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Items: 17


Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.

Hong SR, Wang CL, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T, Lin YC.

Nat Commun. 2018 Apr 30;9(1):1732. doi: 10.1038/s41467-018-03952-z.


G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R.

Sci Signal. 2018 Feb 6;11(516). pii: eaao5749. doi: 10.1126/scisignal.aao5749.


CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R.

Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002. No abstract available.


CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R.

Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. Erratum in: Dev Cell. 2018 Jan 22;44(2):271.


Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T.

Cell. 2017 Jan 12;168(1-2):264-279.e15. doi: 10.1016/j.cell.2016.12.032. Epub 2017 Jan 12.


An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.

Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW.

EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4.


Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.

Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG.

Nature. 2015 May 7;521(7550):99-104. doi: 10.1038/nature14424. Epub 2015 Apr 29.


Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia.

Pusapati GV, Rohatgi R.

EMBO J. 2014 Sep 1;33(17):1852-4. doi: 10.15252/embj.201489294. Epub 2014 Jul 17. No abstract available.


EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.

Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R.

Dev Cell. 2014 Mar 10;28(5):483-96. doi: 10.1016/j.devcel.2014.01.021. Epub 2014 Feb 27.


A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.

Armacki M, Joodi G, Nimmagadda SC, de Kimpe L, Pusapati GV, Vandoninck S, Van Lint J, Illing A, Seufferlein T.

Oncogene. 2014 Feb 27;33(9):1167-80. doi: 10.1038/onc.2013.43. Epub 2013 Mar 18.


Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.

Pusapati GV, Luchetti G, Pfeffer SR.

J Biol Chem. 2012 Dec 7;287(50):42129-37. doi: 10.1074/jbc.M112.414565. Epub 2012 Oct 22.


RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.

Nottingham RM, Pusapati GV, Ganley IG, Barr FA, Lambright DG, Pfeffer SR.

J Biol Chem. 2012 Jun 29;287(27):22740-8. doi: 10.1074/jbc.M112.362558. Epub 2012 May 25.


Protein kinase D regulates RhoA activity via rhotekin phosphorylation.

Pusapati GV, Eiseler T, Rykx A, Vandoninck S, Derua R, Waelkens E, Van Lint J, von Wichert G, Seufferlein T.

J Biol Chem. 2012 Mar 16;287(12):9473-83. doi: 10.1074/jbc.M112.339564. Epub 2012 Jan 6.


Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.

Azoitei N, Kleger A, Schoo N, Thal DR, Brunner C, Pusapati GV, Filatova A, Genze F, Möller P, Acker T, Kuefer R, Van Lint J, Baust H, Adler G, Seufferlein T.

Neuro Oncol. 2011 Jul;13(7):710-24. doi: 10.1093/neuonc/nor084.


Protein kinase D2 is an essential regulator of murine myoblast differentiation.

Kleger A, Loebnitz C, Pusapati GV, Armacki M, Müller M, Tümpel S, Illing A, Hartmann D, Brunner C, Liebau S, Rudolph KL, Adler G, Seufferlein T.

PLoS One. 2011 Jan 27;6(1):e14599. doi: 10.1371/journal.pone.0014599.


Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.

Azoitei N, Pusapati GV, Kleger A, Möller P, Küfer R, Genze F, Wagner M, van Lint J, Carmeliet P, Adler G, Seufferlein T.

Gut. 2010 Oct;59(10):1316-30. doi: 10.1136/gut.2009.206813. Epub 2010 Aug 23.


Role of the second cysteine-rich domain and Pro275 in protein kinase D2 interaction with ADP-ribosylation factor 1, trans-Golgi network recruitment, and protein transport.

Pusapati GV, Krndija D, Armacki M, von Wichert G, von Blume J, Malhotra V, Adler G, Seufferlein T.

Mol Biol Cell. 2010 Mar 15;21(6):1011-22. doi: 10.1091/mbc.E09-09-0814. Epub 2010 Jan 20.

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