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Microbiota of the Oropharynx and Endoscope Compared to the Esophagus.

Okereke IC, Miller AL, Hamilton CF, Booth AL, Reep GL, Andersen CL, Reynolds ST, Pyles RB.

Sci Rep. 2019 Jul 15;9(1):10201. doi: 10.1038/s41598-019-46747-y.


Development of a Novel ex vivo Nasal Epithelial Cell Model Supporting Colonization With Human Nasal Microbiota.

Charles DD, Fisher JR, Hoskinson SM, Medina-Colorado AA, Shen YC, Chaaban MR, Widen SG, Eaves-Pyles TD, Maxwell CA, Miller AL, Popov VL, Pyles RB.

Front Cell Infect Microbiol. 2019 May 21;9:165. doi: 10.3389/fcimb.2019.00165. eCollection 2019.


Cultivated Human Vaginal Microbiome Communities Impact Zika and Herpes Simplex Virus Replication in ex vivo Vaginal Mucosal Cultures.

Amerson-Brown MH, Miller AL, Maxwell CA, White MM, Vincent KL, Bourne N, Pyles RB.

Front Microbiol. 2019 Jan 14;9:3340. doi: 10.3389/fmicb.2018.03340. eCollection 2018.


Increased Frequency of Virus Shedding by Herpes Simplex Virus 2-Infected Guinea Pigs in the Absence of CD4+ T Lymphocytes.

Bourne N, Perry CL, Banasik BN, Miller AL, White M, Pyles RB, Schäfer H, Milligan GN.

J Virol. 2019 Feb 5;93(4). pii: e01721-18. doi: 10.1128/JVI.01721-18. Print 2019 Feb 15.


Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2.

Bourne N, Banasik BN, Perry CL, Miller AL, White M, Pyles RB, Milligan GN.

Virology. 2019 Jan 2;526:180-188. doi: 10.1016/j.virol.2018.10.023. Epub 2018 Nov 6.


Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial.

Vincent KL, Moss JA, Marzinke MA, Hendrix CW, Anton PA, Pyles RB, Guthrie KM, Dawson L, Olive TJ, Butkyavichene I, Churchman SA, Cortez JM Jr, Fanter R, Gunawardana M, Miller CS, Yang F, Rosen RK, Vargas SE, Baum MM.

PLoS Med. 2018 Sep 28;15(9):e1002655. doi: 10.1371/journal.pmed.1002655. eCollection 2018 Sep.


Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc.

Vincent KL, Moss JA, Marzinke MA, Hendrix CW, Anton PA, Gunawardana M, Dawson LN, Olive TJ, Pyles RB, Baum MM.

PLoS One. 2018 Aug 22;13(8):e0201952. doi: 10.1371/journal.pone.0201952. eCollection 2018.


Production and transplantation of bioengineered lung into a large-animal model.

Nichols JE, La Francesca S, Niles JA, Vega SP, Argueta LB, Frank L, Christiani DC, Pyles RB, Himes BE, Zhang R, Li S, Sakamoto J, Rhudy J, Hendricks G, Begarani F, Liu X, Patrikeev I, Pal R, Usheva E, Vargas G, Miller A, Woodson L, Wacher A, Grimaldo M, Weaver D, Mlcak R, Cortiella J.

Sci Transl Med. 2018 Aug 1;10(452). pii: eaao3926. doi: 10.1126/scitranslmed.aao3926.


Spectrum of activity testing for therapeutics against all four dengue virus serotypes in AG129 mouse models: Proof-of-concept studies with the adenosine nucleoside inhibitor NITD-008.

Milligan GN, White M, Zavala D, Pyles RB, Sarathy VV, Barrett ADT, Bourne N.

Antiviral Res. 2018 Jun;154:104-109. doi: 10.1016/j.antiviral.2018.04.012. Epub 2018 Apr 14.


Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2.

Veselenak RL, Milligan GN, Miller AL, Pyles RB, Bourne N.

Virology. 2018 May;518:349-357. doi: 10.1016/j.virol.2018.03.019. Epub 2018 Mar 28.


Protection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice.

Gallay PA, Chatterji U, Kirchhoff A, Gandarilla A, Pyles RB, Baum MM, Moss JA.

Open Virol J. 2018 Feb 28;12:1-13. doi: 10.2174/1874357901812010001. eCollection 2018.


A lethal model of disseminated dengue virus type 1 infection in AG129 mice.

Milligan GN, Sarathy VV, White MM, Greenberg MB, Campbell GA, Pyles RB, Barrett ADT, Bourne N.

J Gen Virol. 2017 Oct;98(10):2507-2519. doi: 10.1099/jgv.0.000923. Epub 2017 Sep 27.


Prevention of vaginal and rectal HIV transmission by antiretroviral combinations in humanized mice.

Gallay PA, Chatterji U, Kirchhoff A, Gandarilla A, Gunawardana M, Pyles RB, Marzinke MA, Moss JA, Baum MM.

PLoS One. 2017 Sep 7;12(9):e0184303. doi: 10.1371/journal.pone.0184303. eCollection 2017.


Vaginal ecosystem modeling of growth patterns of anaerobic bacteria in microaerophilic conditions.

Medina-Colorado AA, Vincent KL, Miller AL, Maxwell CA, Dawson LN, Olive T, Kozlova EV, Baum MM, Pyles RB.

Anaerobe. 2017 Jun;45:10-18. doi: 10.1016/j.anaerobe.2017.04.014. Epub 2017 Apr 26.


Correction: Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury.

Grimes L, Doyle A, Miller AL, Pyles RB, Olah G, Szabo C, Hoskinson S, Eaves-Pyles T.

PLoS One. 2017 Jan 19;12(1):e0170722. doi: 10.1371/journal.pone.0170722. eCollection 2017.


Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury.

Grimes L, Doyle A, Miller AL, Pyles RB, Olah G, Szabo C, Hoskins S, Eaves-Pyles T.

PLoS One. 2016 Dec 1;11(12):e0166770. doi: 10.1371/journal.pone.0166770. eCollection 2016. Erratum in: PLoS One. 2017 Jan 19;12 (1):e0170722.


New Systems for Studying Intercellular Interactions in Bacterial Vaginosis.

Herbst-Kralovetz MM, Pyles RB, Ratner AJ, Sycuro LK, Mitchell C.

J Infect Dis. 2016 Aug 15;214 Suppl 1:S6-S13. doi: 10.1093/infdis/jiw130. Review.


Acute Otitis Media and Other Complications of Viral Respiratory Infection.

Chonmaitree T, Trujillo R, Jennings K, Alvarez-Fernandez P, Patel JA, Loeffelholz MJ, Nokso-Koivisto J, Matalon R, Pyles RB, Miller AL, McCormick DP.

Pediatrics. 2016 Apr;137(4). pii: e20153555. doi: 10.1542/peds.2015-3555. Epub 2016 Mar 28.


Determining Persistence of Bocavirus DNA in the Respiratory Tract of Children by Pyrosequencing.

Wagner JC, Pyles RB, Miller AL, Nokso-Koivisto J, Loeffelholz MJ, Chonmaitree T.

Pediatr Infect Dis J. 2016 May;35(5):471-6. doi: 10.1097/INF.0000000000001058.


Evaluation of Simultaneous Transmission of Chikungunya Virus and Dengue Virus Type 2 in Infected Aedes aegypti and Aedes albopictus (Diptera: Culicidae).

Nuckols JT, Huang YJ, Higgs S, Miller AL, Pyles RB, Spratt HM, Horne KM, Vanlandingham DL.

J Med Entomol. 2015 May;52(3):447-51. doi: 10.1093/jme/tjv017. Epub 2015 Mar 15.


Use of a Guinea pig-specific transcriptome array for evaluation of protective immunity against genital chlamydial infection following intranasal vaccination in Guinea pigs.

Wali S, Gupta R, Veselenak RL, Li Y, Yu JJ, Murthy AK, Cap AP, Guentzel MN, Chambers JP, Zhong G, Rank RG, Pyles RB, Arulanandam BP.

PLoS One. 2014 Dec 11;9(12):e114261. doi: 10.1371/journal.pone.0114261. eCollection 2014.


Duration of rhinovirus shedding in the upper respiratory tract in the first year of life.

Loeffelholz MJ, Trujillo R, Pyles RB, Miller AL, Alvarez-Fernandez P, Pong DL, Chonmaitree T.

Pediatrics. 2014 Dec;134(6):1144-50. doi: 10.1542/peds.2014-2132. Epub 2014 Nov 17.


A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic disease.

Sarathy VV, White M, Li L, Gorder SR, Pyles RB, Campbell GA, Milligan GN, Bourne N, Barrett AD.

J Virol. 2015 Jan 15;89(2):1254-66. doi: 10.1128/JVI.01320-14. Epub 2014 Nov 12.


Development and utilization of a custom PCR array workflow: analysis of gene expression in mycoplasma genitalium and guinea pig (Cavia porcellus).

Veselenak RL, Miller AL, Milligan GN, Bourne N, Pyles RB.

Mol Biotechnol. 2015 Feb;57(2):172-83. doi: 10.1007/s12033-014-9813-6.


Symptomatic and asymptomatic respiratory viral infections in the first year of life: association with acute otitis media development.

Chonmaitree T, Alvarez-Fernandez P, Jennings K, Trujillo R, Marom T, Loeffelholz MJ, Miller AL, McCormick DP, Patel JA, Pyles RB.

Clin Infect Dis. 2015 Jan 1;60(1):1-9. doi: 10.1093/cid/ciu714. Epub 2014 Sep 9.


Role of Human Bocavirus in Upper Respiratory Tract Infections and Acute Otitis Media.

Nokso-Koivisto J, Pyles RB, Miller AL, Jennings K, Loeffelholz M, Chonmaitree T.

J Pediatric Infect Dis Soc. 2014 Jun;3(2):98-103. doi: 10.1093/jpids/pit061. Epub 2013 Oct 6.


Cultivated vaginal microbiomes alter HIV-1 infection and antiretroviral efficacy in colonized epithelial multilayer cultures.

Pyles RB, Vincent KL, Baum MM, Elsom B, Miller AL, Maxwell C, Eaves-Pyles TD, Li G, Popov VL, Nusbaum RJ, Ferguson MR.

PLoS One. 2014 Mar 27;9(3):e93419. doi: 10.1371/journal.pone.0093419. eCollection 2014.


A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.

Grover RK, Zhu X, Nieusma T, Jones T, Boreo I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, Jelinek DF, Kyle RA, Pyles RB, Glass JI, Ward AB, Wilson IA, Lerner RA.

Science. 2014 Feb 7;343(6171):656-661. doi: 10.1126/science.1246135.


Global expression of molecular transporters in the human vaginal tract: implications for HIV chemoprophylaxis.

Gunawardana M, Mullen M, Moss JA, Pyles RB, Nusbaum RJ, Patel J, Vincent KL, Wang C, Guo C, Yuan YC, Warden CD, Baum MM.

PLoS One. 2013 Oct 15;8(10):e77340. doi: 10.1371/journal.pone.0077340. eCollection 2013.


Quantification of bacterial uropathogens in preclinical samples using real-time PCR assays.

Enderle JL, Miller AL, Pyles RB.

Curr Microbiol. 2014 Feb;68(2):220-6. doi: 10.1007/s00284-013-0465-8. Epub 2013 Oct 10.


Association between body mass index, sexually transmitted infections, and contraceptive compliance.

DeMaria AL, Lugo JM, Rahman M, Pyles RB, Berenson AB.

J Womens Health (Larchmt). 2013 Dec;22(12):1062-8. doi: 10.1089/jwh.2012.4116. Epub 2013 Oct 4.


Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.

Eaves-Pyles T, Patel J, Arigi E, Cong Y, Cao A, Garg N, Dhiman M, Pyles RB, Arulanandam B, Miller AL, Popov VL, Soong L, Carlsen ED, Coletta C, Szabo C, Almeida IC.

Mol Med. 2013 Aug 28;19:263-75. doi: 10.2119/molmed.2013.00081.


A Vaxfectin(®)-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes.

Veselenak RL, Shlapobersky M, Pyles RB, Wei Q, Sullivan SM, Bourne N.

Vaccine. 2012 Nov 19;30(49):7046-51. doi: 10.1016/j.vaccine.2012.09.057. Epub 2012 Oct 4.


Commensal bacteria modulate innate immune responses of vaginal epithelial cell multilayer cultures.

Rose WA 2nd, McGowin CL, Spagnuolo RA, Eaves-Pyles TD, Popov VL, Pyles RB.

PLoS One. 2012;7(3):e32728. doi: 10.1371/journal.pone.0032728. Epub 2012 Mar 7.


Viral load and acute otitis media development after human metapneumovirus upper respiratory tract infection.

Nokso-Koivisto J, Pyles RB, Miller AL, Patel JA, Loeffelholz M, Chonmaitree T.

Pediatr Infect Dis J. 2012 Jul;31(7):763-6. doi: 10.1097/INF.0b013e3182539d92.


Comparison of the FilmArray Respiratory Panel and Prodesse real-time PCR assays for detection of respiratory pathogens.

Loeffelholz MJ, Pong DL, Pyles RB, Xiong Y, Miller AL, Bufton KK, Chonmaitree T.

J Clin Microbiol. 2011 Dec;49(12):4083-8. doi: 10.1128/JCM.05010-11. Epub 2011 Oct 12.


Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix.

Buckner LR, Schust DJ, Ding J, Nagamatsu T, Beatty W, Chang TL, Greene SJ, Lewis ME, Ruiz B, Holman SL, Spagnuolo RA, Pyles RB, Quayle AJ.

J Reprod Immunol. 2011 Dec;92(1-2):8-20. doi: 10.1016/j.jri.2011.08.002. Epub 2011 Sep 22.


Viral-bacterial interactions and risk of acute otitis media complicating upper respiratory tract infection.

Pettigrew MM, Gent JF, Pyles RB, Miller AL, Nokso-Koivisto J, Chonmaitree T.

J Clin Microbiol. 2011 Nov;49(11):3750-5. doi: 10.1128/JCM.01186-11. Epub 2011 Sep 7.


Toll-like receptor 3 agonist protection against experimental Francisella tularensis respiratory tract infection.

Pyles RB, Jezek GE, Eaves-Pyles TD.

Infect Immun. 2010 Apr;78(4):1700-10. doi: 10.1128/IAI.00736-09. Epub 2010 Feb 1.


Mucosal treatments for herpes simplex virus: insights on targeted immunoprophylaxis and therapy.

McGowin CL, Pyles RB.

Future Microbiol. 2010 Jan;5(1):15-22. doi: 10.2217/fmb.09.111. Review.


Mycoplasma genitalium rapidly disseminates to the upper reproductive tracts and knees of female mice following vaginal inoculation.

McGowin CL, Spagnuolo RA, Pyles RB.

Infect Immun. 2010 Feb;78(2):726-36. doi: 10.1128/IAI.00840-09. Epub 2009 Dec 7.


FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection.

Rose WA 2nd, McGowin CL, Pyles RB.

Virol J. 2009 Nov 10;6:195. doi: 10.1186/1743-422X-6-195.


High-throughput multistrain polymerase chain reaction quantification of Chlamydia trachomatis from clinical and preclinical urogenital specimens.

McGowin CL, Whitlock GC, Pyles RB.

Diagn Microbiol Infect Dis. 2009 Jun;64(2):117-23. doi: 10.1016/j.diagmicrobio.2009.01.032. Epub 2009 Apr 2.


Mycoplasma genitalium-encoded MG309 activates NF-kappaB via Toll-like receptors 2 and 6 to elicit proinflammatory cytokine secretion from human genital epithelial cells.

McGowin CL, Ma L, Martin DH, Pyles RB.

Infect Immun. 2009 Mar;77(3):1175-81. doi: 10.1128/IAI.00845-08. Epub 2008 Dec 22.


Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.

Liang Y, Ishida H, Lenz O, Lin TI, Nyanguile O, Simmen K, Pyles RB, Bourne N, Yi M, Li K, Lemon SM.

Gastroenterology. 2008 Nov;135(5):1710-1718.e2. doi: 10.1053/j.gastro.2008.07.023. Epub 2008 Jul 22.


An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).

Rose WA 2nd, Tuthill C, Pyles RB.

Int J Antimicrob Agents. 2008 Sep;32(3):262-6. doi: 10.1016/j.ijantimicag.2008.04.010. Epub 2008 Jul 10.


Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia.

Herbst-Kralovetz MM, Quayle AJ, Ficarra M, Greene S, Rose WA 2nd, Chesson R, Spagnuolo RA, Pyles RB.

Am J Reprod Immunol. 2008 Mar;59(3):212-24. doi: 10.1111/j.1600-0897.2007.00566.x. Epub 2008 Jan 12.


Role of primary human alveolar epithelial cells in host defense against Francisella tularensis infection.

Gentry M, Taormina J, Pyles RB, Yeager L, Kirtley M, Popov VL, Klimpel G, Eaves-Pyles T.

Infect Immun. 2007 Aug;75(8):3969-78. Epub 2007 May 14.


CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity.

Kawana K, Quayle AJ, Ficarra M, Ibana JA, Shen L, Kawana Y, Yang H, Marrero L, Yavagal S, Greene SJ, Zhang YX, Pyles RB, Blumberg RS, Schust DJ.

J Biol Chem. 2007 Mar 9;282(10):7368-75. Epub 2007 Jan 10.

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