyakaew J, Wangkarn S, Chandet N, Inta A, Kittiwachana S, Pyne SG, Mungkornasawakul P.

Nat Prod Res. 2017 Oct 26:1-4. doi: 10.1080/14786419.2017.1395436. [Epub ahead of print]

PMID:
29072094
7.

Resolution and identification of scalemic caged xanthones from the leaf extract of Garcinia propinqua having potent cytotoxicities against colon cancer cells.

Sriyatep T, Tantapakul C, Andersen RJ, Patrick BO, Pyne SG, Muanprasat C, Seemakhan S, Borwornpinyo S, Laphookhieo S.

Fitoterapia. 2018 Jan;124:34-41. doi: 10.1016/j.fitote.2017.10.009. Epub 2017 Oct 12.

PMID:
29031558
8.

A brief review of single-cell transcriptomic technologies.

Kalisky T, Oriel S, Bar-Lev TH, Ben-Haim N, Trink A, Wineberg Y, Kanter I, Gilad S, Pyne S.

Brief Funct Genomics. 2018 Jan 1;17(1):64-76. doi: 10.1093/bfgp/elx019.

PMID:
28968725
9.

Sphingosine 1-phosphate and cancer.

Pyne NJ, El Buri A, Adams DR, Pyne S.

Adv Biol Regul. 2018 May;68:97-106. doi: 10.1016/j.jbior.2017.09.006. Epub 2017 Sep 15. Review.

PMID:
28942351
10.

Gene-Set Reduction for Analysis of Major and Minor Gleason Scores Based on Differential Gene-Set Expressions and Biological Pathways in Prostate Cancer.

Dinu I, Poudel S, Pyne S.

Cancer Inform. 2017 Sep 11;16:1176935117730016. doi: 10.1177/1176935117730016. eCollection 2017.

11.

Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships.

Umsumarng S, Pitchakarn P, Yodkeeree S, Punfa W, Mapoung S, Ramli RA, Pyne SG, Limtrakul P.

Phytomedicine. 2017 Oct 15;34:182-190. doi: 10.1016/j.phymed.2017.08.004. Epub 2017 Aug 3.

PMID:
28899501
12.

The Effect of Intra-articular Cocktail Versus Femoral Nerve Block for Patients Undergoing Hip Arthroscopy.

Childs S, Pyne S, Nandra K, Bakhsh W, Mustafa SA, Giordano BD.

Arthroscopy. 2017 Dec;33(12):2170-2176. doi: 10.1016/j.arthro.2017.06.036. Epub 2017 Aug 31.

PMID:
28866348
13.

Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?

Pyne NJ, Pyne S.

Trends Mol Med. 2017 Sep;23(9):786-798. doi: 10.1016/j.molmed.2017.07.001. Epub 2017 Aug 5. Review.

PMID:
28789830
14.

Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors.

Pyne NJ, Adams DR, Pyne S.

Trends Pharmacol Sci. 2017 Jul;38(7):581-591. doi: 10.1016/j.tips.2017.04.003. Epub 2017 Jun 9. Review.

PMID:
28606480
15.

2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae).

Auranwiwat C, Wongsomboon P, Thaima T, Rattanajak R, Kamchonwongpaisan S, Willis AC, Lie W, Pyne SG, Limtharakul Née Ritthiwigrom T.

Fitoterapia. 2017 Jul;120:103-107. doi: 10.1016/j.fitote.2017.06.002. Epub 2017 Jun 9.

PMID:
28596029
16.

Oxazolidinones and 2,5-Dihydrofurans via Zinc-Catalyzed Regioselective Allenylation Reactions of l-α-Amino Aldehydes.

Zamani F, Pyne SG, Hyland CJT.

J Org Chem. 2017 Jul 7;82(13):6819-6830. doi: 10.1021/acs.joc.7b00969. Epub 2017 Jun 14.

PMID:
28557457
17.

Partial identification in the statistical matching problem.

Ahfock D, Pyne S, Lee SX, McLachlan GJ.

Comput Stat Data Anal. 2016 Dec;104:79-90. doi: 10.1016/j.csda.2016.06.005.

18.

Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua.

Sriyatep T, Andersen RJ, Patrick BO, Pyne SG, Muanprasat C, Seemakhan S, Borwornpinyo S, Laphookhieo S.

J Nat Prod. 2017 May 26;80(5):1658-1667. doi: 10.1021/acs.jnatprod.7b00240. Epub 2017 May 10.

PMID:
28489373
19.

Sphingosine kinase 2 and multiple myeloma.

Pyne NJ, Pyne S.

Oncotarget. 2017 Jul 4;8(27):43596-43597. doi: 10.18632/oncotarget.17420. No abstract available.

20.

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells.

Pyne NJ, Pyne S.

Molecules. 2017 Feb 23;22(3). pii: E344. doi: 10.3390/molecules22030344. Review.

21.

Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.

Barbour M, McNaughton M, Boomkamp SD, MacRitchie N, Jiang HR, Pyne NJ, Pyne S.

Br J Pharmacol. 2017 Jan;174(2):210-222. doi: 10.1111/bph.13670. Epub 2016 Dec 20.

22.

Deformation-induced transitional myofibroblasts contribute to compensatory lung growth.

Bennett RD, Ysasi AB, Wagner WL, Valenzuela CD, Tsuda A, Pyne S, Li S, Grimsby J, Pokharel P, Livak KJ, Ackermann M, Blainey P, Mentzer SJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L79-L88. doi: 10.1152/ajplung.00383.2016. Epub 2016 Nov 11.

23.

Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes.

Marusyk A, Tabassum DP, Janiszewska M, Place AE, Trinh A, Rozhok AI, Pyne S, Guerriero JL, Shu S, Ekram M, Ishkin A, Cahill DP, Nikolsky Y, Chan TA, Rimawi MF, Hilsenbeck S, Schiff R, Osborne KC, Letai A, Polyak K.

Cancer Res. 2016 Nov 15;76(22):6495-6506. doi: 10.1158/0008-5472.CAN-16-1457. Epub 2016 Sep 26.

24.

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.

Evangelisti C, Evangelisti C, Buontempo F, Lonetti A, Orsini E, Chiarini F, Barata JT, Pyne S, Pyne NJ, Martelli AM.

Leukemia. 2016 Nov;30(11):2142-2151. doi: 10.1038/leu.2016.208. Epub 2016 Jul 27. Review.

PMID:
27461062
25.

Two new bioactive iridoids from Rothmannia wittii.

Chaipukdee N, Kanokmedhakul K, Kanokmedhakul S, Lekphrom R, Pyne SG.

Fitoterapia. 2016 Sep;113:97-101. doi: 10.1016/j.fitote.2016.07.007. Epub 2016 Jul 16.

PMID:
27431771
26.

The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction.

Dalton N, Gordon CP, Boyle TP, Vandegraaf N, Deadman J, Rhodes DI, Coates JA, Pyne SG, Keller PA, Bremner JB.

Org Biomol Chem. 2016 Jul 7;14(25):6010-23. doi: 10.1039/c6ob00950f. Epub 2016 May 26.

PMID:
27225230
27.

Fire in the mind: changing understandings of fire in Western civilization.

Pyne SJ.

Philos Trans R Soc Lond B Biol Sci. 2016 Jun 5;371(1696). pii: 20150166. doi: 10.1098/rstb.2015.0166.

28.

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.

MacRitchie N, Volpert G, Al Washih M, Watson DG, Futerman AH, Kennedy S, Pyne S, Pyne NJ.

Cell Signal. 2016 Aug;28(8):946-55. doi: 10.1016/j.cellsig.2016.03.014. Epub 2016 Apr 6.

29.

Sphingosine Kinases: Emerging Structure-Function Insights.

Adams DR, Pyne S, Pyne NJ.

Trends Biochem Sci. 2016 May;41(5):395-409. doi: 10.1016/j.tibs.2016.02.007. Epub 2016 Mar 25. Review.

PMID:
27021309
30.

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.

Pyne S, Adams DR, Pyne NJ.

Prog Lipid Res. 2016 Apr;62:93-106. doi: 10.1016/j.plipres.2016.03.001. Epub 2016 Mar 10. Review.

PMID:
26970273
32.

Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.

Promchai T, Jaidee A, Cheenpracha S, Trisuwan K, Rattanajak R, Kamchonwongpaisan S, Laphookhieo S, Pyne SG, Ritthiwigrom T.

J Nat Prod. 2016 Apr 22;79(4):978-83. doi: 10.1021/acs.jnatprod.5b01054. Epub 2016 Mar 1.

PMID:
26928423
33.

Synthesis of Bridged Heterocycles via Sequential 1,4- and 1,2-Addition Reactions to α,β-Unsaturated N-Acyliminium Ions: Mechanistic and Computational Studies.

Yazici A, Wille U, Pyne SG.

J Org Chem. 2016 Feb 19;81(4):1434-49. doi: 10.1021/acs.joc.5b02572. Epub 2016 Feb 8.

PMID:
26816207
34.

Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2.

Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC.

Pharmacology. 2016;97(3-4):114-25. doi: 10.1159/000443180. Epub 2016 Jan 7.

PMID:
26734728
35.

Modeling of inter-sample variation in flow cytometric data with the joint clustering and matching procedure.

Lee SX, McLachlan GJ, Pyne S.

Cytometry A. 2016 Jan;89(1):30-43. doi: 10.1002/cyto.a.22789. Epub 2015 Oct 22.

36.

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation.

Pyne NJ, McNaughton M, Boomkamp S, MacRitchie N, Evangelisti C, Martelli AM, Jiang HR, Ubhi S, Pyne S.

Adv Biol Regul. 2016 Jan;60:151-159. doi: 10.1016/j.jbior.2015.09.001. Epub 2015 Sep 25. Review.

PMID:
26429117
37.

Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum.

Jaidee A, Promchai T, Trisuwan K, Laphookhieo S, Rattanajak R, Kamchonwongpaisan S, Pyne SG, Ritthiwigrom T.

Nat Prod Commun. 2015 Jul;10(7):1175-7. Erratum in: Nat Prod Commun. 2015 Dec;10(12):2203.

PMID:
26411003
38.

Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics.

Wales SM, Hammer KA, Somphol K, Kemker I, Schröder DC, Tague AJ, Brkic Z, King AM, Lyras D, Riley TV, Bremner JB, Keller PA, Pyne SG.

Org Biomol Chem. 2015 Nov 28;13(44):10813-24. doi: 10.1039/c5ob01638j. Epub 2015 Sep 9.

PMID:
26349598
39.

Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis.

Wangchuk P, Navarro S, Shepherd C, Keller PA, Pyne SG, Loukas A.

Sci Rep. 2015 Aug 4;5:12845. doi: 10.1038/srep12845.

40.

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis.

Boomkamp SD, Byun HS, Ubhi S, Jiang HR, Pyne S, Bittman R, Pyne NJ.

Chem Phys Lipids. 2016 Jan;194:2-11. doi: 10.1016/j.chemphyslip.2015.07.001. Epub 2015 Jul 14.

PMID:
26187854
41.

Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria.

Wales SM, Hammer KA, King AM, Tague AJ, Lyras D, Riley TV, Keller PA, Pyne SG.

Org Biomol Chem. 2015 May 28;13(20):5743-56. doi: 10.1039/c5ob00576k. Epub 2015 Apr 22.

PMID:
25901416
42.

Teaching ultrasound procedural skills-low cost phantoms and animal models.

Wojtczak JA, Pyne S.

Middle East J Anaesthesiol. 2014 Oct;22(6):603-8.

PMID:
25669005
43.

Regioselective and diastereoselective borono-Mannich reactions with pinacol allenylboronate.

Thaima T, Pyne SG.

Org Lett. 2015 Feb 20;17(4):778-81. doi: 10.1021/ol503424k. Epub 2015 Feb 5.

PMID:
25654247
44.

Innovations in using virtual reality to study how children cross streets in traffic: evidence for evasive action skills.

Morrongiello BA, Corbett M, Milanovic M, Pyne S, Vierich R.

Inj Prev. 2015 Aug;21(4):266-70. doi: 10.1136/injuryprev-2014-041357. Epub 2015 Jan 6.

PMID:
25564045
45.

A new 1,6-benzoxazocine-5-one alkaloid isolated from the aerial parts of Peristrophe lanceolaria.

Prapalert W, Santiarworn D, Liawruangrath S, Liawruangrath B, Pyne SG.

Nat Prod Commun. 2014 Oct;9(10):1433-5.

PMID:
25522531
46.

Crystal Structure of Sphingosine Kinase 1 with PF-543.

Wang J, Knapp S, Pyne NJ, Pyne S, Elkins JM.

ACS Med Chem Lett. 2014 Oct 27;5(12):1329-33. doi: 10.1021/ml5004074. eCollection 2014 Dec 11.

47.

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease.

Lim KG, Gray AI, Anthony NG, Mackay SP, Pyne S, Pyne NJ.

Arch Toxicol. 2014 Dec;88(12):2213-32. doi: 10.1007/s00204-014-1386-4. Epub 2014 Oct 25. Review.

PMID:
25344023
48.

AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer.

Priolo C, Pyne S, Rose J, Regan ER, Zadra G, Photopoulos C, Cacciatore S, Schultz D, Scaglia N, McDunn J, De Marzo AM, Loda M.

Cancer Res. 2014 Dec 15;74(24):7198-204. doi: 10.1158/0008-5472.CAN-14-1490. Epub 2014 Oct 16.

49.

Laser microdissection of the alveolar duct enables single-cell genomic analysis.

Bennett RD, Ysasi AB, Belle JM, Wagner WL, Konerding MA, Blainey PC, Pyne S, Mentzer SJ.

Front Oncol. 2014 Sep 24;4:260. doi: 10.3389/fonc.2014.00260. eCollection 2014.

50.

Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of P-glycoprotein function.

Umsumarng S, Pitchakarn P, Sastraruji K, Yodkeeree S, Ung AT, Pyne SG, Limtrakul P.

Basic Clin Pharmacol Toxicol. 2015 May;116(5):390-7. doi: 10.1111/bcpt.12331. Epub 2014 Oct 24.

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