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Items: 21


Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.

Puyang X, Furman C, Zheng GZ, Wu ZJ, Banka D, Aithal K, Agoulnik S, Bolduc DM, Buonamici S, Caleb B, Das S, Eckley S, Fekkes P, Hao MH, Hart A, Houtman R, Irwin S, Joshi JJ, Karr C, Kim A, Kumar N, Kumar P, Kuznetsov G, Lai WG, Larsen N, Mackenzie C, Martin LA, Melchers D, Moriarty A, Nguyen TV, Norris J, O'Shea M, Pancholi S, Prajapati S, Rajagopalan S, Reynolds DJ, Rimkunas V, Rioux N, Ribas R, Siu A, Sivakumar S, Subramanian V, Thomas M, Vaillancourt FH, Wang J, Wardell S, Wick MJ, Yao S, Yu L, Warmuth M, Smith PG, Zhu P, Korpal M.

Cancer Discov. 2018 Sep;8(9):1176-1193. doi: 10.1158/2159-8290.CD-17-1229. Epub 2018 Jul 10.


Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.

Korpal M, Puyang X, Jeremy Wu Z, Seiler R, Furman C, Oo HZ, Seiler M, Irwin S, Subramanian V, Julie Joshi J, Wang CK, Rimkunas V, Tortora D, Yang H, Kumar N, Kuznetsov G, Matijevic M, Chow J, Kumar P, Zou J, Feala J, Corson L, Henry R, Selvaraj A, Davis A, Bloudoff K, Douglas J, Kiss B, Roberts M, Fazli L, Black PC, Fekkes P, Smith PG, Warmuth M, Yu L, Hao MH, Larsen N, Daugaard M, Zhu P.

Nat Commun. 2017 Jul 24;8(1):103. doi: 10.1038/s41467-017-00147-w.


Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.

Teng T, Tsai JH, Puyang X, Seiler M, Peng S, Prajapati S, Aird D, Buonamici S, Caleb B, Chan B, Corson L, Feala J, Fekkes P, Gerard B, Karr C, Korpal M, Liu X, T Lowe J, Mizui Y, Palacino J, Park E, Smith PG, Subramanian V, Wu ZJ, Zou J, Yu L, Chicas A, Warmuth M, Larsen N, Zhu P.

Nat Commun. 2017 May 25;8:15522. doi: 10.1038/ncomms15522.


Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms.

Korpal M, Feala J, Puyang X, Zou J, Ramos AH, Wu J, Baumeister T, Yu L, Warmuth M, Zhu P.

J Vis Exp. 2015 Dec 9;(106):e52879. doi: 10.3791/52879.


Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.

Darman RB, Seiler M, Agrawal AA, Lim KH, Peng S, Aird D, Bailey SL, Bhavsar EB, Chan B, Colla S, Corson L, Feala J, Fekkes P, Ichikawa K, Keaney GF, Lee L, Kumar P, Kunii K, MacKenzie C, Matijevic M, Mizui Y, Myint K, Park ES, Puyang X, Selvaraj A, Thomas MP, Tsai J, Wang JY, Warmuth M, Yang H, Zhu P, Garcia-Manero G, Furman RR, Yu L, Smith PG, Buonamici S.

Cell Rep. 2015 Nov 3;13(5):1033-45. doi: 10.1016/j.celrep.2015.09.053. Epub 2015 Oct 22.


Protective effect of spermidine on salt stress induced oxidative damage in two Kentucky bluegrass (Poa pratensis L.) cultivars.

Puyang X, An M, Han L, Zhang X.

Ecotoxicol Environ Saf. 2015 Jul;117:96-106. doi: 10.1016/j.ecoenv.2015.03.023. Epub 2015 Apr 1.


Risk assessment of heavy metals in water and two fish species from golf course ponds in Beijing, China.

PuYang X, Gao C, Han L.

Bull Environ Contam Toxicol. 2015 Apr;94(4):437-43. doi: 10.1007/s00128-015-1476-x. Epub 2015 Jan 31.


NAMPT is the cellular target of STF-31-like small-molecule probes.

Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH, Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL.

ACS Chem Biol. 2014 Oct 17;9(10):2247-54. doi: 10.1021/cb500347p. Epub 2014 Aug 7.


[Study on germination rate of zoysia (Zoysia japonica Steud.) seeds using near infrared reflectance spectroscopy].

Liang XH, Zhang LJ, Fan B, Mao WH, Mao WH, Puyang XH, Han LB.

Guang Pu Xue Yu Guang Pu Fen Xi. 2013 Oct;33(10):2642-5. Chinese.


Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.

Lamarche MJ, Borawski J, Bose A, Capacci-Daniel C, Colvin R, Dennehy M, Ding J, Dobler M, Drumm J, Gaither LA, Gao J, Jiang X, Lin K, McKeever U, Puyang X, Raman P, Thohan S, Tommasi R, Wagner K, Xiong X, Zabawa T, Zhu S, Wiedmann B.

Antimicrob Agents Chemother. 2012 Oct;56(10):5149-56. doi: 10.1128/AAC.00946-12. Epub 2012 Jul 23.


Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors.

Puyang X, Poulin DL, Mathy JE, Anderson LJ, Ma S, Fang Z, Zhu S, Lin K, Fujimoto R, Compton T, Wiedmann B.

Antimicrob Agents Chemother. 2010 May;54(5):1981-7. doi: 10.1128/AAC.01236-09. Epub 2010 Feb 22.


Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.

Borawski J, Troke P, Puyang X, Gibaja V, Zhao S, Mickanin C, Leighton-Davies J, Wilson CJ, Myer V, Cornellataracido I, Baryza J, Tallarico J, Joberty G, Bantscheff M, Schirle M, Bouwmeester T, Mathy JE, Lin K, Compton T, Labow M, Wiedmann B, Gaither LA.

J Virol. 2009 Oct;83(19):10058-74. doi: 10.1128/JVI.02418-08. Epub 2009 Jul 15.


From proteomics to systems biology of bacterial pathogens: approaches, tools, and applications.

Plikat U, Voshol H, Dangendorf Y, Wiedmann B, Devay P, Müller D, Wirth U, Szustakowski J, Chirn GW, Inverardi B, Puyang X, Brown K, Kamp H, Hoving S, Ruchti A, Brendlen N, Peterson R, Buco J, Oostrum Jv, Peitsch MC.

Proteomics. 2007 Mar;7(6):992-1003.


Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.

Dean CR, Narayan S, Richards J, Daigle DM, Esterow S, Leeds JA, Kamp H, Puyang X, Wiedmann B, Mueller D, Voshol H, van Oostrum J, Wall D, Koehn J, Dzink-Fox J, Ryder NS.

Antimicrob Agents Chemother. 2007 Mar;51(3):1004-10. Epub 2007 Jan 12.


Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415.

Dean CR, Narayan S, Daigle DM, Dzink-Fox JL, Puyang X, Bracken KR, Dean KE, Weidmann B, Yuan Z, Jain R, Ryder NS.

Antimicrob Agents Chemother. 2005 Aug;49(8):3129-35.


The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis.

Raman S, Song T, Puyang X, Bardarov S, Jacobs WR Jr, Husson RN.

J Bacteriol. 2001 Oct;183(20):6119-25.


Two-dimensional direct-reading fluorescence spectrograph for DNA sequencing by capillary array electrophoresis.

Zhang J, Yang M, Puyang X, Fang Y, Cook LM, Dovichi NJ.

Anal Chem. 2001 Mar 15;73(6):1234-9.


IS1626, a new IS900-related Mycobacterium avium insertion sequence.

Puyang X, Lee K, Pawlichuk C, Kunimoto DY.

Microbiology. 1999 Nov;145 ( Pt 11):3163-8.


A multiple-capillary electrophoresis system for small-scale DNA sequencing and analysis.

Zhang J, Voss KO, Shaw DF, Roos KP, Lewis DF, Yan J, Jiang R, Ren H, Hou JY, Fang Y, Puyang X, Ahmadzadeh H, Dovichi NJ.

Nucleic Acids Res. 1999 Dec 15;27(24):e36.


A mycobacterial extracytoplasmic sigma factor involved in survival following heat shock and oxidative stress.

Fernandes ND, Wu QL, Kong D, Puyang X, Garg S, Husson RN.

J Bacteriol. 1999 Jul;181(14):4266-74. Erratum in: J Bacteriol 1999 Oct;181(19):6222.

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