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Items: 16

1.

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.

Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA.

Development. 2018 Jul 9;145(13). pii: dev162396. doi: 10.1242/dev.162396.

2.

Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.

Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA.

J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051. Epub 2017 Dec 1.

3.

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.

Rockel JS, Yu C, Whetstone H, Craft AM, Reilly K, Ma H, Tsushima H, Puviindran V, Al-Jazrawe M, Keller GM, Alman BA.

J Clin Invest. 2016 May 2;126(5):1649-63. doi: 10.1172/JCI80205. Epub 2016 Mar 28.

4.

Irx3 is required for postnatal maturation of the mouse ventricular conduction system.

Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH.

Sci Rep. 2016 Jan 20;6:19197. doi: 10.1038/srep19197.

5.

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M.

N Engl J Med. 2015 Sep 3;373(10):895-907. doi: 10.1056/NEJMoa1502214. Epub 2015 Aug 19.

6.

T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.

Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui CC, Gondo Y.

PLoS One. 2015 Mar 11;10(3):e0119455. doi: 10.1371/journal.pone.0119455. eCollection 2015.

7.

Mutant IDH is sufficient to initiate enchondromatosis in mice.

Hirata M, Sasaki M, Cairns RA, Inoue S, Puviindran V, Li WY, Snow BE, Jones LD, Wei Q, Sato S, Tang YJ, Nadesan P, Rockel J, Whetstone H, Poon R, Weng A, Gross S, Straley K, Gliser C, Xu Y, Wunder J, Mak TW, Alman BA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34. doi: 10.1073/pnas.1424400112. Epub 2015 Feb 17.

8.

The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.

Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC, Angers S.

Sci Signal. 2014 Dec 9;7(355):ra117. doi: 10.1126/scisignal.2005608.

PMID:
25492966
9.

A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.

Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC.

Dev Cell. 2014 Apr 28;29(2):241-9. doi: 10.1016/j.devcel.2014.03.002. Epub 2014 Apr 10.

10.

Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.

Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC.

Dev Cell. 2014 Apr 28;29(2):233-40. doi: 10.1016/j.devcel.2014.03.001. Epub 2014 Apr 10.

11.

Obesity-associated variants within FTO form long-range functional connections with IRX3.

Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA.

Nature. 2014 Mar 20;507(7492):371-5. doi: 10.1038/nature13138. Epub 2014 Mar 12.

12.

Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.

Law KK, Makino S, Mo R, Zhang X, Puviindran V, Hui CC.

PLoS One. 2012;7(11):e50193. doi: 10.1371/journal.pone.0050193. Epub 2012 Nov 16.

13.

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.

Li ZJ, Nieuwenhuis E, Nien W, Zhang X, Zhang J, Puviindran V, Wainwright BJ, Kim PC, Hui CC.

Development. 2012 Nov;139(22):4152-61. doi: 10.1242/dev.081190. Epub 2012 Oct 3.

14.

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.

Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13576-81. doi: 10.1073/pnas.1106911108. Epub 2011 Aug 8.

15.

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.

Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, Neely GG, Dietzl G, Manoukian A, Funovics M, Prager G, Wagner O, Ferrandon D, Aberger F, Hui CC, Esterbauer H, Penninger JM.

Cell. 2010 Jan 8;140(1):148-60. doi: 10.1016/j.cell.2009.12.027.

16.

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

Cheung HO, Zhang X, Ribeiro A, Mo R, Makino S, Puviindran V, Law KK, Briscoe J, Hui CC.

Sci Signal. 2009 Jun 23;2(76):ra29. doi: 10.1126/scisignal.2000405.

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