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Items: 1 to 50 of 341

1.

Discovery of N-substituted 3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acids as highly potent third generation inhibitors of human arginase I and II.

Van Zandt MC, Jagdmann GE, Whitehouse D, Ji MK, Savoy J, Potapova O, Cousido-Siah A, Mitschler A, Howard EI, Pyle AM, Podjarny AD.

J Med Chem. 2019 Aug 13. doi: 10.1021/acs.jmedchem.9b00931. [Epub ahead of print]

PMID:
31408339
2.

CRISPR for Neuromuscular Disorders: Gene Editing and Beyond.

Young CS, Pyle AD, Spencer MJ.

Physiology (Bethesda). 2019 Sep 1;34(5):341-353. doi: 10.1152/physiol.00012.2019.

PMID:
31389773
3.

Variable management strategies for NEC totalis: a national survey.

Pyle AK, Shabanova V, Cleary MA, Ozgediz D, Cummings CL, Kamin DS, Mercurio MR.

J Perinatol. 2019 Aug 1. doi: 10.1038/s41372-019-0448-0. [Epub ahead of print]

PMID:
31371831
4.

Sensitive detection of structural features and rearrangements in long, structured RNA molecules.

Adams RL, Huston NC, Tavares RCA, Pyle AM.

Methods Enzymol. 2019;623:249-289. doi: 10.1016/bs.mie.2019.04.002. Epub 2019 Apr 22.

PMID:
31239050
5.

Correction: Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmüller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R.

Genet Med. 2019 Apr 26. doi: 10.1038/s41436-019-0506-1. [Epub ahead of print]

PMID:
31028354
6.

Recent advances in understanding the molecular genetic basis of mitochondrial disease.

Thompson K, Collier JJ, Glasgow RIC, Robertson FM, Pyle A, Blakely EL, Alston CL, Oláhová M, McFarland R, Taylor RW.

J Inherit Metab Dis. 2019 Apr 25. doi: 10.1002/jimd.12104. [Epub ahead of print]

PMID:
31021000
7.

Buprenorphine/naloxone induction in a Canadian emergency department with rapid access to community-based addictions providers.

Hu T, Snider-Adler M, Nijmeh L, Pyle A.

CJEM. 2019 Jul;21(4):492-498. doi: 10.1017/cem.2019.24. Epub 2019 Apr 22.

PMID:
31006398
8.

Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures.

Tavares RCA, Pyle AM, Somarowthu S.

J Mol Biol. 2019 Apr 5;431(8):1592-1603. doi: 10.1016/j.jmb.2019.03.012. Epub 2019 Mar 16.

9.

RIG-I Selectively Discriminates against 5'-Monophosphate RNA.

Ren X, Linehan MM, Iwasaki A, Pyle AM.

Cell Rep. 2019 Feb 19;26(8):2019-2027.e4. doi: 10.1016/j.celrep.2019.01.107.

10.

Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization.

Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS.

Stem Cell Res Ther. 2019 Feb 12;10(1):52. doi: 10.1186/s13287-019-1147-7.

11.

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts.

Guyatt AL, Brennan RR, Burrows K, Guthrie PAI, Ascione R, Ring SM, Gaunt TR, Pyle A, Cordell HJ, Lawlor DA, Chinnery PF, Hudson G, Rodriguez S.

Hum Genomics. 2019 Jan 31;13(1):6. doi: 10.1186/s40246-018-0190-2.

12.

NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses.

Van Bergen NJ, Guo Y, Rankin J, Paczia N, Becker-Kettern J, Kremer LS, Pyle A, Conrotte JF, Ellaway C, Procopis P, Prelog K, Homfray T, Baptista J, Baple E, Wakeling M, Massey S, Kay DP, Shukla A, Girisha KM, Lewis LES, Santra S, Power R, Daubeney P, Montoya J, Ruiz-Pesini E, Kovacs-Nagy R, Pritsch M, Ahting U, Thorburn DR, Prokisch H, Taylor RW, Christodoulou J, Linster CL, Ellard S, Hakonarson H.

Brain. 2019 Jan 1;142(1):50-58. doi: 10.1093/brain/awy310.

PMID:
30576410
13.

Buprenorphine-naloxone.

Hu T, Nijmeh L, Pyle A.

CMAJ. 2018 Nov 26;190(47):E1389. doi: 10.1503/cmaj.180776. No abstract available.

PMID:
30478217
14.

Small molecules that target group II introns are potent antifungal agents.

Fedorova O, Jagdmann GE Jr, Adams RL, Yuan L, Van Zandt MC, Pyle AM.

Nat Chem Biol. 2018 Dec;14(12):1073-1078. doi: 10.1038/s41589-018-0142-0. Epub 2018 Oct 15.

15.

Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses.

Widdrington JD, Gomez-Duran A, Pyle A, Ruchaud-Sparagano MH, Scott J, Baudouin SV, Rostron AJ, Lovat PE, Chinnery PF, Simpson AJ.

Front Immunol. 2018 Sep 27;9:2217. doi: 10.3389/fimmu.2018.02217. eCollection 2018.

16.

Instability of the mitochondrial alanyl-tRNA synthetase underlies fatal infantile-onset cardiomyopathy.

Sommerville EW, Zhou XL, Oláhová M, Jenkins J, Euro L, Konovalova S, Hilander T, Pyle A, He L, Habeebu S, Saunders C, Kelsey A, Morris AAM, McFarland R, Suomalainen A, Gorman GS, Wang ED, Thiffault I, Tyynismaa H, Taylor RW.

Hum Mol Genet. 2019 Jan 15;28(2):258-268. doi: 10.1093/hmg/ddy294.

17.

Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.

Elion DL, Jacobson ME, Hicks DJ, Rahman B, Sanchez V, Gonzales-Ericsson PI, Fedorova O, Pyle AM, Wilson JT, Cook RS.

Cancer Res. 2018 Nov 1;78(21):6183-6195. doi: 10.1158/0008-5472.CAN-18-0730. Epub 2018 Sep 17.

PMID:
30224377
18.

Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus.

Mihaylova VT, Kong Y, Fedorova O, Sharma L, Dela Cruz CS, Pyle AM, Iwasaki A, Foxman EF.

Cell Rep. 2018 Sep 11;24(11):3000-3007.e3. doi: 10.1016/j.celrep.2018.08.033.

19.

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes.

Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D.

Nat Commun. 2018 Sep 7;9(1):3634. doi: 10.1038/s41467-018-05573-y.

20.

Early Antibiotic Exposure and Adverse Outcomes in Preterm, Very Low Birth Weight Infants.

Cantey JB, Pyle AK, Wozniak PS, Hynan LS, Sánchez PJ.

J Pediatr. 2018 Dec;203:62-67. doi: 10.1016/j.jpeds.2018.07.036. Epub 2018 Aug 29.

PMID:
30172430
21.

Cell-free mitochondrial DNA in progressive multiple sclerosis.

Lowes H, Pyle A, Duddy M, Hudson G.

Mitochondrion. 2019 May;46:307-312. doi: 10.1016/j.mito.2018.07.008. Epub 2018 Aug 8.

22.

Clonal expansion of mtDNA deletions: different disease models assessed by digital droplet PCR in single muscle cells.

Trifunov S, Pyle A, Valentino ML, Liguori R, Yu-Wai-Man P, Burté F, Duff J, Kleinle S, Diebold I, Rugolo M, Horvath R, Carelli V.

Sci Rep. 2018 Aug 3;8(1):11682. doi: 10.1038/s41598-018-30143-z.

23.

Management options and parental voice in the treatment of trisomy 13 and 18.

Pyle AK, Fleischman AR, Hardart G, Mercurio MR.

J Perinatol. 2018 Sep;38(9):1135-1143. doi: 10.1038/s41372-018-0151-6. Epub 2018 Jul 6. No abstract available.

PMID:
29977011
24.

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site.

Schult P, Roth H, Adams RL, Mas C, Imbert L, Orlik C, Ruggieri A, Pyle AM, Lohmann V.

Nat Commun. 2018 Jul 4;9(1):2613. doi: 10.1038/s41467-018-05053-3.

25.

Author Correction: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.

Floros VI, Pyle A, Dietmann S, Wei W, Tang WWC, Irie N, Payne B, Capalbo A, Noli L, Coxhead J, Hudson G, Crosier M, Strahl H, Khalaf Y, Saitou M, Ilic D, Surani MA, Chinnery PF.

Nat Cell Biol. 2018 Aug;20(8):991. doi: 10.1038/s41556-018-0064-9.

PMID:
29674682
26.

Suicide Prevention for School Communities: An Educational Initiative for Student Safety.

Roberts DC, Taylor ME, Pyle AD.

NASN Sch Nurse. 2018 May;33(3):168-176. doi: 10.1177/1942602X18766499.

PMID:
29658849
27.

Defective mitochondrial protease LonP1 can cause classical mitochondrial disease.

Peter B, Waddington CL, Oláhová M, Sommerville EW, Hopton S, Pyle A, Champion M, Ohlson M, Siibak T, Chrzanowska-Lightowlers ZMA, Taylor RW, Falkenberg M, Lightowlers RN.

Hum Mol Genet. 2018 May 15;27(10):1743-1753. doi: 10.1093/hmg/ddy080.

28.

Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmüller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R.

Genet Med. 2018 Oct;20(10):1224-1235. doi: 10.1038/gim.2017.251. Epub 2018 Mar 8. Erratum in: Genet Med. 2019 Apr 26;:.

29.

A minimal RNA ligand for potent RIG-I activation in living mice.

Linehan MM, Dickey TH, Molinari ES, Fitzgerald ME, Potapova O, Iwasaki A, Pyle AM.

Sci Adv. 2018 Feb 21;4(2):e1701854. doi: 10.1126/sciadv.1701854. eCollection 2018 Feb.

30.

A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies.

Bartsakoulia M, Pyle A, Troncoso-Chandía D, Vial-Brizzi J, Paz-Fiblas MV, Duff J, Griffin H, Boczonadi V, Lochmüller H, Kleinle S, Chinnery PF, Grünert S, Kirschner J, Eisner V, Horvath R.

Hum Mol Genet. 2018 Apr 1;27(7):1186-1195. doi: 10.1093/hmg/ddy033.

31.

Environmentally Triggerable Retinoic Acid-Inducible Gene I Agonists Using Synthetic Polymer Overhangs.

Palmer CR, Jacobson ME, Fedorova O, Pyle AM, Wilson JT.

Bioconjug Chem. 2018 Mar 21;29(3):742-747. doi: 10.1021/acs.bioconjchem.7b00697. Epub 2018 Jan 19.

32.

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.

Floros VI, Pyle A, Dietmann S, Wei W, Tang WCW, Irie N, Payne B, Capalbo A, Noli L, Coxhead J, Hudson G, Crosier M, Strahl H, Khalaf Y, Saitou M, Ilic D, Surani MA, Chinnery PF.

Nat Cell Biol. 2018 Feb;20(2):144-151. doi: 10.1038/s41556-017-0017-8. Epub 2018 Jan 15. Erratum in: Nat Cell Biol. 2018 Apr 19;:.

33.

Opening One's Eyes to Mosaicism in Progressive External Ophthalmoplegia.

Sommerville EW, Jones RL, Hardy SA, Blakely EL, Pyle A, Schaefer AM, Chinnery PF, Turnbull DM, Gorman GS, Taylor RW.

Neurol Genet. 2017 Dec 15;3(6):e202. doi: 10.1212/NXG.0000000000000202. eCollection 2017 Dec. No abstract available.

34.

ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs.

Hicks MR, Hiserodt J, Paras K, Fujiwara W, Eskin A, Jan M, Xi H, Young CS, Evseenko D, Nelson SF, Spencer MJ, Handel BV, Pyle AD.

Nat Cell Biol. 2018 Jan;20(1):46-57. doi: 10.1038/s41556-017-0010-2. Epub 2017 Dec 18.

35.

Lessons Learned from 78 Long Days in the NICU.

Pyle A.

Narrat Inq Bioeth. 2017;7(3):192-194. doi: 10.1353/nib.2017.0060. No abstract available.

PMID:
29249706
36.

Narrative Symposium: Challenges With Care During Labor and Delivery.

Morrell E, Johnson N, Echegaray L, Fairchild K, Pyle A, Mckee EE, Tillinger E, Diaz-Tello F, Knowlton S, Kracen A, Rendina N, Terlizzi K, Rand K, Lebedevitch C.

Narrat Inq Bioeth. 2017;7(3):182-E6. doi: 10.1353/nib.2017.0075. No abstract available.

PMID:
29249702
37.

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease.

Bury AG, Pyle A, Elson JL, Greaves L, Morris CM, Hudson G, Pienaar IS.

Ann Neurol. 2017 Dec;82(6):1016-1021. doi: 10.1002/ana.25099. Epub 2017 Dec 4.

PMID:
29149768
38.

An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron.

Zhao C, Liu F, Pyle AM.

RNA. 2018 Feb;24(2):183-195. doi: 10.1261/rna.063479.117. Epub 2017 Nov 6.

39.

NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.

Zhou T, Ren X, Adams RL, Pyle AM.

J Virol. 2017 Dec 14;92(1). pii: e01253-17. doi: 10.1128/JVI.01253-17. Print 2018 Jan 1.

40.

The SMAD3 transcription factor binds complex RNA structures with high affinity.

Dickey TH, Pyle AM.

Nucleic Acids Res. 2017 Nov 16;45(20):11980-11988. doi: 10.1093/nar/gkx846.

41.

Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.

Ren X, Gelinas AD, von Carlowitz I, Janjic N, Pyle AM.

Nat Commun. 2017 Oct 9;8(1):810. doi: 10.1038/s41467-017-00864-2.

42.

Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization.

Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS.

Stem Cell Res Ther. 2017 Oct 2;8(1):217. doi: 10.1186/s13287-017-0652-9. Erratum in: Stem Cell Res Ther. 2019 Feb 12;10(1):52.

43.

De novo CTBP1 variant is associated with decreased mitochondrial respiratory chain activities.

Sommerville EW, Alston CL, Pyle A, He L, Falkous G, Naismith K, Chinnery PF, McFarland R, Taylor RW.

Neurol Genet. 2017 Sep 22;3(5):e187. doi: 10.1212/NXG.0000000000000187. eCollection 2017 Oct.

44.

RNA Structural Variability and Functional Versatility Challenge RNA Structural Modeling and Design.

Schlick T, Pyle A.

Biophys J. 2017 Jul 25;113(2):E1-E2. doi: 10.1016/j.bpj.2017.06.040. Epub 2017 Jun 29. No abstract available.

45.

Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ.

Widdrington JD, Gomez-Duran A, Steyn JS, Pyle A, Ruchaud-Sparagano MH, Scott J, Baudouin SV, Rostron AJ, Simpson J, Chinnery PF.

J Allergy Clin Immunol. 2017 Nov;140(5):1461-1464.e8. doi: 10.1016/j.jaci.2017.04.048. Epub 2017 Jun 17. No abstract available.

46.

The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand.

Zhao C, Pyle AM.

Curr Opin Struct Biol. 2017 Dec;47:30-39. doi: 10.1016/j.sbi.2017.05.002. Epub 2017 May 18. Review.

47.

Functional RNA structures throughout the Hepatitis C Virus genome.

Adams RL, Pirakitikulr N, Pyle AM.

Curr Opin Virol. 2017 Jun;24:79-86. doi: 10.1016/j.coviro.2017.04.007. Epub 2017 May 13. Review.

48.

Creation of a Novel Humanized Dystrophic Mouse Model of Duchenne Muscular Dystrophy and Application of a CRISPR/Cas9 Gene Editing Therapy.

Young CS, Mokhonova E, Quinonez M, Pyle AD, Spencer MJ.

J Neuromuscul Dis. 2017;4(2):139-145. doi: 10.3233/JND-170218.

49.

Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia.

Minnerop M, Kurzwelly D, Wagner H, Soehn AS, Reichbauer J, Tao F, Rattay TW, Peitz M, Rehbach K, Giorgetti A, Pyle A, Thiele H, Altmüller J, Timmann D, Karaca I, Lennarz M, Baets J, Hengel H, Synofzik M, Atasu B, Feely S, Kennerson M, Stendel C, Lindig T, Gonzalez MA, Stirnberg R, Sturm M, Roeske S, Jung J, Bauer P, Lohmann E, Herms S, Heilmann-Heimbach S, Nicholson G, Mahanjah M, Sharkia R, Carloni P, Brüstle O, Klopstock T, Mathews KD, Shy ME, de Jonghe P, Chinnery PF, Horvath R, Kohlhase J, Schmitt I, Wolf M, Greschus S, Amunts K, Maier W, Schöls L, Nürnberg P, Zuchner S, Klockgether T, Ramirez A, Schüle R.

Brain. 2017 Jun 1;140(6):1561-1578. doi: 10.1093/brain/awx095. Erratum in: Brain. 2017 Dec 9;:.

50.

Structural Insights into the Mechanism of Group II Intron Splicing.

Zhao C, Pyle AM.

Trends Biochem Sci. 2017 Jun;42(6):470-482. doi: 10.1016/j.tibs.2017.03.007. Epub 2017 Apr 21. Review.

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