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Items: 1 to 50 of 78

1.

Mutations in topoisomerase IIβ result in a B cell immunodeficiency.

Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM.

Nat Commun. 2019 Aug 13;10(1):3644. doi: 10.1038/s41467-019-11570-6.

2.

Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors.

Srivatsan A, Li B, Sanchez DN, Somach SB, da Silva VL, de Souza SJ, Putnam CD, Kolodner RD.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17377-17382. doi: 10.1073/pnas.1906921116. Epub 2019 Aug 13.

PMID:
31409704
3.

Alternative splicing regulates stochastic NLRP3 activity.

Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E.

Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1.

4.

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.

Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, Polleys EJ, Putnam CD, Radchenko EA, Saada AA, Sakofsky CJ, Shim EY, Stracy M, Xia J, Yan Z, Yin Y, Aguilera A, Argueso JL, Freudenreich CH, Gasser SM, Gordenin DA, Haber JE, Ira G, Jinks-Robertson S, King MC, Kolodner RD, Kuzminov A, Lambert SA, Lee SE, Miller KM, Mirkin SM, Petes TD, Rosenberg SM, Rothstein R, Symington LS, Zawadzki P, Kim N, Lisby M, Malkova A.

Microb Cell. 2019 Jan 7;6(1):1-64. doi: 10.15698/mic2019.01.664. Review.

5.

EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome.

Pathak SJ, Mueller JL, Okamoto K, Das B, Hertecant J, Greenhalgh L, Cole T, Pinsk V, Yerushalmi B, Gurkan OE, Yourshaw M, Hernandez E, Oesterreicher S, Naik S, Sanderson IR, Axelsson I, Agardh D, Boland CR, Martin MG, Putnam CD, Sivagnanam M.

Hum Mutat. 2019 Feb;40(2):142-161. doi: 10.1002/humu.23688. Epub 2018 Nov 29.

PMID:
30461124
6.

The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair.

Graham WJ 5th, Putnam CD, Kolodner RD.

J Biol Chem. 2018 Nov 23;293(47):18055-18070. doi: 10.1074/jbc.RA118.005439. Epub 2018 Sep 20.

7.

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects.

Srivatsan A, Li BZ, Szakal B, Branzei D, Putnam CD, Kolodner RD.

Nat Commun. 2018 Sep 11;9(1):3680. doi: 10.1038/s41467-018-06131-2.

8.

Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners.

Goellner EM, Putnam CD, Graham WJ 5th, Rahal CM, Li BZ, Kolodner RD.

Nat Struct Mol Biol. 2018 Aug;25(8):650-659. doi: 10.1038/s41594-018-0092-y. Epub 2018 Jul 30.

PMID:
30061603
9.

SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.

Liang J, Li BZ, Tan AP, Kolodner RD, Putnam CD, Zhou H.

PLoS Genet. 2018 Mar 5;14(3):e1007250. doi: 10.1371/journal.pgen.1007250. eCollection 2018 Mar.

10.

Cdc73 suppresses genome instability by mediating telomere homeostasis.

Nene RV, Putnam CD, Li BZ, Nguyen KG, Srivatsan A, Campbell CS, Desai A, Kolodner RD.

PLoS Genet. 2018 Jan 10;14(1):e1007170. doi: 10.1371/journal.pgen.1007170. eCollection 2018 Jan.

11.

Analyzing Genome Rearrangements in Saccharomyces cerevisiae.

Srivatsan A, Putnam CD, Kolodner RD.

Methods Mol Biol. 2018;1672:43-61. doi: 10.1007/978-1-4939-7306-4_5.

12.

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae.

Putnam CD, Kolodner RD.

Genetics. 2017 Jul;206(3):1187-1225. doi: 10.1534/genetics.112.145805. Review.

13.

Guinier peak analysis for visual and automated inspection of small-angle X-ray scattering data.

Putnam CD.

J Appl Crystallogr. 2016 Aug 4;49(Pt 5):1412-1419. eCollection 2016 Oct 1.

14.

Correction: Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements.

Albuquerque CP, Wang G, Lee NS, Kolodner RD, Putnam CD, Zhou H.

PLoS Genet. 2016 Aug 31;12(8):e1006302. doi: 10.1371/journal.pgen.1006302. eCollection 2016 Aug.

15.

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers.

Putnam CD, Srivatsan A, Nene RV, Martinez SL, Clotfelter SP, Bell SN, Somach SB, de Souza JE, Fonseca AF, de Souza SJ, Kolodner RD.

Nat Commun. 2016 Apr 13;7:11256. doi: 10.1038/ncomms11256.

16.

Evolution of the methyl directed mismatch repair system in Escherichia coli.

Putnam CD.

DNA Repair (Amst). 2016 Feb;38:32-41. doi: 10.1016/j.dnarep.2015.11.016. Epub 2015 Dec 2. Review.

17.

Exonuclease 1-dependent and independent mismatch repair.

Goellner EM, Putnam CD, Kolodner RD.

DNA Repair (Amst). 2015 Aug;32:24-32. doi: 10.1016/j.dnarep.2015.04.010. Epub 2015 Apr 30. Review.

18.

PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.

Goellner EM, Smith CE, Campbell CS, Hombauer H, Desai A, Putnam CD, Kolodner RD.

Mol Cell. 2014 Jul 17;55(2):291-304. doi: 10.1016/j.molcel.2014.04.034. Epub 2014 Jun 26.

19.

Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae.

Campbell CS, Hombauer H, Srivatsan A, Bowen N, Gries K, Desai A, Putnam CD, Kolodner RD.

PLoS Genet. 2014 May 8;10(5):e1004327. doi: 10.1371/journal.pgen.1004327. eCollection 2014 May.

20.

DNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures.

Putnam CD, Pallis K, Hayes TK, Kolodner RD.

PLoS Genet. 2014 Apr 3;10(4):e1004277. doi: 10.1371/journal.pgen.1004277. eCollection 2014 Apr.

21.

A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability.

Allen-Soltero S, Martinez SL, Putnam CD, Kolodner RD.

Mol Cell Biol. 2014 Apr;34(8):1521-34. doi: 10.1128/MCB.00960-13. Epub 2014 Feb 18.

22.

Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.

Smith CE, Mendillo ML, Bowen N, Hombauer H, Campbell CS, Desai A, Putnam CD, Kolodner RD.

PLoS Genet. 2013 Oct;9(10):e1003869. doi: 10.1371/journal.pgen.1003869. Epub 2013 Oct 31.

23.

DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals.

Hura GL, Tsai CL, Claridge SA, Mendillo ML, Smith JM, Williams GJ, Mastroianni AJ, Alivisatos AP, Putnam CD, Kolodner RD, Tainer JA.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17308-13. doi: 10.1073/pnas.1308595110. Epub 2013 Oct 7.

24.

Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements.

Albuquerque CP, Wang G, Lee NS, Kolodner RD, Putnam CD, Zhou H.

PLoS Genet. 2013;9(8):e1003670. doi: 10.1371/journal.pgen.1003670. Epub 2013 Aug 1. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006302.

25.

Bioinformatic identification of genes suppressing genome instability.

Putnam CD, Allen-Soltero SR, Martinez SL, Chan JE, Hayes TK, Kolodner RD.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3251-9. doi: 10.1073/pnas.1216733109. Epub 2012 Nov 5.

26.

Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair.

Hargreaves VV, Putnam CD, Kolodner RD.

J Biol Chem. 2012 Nov 30;287(49):41232-44. doi: 10.1074/jbc.M112.402495. Epub 2012 Oct 8.

27.

Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis.

Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF.

J Clin Immunol. 2013 Jan;33(1):162-71. doi: 10.1007/s10875-012-9767-z. Epub 2012 Aug 29. Review.

28.

Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication.

Hombauer H, Srivatsan A, Putnam CD, Kolodner RD.

Science. 2011 Dec 23;334(6063):1713-6. doi: 10.1126/science.1210770.

29.

A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.

Zimmermann C, Chymkowitch P, Eldholm V, Putnam CD, Lindvall JM, Omerzu M, Bjørås M, Kolodner RD, Enserink JM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18748-53. doi: 10.1073/pnas.1115885108. Epub 2011 Oct 31.

30.

Cancer. Aneuploidy drives a mutator phenotype in cancer.

Kolodner RD, Cleveland DW, Putnam CD.

Science. 2011 Aug 19;333(6045):942-3. doi: 10.1126/science.1211154. No abstract available.

31.

Determination of gross chromosomal rearrangement rates.

Putnam CD, Kolodner RD.

Cold Spring Harb Protoc. 2010 Sep 1;2010(9):pdb.prot5492. doi: 10.1101/pdb.prot5492.

32.

Post-replication repair suppresses duplication-mediated genome instability.

Putnam CD, Hayes TK, Kolodner RD.

PLoS Genet. 2010 May 6;6(5):e1000933. doi: 10.1371/journal.pgen.1000933.

33.

Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation.

Dowen JM, Putnam CD, Kolodner RD.

Mol Cell Biol. 2010 Jul;30(13):3321-8. doi: 10.1128/MCB.01558-09. Epub 2010 Apr 26.

34.

Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry.

Mendillo ML, Putnam CD, Mo AO, Jamison JW, Li S, Woods VL Jr, Kolodner RD.

J Biol Chem. 2010 Apr 23;285(17):13170-82. doi: 10.1074/jbc.M110.108894. Epub 2010 Feb 24.

35.

A conserved MutS homolog connector domain interface interacts with MutL homologs.

Mendillo ML, Hargreaves VV, Jamison JW, Mo AO, Li S, Putnam CD, Woods VL Jr, Kolodner RD.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22223-8. doi: 10.1073/pnas.0912250106. Epub 2009 Dec 22.

36.

Specific pathways prevent duplication-mediated genome rearrangements.

Putnam CD, Hayes TK, Kolodner RD.

Nature. 2009 Aug 20;460(7258):984-9. doi: 10.1038/nature08217. Epub 2009 Jul 29.

37.

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM.

Immunity. 2009 Jun 19;30(6):875-87. doi: 10.1016/j.immuni.2009.05.005. Epub 2009 Jun 4.

38.

Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae.

Putnam CD, Jaehnig EJ, Kolodner RD.

DNA Repair (Amst). 2009 Sep 2;8(9):974-82. doi: 10.1016/j.dnarep.2009.04.021. Epub 2009 May 27. Review.

39.
40.

Coupling distant sites in DNA during DNA mismatch repair.

Kolodner RD, Mendillo ML, Putnam CD.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12953-4. Epub 2007 Jul 30. No abstract available.

41.

Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.

Shell SS, Putnam CD, Kolodner RD.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10956-61. Epub 2007 Jun 15.

42.

The N terminus of Saccharomyces cerevisiae Msh6 is an unstructured tether to PCNA.

Shell SS, Putnam CD, Kolodner RD.

Mol Cell. 2007 May 25;26(4):565-78.

43.
44.

The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model.

Aksentijevich I, Putnam CD, Remmers EF, Mueller JL, Le J, Kolodner RD, Moak Z, Chuang M, Austin F, Goldbach-Mansky R, Hoffman HM, Kastner DL.

Arthritis Rheum. 2007 Apr;56(4):1273-1285. doi: 10.1002/art.22491.

45.

Analysis of gross-chromosomal rearrangements in Saccharomyces cerevisiae.

Schmidt KH, Pennaneach V, Putnam CD, Kolodner RD.

Methods Enzymol. 2006;409:462-76.

PMID:
16793418
46.

Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae.

Pennaneach V, Putnam CD, Kolodner RD.

Mol Microbiol. 2006 Mar;59(5):1357-68. Review.

47.

Protein mimicry of DNA and pathway regulation.

Putnam CD, Tainer JA.

DNA Repair (Amst). 2005 Dec 8;4(12):1410-20. Epub 2005 Oct 13. Review.

PMID:
16226493
48.

Saccharomyces cerevisiae as a model system to define the chromosomal instability phenotype.

Putnam CD, Pennaneach V, Kolodner RD.

Mol Cell Biol. 2005 Aug;25(16):7226-38.

49.

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.

Wang Y, Putnam CD, Kane MF, Zhang W, Edelmann L, Russell R, Carrión DV, Chin L, Kucherlapati R, Kolodner RD, Edelmann W.

Nat Genet. 2005 Jul;37(7):750-5. Epub 2005 Jun 19.

PMID:
15965476
50.

Chromosome healing through terminal deletions generated by de novo telomere additions in Saccharomyces cerevisiae.

Putnam CD, Pennaneach V, Kolodner RD.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13262-7. Epub 2004 Aug 24.

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