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Items: 1 to 50 of 57

1.

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals.

Srivastava R, Cao Z, Nedeva C, Naim S, Bachmann D, Rabachini T, Gangoda L, Shahi S, Glab J, Menassa J, Osellame L, Nelson T, Fernandez-Marrero Y, Brown F, Wei A, Ke F, O'Reilly L, Doerflinger M, Allison C, Kueh A, Ramsay R, Smith BJ, Mathivanan S, Kaufmann T, Puthalakath H.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15469-15474. doi: 10.1073/pnas.1904523116. Epub 2019 Jul 16.

2.

Semiquantitative Proteomics Enables Mapping of Murine Neutrophil Dynamics following Lethal Influenza Virus Infection.

Liu C, Oveissi S, Downs R, Kirby J, Nedeva C, Puthalakath H, Faou P, Duan M, Chen W.

J Immunol. 2019 Aug 15;203(4):1064-1075. doi: 10.4049/jimmunol.1900337. Epub 2019 Jul 15.

PMID:
31308090
3.

Sepsis: Inflammation Is a Necessary Evil.

Nedeva C, Menassa J, Puthalakath H.

Front Cell Dev Biol. 2019 Jun 20;7:108. doi: 10.3389/fcell.2019.00108. eCollection 2019. Review.

4.

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly.

Tixeira R, Phan TK, Caruso S, Shi B, Atkin-Smith GK, Nedeva C, Chow JDY, Puthalakath H, Hulett MD, Herold MJ, Poon IKH.

Cell Death Differ. 2019 May 1. doi: 10.1038/s41418-019-0342-5. [Epub ahead of print]

PMID:
31043701
5.

Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway.

Zhao WB, Lu Q, Nguyen MN, Su Y, Ziemann M, Wang LN, Kiriazis H, Puthalakath H, Sadoshima J, Hu HY, Du XJ.

Br J Pharmacol. 2019 Jul;176(14):2465-2481. doi: 10.1111/bph.14674. Epub 2019 May 30.

6.

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins.

Zanker D, Pang K, Oveissi S, Lu C, Faou P, Nowell C, Mbogo GW, Carotta S, Quillici C, Karupiah G, Hibbs ML, Nutt SL, Neeson P, Puthalakath H, Chen W.

Immunol Cell Biol. 2018 Oct;96(9):981-993. doi: 10.1111/imcb.12163. Epub 2018 Jun 3.

PMID:
29738610
7.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

8.

BH3-only proteins: the thorny end of the ER stress response.

Glab JA, Doerflinger M, Puthalakath H.

Cell Death Dis. 2017 Jun 22;8(6):e2889. doi: 10.1038/cddis.2017.283. No abstract available.

9.

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.

Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H.

Cell Death Differ. 2017 May;24(5):944-950. doi: 10.1038/cdd.2017.53. Epub 2017 Apr 14.

10.

BH3-Only Proteins in Health and Disease.

Glab JA, Mbogo GW, Puthalakath H.

Int Rev Cell Mol Biol. 2017;328:163-196. doi: 10.1016/bs.ircmb.2016.08.005. Epub 2016 Sep 28. Review.

PMID:
28069133
11.

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice.

Doerflinger M, Glab J, Nedeva C, Jose I, Lin A, O'Reilly L, Allison C, Pellegrini M, Hotchkiss RS, Puthalakath H.

Sci Rep. 2016 Oct 3;6:34702. doi: 10.1038/srep34702.

12.

Isolation of Cardiomyocytes and Cardiofibroblasts for Ex Vivo Analysis.

Mbogo GW, Nedeva C, Puthalakath H.

Methods Mol Biol. 2016;1419:117-29. doi: 10.1007/978-1-4939-3581-9_10.

PMID:
27108436
13.

Experimental In Vivo Sepsis Models to Monitor Immune Cell Apoptosis and Survival in Laboratory Mice.

Doerflinger M, Glab J, Puthalakath H.

Methods Mol Biol. 2016;1419:69-81. doi: 10.1007/978-1-4939-3581-9_6.

PMID:
27108432
14.

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.

Isbel L, Srivastava R, Oey H, Spurling A, Daxinger L, Puthalakath H, Whitelaw E.

PLoS Genet. 2015 Dec 1;11(12):e1005693. doi: 10.1371/journal.pgen.1005693. eCollection 2015 Dec.

15.

Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.

Marshall B, Puthalakath H, Caria S, Chugh S, Doerflinger M, Colman PM, Kvansakul M.

Cell Death Dis. 2015 Mar 12;6:e1680. doi: 10.1038/cddis.2015.52.

16.

BH3-only proteins: a 20-year stock-take.

Doerflinger M, Glab JA, Puthalakath H.

FEBS J. 2015 Mar;282(6):1006-16. doi: 10.1111/febs.13190. Epub 2015 Jan 26. Review.

17.

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.

Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Review.

18.

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

Herold MJ, O'Reilly LA, Lin A, Srivastava R, Doerflinger M, Bouillet P, Strasser A, Puthalakath H.

Cell Death Dis. 2014 Jul 31;5:e1354. doi: 10.1038/cddis.2014.290. No abstract available.

19.

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.

Gangoda L, Doerflinger M, Srivastava R, Narayan N, Edgington LE, Orian J, Hawkins C, O'Reilly LA, Gu H, Bogyo M, Ekert P, Strasser A, Puthalakath H.

Cell Death Differ. 2014 Nov;21(11):1815-24. doi: 10.1038/cdd.2014.98. Epub 2014 Jul 11.

20.

Role of p53 in cAMP/PKA pathway mediated apoptosis.

Rahimi A, Lee YY, Abdella H, Doerflinger M, Gangoda L, Srivastava R, Xiao K, Ekert PG, Puthalakath H.

Apoptosis. 2013 Dec;18(12):1492-9. doi: 10.1007/s10495-013-0895-6.

PMID:
24002658
21.

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

Salmanidis M, Brumatti G, Narayan N, Green BD, van den Bergen JA, Sandow JJ, Bert AG, Silke N, Sladic R, Puthalakath H, Rohrbeck L, Okamoto T, Bouillet P, Herold MJ, Goodall GJ, Jabbour AM, Ekert PG.

Cell Death Differ. 2013 Oct;20(10):1370-80. doi: 10.1038/cdd.2013.92. Epub 2013 Jul 19.

22.

CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)-mediated apoptosis.

Lee YY, Moujalled D, Doerflinger M, Gangoda L, Weston R, Rahimi A, de Alboran I, Herold M, Bouillet P, Xu Q, Gao X, Du XJ, Puthalakath H.

Cell Death Differ. 2013 Jul;20(7):941-52. doi: 10.1038/cdd.2013.29. Epub 2013 Apr 12.

23.

Cre transgene results in global attenuation of the cAMP/PKA pathway.

Gangoda L, Doerflinger M, Lee YY, Rahimi A, Etemadi N, Chau D, Milla L, O'Connor L, Puthalakath H.

Cell Death Dis. 2012 Aug 9;3:e365. doi: 10.1038/cddis.2012.110.

24.

The PKA paradox: is Bim the answer?

Coley AM, Moujalled D, Puthalakath H.

Cell Cycle. 2011 Mar 1;10(5):729-30. Epub 2011 Mar 1. No abstract available.

PMID:
21311230
25.

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim.

Moujalled D, Weston R, Anderton H, Ninnis R, Goel P, Coley A, Huang DC, Wu L, Strasser A, Puthalakath H.

EMBO Rep. 2011 Jan;12(1):77-83. doi: 10.1038/embor.2010.190. Epub 2010 Dec 10.

26.

Endoplasmic reticulum stress and BCL-2 family members.

Weston RT, Puthalakath H.

Adv Exp Med Biol. 2010;687:65-77. Review.

PMID:
20919638
27.

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

O'Reilly LA, Kruse EA, Puthalakath H, Kelly PN, Kaufmann T, Huang DC, Strasser A.

J Immunol. 2009 Jul 1;183(1):261-9. doi: 10.4049/jimmunol.0803853.

28.

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G.

Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17. Review.

29.

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, Cretney E, Smyth MJ, Silke J, Hakem R, Bouillet P, Mak TW, Dixit VM, Strasser A.

Immunity. 2009 Jan 16;30(1):56-66. doi: 10.1016/j.immuni.2008.10.017.

30.

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM.

Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005.

31.

Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.

Wong WW, Puthalakath H.

IUBMB Life. 2008 Jun;60(6):390-7. doi: 10.1002/iub.51. Review.

32.

Ubiquitylation and cancer development.

Miasari M, Puthalakath H, Silke J.

Curr Cancer Drug Targets. 2008 Mar;8(2):118-23. Review.

PMID:
18336194
33.

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.

Lee EF, Czabotar PE, van Delft MF, Michalak EM, Boyle MJ, Willis SN, Puthalakath H, Bouillet P, Colman PM, Huang DC, Fairlie WD.

J Cell Biol. 2008 Jan 28;180(2):341-55. doi: 10.1083/jcb.200708096. Epub 2008 Jan 21.

34.

Fold up or perish: unfolded protein response and chemotherapy.

Strasser A, Puthalakath H.

Cell Death Differ. 2008 Feb;15(2):223-5. Epub 2007 Nov 30. No abstract available.

35.

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain.

Strasser A, Puthalakath H, O'Reilly LA, Bouillet P.

Immunol Cell Biol. 2008 Jan;86(1):57-66. Epub 2007 Nov 20. Review.

PMID:
18026176
36.

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics.

Cragg MS, Kuroda J, Puthalakath H, Huang DC, Strasser A.

PLoS Med. 2007 Oct;4(10):1681-89; discussion 1690.

37.

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

Huntington ND, Puthalakath H, Gunn P, Naik E, Michalak EM, Smyth MJ, Tabarias H, Degli-Esposti MA, Dewson G, Willis SN, Motoyama N, Huang DC, Nutt SL, Tarlinton DM, Strasser A.

Nat Immunol. 2007 Aug;8(8):856-63. Epub 2007 Jul 8.

38.

ER stress triggers apoptosis by activating BH3-only protein Bim.

Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A.

Cell. 2007 Jun 29;129(7):1337-49.

39.

Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma.

Kelly PN, Puthalakath H, Adams JM, Strasser A.

Blood. 2007 Jun 1;109(11):4907-13. Epub 2007 Feb 22.

40.

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC, Kimura S, Ottmann OG, Druker BJ, Villunger A, Roberts AW, Strasser A.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14907-12. Epub 2006 Sep 22. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16614.

41.

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

Adams JM, Huang DC, Strasser A, Willis S, Chen L, Wei A, van Delft M, Fletcher JI, Puthalakath H, Kuroda J, Michalak EM, Kelly PN, Bouillet P, Villunger A, O'Reilly L, Bath ML, Smith DP, Egle A, Harris AW, Hinds M, Colman P, Cory S.

Cold Spring Harb Symp Quant Biol. 2005;70:469-77.

PMID:
16869785
42.

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers.

Huntington ND, Xu Y, Puthalakath H, Light A, Willis SN, Strasser A, Tarlinton DM.

Nat Immunol. 2006 Feb;7(2):190-8. Epub 2005 Dec 25.

PMID:
16378097
43.
44.

Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate.

Navarro C, Puthalakath H, Adams JM, Strasser A, Lehmann R.

Nat Cell Biol. 2004 May;6(5):427-35. Epub 2004 Apr 11.

PMID:
15077115
45.

Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.

O'Reilly LA, Divisekera U, Newton K, Scalzo K, Kataoka T, Puthalakath H, Ito M, Huang DC, Strasser A.

Cell Death Differ. 2004 Jul;11(7):724-36.

46.

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.

Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG.

Biochem J. 2004 Feb 1;377(Pt 3):597-605.

47.

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells.

Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A.

J Exp Med. 2003 Oct 6;198(7):1119-26. Epub 2003 Sep 29.

48.
49.

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes.

Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H, Pellegrini M, Cory S, Adams JM, Strasser A.

Nature. 2002 Feb 21;415(6874):922-6. Erratum in: Nature 2002 Jul 4;618(6893):108.

PMID:
11859372
50.

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.

Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A.

Science. 2001 Sep 7;293(5536):1829-32. Erratum in: Science 2002 Aug 16;297(5584):1122.

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